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Frontline vs Advantix for Dogs

Comparing Frontline vs Advantix for Dogs' Fleas and Ticks

By November 08, 2012 | See Comments

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Frontline vs Advantix for Dogs

Frontline vs Advantix: K9 Advantix and Frontline Plus for Dogs are some of the top flea and tick treatments--but how do you know which is better for your dog? Here are the key differences.

Biting pests like fleas and ticks can mean unwanted pain and discomfort for dogs, and some serious illnesses can result—some tick bites can lead to Lyme disease or other diseases, and fleas can carry tapeworm. 

Protecting your dog is a no-brainer, but how do you know which repellent will work best for your dog? With so many options, like Comfortis and Revolution for dogs, it can be tough to discern which medication is right for your pooch.

You’ve probably been recommended Frontline Plus or  K9 Advantix 2, or heard about one or both. Depending on what pests your dog is exposed to, how old your dog is, and what your dog’s lifestyle is like, one brand might be better suited to your pet than the other.

Frontline Vs. Advantix: What types of pests does each brand protect against?

  • Advantix kills fleas, ticks, mosquitoes and chewing lice and also repels ticks, fleas, biting flies, and mosquitoes. If you live in an area with lots of mosquitoes or flies, this may be the best choice.

  • Frontline Plus kills fleas, ticks, and chewing lice, and prevents fleas from laying new eggs.

Frontline Vs Advantix: How long does a dose last?

Both products last one month after application, and both are waterproof, so they’ll keep working if your dog goes swimming or needs a bath.

Should my dog be kept inside or alone after the dose?

  • After applying K9 Advantix, wait 48 hours before bathing your dog or letting it swim in a lake or pond—the medicine is dangerous to aquatic life.

  • K9 Advantix cannot be used on cats, and you should keep your dog away from any cats for 24 hours after applying the dose.

  • After applying Frontline Plus, don’t let your pet get wet until the product is dry, which usually takes 24 hours.

Are there any side effects to Frontline Vs Advantix?

Both products may cause some temporary skin irritation. If this persists or worsens after a few days, you should talk to a veterinarian.

My puppy is only a few weeks old. Can I still use K9 Advantix or Frontline Plus?

K9 Advantix can be used on dogs at least 7 weeks old, and Frontline Plus can be used on dogs at least 8 weeks old.

My dog is pregnant or nursing. Can I still use one of these medications?

  • Frontline Plus is approved for use on dogs that are pregnant, lactating, or breeding.

  • You should consult a veterinarian before using K9 Advantix on pregnant or nursing dogs.

Frontline Vs Advantix: How do they work?

  • Both products are topical medications, meaning you place the medicine on your dog’s skin. You’ll have to brush aside your dog’s hair and be sure the medicine is applied directly to the skin, to prevent it from coming off.

  • When applying Frontline Plus, apply the entire dose to one spot on your dog’s shoulder blades.

  • When applying K9 Advantix to a dog that weighs up to 20 pounds, apply the dose to 2 or 3 spots on your dog’s back from the shoulder blades to the base of the tail. If your dog is over 21 pounds, separate the dose into 4 to 6 spots along the back from the shoulder to the tail.

Having a dog that’s suffering from fleas and ticks can be stressful on you as well as uncomfortable and dangerous for your dog. Be sure to treat your pet for the pests in your area, and you’ll both be happier and healthier.

More on Fleas and Ticks

Flea and Tick Questions Answered
How do Dogs Get Fleas?
Get Rid of Fleas in 8 Steps - Infographic
My Dog Has Fleas, What Should I Do?
Are Flea and Tick Treatments Safe?
All Your Advantage II Questions Answered

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian with respect to your pet. It has, however, been verified by a licensed veterinarian for accuracy.






Yep. Read my comments. Experiencing the same problems with my poor little female dog. The makers of ADVANTIX II should be ashamed of themselves for ripping off us hard working Americans with this high priced worthless product. I am giving my dog a flea bath. She has never had fleas until now. Thank ADVANTIX II for infesting out animals with fleas. I mean they are making a colony on my poor dog. This stuff is preventing none of your claims period. Sorry to you for being duped by ADVANTIX II. LIKE ALL THE REST OF US.


After spending 55.00 $ on Advantix II at my local walmart. I applied as directed. Not but a few days later my dog who has never had fleas began itching and scratching uncontrollably. Read the instruction which said another dose could be applied after the first dose had been on her for 7 days. After doing that my poor dog just got worse. Another downer was now I had to wait another 30 day to apply my FRONTLINE PLUS. Which had always worked before. After contacting my vet. I was informed that they Advantix II sold in walmart and all pet stores is not pharmaceutically equivalent to what a vet. would provide you with. Where the FRONTLINE PLUS is. So this Advantix II sold in stores for the ridiculous price of 55.00 $ is bogus. Thats right it does not work period. Notta. ZERO. What a scam this advantix II is. Ripping off us hard working Americans with BOGUS STUFF. Now I am having to give my dog its first flea bath ever with this 11.00 $ ADAMS tick and flea shampoo. That kills flea eggs also. SO THEY CLAIM. As I wait the 5 days left until 30 days has passed. I do not want to KILL or make my dog SICK by applying my FRONTLINE PLUS a day early. Thus why I am giving her a flea bath. Fleas are running around on her body like nothing at all was applied to her. MY POOR JELLY BEAN. Someone making serious money while are pets end up suffering from their greed and lies. Well enough said. You have been warned. I will not even but the real stuff from the vet of Advantix II. Never again. Fool me once shame on you. Fool me twice shame on me. TICKED OFF (pardon the pun). Put this product from stores on your own pets (the makers and owners of this BOGUS PRODUCT). BET YOU 55.00 $ they do not use it themselves. THINK ??????????? ALL I HAVE HEARD FOR OVER A MONTH AND A HALF IS MY WIFE SAYING. OUR POOR DOG. DO SOMETHING FOR HER HONEY. SO A BATH WITH FLEA SHAMPOO IT IS. YOU TICK ME OFF ADVANTIX II. Might as well be selling water from your faucets and claiming all of your BOGUS claims. Would be no different the selling what you are producing. Modern day TONIC salesman. Referring to the con-artist of old west times. Want to cuss but not on here. TIP. YOU ALL HAVE BEEN WARNED !!!


I have a 3.5 month old pup that has had two doses of Advantix II and it isn't working to keep ticks off of him. Last night I found one that was starting to be engorged.


Why does my dog keep scratching and digging at herself two weeks after applying the medicine? The box says it starts to work within 4 hours do I need to reapply?

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