Nexgard Chewables
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At a Glance
#1 vet-recommended flea and tick control1โ€ฏthat kills fleas fast, before they can lay eggs
The only FDA-approved product for the prevention of infections that cause Lyme disease. NexGard kills infected black-legged ticks before Lyme infections can be transmitted.
Quickly kills fleas and ticks for a full month
Each beef-flavored chew is easy to give because dogs love the taste

Nexgard Chewables

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At a Glance
#1 vet-recommended flea and tick control1โ€ฏthat kills fleas fast, before they can lay eggs
The only FDA-approved product for the prevention of infections that cause Lyme disease. NexGard kills infected black-legged ticks before Lyme infections can be transmitted.
Quickly kills fleas and ticks for a full month
Each beef-flavored chew is easy to give because dogs love the taste

Ultimate Guide to Nexgard Chewables

Meet the First Non-Topical Flea and Tick Killer: Nexgard Chewables!

Nexgard Chewables is the #1 veterinarian-approved flea and tick control medication for your dogs. Nexgard Chewables is a revolutionary monthly soft chew because it is the first oral flea and tick preventative of its kind. Nexgard Chewables ensure that your pup is in the best lovable condition that he or she can be.

How does Nexgard Chewables work?

Nexgard Chewables is a monthly flea treatment with one active ingredient Afoxolaner (the generic name for the brand name Nexgard). Afoxolaner is known to effectively prevent and control adult flea infestations before they lay eggs. It also kills ticks too!

Once the dog ingests Nexgard Chewables, the chew's ingredient actively distributes throughout the body so that when the blood-sucking parasites bite your dog, their exposure to afoxolaner kills them.

A big plus is that Nexgard Chewables (and all Nexgard products) will kill infected black-legged ticks before they can transmit Lyme Disease.

How is Nexgard Chewables administered?

Nexgard for dogs is administered orally once a month and protects your dog for the next 30 days. These are beef-flavored chewable that can be digested with or without food or water. However, if the dog vomits within the next two hours, give another full dose and try to give with food.

Nexgard Chewables Dosage Chart

Based on the weight of the dog, each dog receives a milligram amount of afoxolaner:

Weight Box Color Dosage of Afoxolaner per chew (mg)
4.0 - 10.0 lbs Orange 11.3 mg
10.1 - 24.0 lbs. Blue 28.3 mg
24.1 - 60.0 lbs Purple 68 mg
60.1 - 120.0 lbs. Red 136 mg
Which dogs should you be aware of not giving Nexgard Chewables?

Dogs with a history of seizures or neurological disorders. Dogs that are breeding, pregnant, or lactating. Be wary of those with kidney or liver disease.

No monitoring needed. No negative drug interaction with afoxolaner reported, but be sure to tell your veterinarian about any other pills or supplements that your dog is taking.

What are the potential side effects of which you should be aware?

If any of the below unfriendly reactions are observed to Nexgard Chewables for Dogs, contact your veterinarian or emergency veterinarian clinic:

  • Vomiting
  • Lethargy
  • Decreased appetite
  • Dry or flaky skin
  • Diarrhea
Frequently Asked Questions
Is Nexgard Chewable?

Nexgard is a first-of-its-kind beef-flavored oral chew for tick and flea prevention.

How to Administer Nexgard Chewables?

You can administer Nexgard to your dog orally once a month.

You can give them the chewable with or without food or water. But if your dog vomits within two hours of administration, then try again with food.

What Is Nexgard Chewables?

Nexgard Chewables are one of the most veterinarian preferred flea and tick control medications for your dogs. Nexgard is a first-of-its-kind oral chew for tick and flea prevention.

The monthly soft chew Nexgard Chewables ensure that your dog remains in the best conditions possible.

How Long Does Nexgard Chewables Last?

Nexgard Chewable, once administered, can protect your dog for the next 30 days.

Is Nexgard Chewables Safe for Dogs?

Nexgard Chewables are recommended by the top veterinarians, and dog owner reviews demonstrate 4.5+ stars out of 5 and 94% of reviewers recommend this product.

The best part is that these medicines are not potentially toxic or messy.

Can You Split Nexgard Chewables?

Any flea and tick medication should be given, as per the prescribed quantity. If you want to split the chewable, please contact your veterinarian and get his advice.

The beef-flavored chewable is liked by the dogs. Most of them take it without a fuss. If your dog rejects the medicine, administer it in full or split and mix with food as advised by your veterinarian.

Do Nexgard Chewables Work?

Yes, they effectively help prevent your dogs from fleas and teaks post-administration.

Do You Need a Prescription for Nexgard Chewables for Dogs?

Nexgard Chewables is a prescription medicine. It is one-of-a-kind FDA-approved chewable for dogs to treat fleas and teaks.

How Does Nexgard Chewables Work?

Afoxolaner (the generic name for the brand name Nexgard) is the active ingredient in Nexgard Chewables. The monthly medication helps effectively control and prevent adult flea infections before they start laying eggs.

Post ingestion of Nexgard (afoxolaner) Chewables in your dog's body, the active ingredients spread throughout the body. When the parasite attacks your dog, they get exposed to the afoxolaner, which kills them.

A big advantage of the Nexgard Chewable is that it kills the ticks before they can start to spread Lyme disease. It helps provide your dog with better protection against both the flea and the ticks.

How Fast Does Nexgard Chewables Work?

Post 4 hours of ingestion, the medicine starts to kill fleas and ticks after 12 hours. The majority of the fleas die within hours of contact with afoxolaner from a treated dog. This medicine does not prevent home flea infestations, but it can ensure to reduce the number of fleas. The fewer the number of fleas, the lesser the hatching of new fleas.

How Often to Give Nexgard Chewables?

Nexgard Chewable, once administered, can protect your dog for the next 30 days.

I Still See Fleas in My House, and My Dog Is Still Itching. What Is Wrong With Nexgard?

Nexgard Chewables does not prevent home infestation, but it can ensure to reduce the number of fleas and ticks on your dog. But the fleas from your house can still get to your dog.

Afoxolaner remains in the dog's body for the next 30days. During this period, the insects that bite your dog get exposed to the medicine. That may be why you see your dog itch.

What Are the Potential Side Effects of Which You Should Be Aware?

Post administration of the Nexgard Chewables, if you observe any out-of-the-ordinary reactions, contact your dog's veterinarian immediately.

Also, it is crucial to get in touch with the veterinarian if your dog exhibits any of the unfriendly reactions listed below

  • Diarrhea
  • Lethargy
  • Vomiting
  • Dry or flaky skin
  • Decreased appetite
Is Nexgard Chewables for Puppies?

You can administer Nexgard Chewables pills to your puppies if they weigh 4 pounds and are at least 8 weeks old.

Is Nexgard Chewables for Cats?

Nexgard Chewables are made for your dogs only, hence do not administer them to your cat. There are many equivalents of Nexgard Chewables for cats in the market, like Revolution Plus for Cats (topical) and Capstar Flea Killer for Cats (oral).

Which Dogs Should You Be Aware Of Not Giving Nexgard Chewables?

You should not administer to your dog if it has a history of seizures or neurological disorders. Also if your dog is breeding, pregnant, or lactating, avoid administration of the medicine.

Check for any kidney or liver diseases before giving the pills.

There is no negative interaction with afoxolaner reported yet, hence, you need not monitor post-application. But contact your veterinarian before opting for the medication. Inform him of the ongoing medications for your dog.
Concluding Thoughts

The most important thing that you should know about Nexgard Chewables is its 30-day mission to protect your dog from adult fleas (and their reproduction) and ticks (that can transmit Lyme Disease). Also, what is so awesome about Nexgard Chewables is its revolutionary chewable texture as a flea and tick preventative for dogs.

DISCLAIMER: Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition.

  • Boehringer-Ingelheim Brand
  • Flea & Tick Pharmacy
  • Protection Wellness Philosophy
  • Prescription Pharmacy Type
  • Boehringer-Ingelheim Manufacturer
  • Oral Application
  • Dog Pet Type

NexGard contain afoxolaner which is absorbed into the bloodstream after ingestion. When fleas and ticks ingest blood containing afoxolaner, it causes hyperexcitation and death in these parasites.



Afoxolaner helps to control teak and flea infestation among dogs. After taking the medication, the compound reaches the different parts of the body as ticks or fleas attack the dog to get exposure to the drug and die while having their blood meal. The medication is also in use to treat demodectic mange and sarcoptic mange. In such cases, the recommendation of the medicine gets considered off-label.


Afoxolaner is an isoxazoline compound that helps in providing extended efficacy against tick and flea control with a single oral administration. The effectiveness of the medication substantiates higher demand for infestation treatment.ย 

Special Precautions

Caution is advisable for administering the drug towpath with a history of seizures. It is also recommended to use the drug cautiously for pregnant, lactating, or breeding dogs. The medication can last for 4 to 6 weeks.

The GABA-mediated changes in mammals are due to the behavioral and neurological effects of the medication. The binding of the receptors is possible for the medication as per the Committee for Medicinal Products for Veterinary Use.

Mechanism of Action

The medication belongs to the isoxazoline chemical compound group and acts as an acaricide and insecticide. The actions of the medicine as an antagonist for neurotransmitter GABA receptors help to carry out its specific functions. The chloride channel modulators bind to the target sites and block before or after synaptic transfer of chloride irons through the cell membranes. The hyperexcitation of prolonged exposure to the medication leads to an aggravated activity of the center of the system, leading to the death of parasites. Competitive toxicity study The impact of afoxolaner occurs on the GABA-gated chloride channels via sites different from cyclodienes.

Known Drug Interactions

The prevailing research data does not showcase any drug interaction with other medications. However, it is advisable to inform your veterinarian about any medication your pet is currently taking. It will help to avoid any chance of drug interaction.

Brand/Generic Equivalents


In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard.

Over the 90-day study period, all observations of potential adverse reactions were recorded. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. The most frequently reported adverse reaction was vomiting. The occurrence of vomiting was generally selflimiting and of short duration and tended to decrease with subsequent doses in both groups. Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses.

Dogs and puppies 8 weeks of age and older weighing 4 pounds of body weight or greater

NexGard can be administered with or without food. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, redose with another full dose. If a dose is missed, administer NexGard and resume a monthly dosing schedule.

Flea Treatment and Prevention: Treatment with NexGard may begin at any time of the year. In areas where fleas are common year-round, monthly treatment with NexGard should continue the entire year without interruption. To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea control product.

Store at or below 30ยฐC (86ยฐF) with excursions permitted up to 40ยฐC (104ยฐF).

Nexgard is manufactured by Boehringer-Ingelheim

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