It is important to take a few precautions before administering Salix to the pet. Avoid Salix if the pet is allergic to it or other sulfonamides. As the drug is a potent diuretic-saluretic, large amounts of the drug would cause dehydration and electrolyte imbalance. Therefore, never prescribe the drug to animals with electrolyte imbalance. Use with extreme caution in animals suffering from diabetes and kidney disease. Salix can interact with ototoxic antibiotics such as gentamicin or streptomycin; NSAIDS such as aspirin or Rimadyl; phenothiazines such as acepromazine; and Insulin, digoxin, and beta blockers such as propranolol. Therefore, do not administer the Salix in combination with these drugs. Check the potassium levels in pets before administering the medicine. Salix could reduce serum calcium levels and might be responsible for tetany in animals that have hypocalcemic tendency.