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At a Glance
Helps older dogs with behavioral problems associated with old age
Manages symptoms associated with Cushing’s Disease
Once a day dosage
This product requires a prescription.



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Rated 4.5 out of 5 by 19 reviewers.
Rated 4 out of 5by Hoping for a MiracleReuben began taking selegeline, aka anapryl, on May 10 1918. Prior to this he had all of the symptoms, including getting stuck in corners, constant pacing, running/bumping into walls, furniture, etc., having 'accidents' in the house, etc. Noticed a remarkable improvement within two weeks of starting meds. He was ringing his 'bell' to go potty outside, much more energetic, etc. Now, almost two months later, he seems to have reverted to his prior behavior, perhaps even worse. Reuben is 14 years old and has been my constant companion all that time. He even goes to work with me and stays at my desk, as he is today. However, after much discussion with my counselor, friends and prayer, I have come to the conclusion that he is not the same dog. I seem to scare/startle him and sometimes he shakes when he sees me. He seems to be either fearful or anxious most all the time, except when he is sleeping, which is close to 22 hours a day. He has also been a diabetic for 4 and a half years and on insulin injections twice daily. I make his food at home (google Ruby Stewbie), which has improved his overall health and he loves it and his diabetes has been much easier to control. He has cataracts and sees very little and his hearing is almost gone (he can't hear me whistling ten feet away). He is basically non responsive and though he is very excited at mealtimes (he still loves to eat), that is about his only enjoyment. He is back to doing most of his potty chores in the house, and I keep diapers on him all of the time. I will not be ordering again and very, very sadly, will be saying my final good bye to my dear little Reuben tomorrow at 5pm. I would certainly recommend this to others as it did give us that all too brief time of some clarity for him. Maybe I should have started sooner, but I don't know. 06/28/2018
Rated 4 out of 5by doing okaySeems to help him to be oriented. Not completely but better. 03/23/2018
Rated 5 out of 5by Miracle drug This turned my dog almost back to his old self. It is a miracle drug. So thankful it has helped my 14 year old min pin. 07/06/2016
Rated 2 out of 5by easy to adminstarWe notice some improvement, still hoping more to come with ordering second order 05/08/2016
Rated 1 out of 5by Didn't seem to make a differenceDidn't seem to make a differencein the dogSelegiline is used to treat Canine Cognitive Dysfunction Syndrome. It can also be used to treat symptoms associated with pituitary-dependent Cushings Disease in dogs. Selegiline comes in easy-to-administer oral tablets with five different strengths.Selegiline is a monoamine oxidase inhibitor (MAOI). Usage of selegiline is meant to result in enhanced catecholaminergic nerve function and increased dopamine levels helping dogs with cognitive dysfunction caused by aging. 04/27/2015
Rated 4 out of 5by Works for my 12 year old Bichon FriseMy Belle has been taking this product for approximately 4 years now. It has definitely extended her life. I am very happy we found this for her. 01/21/2015
Rated 5 out of 5by This product is only available for senior dogsHalf the price of my vet...but I was promised free shipping which I didn't get. 11/02/2014
Rated 4 out of 5by Works well!I use this for my aging dogs when they start to get a little disoriented or show the signs of mental slowing. The medication takes about a week to see the effect but it works great! If you have an older dog that forgets to go outside to urinate or can't remember where the dog door is or stands around looking lost at times, it may be a sign that they need some medication help. I have been using this medication since 2002 when my first old girl started to lose it after she lost her sight, it brought her back to her old self and helped her cope with her disability. 08/15/2014
Rated 5 out of 5by Really improved quality of life for my old dog.We used selegiline once for about 6 months when Hunter was 12 - he was having trouble adjusting after the loss of his best dog pal with anxiety and fear of going outdoors or even open spaces indoors. This worked beautifully and he weaned off fine. We started to give it to him again at age 16 for nighttime restlessness and anxiety and it has again worked beautifully for him, he sleeps through the night and has no problem with anxiety. Still seems to have some mild confusion. He will turn 17 in 2 weeks (!) and quality of life is still pretty good. It is quite expensive, but prices on PetCareRx make it doable. 05/21/2014
Rated 5 out of 5by Selegiline Gave my Dog his Personality BackMy 13 year old Lab has dementia. This drug is a miracle. He acts like himself. Before Selegiline, he wasn't eating, forgot how to navigate stairs, barked at walls and furniture, and was generally confused. He's had zero bad side effects. 12/29/2013
Rated 4 out of 5by Helping my 15 yr old Wire Fox TerrierStarted the drug on my vet' recommendation due to my little dog's declining canine cognitive dysfunction. She has been on it a month + now and it has helped. Much less whimpering, waking up in middle of night wandering around . We also started her on special diet. The 2 combined are helping. She is not like her younger self, but less anxious, less stressed and more oriented to time, place.I highly recommend you try this for your elderly dog with declining cognition. Depending on each dog's condition, the improvements vary for each dog.For us it has helped, and our dog seems better, but she is not cured of her CDS; others have reported dramatic results. Results are not the same for every dog. 07/18/2013
Rated 4 out of 5by It seems to helpMy girl (we think she's a Tibetan Terrier) is getting up in years and suffers from some chronic illnesses as well. We started selegiline a couple of months ago. At first I thought maybe, just maybe it was helping with her cognitive functions. Now I'm sure it is. She's not what she once was but at least she's not sleeping 24/7. She still gets herself into corners and stands there but I think it may be at least partly a vision issue. She's more responsive than she had been and seems to be enjoying her life, quiet as it is, more. 07/16/2013
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