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About Advantage Multi for Cats - Topical Heartworm

Key Ingredients Imidacloprid and Moxidectin Are Used to Control Fleas and Prevent Heartworm

By Team PetCareRx.

indications for Advantage Multi for Cats

Advantage Multi for Cats are found in topical prescription medications with effective components for flea control and heartworm prevention, and come with endectocides, endoparasiticides and ectoparasiticides properties. Medications with Advantage Multi for Cats commonly are used for the prevention of heartworm disease caused by L3 and L4 larvae of Dirofilaria immitis. These medications are chiefly indicated for the treatment of flea infestations (Ctenocephalides felis) and ear mite infestations (Otodectes cynotis). Medications with Advantage Multi for Cats are effective as a treatment strategy for flea allergy dermatitis (FAD) and also for the elimination of certain intestinal parasites in cats. Imidacloprid exhibits high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the CNS of the flea, resulting in the paralysis and death of the insect. Moxidectin is efficient to fight internal and external parasites including larval stages (L3, L4) of Dirofilaria immitis and gastrointestinal nematodes. Moxidectin interacts with GABA and glutamate-gated chloride channels, resulting in the opening of the chloride channels on the postsynaptic junction. This action triggers the inflow of chloride ions and creates a permanent resting state, resulting in the paralysis and eventually the death of the parasite.


Medications with Advantage Multi for Cats need to be used with extra caution on breeding, pregnant, nursing and geriatric cats. These medications are not recommended to be used on sick, injured or underweight cats (less than 2lbs), and cats less than 9 weeks old. Oral ingestion of these medications could result in conditions like decreased appetite, vomiting and hyper salivation. In households with multiple pets, the treated cats need to be kept isolated from others at least for 30 minutes after application. Also, keep children away from the treated pets for 2 hours after application.


The suggested minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin (once in a month), by topical administration.

Side Effects

In rare instances, pets are reported to exhibit side effects like behavioral changes, uneasiness, increased thirst, hyper-salivation, tiredness, and coughing and gagging.

Brand/Generic equivalents

AdvocateAceprom, acetylpromazine, Combistress, Neurotranq, Promace and Vetranquil

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Advantage Multi for Cats at a glance

  • 1For cats
  • 2A heartworm and other parasite preventative
  • 3A topical medication
  • 4Treats flea allergy dermatitis and prevents heartworm, hookworm, roundworm, whipworm, fleas, and ear mites
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