Frontline Plus for Dogs
Frontline Plus for Dogs
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At a Glance
Kills fleas at every part of the flea life cycle from eggs to larvae to adult
Kills ticks and prevents their dangerous diseases (e.g., Lyme disease)
Requires a monthly, sterile pipette to be applied between the dog 's shoulders
Works for the next 30 days via the oil glands in the dog 's skin and hair

Frontline Plus for Dogs

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At a Glance
Kills fleas at every part of the flea life cycle from eggs to larvae to adult
Kills ticks and prevents their dangerous diseases (e.g., Lyme disease)
Requires a monthly, sterile pipette to be applied between the dog 's shoulders
Works for the next 30 days via the oil glands in the dog 's skin and hair

Ultimate Guide to Frontline Plus For Dogs

Meet the Trusted Parasite Treatment: Frontline Plus For Dogs!

Frontline Plus For Dogs is a veterinarian-recommended dog flea and tick treatment trusted by its customers for 20 years! Frontline Plus is a monthly, spot-on treatment that protects your pet for the next 30 days. From a first-time pet parent to a Frontline dog expert, Frontline Plus guarantees an easy-to-use and effective treatment for your dogs!

How does Frontline Plus For Dogs work?

Frontline Plus For Dogs is a medication with two powerful active ingredients (secret weapons) - Fipronil and (S)-methoprene - that kill adult ticks and fleas at every step of the flea 's life cycle. Frontline Plus kills the parasites on contact by storing itself in the oil glands in your pet 's skin and hair follicles continuously for the next 30 days.

Active ingredient Fipronil is a phenylpyrazole insecticide that disrupts the insect 's central nervous system by blocking the GABA-gated chloride channel that regulates cellular excitability and glutamate-gated chloride (GluCl) channels that controls movement, feeding, and behavior. This causes hyper excitement to the contaminated insect 's nerves and muscles.

Active ingredient (S)-methoprene is an insecticide chemical that controls hatching flea eggs and obstructs the development of the immature flea (i.e., flea pupae and larvae) into a breeding adult.

How is Frontline Plus administered?

Frontline Plus For Dogs is a monthly, spot-on treatment that is applied between a dog 's shoulders and protects your dog for the next 30 days. Frontline Plus products start killing fleas after four hours and effectively kill 100% fleas after 12 hours.

Frontline For Dogs comes in four different color boxes depending on the dog 's weight with differing milliliter (mL) application amounts. Each box has the same percentage of the active ingredients and comes in 3- and 6-month supplies. See the dosage chart below:

Body Weight

Application amount (mL)

5 - 22 lbs.

0.67

23 - 44 lbs.

1.34

45 - 88 lbs.

2.68

89 - 132 lbs.

4.02


What are the precautions of which you should be aware?

Consult your veterinarian before using Frontline Plus because of any potentially negative interactions with other medications that your dog may be taking, like another flea and tick control product.

Also, ensure that your dog is dry before application and that they are not wet for 24 hours after application.

What are the potential side effects of which you should be aware?

Slight irritation at the point of application may be experienced. If the irritation persists, contact your vet immediately.

Frequently Asked Questions
  1. Why am I seeing more fleas on my dog or in my home after applying Frontline Plus For Dogs?

    On the dog, the fleas that come into contact with Frontline Plus rise to the top of the haircoat as they die. In terms of the home, those fleas must have been eggs before you started using the medication. Consecutive monthly applications year-round of Frontline Plus For Dogs will assist with the elimination of an indoor infestation.

  2. Is there Frontline Plus for small dogs?

    Frontline Plus 5 - 22 lbs. is the orange box and for the smallest dogs that can use the medication.

  3. Is Frontline Plus for puppies?

    Frontline Plus for Dogs is safe for use on dogs 8 weeks and older.

  4. Is there other Frontline pet medicine for cats?

    Yes. Frontline Plus For Cats uses the same ingredients, has the same administration, and gives the same results. Frontline Plus can be used on dogs and cats ONLY.

  5. What are the reviews for Frontline Plus?

    Frontline Plus For Dogs reviews rate at 4.5 out of 5 stars. Most reviewers say that Frontline Plus is a quality and effective product for their dogs in any environment, and it is the only widely-trusted flea and tick medicine for their furry best friends.

  6. Explain the Frontline Plus application.

    Frontline Plus must be applied to a pet that is dry and then dry after 24-hours after application. It is a topical solution, spot-on treatment that is applied between the pet 's shoulders via a sterile applicator (i.e., pipette) every 30 days.

Concluding Thoughts

The most important thing that you should know about Frontline Plus For Dogs is its power to protect your dog and home from external parasites (i.e., fleas during their life cycle, ticks, lice, and chewing lice). Dogs should be pampered and protected with the best flea and tick treatment out there in order to have the best quality of life.

DISCLAIMER: FDA law restricts Frontline Plus For Dogs only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian if this is a suitable product for your pet and for your home.

How Effective Is Frontline Plus for Dogs?
Answer

Frontline Plus for Dogs is very effective and one of the best flea and tick control measures for dogs. When you use Frontline Plus, dogs are able to get rid of pesky parasites residing on their bodies. Frontline for ticks and fleas guarantees 100 percent flea and tick removal from your dogโ€™s skin. The medication does not only destroy adult fleas and ticks, but it also takes care of all the other stages of these parasites. Besides, Frontline for ticks and fleas starts to take effect within just 24 hours of application. And its presence in your dogโ€™s skin and hair follicles over the next 30 days continuously kills fleas and ticks in the various stages of their life cycles.

Why Is Frontline Plus Not Working on My Dog?
Answer

Before you can know why it is not working for your dog, you first need to know the answer to another question โ€“ how does Frontline work? Frontline plus has two powerful active ingredients known as Fipronil and (S)-methoprene. These two help kill the fleas and ticks, no matter what part of the life cycle they are in. They do so by positioning themselves in the hair follicles of your dogs for 30 days. The medication might not be working probably because it is being washed off and cannot store itself in the said positions. This could happen due to numerous reasons, but most probably because you are bathing your dog too early into the treatment. It is also possible that you are using a dog shampoo that is wearing out the presence of the medication. Ideally, you should wait 24 hours before bathing your dog after you have applied Frontline Plus.

How Long Does It Take Frontline Plus to Start Working?
Answer

Frontline Plus dog tick and flea control will take only 24 hours to start working. During that time, the medication will have spread all over its skin and body. Frontline Plus requires 24 hours to kill all the fleas on your dogโ€™s skin. It takes another 24 hours (total 48 hours) to destroy the tick infestation on their skin. After application, your dog will be safe from fleas and ticks for the next 30 days or so. During that time, the medication will continue to reside in the skin and hair follicles of your dog. In those positions, the Frontline Plus will continue to work its magic and fend off any flea or tick that might try to infest your dogโ€™s skin or take up territory.

How Long After Frontline Plus Can I Bathe My Dog?
Answer

You can bathe your dog 24 hours after you have applied the Frontline Plus for Dogs.

Can You Buy Frontline Plus Over the Counter?
Answer

Yes, you can buy Frontline Plus over the counter. Frontline for dog fleas is a flea and tick treatment medication that does not require any prescription for purchase. Unlike many other pet medications, this one does not need a vetโ€™s prior approval for usage. However, it is expected that you read the instructions on the bottle before you apply it, or talk to a vet if you are confused.

How Often Do You Apply Frontline Plus for Dogs?
Answer

You should apply Frontline Plus for Dogs every 30 days. Under critical circumstances, and the supervision of a vet, you can also apply every 2 weeks. Frontline for puppies should be applied in a much lesser amount (under 1 mL) per body weight than adult dogs.

What to Do if Dog Still Has Fleas After Frontline?
Answer

You can bathe your dog and reapply if your dog still has fleas after Frontline treatment. You should wait for at least 24 hours to see if the first application is working or not.

Do Fleas Jump off After Treatment?
Answer

Fleas are usually dead within 24 hours after you have used the Frontline Plus treatment.

Frontline plus contains two active ingredients - Fipronil and S-methoprene.

Dogs taking Frontline Plus may experience a slight irritation at the point of application. If the irritation persists, contact your vet immediately.

Frontline Plus should be administered once a month. To apply the medication, open the pouch by holding it upright and snapping the tip, holding it away from your face and body. Part the hair between your dogโ€™s shoulder blades, placing the tip of the applicator on the exposed skin and squeezing out the entire contents of the tube. Do not simply apply to the hair.

Store Frontline Plus at room temperature.

Frontline is manufactured by Merial
Option UPC/SKU
Orange - 5-22 lbs., 3 Month Supply 350604287001
Blue - 23-44 lbs., 3 Month Supply 350604287100
Purple - 45-88 lbs., 3 Month Supply 350604287209
Red - 89-132 lbs., 3 Month Supply 350604287308
Orange - 5-22 lbs., 6 Month Supply 350604288008
Blue - 23-44 lbs., 6 Month Supply 350604288107
Purple - 45-88 lbs., 6 Month Supply 350604288206
Red - 89-132 lbs., 6 Month Supply 350604288305

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