Advantage Multi for Cats
Advantage Multi for Cats
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At a Glance
Two active ingredients to prevent and kill fleas, mites, and intestinal parasites
Active ingredient imidacloprid that paralyzes and kills adult fleas on contact
Active ingredient moxidectin is a parasiticide that protects against three intestinal parasites (i.e., roundworms, hookworms, and whipworms) and is a 100% effective heartworm preventative in cats
Monthly topical solution that effectively works for the next 30 days

Advantage Multi for Cats

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At a Glance
Two active ingredients to prevent and kill fleas, mites, and intestinal parasites
Active ingredient imidacloprid that paralyzes and kills adult fleas on contact
Active ingredient moxidectin is a parasiticide that protects against three intestinal parasites (i.e., roundworms, hookworms, and whipworms) and is a 100% effective heartworm preventative in cats
Monthly topical solution that effectively works for the next 30 days

Advantage Multi Logo

Ultimate Guide to Advantage Multi for Cats

Meet the Feline Parasite Protector: Advantage Multi for Cats!

Advantage Multi for Cats is a veterinarian-recommended topical prescription medication used for flea control, heartworm prevention, sarcoptic mange treatment, and elimination of hookworms, roundworms, and whipworms in cats. Advantage Multi for Cats is a monthly, topical solution that ensures your cat is in a happy and comfortable condition!

How does Advantage Multi for Cats work?

Advantage Multi for Cats is a medication with two active ingredients - Imidacloprid and Moxidectin.

Imidacloprid is a systemic insecticide that binds to invertebrates' receptors of insect nerve cells. The insecticide disrupts and damages the insect's central nervous system (CNS) through important chloride channels. The fleas eventually die on contact with cats' skin and hair coat via insect paralysis.

Moxidectin is an avermectin parasiticide and heartworm preventative from the heartworm's immature form called Dirofilaria immitis to adult heartworms. Moxidectin treats three intestinal parasites (i.e., hookworms, roundworms, and whipworms) in cats. Moxidectin is efficient in eliminating internal and external parasites in the larval stage.

Together, they can eliminate ear mites infestation (Otodectes cynotis).

How is Advantage Multi for Cats administered?

Advantage Multi for Cats is administered topically with an easy-to-apply single dose applicator tube (i.e., pipette) directly on the skin between the cat's shoulder blades. The medication should be applied three to four spots along the cat's spine. Advantage Multi for Cats begins to kill fleas within four hours and kills 98% of fleas within 12 hours.

After applying your cat's treatment, wait two hours to pet your cat, and 24 hours to bathe your cat. This is in order for the medication to be properly absorbed into the cat's skin and work as effectively as possible.

Below is a dosage chart with three strengths and three boxes, depending on the cat's body weight. The usual monthly dosage is 4.5 mg imidacloprid per pound and 0.45 mg moxidectin per pound once a month by topical administration.

Body Weight



2 - 5 lbs.



5.1 - 9 lbs.



9.1 - 18 lbs.



The above two packages that are available have a 6-month supply.

What are the precautions of which you should be aware?

Inform your veterinarian of any medications, supplements, and vitamins that your cat already takes, due to possible negative interactions with Advantage Multi for Cats.

The medication is not recommended to be given to sick, injured, or underweight cats. Be wary with pregnant, breeding, nursing, and geriatric cats.

After treatment, ensure that the treated cat is away from any other household pets for at least 30 minutes. You must avoid petting your cat for two hours after application.

What are the potential side effects of which you should be aware?

Advantage Multi for Cats's most common adverse reactions reported may include behavioral changes, coughing, drowsiness, polypdipsia, decreased appetite, vomiting, and hypersalivation. Immediately contact your veterinarian if you observe any of these listed. 

Frequently Asked Questions
  1. What is Advantage Multi for Cats?

    Advantage Multi for Cats is a #1 cat medication in flea and ear mite infestation control, heartworm prevention, and intestinal parasitic worm treatment in cats. Together with its insecticide imidacloprid and a parasiticide moxidectin, this medication is a monthly, 100% effective topical solution against most internal and external parasites!

  2. What is the difference between Advantage Multi for Cats versus
    Advantage Multi for Dogs?

    Advantage Multi for Dogs is the #1 dog medication in flea prevention, heartworm control, and intestinal parasitic worm killing. Both use the same active ingredients and kill 98% of fleas within 12 hours of application. Both even have the same administration and side effects. The only difference is the dosage depending on different body weight.

  3. What do the Advantage Multi for Cats reviews say?

    Advantage Multi for Cats reviews rate 4.5 out of 5 stars. Most reviewers say that Advantage Multi for Cats is medication that is effective and that they trust for their cats.

  4. Is Advantage Multi for Cats for kittens?

    Advantage Multi for Cats can be administered to kittens that are at least 9 weeks old and weighing 2 pounds.

Concluding Thoughts

The most important thing that you should know about Advantage Multi for Cats is its multi-use power to protect your cat from most internal and external parasites at all life stages.

From a preventative of the fatal heartworm disease to controlling the ear mites and breaking the flea life cycle to killing dangerous intestinal worms, this veterinary product is a powerhouse on the market!

DISCLAIMER: FDA law restricts Advantage Multi for Cats only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian whether Advantage Multi for Cats is suitable for your cat. Ask your licensed veterinarian to prescribe an exact dosage and other specifications prescribed for your cat.

Advantage Multi for Cats contains 10% Imidacloprid, 1% Moxidectin

Advantage Multi for Cats are found in topical prescription medications with effective components for flea control and heartworm prevention, and come with endectocides, endoparasiticides and ectoparasiticides properties. Medications with Advantage Multi for Cats commonly are used for the prevention of heartworm disease caused by L3 and L4 larvae of Dirofilaria immitis. These medications are chiefly indicated for the treatment of flea infestations (Ctenocephalides felis) and ear mite infestations (Otodectes cynotis). Medications with Advantage Multi for Cats are effective as a treatment strategy for flea allergy dermatitis (FAD) and also for the elimination of certain intestinal parasites in cats. Imidacloprid exhibits high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the CNS of the flea, resulting in the paralysis and death of the insect. Moxidectin is efficient to fight internal and external parasites including larval stages (L3, L4) of Dirofilaria immitis and gastrointestinal nematodes. Moxidectin interacts with GABA and glutamate-gated chloride channels, resulting in the opening of the chloride channels on the postsynaptic junction. This action triggers the inflow of chloride ions and creates a permanent resting state, resulting in the paralysis and eventually the death of the parasite.

In some rare cases, cats that are sensitive to the ingredients in Advantage Multi for Cats may experience sluggishness, changes in behavior, general discomfort, excessive salivation, increase in thirst, coughing, and/or gagging. If these symptoms persist, consult your veterinarian immediately. Oily buildup or stiffness may occur around the area of application.

Advantage Multi for Cats is not to be used on sickly or underweight cats, and is only ment to be used topically. If ingested orally, it can cause hypersalivation, tremors, vomiting, and appetite loss.

Medications with Advantage Multi for Cats need to be used with extra caution on breeding, pregnant, nursing and geriatric cats. These medications are not recommended to be used on sick, injured or underweight cats (less than 2lbs), and cats less than 9 weeks old. Oral ingestion of these medications could result in conditions like decreased appetite, vomiting and hyper salivation. In households with multiple pets, the treated cats need to be kept isolated from others at least for 30 minutes after application. Also, keep children away from the treated pets for 2 hours after application.

In rare instances, pets are reported to exhibit side effects like behavioral changes, uneasiness, increased thirst, hyper-salivation, tiredness, and coughing and gagging.

The suggested minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin (once in a month), by topical administration.

Consult a veterinarian to determine the proper dosage of Advantage Multi for Cats for your pet. Break the seal and remove the cap of a tube of the appropriate dosage; part the hair at the base of the catโ€™s head, place the tip of the tube on the exposed skin and apply the entire contents of the tube. Lift the tube away from the skin and then release the pressure.

Keep the product away from the catโ€™s eyes; do not allow the cat to lick the product or ingest it in any way, and keep pets separated from each other to prevent them from licking each otherโ€™s application sites.

Store Advantage Multi for Cats in a cool, dry place.

Advantage is manufactured by Bayer
Option UPC/SKU
Orange - 5.1-9 lbs., 6 Month Supply 724089914385
Purple - 9.1-18 lbs., 6 Month Supply 724089914460

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

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