Product Comparison: Frontline vs Advantage for Cats Flea and Tick Protection Options for Your Cat

Product Comparison: Frontline vs Advantage for Cats
expert or vet photo
vet verified PetCareRx Staff Veterinarian DVM

Thumbnail of Advantage II for Cats

Advantage II for Cats

Flea & Tick
{{petcare_price|currency}} Price in Cart w/PetPlus {{petplus_price|currency}} See PetPlus Price in Cart

Compare the different aspects of Frontline vs Advantage. You'll learn what you need to know to decide which one is best for your feline.

How to Decide Between Frontline vs. Advantage for Cats?

Wondering how to choose between Frontline vs. Advantage for cats? Both medications are effective at stopping flea growth and development, but there are a few key differences that should be addressed:

  • Frontline Plus will kill flea growth and inhibit further development within 24 hours of application and continue working for one month (post-application).
  • Frontline Plus will also protects against ticks and lice.
  • Advantage II begins working within 12 hours of application and will also continue to kill fleas/eggs for one month post-application.
  • Advantage II does not kill ticks or lice.

These days, cat owners have more tools than ever to control parasites. Makers of such parasite control products have improved their formulations to be more effective at keeping your cat pest free. However, just because the medication has gotten more effective does not mean that pet parents don't need to compare flea treatments for cats. There are so many to choose from, like Advantage Multi for cats or Revolution for cats, it is important to know what they all do. Two popular examples are Advantage for Cats and Frontline for Cats, but what exactly is the difference between them? Which medication comes out on top in Frontline vs Advantage?

Below, we outline the particular benefits of these improved products—Advantage II for cats and Frontline Plus for Cats—so you can make an informed decision about which will be best for your cat.

Advantage II for Cats

BayerDVM replaced Advantage for Cats with Advantage II, now including an insect growth regulator (IGR) in the mix. This IGR inhibits the growth of flea eggs, thus interrupting the flea life cycle, stopping fleas before they even start growing.

One great asset of Advantage II is that not only will it start killing adult and larvae fleas within 12 hours of application, one application will keep fleas at bay for a full month. Any re-infestation of adult fleas after the first strike will be killed within 2 additional hours.

Other benefits of Advantage II for Cats is that the formulation is waterproof—so no need for reapplication after baths—and the product kills fleas on contact, so the pests don’t have to bite your cat to get killed.

Advantage II should only be used on cats and kittens who are 7 weeks of age or older.

Frontline Plus for Cats

Like Advantage II, Frontline Plus for Cats contains an agent that inhibits flea growth and development. This product replaces Frontline for Cats with a more effective parasite control.

Frontline Plus starts killing fleas within 24 hours of application and then goes on keeping fleas away for one month by stopping the next generation of fleas from being born. What’s more, Frontline Plus is also effective at killing chewing lice and ticks, which can carry Lyme disease.

This parasite control is waterproof, so reapplication after bathing won’t be necessary.

Use of Frontline Plus should start with cats and kittens 8 weeks of age or older.

Which Should You Buy?

When choosing between Frontline vs Advantage for cats, pet owners should consider their cats’ risk of exposure to pests. Those whose cats are exposed to ticks and lice may want to purchase Frontline Plus. Other owners may be less concerned about ticks or lice, in which case Advantage II, which has fewer ingredients, may be better for your cat.

Also, make sure to ask your vet which product they would recommend for your particular cat and their lifestyle. Let your vet know if your cat is an indoor-only pet, as less frequent treatments might make sense. Also, be sure to discuss any health conditions your cat may have, and whether a spot-on treatment like Advantage II or Frontline Plus might affect them one way or another.

Whichever product you choose—Advantage II or Frontline Plus—your cat will surely be happier for it!

Frontline Plus vs Advantage II

Frontline Plus for Cats:

Advantage II: Effective 1 month; kills fleas within 12 hours. Waterproof against Adult fleas, flea larvae, and eggs. Recommended for 7 weeks and older.

Frontline Plus: Effective 1 month; kills pests within 24 hours. Waterproof against Adult fleas, flea larvae, and eggs; chewing lice; ticks. Recommended for 8 weeks and older.


Pests controlled


Recommended age of application

Advantage II

Effective 1 month; kills fleas within 12 hours

Adult fleas, flea larvae, and eggs


7 weeks and older

Frontline Plus

Effective 1 month; kills pests within 24 hours

Adult fleas, flea larvae, and eggs; chewing lice; ticks


8 weeks and older

Frequently Asked Questions

Which is better: Advantage II or Frontline Plus?

For cats, Advantage II and Frontline Plus are both effective medications for eliminating fleas in all life stages and also last up to a month. Advantage II kills pests 12 hours earlier and works for cats a week earlier than Frontline Plus. Frontline Plus is waterproof against chewing lice and ticks. When it comes to severe infestations and broad-spectrum protection, Frontline Plus has become the better choice between the two.

What is the difference between Frontline and Frontline Plus?

Frontline and Frontline Plus are both used to prevent fleas and ticks. Both use the spot-on treatment via a pipette between the cat’s shoulder blades. However, Frontline Plus comes with a dual-action formula that not only kills fleas and ticks on your pet but prevents eggs and larvae infestations in and around your home.

Is Frontline Plus still effective?

Frontline Plus is 100% effective in treating all life stages of fleas and ticks within 12 to 24 hours following spot-on treatment, says Cambridge VetCare Animal Clinic. Frontline Plus works by a 24-hour-long process called translocation, where the medication spreads all over your pet’s body through the oil glands.

Which Frontline product is best?

According to 2022 Insider’s 5 Best Fleas and Tick Medicines, Frontline Plus is our top nonprescription recommendation! In just one easy application, Frontline Plus kills ticks and fleas, controls flea infestations, and kills chewing lice.
More on Protecting Your Cat

Is Cat Flea Control Necessary?
The Best Cat Breakaway Collars and Special Collars
Flea and Tick Season: When To Use What Treatment
How To Use Spot On Flea and Tick Treatment

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian with respect to your pet. It has, however, been verified by a licensed veterinarian for accuracy.

Was this article helpful?

You May Also Like