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Product Comparison: Frontline vs Advantage for Cats

Flea and Tick Protection Options for Your Cat

By August 21, 2013 | See Comments

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Product Comparison: Frontline vs Advantage for Cats

Compare the different aspects of Frontline vs Advantage. You'll learn what you need to know to decide which one is best for your feline.

These days, cat owners have more tools than ever to control parasites. Makers of such parasite control products have improved their formulations to be more effective at keeping your cat pest free. However, just because the medication has gotten more effective does not mean that pet parents don't need to compare flea treatments for cats. There are so many to choose from, like Advantage Multi for cats or Revolution for cats, it is important to know what they all do. Two popular examples are Advantage for Cats and Frontline for Cats, but what exactly is the difference between them? Which medication comes out on top in Frontline vs Advantage?

Below, we outline the particular benefits of these improved products—Advantage II for cats and Frontline Plus for Cats—so you can make an informed decision about which will be best for your cat.

Advantage II for Cats

BayerDVM replaced Advantage for Cats with Advantage II, now including an insect growth regulator (IGR) in the mix. This IGR inhibits the growth of flea eggs, thus interrupting the flea life cycle, stopping fleas before they even start growing.

One great asset of Advantage II is that not only will it start killing adult and larvae fleas within 12 hours of application, one application will keep fleas at bay for a full month. Any re-infestation of adult fleas after the first strike will be killed within 2 additional hours.

Other benefits of Advantage II for Cats is that the formulation is waterproof—so no need for reapplication after baths—and the product kills fleas on contact so the pests don’t have to bite your cat to get killed.

Advantage II should only be used on cats and kittens who are 7 weeks of age or older.

Frontline Plus for Cats

Like Advantage II, Frontline Plus for Cats contains an agent that inhibits flea growth and development. This product replaces Frontline for Cats with a more effective parasite control.

Frontline Plus starts killing fleas within 24 hours of application and then goes on keeping fleas away for one month by stopping the next generation of fleas from being born. What’s more, Frontline Plus is also effective at killing chewing lice and ticks, which can carry Lyme disease.

This parasite control is waterproof, so reapplication after bathing won’t be necessary.

Use of Frontline Plus should start with cats and kittens 8 weeks of age or older.

Which Should You Buy?

When choosing between Frontline vs Advantage for cats, pet owners should consider their cats’ risk of exposure to pests. Those whose cats are exposed to ticks and lice may want to purchase Frontline Plus. Other owners may be less concerned about ticks or lice, in which case Advantage II, which has fewer ingredients, may be better for your cat.

Also, make sure to ask your vet which product they would recommend for your particular cat and their lifestyle. Let your vet know if your cat is an indoor-only pet, as less frequent treatments might make sense. Also be sure to discuss any health conditions your cat may have, and whether a spot on treatment like Advantage II or Frontline Plus might affect them one way or another.

Whichever product you choose—Advantage II or Frontline Plus—your cat will surely be happier for it!



Pests controlled


Recommended age of application

Advantage II

Effective 1 month; kills fleas within 12 hours

Adult fleas, flea larvae, and eggs


7 weeks and older

Frontline Plus

Effective 1 month; kills pests within 24 hours

Adult fleas, flea larvae, and eggs; chewing lice; ticks


8 weeks and older


More on Protecting Your Cat

Is Cat Flea Control Necessary?
The Best Cat Breakaway Collars and Special Collars
Flea and Tick Season: When To Use What Treatment
How To Use Spot On Flea and Tick Treatment

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian with respect to your pet. It has, however, been verified by a licensed veterinarian for accuracy.


Frontline had worked well in the past but this year Frontline was worthless. The problem just got worse. We bought Advantage and by the next day the cat had stopped scratching.


I knew frontline just wasn't working
anymore!! It's like using the same deodorant for years, it just stops working... so you have to switch them up in a healthy manner.cant go from using a high quality to hartz( which don't use their products, esp on kittens, watched a heartbreaking accident years ago, the young lady didn't know a simple HARTZ flea collar could make her kitten seriously ill, then death...super sad) we have to be careful w our furr babies products, switching their flea meds w care.. I am in love with advantage II for cats... it's just refreshing to know something WORKS with out having to obsess over it, it's money well spent and everyone is happy...I think frontline should reimburse us for their bullshit prices they make us pay, just to rob us, knowing the product is hardly working in the USA anymore the way it should be .. people are shocked and shouldn't be... fleas think of frontline as a soft drink, it simply doesn't break any part of their may as well take 60$ n flush it, then spritz your cat w apple juice and ask God.. why!? Why aren't the fleas dieing!? Why is my house infested, why why why..


How long after treating with Frontline did you use Advantage? Did you have to wait a certain length of time? Frontline certainly not working after 10 days. Can't wait to use the Advantage. Thanks


There is only anecdotal evidence of this...but let me add my anecdote to the fire and you can judge for yourself.
I have a fully indoor medium hair cat, she has never been outside since she was picked up by the shelter I adopted her from. I have kept her inside because my area is rife with stray cats who are quite obviously sick, malnourished, and suffering from skin conditions.
A few months into bringing her home, she got fleas. I asked for the vet's recommendation and he suggested frontline and a dawn dish soap bath every 4 weeks. So I did this and she would have reduced fleas for 48 hours, max. I kept on, treated the carpet and the perimeter of the house, constantly vacuuming and cleaning and washing rugs. The same issues continued.
Finally, I read that some people have been having issues because the fleas have become resistant to the active ingredient in frontline. These people suggested advantage or revolution. We tried Advantage II and have had no issues since.
Go Advantage if you have the option, not even worth the potential annoyance of Frontline.


I keep reading that Frontline didn't work this year - although it has in the past. Is there any reason for that?


i used frontline for 2 months and the flea population kept growing. today i used advantage II on my cats and the dead fleas were falling off within hours! i wish i would have used advantage first and so do my cats.

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