Heartgard Plus Chewables for Dogs
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At a Glance
#1 Vet-recommended heartworm preventive
Effectively prevents heartworms
Dogs (6+ weeks of age, no weight requirement)
Also treats and controls roundworms & hookworms
Only given once a month, delicious real-beef chew

Heartgard Plus Chewables for Dogs

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At a Glance
#1 Vet-recommended heartworm preventive
Effectively prevents heartworms
Dogs (6+ weeks of age, no weight requirement)
Also treats and controls roundworms & hookworms
Only given once a month, delicious real-beef chew

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Ultimate Guide to Heartgard Plus Chewables for Dogs

Meet Top Heart Protector: Heartgard Plus Chewables for Dogs!

Heartgard Plus Chewables is the veterinarian, FDA, and EPA-approved medication that protects your dogs from dangerous internal parasites, such as heartworms, roundworms, hookworms, and ascarids. Safe and effective, Heartgard Plus Chewables is a real beef chewable taken monthly to especially prevent vicious heartworm disease.

As a preventative drug, Heartgard Plus Chewables should only be used on untreated dogs. Make sure your pup is tested by your veterinarian before use.

How do Heartgard Plus Chewables work?

Heartgard Plus Chewables is a medication with two active ingredients. Ivermectin and Pyrantel are both anthelmintics or dewormers.

Ivermectin is commonly known as a heartworm preventative by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis). It is a monthly anti-parasitic agent that paralyzes, kills, and treats infections caused by gastrointestinal parasites. Pyrantel pamoate is used to treat roundworm, hookworm, and stomach worm parasites in dogs.

NOTE: FDA-approved Ivermectin has broad-spectrum anti-parasitic and anti-viral activity in vitro. It is an inhibitor of the virus SARS-CoV-2 that causes COVID-19. Ivermectin is widely available due to its inclusion on the World Health Organization's (WHO) list of essential medicines.

How are Heartgard Plus Chewables administered?

Heartgard Plus Chewables are administered orally once a month and protect your dog to be worm-free for the next 30 days. These real beef-flavored chewable tablets can be used as dog treats or eaten with the dog's food. Heartgard Plus Chewables are used year-round for maximum prevention effectiveness.

Weight Ivermectin/Pyrantel Content per tablet (mcg/mg) No. of Tablets
0 - 25 lbs.68/57One
26 - 50 lbs.136/114One
51 - 100 lbs.272/227One
What are the precautions of which you should be aware?

Most importantly, ensure that every dog is tested for heartworm infection before beginning prevention therapy and using Heartgard Plus Chewables.

Oral Heartgard Plus Chewables are effective against the tissue heartworm larval stage of D. immitis for a month after infections of the preventative. However, Heartgard Plus Chewables cannot prevent the development of the adult stage.

Use with caution for collies and other herding dog breeds. These breeds have been known to have adverse reactions to ivermectin at elevated dose levels. Lastly, use the right and recommended dose level for pregnant or breeding dogs, stud dogs, and puppies at least 6 weeks old.

What are the potential side effects of which you should be aware?

Heartgard Plus Chewables is well tolerated by most dogs. Some unfriendly but uncommon reactions have been reported, such as vomiting, diarrhea, depression, lethargy, and hypersalivation. An overdose may cause tremors, disorientation, mydriasis, blindness, or loss of appetite.

Frequently Asked Questions
What Is Heartgard Plus?

Heartgard Plus for dogs is a chewable heartworm medicine for dogs. The Heartgard medication is heartworm chewable for dogs, which offers protection against heartworms. These heartworm chews kill heartworms before they even pose a serious health threat to your dog.

Heartworm infestation may progress to become what is called heartworm disease, which causes significant damage to vital organs. This can lead to severe lung issues, heart failure, and untimely death. Therefore, it's a must to have your canine friend on a monthly cycle of Heartgard Plus dewormer.

Do I Need a Prescription for Heartgard Plus for Dogs?

Yes, Heartgard Plus is a prescription medicine and requires Heartgard prescribing information to purchase. All effective heartworm medications, including Heartgard Plus, require a prescription in the US.

While purchasing Heartgard plus chewables without a vet is possible, it involves a lot of risks. Therefore, it's advisable to get FDA-approved preventives like Heartgard Plus with a proper prescription from your vet.

Does Heartgard Plus Kill Tapeworms?

Heartgard plus ingredients include Ivermectin and Pyrantel Pamoate. The Heartgard Plus Ivermectin Pyrantel tablets offer protection against heartworms, roundworms, and hookworms.

Unfortunately, Heartgard Plus doesn't offer protection against tapeworms. For tapeworms, you'll need another prescription drug called Praziquantel.

Does Heartgard Plus Kill Roundworms?

Yes, Heartgard Plus kills roundworms and offers protection against health issues caused by these worms. The Heartgard Plus medicine is effective against two species of roundworms and three species of hookworms.

It's essential to safeguard your dog against roundworms as a single roundworm can lay up to 1,00,000 eggs in a single day in the intestines of infected dogs and cause weight loss, diarrhea, vomiting, malnutrition, and weakness.

What Is the Difference Between Heartgard and Heartgard Plus?

While Heartgard Plus and Heartgard for dogs may sound similar, there is a fundamental difference between the two. While Heartgard offers protection against heartworm disease alone, Heartgard Plus tablets are effective against three types of worms, including heartworm, roundworm, and hookworm.

The Heartgard Plus is the better option among the two as it offers wider protection against diseases. But, on the other hand, Heartgard medication is ideal for dogs that are already fighting heartworm disease and need a concentrated dose.

How Long Does Heartgard Plus Last?

Most heartworm preventive medications like Heartgard Plus require monthly administration. Monthly preventives like Heartgard and Heartgard Plus don't stay in your dog's bloodstream for over 30 days. The active ingredients in the medication work to eliminate any larvae that must have been in the system for the last 30 days, clearing the body each month. The main reason the medication is only needed once a month is that it takes more than a month for larvae to grow enough to infect body tissues.

What Is the Difference Between Heartgard and Tri-Heart Plus?

Heartgard and Tri-Heart Plus are two different medications with the same purpose. The only difference between the two is that Heartgard Plus is a soft beefy chew, whereas Tri-Heart Plus is a chewable, beef-flavored tablet.

It may surprise you to know that these two most popular medications for dogs are more alike than they are different. Both Heartgard Plus and Tri-Heart Plus have Pyrantel Pamoate and Ivermectin to prevent heartworms, hookworms, and roundworms.

These chews are both prescription medicines safe for pregnant or breeding dogs and puppies over six weeks of age.

How Often Do You Give Heartgard Plus?

Because heartworm and other larvae take at least 30 days to reach the stage where they penetrate body tissues, Heartgard Plus is administered monthly.

There are two kinds of heartworm preventives - monthly preventives administered orally and injectable preventives requiring dosage every six or 12 months. Either type is fine as long as you adhere strictly to the schedule.

Can a Dog Overdose on Heartgard Plus?

Yes, if your dog consumes 10-20 times more than the recommended dosage, there is a high risk of overdosing. The Heartgard Plus medication is recommended to administer every month at a recommended minimum dosage of 6 mcg of ivermectin and 5 mg of pyrantel per kilogram of the body weight.

In the case of overdose, you may see symptoms like lethargy, depression, vomiting, dilated pupils, disorientation, loss of appetite, blindness, and coma, among others. Always consult your vet and get a prescription for recommended dosage before administering Heartgard Plus to your dog.

Can You Cut Heartgard Plus in Half?
According to Merial, the Heartgard Plus manufacturer, it's not recommended to cut or split the Heartgard Plus to halve the dosage. This is because the active ingredient is not spread evenly throughout the tablet. The company doesn't guarantee the effectiveness of the medicines if the dose is split. It's best to get the right size tablets for your dogs from your vet.
Concluding Thoughts

The most important thing that you should know about Heartgard Plus Chewables for Dogs is that it is the top choice preventative against the dangerous heartworm disease in which it gives your dog a layer of protection from stomach worm infestations for 30 days. Heartgard Plus Chewables for Dogs will improve your dog's quality of life.

DISCLAIMER: FDA law restricts Heartgard Plus Chewables for Dogs only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian if it's a good idea to treat all of the animals in your household to control a home flea infestation.

Tri-Heart Plus is a generic/alternative to Heartgard Plus, with the same active ingredients at a lower price.
  • Boehringer-Ingelheim Brand
  • Heartworm & Deworming Pharmacy
  • Boehringer-Ingelheim Manufacturer
  • Beef Flavor
  • Oral Application
  • Dog Pet Type

Should Heartgard Plus Be Given Before or After Meals?

Heartgard for dogs can be used with or without a meal. However, it is recommended to give Heartgard to small dogs with a meal. This is because feeding your dog before or during administering the medication can help reduce the risk of stomach upset or vomiting. Additionally, giving Heartgard chewable with a meal may help improve the absorption of the medication. When taken with food, the medication is more likely to be absorbed and metabolized properly, increasing its effectiveness in preventing heartworm disease.

Does Heartgard Plus Make Dogs Sleepy?

Heartgard Plus for dogs is one of the most used heartworm chews to prevent heartworm disease. While drowsiness or lethargy is not a common side effect of Heartgard Plus, some dogs may experience this side effect.

Can a Dog Still Get Heartworms While on Heartgard Plus?

While Heartgard Plus is highly effective at preventing heartworm disease in dogs, no medication can provide 100% protection against the disease. In rare cases, dogs can still get heartworms while on Heartgard Plus, although the risk is very low. Several factors can contribute to a dog still getting heartworms despite being on Heartgard Plus. For example, if the medication is not administered properly or if doses are missed, the effectiveness of the medication may be compromised. Additionally, if a dog is exposed to mosquitoes carrying heartworm larvae frequently, the risk of infection may be higher.

How Long Should Dogs Be On Heartgard Chewable?

The length of time a dog should be on Heartgard Plus depends on various factors, including the dog's age, breed, and overall health, the local prevalence of heartworm disease, and the risk of exposure to infected mosquitoes. Heartgard Plus is given to dogs monthly for the duration of the heartworm transmission season. In most parts of the United States, this means that dogs should receive Heartgard Plus year-round to provide continuous protection against heartworm disease.

Can I Give Heartgard Plus and Dewormer Together?

If your dog needs treatment for intestinal worms not covered by Heartgard Plus, your veterinarian may recommend a separate dewormer medication. It is usually safe to give Heartgard Plus and a separate dewormer medication together, but you should always follow the specific dosing and administration instructions provided by your veterinarian.

How Long Can a Dog Live With Heartworms Without Treatment?

Many factors, including the severity of the infection and the dog's general health, might affect a dog's life expectancy when they have heartworm disease. Yet, if they do not undergo treatment, it is generally believed that most dogs with heartworm infections will not survive more than two years.

Can I Skip a Month of Heartgard Plus?

If you miss a dose of Heartgard Plus, it is important to contact your veterinarian for advice on how to proceed. Sometimes, your veterinarian may recommend giving the missed dose as soon as possible and resuming the regular monthly schedule. However, if it has been over two months since the last dose, your veterinarian may recommend retesting your dog for heartworm infection before resuming the medication.

How Much Does Heartgard Plus Typically Cost?

A typical monthly dose of Heartgard Plus for a 50-pound dog can range from $6 to $10, depending on the location and provider. However, the cost of Heartgard can vary depending on the size of your dog, with larger dogs requiring higher doses and thus a slightly higher cost per month. Many veterinarians and pet supply stores offer discounts on Heartgard Plus, such as a six-month or 12-month supply, when purchased in larger quantities.

Does Heartgard Plus Work Faster in Puppies or Older Dogs?

The effectiveness of Heartgard Plus does not vary based on the dog's age. Whether a dog is a puppy or an older adult, Heartgard Plus works similarly to prevent heartworm disease. However, Heartgard Plus for puppies can be administered as young as 6 weeks old, according to the manufacturer's label. The American Heartworm Society advises, however, that heartworm testing be done before starting prevention and that puppies be started on heartworm prevention as early as 6โ€“8 weeks of age.

Heartgard contains two active ingredients, ivermectin and pyrantel, that work together to prevent heartworm disease and treat and control hookworms and roundworms.

In clinical field trials with HEARTGARD Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of HEARTGARD: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.

For dogs and puppies 6 weeks of age and older.

Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find HEARTGARD Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended. HEARTGARD Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dogโ€™s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dogโ€™s last exposure to mosquitoes. When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of HEARTGARD Plus must be given within a month (30 days) of the last dose of the former medication. If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD Plus and resumption of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms. Monthly treatment with HEARTGARD Plus also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

Store between 68ยฐF - 77ยฐF (20ยฐC - 25ยฐC). Excursions between 59ยฐF - 86ยฐF (15ยฐC - 30ยฐC) are permitted. Protect product from light.

Medication Guide: Guide to Heartgard Plus for Dogs - Ivermectin


Heartgard is manufactured by Boehringer-Ingelheim
Option UPC/SKU
Blue, 25 lbs. and under, 6 Month Supply 350604401216
Green, 26-50 lbs., 6 Month Supply 350604401315
Brown, 51-100 lbs., 6 Month Supply 350604401414
Brown, 51-100 lbs., 12 Month Supply 350604401438
Blue, 25 lbs. and under, 12 Month Supply 350604401230
Green, 26-50 lbs., 12 Month Supply 350604401339
Blue, 25 lbs. and under, 1 Month Supply 350604000402
Green, 26-50 lbs., 1 Month Supply 350604000419
Brown, 51-100 lbs., 1 Month Supply 350604000426

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