Click to zoom Tap and hold to zoom
Refills on File
Your pet {{refill.petName}} has {{refill.refillsRemaining}} refill{{refill.refillsRemaining>1?'s':''}} for ‘{{refill.options}}’ which will expire on {{refill.expiresOn}}.
{{refill.petName}}'s refills for this have expired on {{refill.expiresOn}}
At a Glance
Helps older dogs with behavioral problems associated with old age
Manages symptoms associated with Cushingโ€™s Disease
Once a day dosage


List Price:
{{list_price * quantity | currency}}
List Price:
{{list_price * quantity | currency}} {{(list_price + 0.01) * quantity | currency}}
List Price:
{{list_price * quantity | currency}}
List Price:
See price in cart Why we cannot show price
List Price: {{list_price * quantity | currency}}
25% OFF w/code: CARE25
PetPlus Price:
{{petplus_price * quantity |currency}}
PetPlus Price:
See price in cart Why we cannot show price
Sale Price:
{{sale_price * quantity|currency}}w/code {{siteCode}}
Your Price:
{{(map_price + 0.01) * quantity | currency}} See price in cart w/code {{siteCode}} Why we cannot show price
{{petplus_savings_amount * quantity|currency}} ({{petplus_savings_percent}}%)
{{coupon_savings_amount * quantity|currency}} ({{coupon_savings_percent}}%)
Join PetPlus today and get this for {{intro_price_total|currency}} Why we cannot show price
Join PetPlus today and {{use_strict_map_rules?"see price in cart":"get this for a special price"}} Why we cannot show price

inlowout of stock
Get notified as soon as this becomes available
Thank you.
We will email {{notifyEmail}} when this is back in stock.
Recommended Alternatives:
Limit ( {{ selected_sku_data.cartLimit }} ) per customer. Orders for more than this may not be fulfilled.
Generic available: Anipryl
Shipping is always free with PetPlus | Arrives in 1-3 days on average
Free shipping over $48* | Arrives in 1-3 days on average
Select Autoship options at checkout
At a Glance
Helps older dogs with behavioral problems associated with old age
Manages symptoms associated with Cushingโ€™s Disease
Once a day dosage

Frequently Bought Together

Total Price

Comprehensive Guide to Selegiline

Meet the Aged Behavioral Problem Manager: Selegiline!

Selegiline is a Monoamine Oxidase Inhibitor (MAOI) that manages behavioral problems associated with middle-aged and older dogs, such as Parkinson's disease, Canine Cognitive Dysfunction Syndrome (senility), and Cushing's Disease. Selegiline is a daily oral tablet for both dogs and cats.

How does Selegiline work?

As a monoamine oxidase inhibitor (MAOI), Selegiline helps in significantly enhancing the concentration of a nervous system messenger chemical known as dopamine, which is used to treat cognitive dysfunction (caused by aging), anxiety, and phobias in animals. Higher levels of dopamine stimulate brain receptors and cognitive processes.

Selegiline contains several ingredients - selegiline hydrochloride, citric acid, lactose monohydrate, maize starch, magnesium stearate, povidone, and talc. Selegiline Hydrochloride (HCL) is an antidepressant that treats Parkinson's disease and depression.

Maize starch in pet foods aids those pets that are suffering from corn allergy. Povidone is a topical cleanser that supports the healing of wounds and skin irritations. Magnesium stearate, povidone, and talc are natural additives. Citric acid is a common additive and a natural functional compound for pet health and wellness.

How is Selegiline administered?

Selegiline is a 5 mg tablet or capsule that is administered orally once a day with or without food. Dogs are usually given in the morning and cats in the evening.

The recommended starting dosage for treating Cushing's disease is .45 mg per pound which is taken in the morning. The recommended starting dosage for Canine C.D.S. is usually .20 to .45 mg per pound.

It may take one month to show significant improvement; however, if no improvement is seen in two months, increase the medication's dosage to .90 mg per pound. Consult your veterinarian for any specifics and adjustments for administration.

What are the potential side effects of which you should be aware?

Selegiline's common adverse reactions include vomiting, disorientation, aggression, hearing loss, decreased appetite, hair loss, trembling, or diarrhea. Overdose symptoms are hypersalivation, panting, or dehydration. Immediately, consult a veterinarian or emergency clinic if any above side effects or any allergic reactions occur.

What are the precautions of which you should be aware?

Be sure to tell your veterinarian about any medications, vitamins, or supplements that your pet is taking.

The following animals have not prescribed Selegiline:

  • Those that are allergic to it

  • Those that are pregnant or lactating

  • Those that have Cushing's disease

  • Those have a pituitary tumor

  • Those that are taking SSRI antidepressants, tricyclic antidepressants, narcotics, or other MAOIs

  • Those that have an adrenal gland-based Cushing's disease

  • Those that are aggressive pets

Frequently asked Questions
What Is Selegiline?

Selegiline is a monoamine oxidase inhibitor. It's a medicine used to treat cognitive dysfunction in dogs and also cats. Vets also prescribe it for pituitary-dependent Cushing's Disease; however, there are no reports to prove its effectiveness.

Selegiline is an effective medication to treat canine cognitive dysfunction associated with aging. Usual symptoms include lack of responsiveness, reduced general awareness, unlearning habits, and memory loss. If you see such signs in your dog, visit the vet as soon as possible to treat the condition.

Does Selegiline Work for Dogs?

Selegiline or L-Deprenyl is the only medication approved by FDA for canine cognitive dysfunction in dogs. While the medication has been proven to help dogs with this dysfunction, the effect varies from dog to dog. Some dogs may show improvement as early as four weeks, and some may take up to 12 weeks. The good news is that most dogs show some improvement in just four weeks, with continued improvement as time passes.

Technically, Selegiline doesn't cure canine cognitive dysfunction but is intended to improve the quality of life for both the dog and the parent. The medicine does this by increasing dopamine levels. Selegiline for dogs is also approved for treating Pituitary Dependent Hyperadrenocorticism (PDH) caused by a pituitary tumor.

What Is Selegiline Used to Treat?

Selegiline is an oral prescription medication meant to treat senility and cognitive dysfunction in dogs. Notably, Selegiline is the only drug approved by the FDA to treat senility in dogs. Vets also prescribe medication to treat Cushing's disease induced by a pituitary tumor. The medicine falls under the antidepressant classification and is designed to improve the quality of life for the dog. It does so by increasing the dopamine levels in the brain.

What Class of Antidepressants Is Selegiline?

Selegiline is classified as Monoamine Oxidase Inhibitors or MAOI. The medication works by increasing the level of dopamine in the brain. For the uninitiated, dopamine is a natural substance required to control movement.

Selegiline is a low-cost, generic form of Anipryl for use in dogs. The medicine is metabolized into methamphetamine, amphetamine, and L-desmethylselegiline. In higher dosages, the medication also inhibits MAO-A, which may result in some anti-anxiety results.

Due to the nature of the medication, Selegiline should not be used with Amitraz, which is also an MAO inhibitor and a bunch of other medications. Some examples of medications to be avoided with Selegiline are Bupropion, Tramadol, Ephedrine, tricyclic, and tetracyclic antidepressants.

What Are the Side Effects of Selegiline?

There are several side-effects of Selegiline in dogs ranging from mild to severe. The most common side effects of Selegiline are vomiting and diarrhea. If these side effects persist, stop administering the drug for a few days and then start again at a lower dose.

There are also nervous system stimulation side effects like restlessness, salivation, repetitive behavior, and hyperactivity. Some rare side effects include trembling, shivering, pruritus, and deafness.

Does Selegiline Cause Hair Loss?

No, Selegiline doesn't cause hair loss in dogs, which is a common misconception. Hair loss is not listed in the side effects caused by the medication. The medication is used for canine Cushing's dysfunction, which causes hair loss, thin or fragile skin, recurrent skin infections, and more. In case your dog is experiencing hair loss after administering Selegiline, consult a veterinarian immediately.

What's the Difference between Selegiline and Rasagiline?

Selegiline and Rasagiline are both classified as MAO-B inhibitors and licensed as such in North America. Selegiline and Rasagiline are both relatively selective and irreversible, with significant differences in their metabolites. While Selegiline is metabolized into amphetamine derivatives, Rasagiline metabolizes into aminoindane.

The difference between the two is that Rasagiline is around 10 times more potent than Selegiline in inhibiting MAO-B. The higher potency of Rasagiline is balanced through dose adjustments. For example, the approved daily dose for Selegiline is 5-10mg, whereas it's 1mg for Rasagiline.

Can Selegiline and Cabergoline Be Used Together?

Cabergoline and Selegiline can be used together as they don't have any chemical interaction. However, it's always best to consult a vet before administering any drug to your pet. Cabergoline is a dopamine-2 receptor agonist with anti-prolactin effects. It's useful for dogs showing signs of pseudopregnancy and post-spay aggression due to high levels of prolactin.

How Long Does It Take for Selegiline to Work in Dogs?

Selegiline hydrochloride is usually administered once a day for two months, and if the condition doesn't improve during this time, the dosage is doubled for an additional month. If you don't see an improvement in your dog's condition even after that, your vet would suggest some other form of treatment.

According to recent data, most dogs show improvement after a month of medication, and some take only a few days or weeks. Most often, dogs continue to show progress for the first three months.

Concluding Thoughts

The most important thing that you should know about Selegiline is that it treats behavioral problems and cognitive dysfunction, such as Parkinson's disease, Canine Cognitive Dysfunction Syndrome, and Cushing's Disease, caused by your pet's aging.

DISCLAIMER: FDA law restricts Selegiline only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427, if this is a suitable product for your pet and your home. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA-approved and/or EPA regulated when and as required by law.

  • Epilepsy & Neural Health Pharmacy
  • Senior Life Stage
  • Oral Application
  • Cat Pet Type
  • Dog Pet Type

Why is my older dog misbehaving all of a sudden?

Older dogs may develop medical conditions that can affect their behavior. Pain, discomfort, or cognitive decline could lead to changes in their behavior. It's a good idea to take your dog to the vet for a thorough examination to rule out any underlying health problems. Dogs are creatures of habit, and any sudden changes in their routine or environment can cause stress and anxiety. This could include changes in the household, such as the addition of a new pet or family member, moving to a new home, or changes in their daily schedule. These changes can disrupt their sense of security and lead to behavioral issues. As dogs age, they may experience cognitive decline similar to human dementia. This condition, known as canine cognitive dysfunction (CCD) or doggy Alzheimer's, can result in disorientation, confusion, changes in sleep patterns, and altered behavior. Older dogs still need mental and physical stimulation to stay happy and healthy. If their daily routine lacks regular exercise, playtime, and mental enrichment, they may exhibit restlessness, boredom, and destructive behavior. Older dogs can develop separation anxiety, especially if they have been used to constant companionship or have experienced recent changes in their living situation. They may exhibit destructive behavior when left alone or show signs of distress when their owners are away. It's possible that your dog's misbehavior is a result of a breakdown in communication or a lack of consistent training. Older dogs may forget or become less responsive to commands they once knew, or they may simply need a refresher course on proper behavior.

How do you treat senior dog anxiety?

Treating senior dog anxiety involves a combination of management strategies, environmental adjustments, and medication. Provide a secure and comfortable space for your senior dog. This could include a designated area with their bed, toys, and familiar items. Make sure they have a quiet retreat where they can go when they feel anxious or overwhelmed. Dogs thrive on routine, and it can help reduce anxiety in senior dogs. Stick to a regular schedule for meals, walks, playtime, and other activities. Predictability and structure can provide a sense of security for your dog. Engage your senior dog in regular mental and physical exercise. This can include puzzle toys, interactive games, short walks, or gentle play sessions. Mental stimulation helps keep their minds active and reduces anxiety. Employ calming techniques such as gentle massages, music designed for dogs, aromatherapy, or the use of anxiety wraps or shirts. These techniques can help promote relaxation and alleviate anxiety symptoms. In severe cases of anxiety, medication prescribed by a veterinarian may be necessary. Anti-anxiety medications or supplements can help alleviate anxiety symptoms and improve your dog's overall well-being. Selegiline, also known as L-deprenyl, is primarily used for the treatment of cognitive dysfunction syndrome (CDS) in dogs, which is similar to Alzheimer's disease in humans. While selegiline is primarily used for the treatment of cognitive dysfunction syndrome (CDS) in dogs, there is some evidence to suggest that it may have a secondary effect in reducing anxiety. Selegiline acts by inhibiting the breakdown of certain neurotransmitters in the brain, including dopamine. It can potentially have a positive impact on mood and anxiety levels in dogs by increasing dopamine levels.

How long does a dog live with Cushing's disease?

The life expectancy of a dog with Cushing's disease can vary depending on several factors, including the underlying cause of the disease, the age and overall health of the dog, and the effectiveness of treatment. There are two main types of Cushing's disease in dogs: pituitary-dependent Cushing's disease (PDH) and adrenal-dependent Cushing's disease (ADH). PDH is the more common form, accounting for about 80-85% of cases, and it typically has a better prognosis compared to ADH. The mainstay of treatment for Cushing's disease in dogs involves medications that help control the overproduction of cortisol. The two commonly used medications are trilostane and mitotane. Trilostane works by inhibiting the enzymes involved in cortisol production, while mitotane selectively destroys the cortisol-producing cells in the adrenal glands. Selegiline (L-deprenyl) can be used to manage some symptoms associated with Cushing's disease in dogs, particularly polyuria (excessive urination) and polydipsia (excessive thirst) commonly seen in affected dogs. Selegiline is an irreversible selective monoamine oxidase-B (MAO-B) inhibitor. By inhibiting MAO-B, selegiline increases dopamine levels in the brain, which can have a positive effect on water balance and reduce the excessive water intake and urination seen in dogs with Cushing's disease.

What is the behavior of a dog with Cushing's?

Dogs with Cushing's disease may exhibit various behavioral changes due to the hormonal imbalances caused by the excessive production of cortisol. Dogs with Cushing's disease often experience polydipsia (excessive thirst) and polyuria (excessive urination). They may need to go outside more frequently or have accidents in the house. Many dogs with Cushing's disease develop an increased appetite, known as polyphagia. They may appear constantly hungry and may beg for food or scavenge more than usual. Some dogs with Cushing's disease may exhibit restlessness, pacing, or an inability to settle down. They may appear anxious, agitated, or exhibit signs of discomfort. Dogs with Cushing's disease may experience disruptions in their sleep patterns. They may have difficulty falling asleep, wake up frequently during the night, or exhibit restless sleep. While increased appetite and thirst are common, some dogs with Cushing's disease may also experience lethargy or weakness. They may have reduced energy levels and appear less interested in exercise or play. Some dogs with Cushing's disease may exhibit changes in behavior or temperament. They may become irritable, moody, or more reactive to certain stimuli. They might also display increased vocalization or become more anxious or fearful.

What are the three stages of Cushing's disease in dogs?

Cushing's disease in dogs, also known as hyperadrenocorticism, is generally described in three stages based on the progression and severity of the condition. In the preclinical stage, the dog has hormonal changes associated with Cushing's disease, but clinical signs may not be evident or may be very mild and nonspecific. Laboratory tests, such as cortisol measurements or an adrenal function test, may reveal abnormalities indicating the presence of Cushing's disease. However, the dog may not exhibit noticeable symptoms yet. In the symptomatic stage, the clinical signs of Cushing's disease become more apparent. Dogs may exhibit various symptoms such as increased thirst and urination, increased appetite, weight gain (especially in the abdomen), hair loss, thinning skin, muscle weakness, panting, lethargy, and susceptibility to infections. These signs result from the excessive levels of cortisol in the body. Diagnostic tests, including blood tests and imaging (such as an abdominal ultrasound), can help confirm the diagnosis during this stage. In the refractory stage, the dog's condition becomes more difficult to manage, and the response to treatment may be limited. Despite appropriate therapy, the clinical signs may persist or worsen. It can occur due to several reasons, including the development of treatment-resistant tumors or other complications. In some cases, additional treatment options or adjustments may be necessary to manage the dog's symptoms effectively.

Selegiline hydrochloride, citric acid, lactose monohydrate, maize starch, magnesium stearate, povidone and talc.

Selegiline Hydrochloride


Selegiline Hydrochloride is a type of monoamine oxidase inhibitor. It helps treat the signs that are due to the cognitive dysfunction disease in cats and dogs. It has also been used greatly for Cushing's disease, a pituitary-dependent condition. There are certain phobias and anxiety in combination with other medications.

Special Precautions

The use of the drugs for pets that have an allergy to Selegiline Hydrochloride should not have the drug. The pets that are on other monoamine oxidase inhibitors should also not have this medication in conjugation. Ideally, avoid applying drugs like meperidine, alpha-2 agonists, tramadol, selective serotonin reuptake inhibitors, tricyclic antidepressants, or tramadol.

Caution is advisable for applying the drug to pets with any debilitating diseases. Lactating and pregnant pets should be treated with caution for keeping them safe as the studies are still on to establish the drug's effect on such pets. Potential abuse of the drug among human beings is high, and therefore, it is advisable to keep the medication in safe conditions to avoid its misuse.

Mechanism of Action

The action of the drug takes place to take care of the monoamine oxidase type B inhibition and other monoamine oxidases at higher doses. The approved formulation of the drug helps to carry out this job successfully to treat canine cognitive dysfunction and Cushing disease in dogs. The actions help to inhibit the dopamine in the central nervous system.ย 

The action of the pituitary-dependent hyperadrenocorticism can happen with the increased dopamine levels in the brain that impacts the ACTH release. It ultimately results in the reduction of cortisol levels. The secondary effects can include the inhibition of the metabolism of phenylethylamine. L-methamphetamine and l-amphetamine are the two metabolic that help in extending the above contribution to the pharmacologic effects.

Known Drug Interactions

Caution is advisable for giving the medication with drugs like amitraz, tetracyclic antidepressants, amitriptyline, tricyclic, bupropion, trazodone, cyclobenzaprine, tramadol, ephedrine, SSRIs, meperidine, pseudoephedrine, metoclopramide, phenylpropanolamine, ย and opioids,ย 

Brand/Generic Equivalents

Not meant for dogs with aggression issues.

Possible side effects include:

Decreased appetite, drooling, vomiting and diarrhea, fatigue, confusion, restlessness, hearing loss, trembling, itching, hair loss, anemia (pale gums). Repetitive behaviors (ex. walking in circles, obsessive interest in something). If your dog suffers an allergic reaction such as hives, swelling of lips, tongue, or face, or difficulty breathing seek immediate emergency veterinary medical attention and discontinue dosages. Other less serious side effects may occur such as nausea or upset stomach, diarrhea, or headache. If these, or any other side effects seem unusual or bothersome to your animal talk to your veterinarian.

Never use Selegiline in animals that are allergic to it or administer the drug to pregnant or nursing animals. Do not use the medicine in dogs that have Cushingโ€™s disease caused by some reason other than a pituitary tumor. Avoid prescribing Selegiline in combination with SSRI antidepressants (fluoxetine), tricyclic antidepressants (clomipramine), narcotics such as meperidine, ephedrine or other MAOIs, insulin, phenytoin, sulfonamides such as Albon, and phenothiazines such as acepromazine. Selegiline is rarely administered to cats. The medicine should only be used after making a proper diagnosis of pituitary-based Cushing's disease. Selegiline is not recommended for adrenal gland-based Cushing's disease.ย 

Possible interactions may occur with ephedrine or other MAOI's. Discontinue selegiline at least 14 days prior to starting treatment with some narcotic pain killers (ex. Demerol), phenylpropanolamine, SSRI's (ex. fluoxetine) and tricyclic antidepressants (ex. amitriptyline). Some narcotic pain killers (ex. Demerol), phenypropanolamine, SSRI's (ex. fluoxetine) and tricyclic antidepressants (ex. amitriptyline) should not be used within 5 weeks of administering selegiline.

If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.

Selegiline is used to treat Cushingโ€™s disease or hyperadrenocorticism and canine cognitive dysfunction (senility). A monoamine oxidase inhibitor (MAOI), Selegiline helps in significantly enhancing the concentration of a nervous system messenger chemical known as dopamine. The higher levels of dopamine stimulate the receptors in the brain, thus augmenting different kinds of cognitive processes.ย 

The major side effects of selegiline include vomiting, diarrhea, drowsiness, disorientation, hair loss, and shaking. The symptoms of overdose usually include salivation, panting, dehydration, and death.ย 

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Selegiline is usually available as 2 mg, 5 mg, 10 mg, 15 mg, and 30 mg tablets. The recommended starting dose for the treatment of Cushing's disease is 0.45 mg/pound to be given in the morning. If the condition of the pet does not show any considerable improvement within 2 months, do increase the dosage of medicine to 0.9 mg/pound once a day. If the situation persists within 1 month of the increased dose, make a thorough diagnosis of the pet. The usual dose for Canine Cognitive Dysfunction is 0.2-0.45 mg/pound. It could take up to one month or more for any substantial improvement. Give your dog the recommended dosage (typically one pill) every morning.

Store in a cool, dry place.

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

Related Articles

Metabolic Enzyme Deficiency in Cats: Causes, Symptoms, and Treatment

What is Feline Metabolic Enzyme Deficiency and How Can It Be Addressed?

Read More

Customer Reviews

Rating Summary 22 review(s)
5 stars
4 stars
3 stars
2 stars
1 star
5 / 5
* = required

New Product Review

Uploaded Image 1
Uploaded Image 2
Uploaded Image 3
  • {{error}}
Showing 1 - {{visible_reviews.length}} of {{total_reviews}}

This product has no reviews yet. Write a review.


My sweet Ziggy is almost 13yrs old and was recently diagnosed with doggy dementia. I noticed he was slow to respond when I called him, he would sit in strang places, stare at walls, and began to forget to eat and drink. I emailed my vet and he scheduled us an appointment immediately. After explaining the behavior changes, I was told Ziggy is in his beginning stages of doggy dementia. This was shocking to hear. My vet prescribed Selegiline. Some say they see results either immediately, weeks, and even months. Well I seen results immediately, like the next day. Ziggy was responding to me, he was eating and drinking. There are some areas that are still off.. For example, he will eat his food from his dish, but won't drink his water that is right next to his food. Now he drinks his water every where but there. In the front yard, bark yard and I have a water bowl in my bedroom next to his bed. This is a freaking miracle drug. So thankful it worked.

Rolanda Hasson recommends this item.
Was this review helpful? 3 0

My dog is back!

Within 24 hours of Jackโ€™s first dose of Selegiline, he was back from senility. No more stuck in corners, no back leg weakness, no fear of stairs, no circling. For him it is a wonder drug.

Jan Hyne recommends this item.
Was this review helpful? 2 1

Quick Easy and On Time

While I don't love that my pet needs medicine, using PetCareRx removes all the hassles in ensuring i have adequate supply for his medical needs. Been getting medicine for about a year now and it's been a great experience.

Jeremy recommends this item.
Was this review helpful? 0 0

Hoping for a Miracle

Reuben began taking selegeline, aka anapryl, on May 10 1918. Prior to this he had all of the symptoms, including getting stuck in corners, constant pacing, running/bumping into walls, furniture, etc., having 'accidents' in the house, etc. Noticed a remarkable improvement within two weeks of starting meds. He was ringing his 'bell' to go potty outside, much more energetic, etc. Now, almost two months later, he seems to have reverted to his prior behavior, perhaps even worse. Reuben is 14 years old and has been my constant companion all that time. He even goes to work with me and stays at my desk, as he is today. However, after much discussion with my counselor, friends and prayer, I have come to the conclusion that he is not the same dog. I seem to scare/startle him and sometimes he shakes when he sees me. He seems to be either fearful or anxious most all the time, except when he is sleeping, which is close to 22 hours a day. He has also been a diabetic for 4 and a half years and on insulin injections twice daily. I make his food at home (google Ruby Stewbie), which has improved his overall health and he loves it and his diabetes has been much easier to control. He has cataracts and sees very little and his hearing is almost gone (he can't hear me whistling ten feet away). He is basically non responsive and though he is very excited at mealtimes (he still loves to eat), that is about his only enjoyment. He is back to doing most of his potty chores in the house, and I keep diapers on him all of the time. I will not be ordering again and very, very sadly, will be saying my final good bye to my dear little Reuben tomorrow at 5pm. I would certainly recommend this to others as it did give us that all too brief time of some clarity for him. Maybe I should have started sooner, but I don't know.

Darling recommends this item.
Was this review helpful? 8 0

doing okay

Seems to help him to be oriented. Not completely but better.

Joan Zimmerman recommends this item.
Was this review helpful? 1 0

Miracle drug

This turned my dog almost back to his old self. It is a miracle drug. So thankful it has helped my 14 year old min pin.

Melski recommends this item.
Was this review helpful? 5 0

easy to adminstar

We notice some improvement, still hoping more to come with ordering second order

veith507 recommends this item.
Was this review helpful? 3 0

Didn't seem to make a difference

Didn't seem to make a differencein the dogSelegiline is used to treat Canine Cognitive Dysfunction Syndrome. It can also be used to treat symptoms associated with pituitary-dependent Cushings Disease in dogs. Selegiline comes in easy-to-administer oral tablets with five different strengths.Selegiline is a monoamine oxidase inhibitor (MAOI). Usage of selegiline is meant to result in enhanced catecholaminergic nerve function and increased dopamine levels helping dogs with cognitive dysfunction caused by aging.

abcdef recommends this item.
Was this review helpful? 0 1

Works for my 12 year old Bichon Frise

My Belle has been taking this product for approximately 4 years now. It has definitely extended her life. I am very happy we found this for her.

Marydeen recommends this item.
Was this review helpful? 2 0

This product is only available for senior dogs

Half the price of my vet...but I was promised free shipping which I didn't get.

Maeilyn recommends this item.
Was this review helpful? 0 0

Works well!

I use this for my aging dogs when they start to get a little disoriented or show the signs of mental slowing. The medication takes about a week to see the effect but it works great! If you have an older dog that forgets to go outside to urinate or can't remember where the dog door is or stands around looking lost at times, it may be a sign that they need some medication help. I have been using this medication since 2002 when my first old girl started to lose it after she lost her sight, it brought her back to her old self and helped her cope with her disability.

Vytas4458 recommends this item.
Was this review helpful? 1 0

Really improved quality of life for my old dog.

We used selegiline once for about 6 months when Hunter was 12 - he was having trouble adjusting after the loss of his best dog pal with anxiety and fear of going outdoors or even open spaces indoors. This worked beautifully and he weaned off fine. We started to give it to him again at age 16 for nighttime restlessness and anxiety and it has again worked beautifully for him, he sleeps through the night and has no problem with anxiety. Still seems to have some mild confusion. He will turn 17 in 2 weeks (!) and quality of life is still pretty good. It is quite expensive, but prices on PetCareRx make it doable.

breeze59 recommends this item.
Was this review helpful? 1 0

Selegiline Gave my Dog his Personality Back

My 13 year old Lab has dementia. This drug is a miracle. He acts like himself. Before Selegiline, he wasn't eating, forgot how to navigate stairs, barked at walls and furniture, and was generally confused. He's had zero bad side effects.

Vic14k recommends this item.
Was this review helpful? 2 0

Helping my 15 yr old Wire Fox Terrier

Started the drug on my vet' recommendation due to my little dog's declining canine cognitive dysfunction. She has been on it a month + now and it has helped. Much less whimpering, waking up in middle of night wandering around . We also started her on special diet. The 2 combined are helping. She is not like her younger self, but less anxious, less stressed and more oriented to time, place.I highly recommend you try this for your elderly dog with declining cognition. Depending on each dog's condition, the improvements vary for each dog.For us it has helped, and our dog seems better, but she is not cured of her CDS; others have reported dramatic results. Results are not the same for every dog.

Gertee recommends this item.
Was this review helpful? 3 0

It seems to help

My girl (we think she's a Tibetan Terrier) is getting up in years and suffers from some chronic illnesses as well. We started selegiline a couple of months ago. At first I thought maybe, just maybe it was helping with her cognitive functions. Now I'm sure it is. She's not what she once was but at least she's not sleeping 24/7. She still gets herself into corners and stands there but I think it may be at least partly a vision issue. She's more responsive than she had been and seems to be enjoying her life, quiet as it is, more.

Phee recommends this item.
Was this review helpful? 3 0

This product helps my dog tremendously.

My dog is an 18 year old Jack RussellTerrier and she has canine cognitive dysfunction. Selegeline helps ease her "alzheimers" symptoms and improves her quality of life. I give her 10 mg capsules; I open the capsules and pour the powder right over her canned food.

RussellMom recommends this item.
Was this review helpful? 3 0

Nellie's second reprieve

Nellie is a purebred German Shorthaired Pointer, dumped in a Cook County Forest Preserve at the age of 8, who found her way to a shelter where my husband and I volunteer. Although we already had 3 dogs, we brought her home to foster and ended up adopting her because no suitable adopter wanted a senior dog with special needs. Nellie was a confused bundle of nerves when we brought her home, hence the name the shelter gave her - (Nervous) Nellie. Over the next year, her problems grew - she had frequent accidents in the house, drank so much water (and then urinated) that we had her blood and urine tested several times, and showed many other signs of canine cognitive disorder. We were so frustrated with her behavior that we considered euthanizing her if we couldn't find a "cure." After giving her (vet prescribed) thyroid medication (to no apparent good) for nearly a year, I did some research and learned about selegiline. I told our vet we were doing no more tests and I wanted this medication for Nellie. We saw signs of improvement within 10 days. She's calmer and more comfortable with us and the other dogs. She is less agitated, therefore pants less, therefore drinks less water, therefore urinates less. She's less confused and therefore more likely to let us know she needs to go out. Where we once had 5 accidents in a 3-day period (and 3 in one day), we've now had only one in the last 2 months. It's a miracle! She's not "perfect" but none of us is. We know the drug works because we ran out for a couple of days (when we miscalculated the amount of time it would take to get a refill) and she lost ground, getting back to the "new normal" once we got the pills again. I can't recommend this medication highly enough. It saved Nellie's life a second time.

Candy_companioncaretaker_of_4_dogs_2_cats_2_p recommends this item.
Was this review helpful? 3 0

Quick and Efficient

Our order was placed on line one day, the vets' office was contacted the next and the meds were sent out the same day. Great Service.

Barbara_owner_of_two_16_year_old_poodles recommends this item.
Was this review helpful? 1 0

Very helpful!

My youngest chld er... my pet dog is in really great shape physically for her age but the mind was slipping a little! (Kind of funny/sad... she would go stand in a corner like a time out and not know how to back up to get out of the corner, constantly walking in circles...) We give her a pill in the morning and evening and she is doing so much better and sleeping well at night! The prices online were so much better than buying them from a vet here.

MK_owner_of_15_year_old_Cocker_Spaniel_Mix recommends this item.
Was this review helpful? 1 0


My story is almost exactly the same as Samuel's including my dog's vets being unfamiliar with the disorder and the medication. I did the research and provided them with the information. My vets told me my dog had all sorts of problems and needed to be put to sleep. They were wrong! This medication has given me my old friend back! He is doing GREAT on this medication for the past 6 months! His symptoms and behaviors including: Confusion, whining, pacing, walking in circles, not responding to his name, agitation, disturbances in sleep/wake cycle, becoming "lost" in familar places in residence, staring at walls, etc etc etc have all either decreased drastically or ceased all together. He is doing GREAT on this medication which is the generic version of Anipryl! *Consistency* in giving your pet this medication is very important! Also some foods and medications should be avoided if your pet is on this medication. Takes about 2-6 weeks for max effect to occur. My dog was already 1000% percent improved in less than 3 days! Remember, your vet might not be familiar with this disorder or this medication! Do the research and show them! I can't tell you how close my dog came to being put to sleep simply because his vets were uninformed and in error. I have my old friend back, and we have more time together now thanks to this medication!

Brian_owner_of_12_year_old_Basset_Hound recommends this item.
Was this review helpful? 5 0


This is the generic for ANIPRYL. It works great for my old dog Stanley!!! Great price also

Linda_Senf recommends this item.
Was this review helpful? 0 0

Back from the brink - A Canine Alzheimer's Disease Story

Be advised - most family veterinarians are not familiar with treating and diagnosing canine aging illnesses that affect a dog's cognitive functions. So, as owner- you sometines need to do the research for your vet...Originially tested on animals, Selegiline the generic for the drug Anipryl is an absolute miracle remedy for Cognitive Dysfunction Syndrome (the canine equivalent of Alzheimer's Disease).Our dog lucy has been taking the medication for over a year, it has literally brought her back from dementia.Cognitive Dysfunction Syndrome has the following symptoms in dogs:A dog does not recognize it's own name when called; &A dog forgets to do things they are accustomed to like walking down stairs, jumping up on a familiar couch or bed; &A dog appears confused and agitated, staring at walls, whimpering at the inability to maneuver throw familiar terrain.*This is a prescription item

Samuel_G recommends this item.
Was this review helpful? 2 0

Page 1 of 1 1