The Best Heartworm, Flea, Ticks, and Parasite Prevention Medicines for Dogs Keep Your Pets Free From Parasite Attacks

The Best Heartworm, Flea, Ticks, and Parasite Prevention Medicines for Dogs

Thumbnail of Heartgard Plus Chewables for Dogs

Heartgard Plus Chewables for Dogs

Heartworm & Deworming
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Many pet owners are concerned about how well their dogs are protected from heartworm, fleas, ticks, and other parasites. This article will examine the best heartworm, flea, tick, and parasite preventative medicines for dogs.

Heartworm, flea, tick, and parasite prevention medicines are a great way to keep your dog healthy. The best thing about these medications is that they protect against more than just one kind of disease at once, so you can save money by buying fewer products. In this article, we'll look at the best Heartworm, flea, tick, and parasite protection for your dog.


Heartworm is a serious threat to dogs and cats. It's a parasitic worm that lives in the heart and lungs of animals, growing up to 12 inches long. Heartworm disease can be spread to pets by mosquitoes.

It's important to keep your pet on heartworm prevention medicine year-round because several different types of mosquitoes can carry this infection. It's shocking to know that more than 100,000 dogs in the USA are infected with Heartworm related diseases every year. Hence it is necessary not to take these diseases lightly and take preventive medicines to avoid any severe health conditions.

Heartgard Plus Chewables

You should give your dog one chewable tablet once a month or as directed by your veterinarian. If you have a small or toy dog breed, use the correct amount for that weight group.

You may begin giving Heartgard Plus Chewables to your dog at six weeks of age and older, when it weighs at least 5 pounds. However, you must wait until four weeks before you start your puppy on this medication if he weighs less than 5 pounds or is under four weeks old when you start treatment.

Interceptor Plus

Interceptor Plus is a monthly heartworm preventative, flea and tick prevention, and dewormer all in one. Interceptor Plus also contains an ingredient that helps to eliminate tapeworms. You can give this medication to dogs over six weeks old and up to 24 pounds of body weight, two tablets per month. The tablet must be administered once a month on the same day for dogs six weeks or older. We recommend administering this medication at least 30 minutes before feeding your pet so that it does not interfere with the absorption of nutrients from their diet.


Trifexis is a chewable tablet that can be given monthly to prevent fleas, heartworms, and intestinal parasites. Trifexis is given every month to protect from these parasites in dogs weighing 5 pounds or more.

Sentinel Spectrum

As the name suggests, this product works to protect against heartworms in dogs and cats. It also protects against several internal parasites, including hookworms, roundworms, tapeworms, fleas, and ticks. It does not need to be given every month, but it is administered orally every three months at the rate of one tablet per 30 pounds of body weight. The medication comes in 3 different sizes: small dog (6-10 lbs), medium dog (11-20 lbs), and large dog (21-40 lbs).

Sentinel Spectrum can be used for puppies at six weeks or older. You can also use it for pregnant or nursing dogs due to its safety profile for breeding animals.

Advantage Multi

One of the best options for your dog is Advantage Multi. This topical treatment is easy to apply and easy to use. It's safe and effective for dogs and puppies over six weeks and cats over eight weeks old.

Advantage Multi for dogs kills fleas before they can lay eggs. It also kills ticks that may transmit Lyme disease, ehrlichiosis, or Rocky Mountain spotted fever. In addition, you can use it during pregnancy and lactation without risk to either the mother or her offspring.

Fleas and Ticks

Fleas and ticks are an annoying problem for dogs. Not only can they cause your dog to scratch itself to the point where it loses hair and skin, but they also carry dangerous diseases such as Lyme disease, Rocky Mountain spotted fever, and anaplasmosis.

Preventing fleas means keeping them off of your pet with a monthly medication that kills fleas in their early stages of development before they harm your dog.

It is estimated that every 1 out of 6-7 dogs carries fleas, resulting in severe conditions later. Hence getting proper prevention medicines for fleas and ticks is important to avoid any flea or tick-related infections in your dog. Following are some medicines that are very effective for flea and tick prevention in dogs.


NexGard is a monthly chewable tablet for dogs and puppies seven weeks or older. NexGard is the first FDA-approved chewable tablet for dogs and puppies, making it easy to administer to your pet.

NexGard works by killing fleas, ticks, and their larvae when consumed by the animal in an infected environment. It also protects your dog from heartworms, so you won't have to worry about administering additional medications or giving your dog an additional pill every month.

Bravecto Chews

Bravecto for dogs is the first chewable, beef-flavored oral flea and tick preventative for dogs over six months of age that provides up to 12 weeks of protection against fleas and ticks. With a convenient single-dose administration, Bravecto also protects your dog from flea infestations and heartworms and prevents infestations by the Asian tiger mosquito that may transmit the Zika virus.

Simparica Plus

Simparica Plus is a monthly chewable tablet that kills fleas and prevents flea infestations for a full month. It's also the only medicine that treats paralysis ticks, which can cause serious illness in dogs.

Simparica Plus is for dogs and puppies seven weeks of age and older. That said, it's not recommended for puppies younger than seven weeks because their immune systems aren't fully developed yet. For example, suppose your dog has had its first set of vaccines. In that case, however, you can start using Simparica Plus immediately. But give him another vaccine within 48 hours after starting treatment with this medication to ensure maximum protection against tick-borne diseases like Lyme disease or Rocky Mountain spotted fever.

Frontline Plus

It is a topical medicine to prevent flea and tick infestation in dogs. Frontline Plus kills fleas, ticks, and lice. The product also repels mosquitoes, sand flies, and stable flies. In addition, frontline Plus is waterproof, so it remains effective even if your pet gets wet.

K9 Advantix II

K9 Advantix II is a once-a-month topical medication used to kill and repels fleas, ticks, and mosquitoes. It's also effective against biting lice. With a unique combination of ingredients, K9 Advantix II starts to kill fleas within 20 minutes of application. In addition, this powerful formula protects your dog against all stages of adult fleas' life cycle, preventing them from developing into eggs or larvae that may cause further infestations in your home.

K9 Advantix II also protects dogs from ticks, including those that can transmit Lyme disease and other tick-borne diseases, such as Ehrlichia and deer ticks which transmit anaplasmosis. In addition to killing all life stages of ticks, it effectively repels them, so they don't come near your pet again for at least three weeks after treatment with K9 Advantix II.

It is important to note that this product does not kill brown or American dog ticks found in southeastern states such as Texas and Florida.


Sentinel is a heartworm, flea, and tick prevention medicine effective against intestinal worms. The chewable tablet is safe for puppies, pregnant dogs, and lactating dogs. It's also safe for dogs with epilepsy.

The only downside of Sentinel for dogs is that it doesn't protect your dog from heartworms but protects them from other parasites like hookworms and roundworms. However, it's a good choice if you can get past the price tag, about $180 per year.


Parasites are a common problem for dogs and, when left untreated, can cause serious health problems in your pet. Parasites can be transmitted to humans through flea, tick bites, and contact with other infected animals. The most common way to treat these infections is by using an oral medication that kills the parasite or prevents it from multiplying further inside your dog's body.

Panacur C

Panacur C Canine Dewormer is the best Heartworm, flea, tick, and parasite protection. This product treats roundworms, hookworms, whipworms, tapeworms, and giardia in dogs. It's available as a powder that can be mixed with food or placed on the back of your dog's tongue. When used correctly, this product will kill all parasites living within your pet, including heartworms.

Panacur has been around for many years, so it's not only safe to use but well known by vets, too, which means you can ask them any questions about how to use the medication safely and effectively on your pet at home.


I hope this article has helped you decide what to treat your dog for when it comes to parasites. I have listed some of the best products on the market, but there are many more options available, so do your research and choose one that suits your needs.

Frequently Asked Questions

Is there a shot for dogs for fleas, ticks, and heartworm?

If you find it difficult to feed your dog monthly doses of heartworm preventive medication, you can administer one shot of ProHeart 6 or 12, which can protect your dog from heartworms. ProHeart 6 is effective for 6 months, whereas ProHeart 12 is effective for 12 months. ProHeart is the only FDA-approved shot against heartworms. However, there are no shots for flea and tick prevention, so you will have to use chewable preventives.

Can you get rid of heartworms without a vet?

A lot of people (including holistic vets) claim that natural remedies can treat heartworms. However, a veterinary doctor has to be consulted if you notice signs of heartworm infection in your dog. Heartworm disease is a very serious one and can even be fatal for a dog if it is not treated in time. Since the worms grow inside a dog's heart, killing them and flushing them out of the body can be quite painful for the dog. Therefore, preventive medicines are the best way to keep heartworms at bay.

How do dogs act if they have heartworms?

A heartworm-positive dog can show several signs, such as a mild but persistent cough, lack of energy, fatigue, loss of appetite, and abrupt weight loss. It is important to note that the dog may not show any symptoms in the early stages. Most symptoms start showing when the dog has been suffering from heartworms for some time. Too many heartworms in the dog's body can even cause blockage in the blood flow and cardiovascular collapse, known as caval syndrome. If that happens, the dog will have sudden difficulty in breathing, pale-colored gums, and very dark-colored urine. At this stage, very few dogs survive if they get immediate treatment.

How much does a heartworm injection cost?

ProHeart 6 can cost between $50 to $150 for one dose (for 6 months), whereas ProHeart 12 can cost between $75 to $350 once a year. As we mentioned above, these are the preventive doses. For heartworm-positive dogs, the treatment happens in several stages. First, the vet administers a shot of Doxycycline, which can cost between $30 to $150. The shot of antibiotics weakens the heartworms. The vet might also administer a shot of steroids if the dog is coughing, which is $10-$40. In the next stage, 3 melarsomine injections will be administered in stages, costing between $500 and $1500. If the dog advances to caval syndrome, the option is surgery, which can cost between $3000-$5000.

What to do if you can't afford heartworm treatment?

If your dog is heartworm positive, but you can’t afford heartworm treatment, you should start the Doxycycline dose and preventive medicines at least. That way, there won't be further infection as the preventive medicines kill heartworm larvae. However, you should understand that without melarsomine, there is no way to flush out the dead heartworm from the dog's body. Therefore, your dog might develop exercise intolerance with time.

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