Tri-Heart Plus
Tri-Heart Plus
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At a Glance
Prevents fatal heartworm disease and controls other gastrointestinal parasites.
Active ingredient Ivermectin is a parasiticide that protects against two intestinal parasites (i.e., roundworms and hookworms) and is a 100% effective heartworm disease preventative.
Active ingredient Pyrantel paralyzes and kills internal parasites.
One beef-flavored chewable tablet per month works for 30 days.

Tri-Heart Plus

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At a Glance
Prevents fatal heartworm disease and controls other gastrointestinal parasites.
Active ingredient Ivermectin is a parasiticide that protects against two intestinal parasites (i.e., roundworms and hookworms) and is a 100% effective heartworm disease preventative.
Active ingredient Pyrantel paralyzes and kills internal parasites.
One beef-flavored chewable tablet per month works for 30 days.

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Total Price

Merck Animal Health Logo

Ultimate Guide to Tri-Heart Plus

Meet the Heart Protector from Parasites: Tri-Heart Plus!

Tri-Heart Plus is an FDA-approved, veterinarian-recommended medication that protects against life-threatening canine heartworm disease and treats and controls roundworms and hookworms.  Tri-Heart Plus is a monthly, beef-flavored chewable tablet that is safe to take year-round. Tri-Heart Plus ensures that your pup is in the best lovable condition!

How do the Tri-Heart Plus ingredients work?

Tri-Heart Plus is a medication with two active ingredients - Ivermectin and Pyrantel.

Ivermectin is a broad-spectrum, anti-parasitic agent that prevents heartworm disease and cures parasitic infections to help to improve your dog's quality of life. Ivermectin paralyzes the parasite through the insect's nervous system and eventually kills the parasite.

The second active ingredient, Pyrantel, is an anti-worm drug (i.e., anthelmintic) that is used to treat roundworm, hookworm, pinworm, and other worm infections.  It also works by paralyzing the parasite so that the body can remove them naturally in the stool.

How is Tri-Heart Plus administered?

Dogs must be tested for heartworm infection before starting a preventive program and before starting to use the medication.  Tri-Heart Plus for dogs is a beef-flavored chewable tablet administered orally once a month and protects your dog for the next 30 days.

Depending on the body weight of your dog, there are three different colored boxes provided with different micrograms of Ivermectin and milligrams of Pyrantel in every tablet.  See the dosage chart below:

Body Weight

Ivermectin (mcg)

Pyrantel (mg)

0 - 25 lbs.

68

57

26 - 50 lbs.

136

114

51 - 100 lbs.

272

227

What are the precautions of which you should be aware?

Test your dog for heartworm disease before using Tri-Heart Plus and before any heartworm prevention therapy. Already infected dogs need to be dewormed before administering Tri-Heart Plus.  

What are the potential side effects of which you should be aware?

Tri-Heart Plus's most common adverse reactions reported are vomiting, depression, depression, anorexia, ataxia (a degenerative neurological disease that causes bad body coordination), convulsions, mydriasis (pupil dilation), hypersalivation, and diarrhea.

Frequently Asked Questions
  1. What do the Tri-Heart Plus reviews say?

    Tri-Heart Plus reviews rate 4.5 out of 5 stars. Most reviewers say that Tri-Heart Plus is a highly effective product that they trust for all of their dogs' hearts.

  2. Which Tri-Heart Plus dosages available?

    The Tri-Heart Plus blue box is for 0 - 25 lbs. dogs, the green box is for Tri-Heart Plus 26 - 50 lbs., and the Tri-Heart Plus 51 - 100 lbs. is the brown box. The Tri-Heart Plus tablets come in 12-pack boxes.

  3. Is the product Tri-Heart Plus heartworm prevention for dogs?

    Tri-Heart Plus is a chewable heartworm medication that is an effective preventative for canine heartworm disease.

  4. Is Tri-Heart Plus for cats?

    No. Tri-Heart Plus is not approved for use for cats. Tri-Heart Plus was made to be an effective preventative for canine heartworm disease and to eliminate other internal parasites only.

  5. Does Tri-Heart Plus prevent fleas?

    No. Tri-Heart Plus tablets are labeled for heartworm prevention, roundworms, and hookworms. The medication is not to affect external parasites.

Concluding Thoughts

The most important thing that you should know about Tri-Heart Plus is its power to prevent, treat, and control for three internal parasites that threaten your furry best friend's heart health and quality of life.

DISCLAIMER: FDA law restricts Tri-Heart Plus to use by or on the order of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.  This informative article does not substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Tri-Heart Plus is a prescription medication for dogs ONLY.

  • Merck Animal Health Brand
  • Heartworm & Deworming Pharmacy
  • Merck Animal Health Manufacturer
  • Oral Application
  • Dog Pet Type

What Does Tri-Heart Plus Cover?
Answer

Tri-Heart Plus is a chewable tablet that is effective against heartworms and other hazardous parasites. Dogs can get infected with hookworms, roundworms, or heartworms at any point in life. Tri-Heart Plus is formulated with a tested combination of Ivermectin and Pyrantel to protect your dogs from these parasites. Tri-Heart Plus chewable tablets effectively prevent heartworms in dogs triggered by Dirofilaria immitis. The tablet is also effective in controlling and treating Ascarids and hookworms in canines and also six-week-old pups.

Are Triheart and Heartgard the Same?
Answer

It is surprising to know that both the top-line medicines are very similar when compared to their differences. The similarities are because of the two main ingredients in their making (Ivermectin and Pyrantel Pamoate). The similarity in ingredients makes them equally effective in preventing heartworms and treating roundworms and hookworms. Both Heartgard Plus and Tri-Heart Plus are available only on a veterinarian prescription. The dosage is also the same and given once every month. Both the medications are safe for breeding and pregnant dogs. The minimum age of puppies should be at least six weeks or more for administering both medicines. However, with all these similarities, the medications still have two key differences. The first difference is that Tri-Heart Plus is a beef-flavored chewable tablet, whereas Heartgard Plus is a soft beefy chew. The second difference is the rates; Tri-Heart Plus is much cheaper than Heartgard Plus, making the former a preferred choice.

Does Tri-Heart Plus Need to be Given with Food?
Answer

The effective dosage of Tri-Heart Plus is once every month or as per the dosage prescribed by your veterinarian. You can give the tablet directly or can even mix it with your dogโ€™s routine food. It totally depends on how comfortable your dog is with taking these chewable tablets. However, the Tri-Heart Plus tablets come in beef flavor, and most dogs just eat it like some treat. We must ensure that the dosage is regular and once every month to protect your dog by eliminating any growing larva before it reaches your dogโ€™s heart.

How Long is Tri-Heart Plus Good For?
Answer

Tri-Heart Plus is good for 30 days only. Hence, be sure to repeat the dosage immediately after a month. If you have missed a dose, give it as soon as you realize it and continue monthly. If the missed dose is over by two weeks, your dog must undergo microfilariae and antigen tests in 6 months. Repeat the tests in 6 months, as sometimes the results are not visible in the initial 6-month heartworm test. Because of its effectiveness of 30 days, you should set reminders for medication so that you do not miss any dose.

Does Tri-Heart Plus Prevent Tapeworms?
Answer

A simple answer to this can be a Yes. The monthly dosage of Tri-Heart Plus is capable of doing a lot more than preventing heartworm diseases. The medication can also control intestinal parasites like tapeworms, whipworms, hookworms, and roundworms. The only thing to remember is a regular dosage every 30 days and without skipping any dosage.

Can I Give My Dog Expired Tri-Heart Plus?
Answer

Any medication that includes Tri-heart Plus, which has reached its expiry date, should not be administered on pets. Tri-Heart Plus is only effective when used within its expiration date and when stored as mentioned on the medicine pack. The expiration date specifies that the active ingredients (Ivermectin and Pyrantel Pamoate) will not work effectively beyond the date.

What's the Difference between Tri-Heart Plus and Heartgard Plus?
Answer

There are two main differences between Tri-Heart Plus and Heartgard Plus. The first difference is that Tri-Heart Plus comes as a beef-flavored chewable tablet, whereas Heartgard Plus is a soft beefy chew. The second difference is the price; Tri-Heart Plus is much cheaper than Heartgard Plus, making the former a preferred choice.

What is the Difference between Trifexis and Tri-Heart Plus?
Answer

The main difference between the two medications is their active ingredients. While Tri-Heart Plus has Ivermectin and Pyrantel Pamoate, Trifexis contains Spinosad and Milbemycin Oxime. Other differences include the minimum dosage age, which is six weeks for Tri-Heart Plus, while it is eight weeks and 6 lbs of weight for Trifexis. Tri-Heart Plus is safe for breeding and pregnant dogs, but Trifexis is not yet proven for safety in pregnant, breeding, and lactating dogs. Trifexis provides extra protection from other hazardous parasites like fleas and whipworms, which cannot be said for Tri-Heart Plus.

Does Tri Heart Plus Require a Prescription?
Answer

Yes, it is mandatory to have a prescription to buy Tri-Heart Plus chewable tablets. You can consult your veterinarian about the same and get them prescribed for your pet dog.

When should I start heartworm prevention for my dog?
Answer

It is recommended to start heartworm prevention for your dog as early as possible, ideally before they are six months old. However, if your dog is older than six months and has not been on heartworm prevention, it is still necessary to start them on a preventative medication as soon as possible. Heartworm prevention medication is typically given monthly, and it is important to give it consistently throughout the year to ensure that your dog remains protected. Your veterinarian can recommend the most appropriate heartworm prevention medication for your dog based on age, weight, and other individual factors. In addition to giving your dog heartworm prevention medication, also have them tested for heartworms annually, even if they are on a preventative medication. This will ensure that any potential heartworm infection is detected early and can be treated before it becomes a serious health issue for your dog.

What are the signs of heartworms in dogs?
Answer

Heartworm disease in dogs can present with a variety of symptoms, which can vary depending on the severity of the infection. In the early stages of the disease, there may be no visible symptoms at all. A persistent cough is one of the most common signs of heartworm disease in dogs. The cough may be dry or may produce a small amount of phlegm. Dogs with heartworm disease may be less active than usual and may tire easily during exercise or play. Dogs with heartworm disease may lose their appetite or have difficulty eating. This can lead to weight loss and muscle wasting. As the heartworms grow and multiply in the lungs and heart, they can make it difficult for your dog to breathe. This can result in shortness of breath, rapid breathing, or wheezing. In advanced cases of heartworm disease, the heart and lungs may become so compromised that fluid accumulates in the abdomen. This can lead to a swollen belly or distended abdomen. Dogs with heartworm disease may have a dull, rough, or dry coat, which can be a sign of poor health. Some dogs may develop an allergic reaction to heartworms, which can cause skin irritation, hives, or other symptoms. In severe cases of heartworm disease, dogs may experience collapse or fainting. This can be a life-threatening emergency. In rare cases, heartworm disease can lead to bleeding problems, including nosebleeds, blood in the urine or stool, or excessive bleeding from wounds.

Is there natural heartworm prevention?
Answer

While there are some natural remedies that are sometimes suggested for heartworm prevention in dogs, it's important to note that there is no scientifically proven natural heartworm prevention method. Heartworm disease is a serious and potentially life-threatening condition, and the most effective way to prevent it is through the use of prescription heartworm prevention medication that has been tested and approved by the FDA. These medications work by killing the immature heartworms that are transmitted to dogs through mosquito bites, preventing them from developing into adult heartworms that can cause serious health problems. That being said, some people believe that adding garlic to a dog's diet can help to repel mosquitoes and reduce the risk of heartworm infection. However, garlic can actually be toxic to dogs in large amounts. Another natural remedy that is sometimes suggested for heartworm prevention in dogs is apple cider vinegar. Advocates claim that adding small amounts of apple cider vinegar to a dog's food or water can make their skin less attractive to mosquitoes, thus reducing the risk of heartworm infection. Some people suggest using neem oil as a natural mosquito repellent for dogs, which may help to reduce the risk of heartworm infection. However, neem oil can be toxic if ingested in large amounts, so it should be used with caution. Some herbal supplements, such as black walnut, wormwood, and clove, are sometimes recommended as natural heartworm preventatives for dogs. But none of these natural remedies have been scientifically proven to prevent heartworm disease in dogs, and relying solely on these methods may put your dog at risk of serious health problems.

Is heartworm treatment lifelong?
Answer

Heartworm treatment is a process used to eliminate adult heartworms that have already developed in a dog's body. The treatment typically involves a series of injections that are administered over several months, along with strict rest and exercise restrictions. Once the adult heartworms have been eliminated, it's necessary to continue with a preventative care plan to prevent re-infection. On the other hand, heartworm prevention refers to the regular use of prescription medication to prevent heartworms from developing in a dog's body in the first place. These medications are typically administered on a monthly basis and work by killing any immature heartworms that may have been transmitted to your dog through mosquito bites. While heartworm treatment is a temporary process that lasts several months, heartworm prevention is an ongoing process that requires regular administration of preventative medication.

How long can a dog go without heartworm pills?
Answer

Some monthly heartworm prevention medications have a "grace period" or "safety factor" of a few days to a couple of weeks, which means that missing a single dose may not immediately put your dog at risk of heartworm infection. However, missing even a single dose of heartworm prevention medication can increase the risk of heartworm infection, and a regular, consistent administration of preventative medication is the best way to ensure that your dog remains healthy and heartworm-free. If you do miss a dose of heartworm prevention medication, it's best to contact your veterinarian for advice on how to proceed.

What ingredient kills heartworms?
Answer

The active ingredient that kills heartworms in most prescription heartworm prevention medications is called ivermectin. Ivermectin works by targeting the immature heartworms (microfilariae) that are transmitted to dogs through mosquito bites, preventing them from developing into adult heartworms that can cause serious health problems. Other prescription heartworm prevention medications may contain different active ingredients, such as milbemycin oxime, selamectin, or moxidectin, which also work to prevent heartworm infection by targeting immature heartworms. You should note that prescription heartworm prevention medications, including those containing ivermectin, milbemycin oxime, selamectin, or moxidectin, are designed to prevent the development of heartworms in their early stages when they are still immature microfilariae. These medications do not work on adult heartworms, which have already developed in a dog's body. To eliminate adult heartworms, a different treatment process involving a series of injections over several months is required. That's why it's crucial to follow your veterinarian's recommended preventative care plan and schedule regular check-ups to ensure that your dog remains healthy and heartworm-free.

Tri Heart Plus contains Ivermectin and Pyrantel pamoate

All dogs should be tested for heartworm infection before starting a preventive program. In a small percentage of ivermectin/ pyrantel treated dogs, digestive and neurological side effects may occur.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427 before giving your pet Tri Heart Plus.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Dogs must be tested for heartworm infection before starting a preventive program like Tri-Heart Plus.

Tri Heart Plus may be administered orally once a month, at the veterinarian prescribed dose. Most dogs will readily chew the medication, but if your dog is used to swallowing pills, break it up into smaller pieces. Make sure the dog consumes the entire dose.

Store Tri Heart Plus in a cool, dry place. Keep Tri Heart Plus away from light. Keep Tri Heart Plus in a secure area away from children or pets.

Tri-Heart Plus is manufactured by Merck Animal Health

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

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Customer Reviews

Rating Summary 86 review(s)
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74
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B
Protect your fur babies
VERIFIED PURCHASER

My pups have used Tri-heart Plus for five years. They are perfectly happy.

Bertha Cantu recommends this item.
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J
Works great
VERIFIED PURCHASER

Tri heart plus is great! It was recommended by my vet and there have been no issues.

Jamai Sowul recommends this item.
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K
Effective and Affordable
VERIFIED PURCHASER

Been using for over a 2 years period on both my dogs and haven't had an issue as all Heart Worm tests have been negative.

Keven K. recommends this item.
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K
Tri heart plus
VERIFIED PURCHASER

Have used PetCareRx for YEARSโ€ฆ would recommend to all of my friends

Kelly A recommends this item.
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R
A Great Choice for Heartworm Prevention and More
VERIFIED PURCHASER

I have been using Tri-Heart Plus for my Cavalier King Charles Spaniel for over a year now, and I am very happy with the results. Tri-Heart Plus is a chewable tablet that protects against heartworm disease, as well as roundworms and hookworms, which can cause serious health problems for dogs. It is easy to administer, as my dog loves the beef flavor and takes it without any fuss. It is also very affordable, compared to some other brands of heartworm prevention. Tri-Heart Plus contains two active ingredients: Ivermectin and Pyrantel. Ivermectin is a broad-spectrum anti-parasitic agent that prevents heartworm larvae from developing into adult worms, and also kills intestinal parasites. Pyrantel is an anti-worm drug that paralyzes and eliminates roundworms and hookworms from the digestive tract. Together, these ingredients provide a comprehensive protection for my dogโ€™s heart and overall health. Since I started using Tri-Heart Plus, I have noticed that my dog has more energy, a shinier coat, and a better appetite. He has not shown any signs of heartworm infection, such as coughing, fatigue, or weight loss. He has also not had any adverse reactions or side effects from the medication, such as vomiting, diarrhea, or itching. He is always happy and playful, and I can tell he feels great. Tri-Heart Plus is a prescription-only medication, so you will need to consult your veterinarian before using it. Your vet will also need to test your dog for heartworm infection, as Tri-Heart Plus is not effective against adult worms. You will need to give your dog one tablet per month, preferably on the same day, to ensure consistent protection. You can also store the tablets at room temperature, away from light and moisture. Tri-Heart Plus is a safe and effective product that I would recommend to any dog owner who wants to prevent heartworm disease and other parasitic infections. It is suitable for dogs of all sizes and ages, as long as they weigh at least 6 pounds and are older than 6 weeks. It is also compatible with pregnant or breeding dogs, and puppies. Tri-Heart Plus has made a positive difference in my dogโ€™s life, and I am sure it will do the same for yours.

Richard recommends this item.
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K
Tri heart plus
VERIFIED PURCHASER

Love Pet Care RXโ€ฆ. Have been a member for YEARS

Kelly recommends this item.
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N
You Canโ€™t Beat the Price
VERIFIED PURCHASER

Tri-Heart Plus is a cheaper version of a well known brand name heart worm product. The exact same product but much cheaper. Why buy the more expensive product?

Neutron26 recommends this item.
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B
Tri-Heart
VERIFIED PURCHASER

It is much cheaper and does not cause tummy issues for my pupper!

Babette recommends this item.
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C
Tri-Heart Plud
VERIFIED PURCHASER

We use this for both our pups. One is 16#. One is 65#. Love it.

Cheryl recommends this item.
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K
Heart worm meds
VERIFIED PURCHASER

This product is affordable and works

Kelli Lowenberg recommends this item.
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C
Necessary for Health and Longevity
VERIFIED PURCHASER

I purchase this brand as itโ€™s much less expensive than the name brand; however, the ingredients are basically the same. My puppy Max eats the tablet without any hesitation. Anywhere mosquitoes fly - this preventative is required.

Cynthia recommends this item.
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T
A+ & Dog approved
VERIFIED PURCHASER

Mr. Cinnamon(8yrs) loves flavor and tx from Tri<3. Vet approves, insurance accepts, delivered w/i states time frame/dog approves. Makes an A+

TAB recommends this item.
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Y
Very good
VERIFIED PURCHASER

Great price and my babies like it

Yanii recommends this item.
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K
Meds
VERIFIED PURCHASER

The medicine works well and is affordable

Kelli Lowenberg recommends this item.
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B
tri-heart plus
VERIFIED PURCHASER

If I could give it more than 5 stars I would.

Brenda Wilson recommends this item.
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2
Excellent product
VERIFIED PURCHASER

My dog has been using these since I adopted him 4 years ago. He loves them and has NEVER had an issue with fleas or ticksโ€ฆ..

2KA2 recommends this item.
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Y
My babies love it
VERIFIED PURCHASER

Easy to chew for my babies and the best price around.

Yani recommends this item.
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K
Cost conscious
VERIFIED PURCHASER

I used to buy Heartgard, but the Tri-Heart Plus is such a better bargain. We can all use a bargain.

Kathleen recommends this item.
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B
best deal for heart worm treatment
VERIFIED PURCHASER

i love this product and so do my dogs. i switch from flea treatments/heart worm in summer and just heart worm treatment in winter

best deal for heart worm options recommends this item.
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J
Great Product
VERIFIED PURCHASER

Caesar love these pills and we love the price.

Johnny recommends this item.
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J
Great Product
VERIFIED PURCHASER

Our Doberman loves them.

Johnny recommends this item.
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K
AWESOME
VERIFIED PURCHASER

My lab has had a few ticks on him over the years and he tests negative each year he gets vaccinated against Lyme Disease!

Kimbo0916 recommends this item.
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A
Dogs like it!
VERIFIED PURCHASER

Great taste, no trouble getting all 4 of my dogs to take the pill. Easy autoship!

Amy recommends this item.
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L
Great price
VERIFIED PURCHASER

I love an excellent generic that does the job!!

Lisa recommends this item.
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G
TRI-HEART PLUS
VERIFIED PURCHASER

The prescription was filled easily and received quickly. I love this service!

Gina Fox recommends this item.
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G
Good product, great price
VERIFIED PURCHASER

Tri-Heart Plus is a good product and this is a great price.

George recommends this item.
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S
Effective but, inconvenient
VERIFIED PURCHASER

My dog weighs 125# & the pill for a 100lb. animal is HUGE! Difficult to administer. Will be switching back to chewable version next time

scott recommends this item.
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B
great med for pet
VERIFIED PURCHASER

this was very easy to get into our dog. it is effective to keep him safe from heartworm danger. product came quickly.

bosslady recommends this item.
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M
Great product, gets the job done
VERIFIED PURCHASER

Great product, gets the job done and our Girl eats it without hesitation. Good flavoring, our Pretty Girl approves!

Mr. Rollin recommends this item.
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M
Tri Heart +
VERIFIED PURCHASER

Great product, seems to be just as effective as the name brand but not as costly. My black lab eats it up like it's a treat so it must not taste bad, so it's really easy to give.

Michelle c recommends this item.
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