Advantage Multi for Cats
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At a Glance
Two active ingredients to prevent and kill fleas, mites, and intestinal parasites
Active ingredient imidacloprid that paralyzes and kills adult fleas on contact
Active ingredient moxidectin is a parasiticide that protects against three intestinal parasites (i.e., roundworms, hookworms, and whipworms) and is a 100% effective heartworm preventative in cats
Monthly topical solution that effectively works for the next 30 days

Advantage Multi for Cats

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At a Glance
Two active ingredients to prevent and kill fleas, mites, and intestinal parasites
Active ingredient imidacloprid that paralyzes and kills adult fleas on contact
Active ingredient moxidectin is a parasiticide that protects against three intestinal parasites (i.e., roundworms, hookworms, and whipworms) and is a 100% effective heartworm preventative in cats
Monthly topical solution that effectively works for the next 30 days

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Ultimate Guide to Advantage Multi for Cats

Meet the Feline Parasite Protector: Advantage Multi for Cats!

Advantage Multi for Cats is a veterinarian-recommended topical prescription medication used for flea control, heartworm prevention, sarcoptic mange treatment, and elimination of hookworms, roundworms, and whipworms in cats. Advantage Multi for Cats is a monthly, topical solution that ensures your cat is in a happy and comfortable condition!

How does Advantage Multi for Cats work?

Advantage Multi for Cats is a medication with two active ingredients - Imidacloprid and Moxidectin.

Imidacloprid is a systemic insecticide that binds to invertebrates' receptors of insect nerve cells. The insecticide disrupts and damages the insect's central nervous system (CNS) through important chloride channels. The fleas eventually die on contact with cats' skin and hair coat via insect paralysis.

Moxidectin is an avermectin parasiticide and heartworm preventative from the heartworm's immature form called Dirofilaria immitis to adult heartworms. Moxidectin treats three intestinal parasites (i.e., hookworms, roundworms, and whipworms) in cats. Moxidectin is efficient in eliminating internal and external parasites in the larval stage.

Together, they can eliminate ear mites infestation (Otodectes cynotis).

How is Advantage Multi for Cats administered?

Advantage Multi for Cats is administered topically with an easy-to-apply single dose applicator tube (i.e., pipette) directly on the skin between the cat's shoulder blades. The medication should be applied three to four spots along the cat's spine. Advantage Multi for Cats begins to kill fleas within four hours and kills 98% of fleas within 12 hours.

After applying your cat's treatment, wait two hours to pet your cat, and 24 hours to bathe your cat. This is in order for the medication to be properly absorbed into the cat's skin and work as effectively as possible.

Below is a dosage chart with three strengths and three boxes, depending on the cat's body weight. The usual monthly dosage is 4.5 mg imidacloprid per pound and 0.45 mg moxidectin per pound once a month by topical administration.

Body Weight



2 - 5 lbs.



5.1 - 9 lbs.



9.1 - 18 lbs.



The above two packages that are available have a 6-month supply.

What are the precautions of which you should be aware?

Inform your veterinarian of any medications, supplements, and vitamins that your cat already takes, due to possible negative interactions with Advantage Multi for Cats.

The medication is not recommended to be given to sick, injured, or underweight cats. Be wary with pregnant, breeding, nursing, and geriatric cats.

After treatment, ensure that the treated cat is away from any other household pets for at least 30 minutes. You must avoid petting your cat for two hours after application.

What are the potential side effects of which you should be aware?

Advantage Multi for Cats's most common adverse reactions reported may include behavioral changes, coughing, drowsiness, polypdipsia, decreased appetite, vomiting, and hypersalivation. Immediately contact your veterinarian if you observe any of these listed. 

Frequently Asked Questions
  1. What is Advantage Multi for Cats?

    Advantage Multi for Cats is a #1 cat medication in flea and ear mite infestation control, heartworm prevention, and intestinal parasitic worm treatment in cats. Together with its insecticide imidacloprid and a parasiticide moxidectin, this medication is a monthly, 100% effective topical solution against most internal and external parasites!

  2. What is the difference between Advantage Multi for Cats versus
    Advantage Multi for Dogs?

    Advantage Multi for Dogs is the #1 dog medication in flea prevention, heartworm control, and intestinal parasitic worm killing. Both use the same active ingredients and kill 98% of fleas within 12 hours of application. Both even have the same administration and side effects. The only difference is the dosage depending on different body weight.

  3. What do the Advantage Multi for Cats reviews say?

    Advantage Multi for Cats reviews rate 4.5 out of 5 stars. Most reviewers say that Advantage Multi for Cats is medication that is effective and that they trust for their cats.

  4. Is Advantage Multi for Cats for kittens?

    Advantage Multi for Cats can be administered to kittens that are at least 9 weeks old and weighing 2 pounds.

Concluding Thoughts

The most important thing that you should know about Advantage Multi for Cats is its multi-use power to protect your cat from most internal and external parasites at all life stages.

From a preventative of the fatal heartworm disease to controlling the ear mites and breaking the flea life cycle to killing dangerous intestinal worms, this veterinary product is a powerhouse on the market!

DISCLAIMER: FDA law restricts Advantage Multi for Cats only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian whether Advantage Multi for Cats is suitable for your cat. Ask your licensed veterinarian to prescribe an exact dosage and other specifications prescribed for your cat.

  • Advantage Brand
  • Heartworm & Deworming Pharmacy
  • Flea & Tick Pharmacy
  • Elanco Animal Health Manufacturer
  • Mature Adult Life Stage
  • Senior Life Stage
  • Kitten Life Stage
  • Adult Life Stage
  • Spot On/Topical Application
  • Cat Pet Type

What Does Advantage Multi for Cats Do?

The Advantage Multi Cat topical solution kills and prevents fleas, mites, and intestinal parasites in cats. The Bayer Advantage Multi for cats uses two active ingredients to kill and prevent all these parasites. Imidacloprid is an active chemical that paralyzes and kills adult fleas the moment it comes in contact with them. Then you have the active ingredient moxidectin. It is mainly a parasiticide. Moxidectin keeps the cat safe from intestinal parasites like roundworms, hookworms, and whipworms. Moxidectin can also effectively prevent heartworms in cats. The Advantage Multi Cats topical solution effectively works for 30 days from the first application.

Is Advantage Multi for Cats Prescription Only?

Yes, the Advantage Multi Cat topical solution is prescription only. That means you cannot buy the Advantage Multi for Cats without a vet prescription. This topical solution is prescription-only because of its contents. Advantage Multi ingredients include a lot of chemicals that you have to administer in a controlled manner. The slightest miscalculations in administering the dosages can lead to serious repercussions. Thus, like many other cat and dog medications, Advantage Multi for Cats is also prescription-only. You cannot buy this topical solution directly off the counter. For purchasing it, you must first obtain clearance from a licensed vet.

Is Advantage Multi Safe for Cats?

Yes, Advantage Multi is safe for cats. The topical solution is also effective in treating parasites in cats. The Advantage Multi for Cats reviews on the internet also suggests the same. However, you should be aware of the Advantage Multi for cats side effects. Those are what can cause problems at times. However, as long as you are aware of the Advantage Multi Cats side effects, and follow your vetโ€™s advice, nothing will go wrong.

How Quickly Does Advantage Multi Work?

The Advantage Multi for cats starts working in about four hours. This topical solution has two active ingredients. The moxidectin is there to kill and prevent fleas as well as intestinal parasites. This key ingredient will start to work in about 24 hours. Then you have the Imidacloprid. This ingredient is present to kill fleas and starts to work in just four hours.

What Kills Ear Mites in Cats?

The Advantage Multi for Cats can kill ear mites. It also deals with fleas and intestinal parasites in cats.

How Often Can You Apply Advantage Multi for Cats?

Apply Advantage Multi for Cats once every 30 days. Its effects continue for at least four weeks from the initial application.

How Long Does Advantage Multi for Cats Last?

Bayer makes the Advantage Multi Cat topical solution to last for at least four weeks or 30 days. Note that the solution starts working in just under four hours of application. After the initial application, the effects of the dosage are there for at least four weeks.

Can Advantage Multi Cause Seizures?

Yes, accidental oral ingestion of the Advantage Multi can cause seizures in cats. Thus, be very careful during the administration of this medication.

Does Advantage Multi Have Any Side Effects?

Yes, Advantage Multi for Cats has a few side effects. Coughing, polydipsia, and drowsiness are some of the most common Advantage Multi Cat side effects. Besides, you might also notice some behavioral changes in your cats. This is something that is not usually seen in the case of other medications or treatments. Alongside all this, you also have some typical side effects. These include a loss in appetite, diarrhea, vomiting, and hypersalivation. There is no need to be alarmed if you discover any of these side effects. However, you must take your cat to the vet immediately if the side effects continue for a prolonged period.

How long does Cat Advantage Multi last?

From the guidelines of the manufacturer, Advantage Multi for cats provides month-long protection against fleas, heartworms, ear mites, hookworms, and roundworms. Therefore, it is recommended to apply the medication once a month to ensure ongoing protection.

Is Advantage Multi for cats waterproof?

Yes, Advantage Multi is waterproof. The medication is designed to remain effective even if your cat gets wet. However, it is important to wait at least 24 hours after applying Advantage Multi before bathing or allowing your cat to swim. This will give the medication the required time to fully absorb into the skin, ensuring its potency. If your cat gets wet before the 24-hour period has passed, it is recommended to reapply the medication to ensure ongoing protection.

Can I bathe my pet cat just after applying Advantage Multi on it?

It is not generally recommended to bathe just after using Advantage Multi for Cats. If you need to bathe your cat within the 24-hour period, it is best to consult with your veterinarian for guidance. In some cases, they may recommend using a gentle, non-medicated shampoo that will not interfere with the medication's effectiveness. However, it is important to avoid using harsh soaps or shampoos that may strip away the medication or irritate your cat's skin.

How should Advantage Multi for cats be kept properly?

Advantage Multi for cats should be kept at room temperature (between 68ยฐF and 77ยฐF or 20ยฐC and 25ยฐC) in a cool, dry area. It's crucial to keep the medicine out of kids' and animals' reach. Furthermore, Advantage Multi for cats has to be stored in its original container until it is time to use it. The drug's stability and efficacy can be impacted by light, moisture, and air; the packaging helps to protect the medication from these external factors.

Can Advantage Multi for cats be used on other animals besides cats?

No, only felines should use Advantage Multi for cats. Since it was created exclusively for use on cats, the components and dosages in this drug may not be suitable for use on other species, such as dogs or other household pets. A different animal may experience negative side effects from using Advantage Multi for cats, including illness or even death. Additionally, utilizing drugs that are not specially designed for a species can result in inadequate treatment and perhaps make the illness worse.

Can humans use Advantage Multi for cats?

No, Advantage Multi for cats must not be used on human beings. This medication is specifically formulated for use on cats and contains ingredients and dosages that are safe for cats but may not be safe for humans.

How can I obtain Advantage Multi for my cat?

To obtain Advantage Multi for your cat, you will need a prescription from a registered veterinarian. Your cat's health situation will be assessed by the vet, who will decide whether Advantage Multi is the best course of action. Once you have a prescription, you may buy Advantage Multi from an accredited veterinary clinic, accredited internet pharmacy, or accredited physical pharmacy. It's crucial to check that the drug hasn't expired and that you're buying it from a reliable provider.

Can Advantage Multi for cats be used for lungworm prevention?

Yes, Advantage Multi for cats can be used to prevent lungworm. Advantage Multi is a broad-spectrum parasiticide that works well against a range of internal and external parasites, including lungworms. However, it is important to note that while Advantage Multi can be effective at preventing lungworms, it may not be the only or best treatment option for all cats. The best treatment for lungworms will depend on the cat's individual health status and the severity of the infection.

Can Advantage Multi for cats be used for tapeworm prevention?

Yes, Advantage Multi for cats can be used to prevent tapeworms. A broad-spectrum parasiticide called Advantage Multi is effective against a number of different internal and external parasites, including tapeworms.

Can Advantage Multi for cats be used for feline infectious peritonitis prevention?

No, Advantage Multi for cats is not effective for feline infectious peritonitis (FIP) prevention. FIP is a coronavirus-based viral illness that can be lethal to cats. FIP cannot currently be properly prevented or treated with a vaccine or medicine.

Advantage Multi for Cats contains 10% Imidacloprid, 1% Moxidectin

Advantage Multi for Cats are found in topical prescription medications with effective components for flea control and heartworm prevention, and come with endectocides, endoparasiticides and ectoparasiticides properties. Medications with Advantage Multi for Cats commonly are used for the prevention of heartworm disease caused by L3 and L4 larvae of Dirofilaria immitis. These medications are chiefly indicated for the treatment of flea infestations (Ctenocephalides felis) and ear mite infestations (Otodectes cynotis). Medications with Advantage Multi for Cats are effective as a treatment strategy for flea allergy dermatitis (FAD) and also for the elimination of certain intestinal parasites in cats. Imidacloprid exhibits high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the CNS of the flea, resulting in the paralysis and death of the insect. Moxidectin is efficient to fight internal and external parasites including larval stages (L3, L4) of Dirofilaria immitis and gastrointestinal nematodes. Moxidectin interacts with GABA and glutamate-gated chloride channels, resulting in the opening of the chloride channels on the postsynaptic junction. This action triggers the inflow of chloride ions and creates a permanent resting state, resulting in the paralysis and eventually the death of the parasite.

In some rare cases, cats that are sensitive to the ingredients in Advantage Multi for Cats may experience sluggishness, changes in behavior, general discomfort, excessive salivation, increase in thirst, coughing, and/or gagging. If these symptoms persist, consult your veterinarian immediately. Oily buildup or stiffness may occur around the area of application.

Advantage Multi for Cats is not to be used on sickly or underweight cats, and is only ment to be used topically. If ingested orally, it can cause hypersalivation, tremors, vomiting, and appetite loss.

Medications with Advantage Multi for Cats need to be used with extra caution on breeding, pregnant, nursing and geriatric cats. These medications are not recommended to be used on sick, injured or underweight cats (less than 2lbs), and cats less than 9 weeks old. Oral ingestion of these medications could result in conditions like decreased appetite, vomiting and hyper salivation. In households with multiple pets, the treated cats need to be kept isolated from others at least for 30 minutes after application. Also, keep children away from the treated pets for 2 hours after application.

In rare instances, pets are reported to exhibit side effects like behavioral changes, uneasiness, increased thirst, hyper-salivation, tiredness, and coughing and gagging.

The suggested minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin (once in a month), by topical administration.

Consult a veterinarian to determine the proper dosage of Advantage Multi for Cats for your pet. Break the seal and remove the cap of a tube of the appropriate dosage; part the hair at the base of the catโ€™s head, place the tip of the tube on the exposed skin and apply the entire contents of the tube. Lift the tube away from the skin and then release the pressure.

Keep the product away from the catโ€™s eyes; do not allow the cat to lick the product or ingest it in any way, and keep pets separated from each other to prevent them from licking each otherโ€™s application sites.

Store Advantage Multi for Cats in a cool, dry place.

Advantage is manufactured by Elanco Animal Health
Option UPC/SKU
Orange - 5.1-9 lbs., 6 Month Supply 724089914385
Purple - 9.1-18 lbs., 6 Month Supply 724089914460

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2. Add to Cart

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3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

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