Frontline vs Advantix for Dogs Comparing Frontline vs Advantix for Dogs' Fleas and Ticks

Frontline vs Advantix for Dogs
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K9 Advantix II for Dogs

Flea & Tick
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Frontline vs Advantix: K9 Advantix and Frontline Plus for Dogs are some of the top flea and tick treatments--but how do you know which is better for your dog? Here are the key differences.

What's the Difference Between Frontline vs. Advantix?

While both medications can help keep your dog safe from pests, the main difference between Frontline vs. Advantix are as follows:

  • Advantix kills fleas, ticks, mosquitoes and chewing lice and also repels ticks, fleas, biting flies, and mosquitoes. If you live in an area with lots of mosquitoes or flies, this may be the best choice. You should consult your veterinarian before using Advantix on a pregnant dog.
  • Frontline Plus kills fleas, ticks, and chewing lice, and prevents fleas from laying new eggs. Frontline is approved for use on pregnant dogs.

Other differences between the two medications, as well as additional details (such as side effects, dosage, etc.) are covered below.

Biting pests like fleas and ticks can mean unwanted pain and discomfort for dogs, and some serious illnesses can result—some tick bites can lead to Lyme disease or other diseases, and fleas can carry tapeworm. 

Protecting your dog is a no-brainer, but how do you know which repellent will work best for your dog? With so many options, like Comfortis and Revolution for dogs, it can be tough to discern which medication is right for your pooch.

You’ve probably been recommended Frontline Plus or  K9 Advantix 2, or heard about one or both. Depending on what pests your dog is exposed to, how old your dog is, and what your dog’s lifestyle is like, one brand might be better suited to your pet than the other.

Frontline Vs Advantix: How long does a dose last?

Both products last one month after application, and both are waterproof, so they’ll keep working if your dog goes swimming or needs a bath.

Should my dog be kept inside or alone after the dose?

  • After applying K9 Advantix, wait 48 hours before bathing your dog or letting it swim in a lake or pond—the medicine is dangerous to aquatic life.

  • K9 Advantix cannot be used on cats, and you should keep your dog away from any cats for 24 hours after applying the dose.

  • After applying Frontline Plus, don’t let your pet get wet until the product is dry, which usually takes 24 hours.

Are there any side effects to Frontline Vs Advantix?

Both products may cause some temporary skin irritation. If this persists or worsens after a few days, you should talk to a veterinarian.

My puppy is only a few weeks old. Can I still use K9 Advantix or Frontline Plus?

K9 Advantix can be used on dogs at least 7 weeks old, and Frontline Plus can be used on dogs at least 8 weeks old.

My dog is pregnant or nursing. Can I still use one of these medications?

  • Frontline Plus is approved for use on dogs that are pregnant, lactating, or breeding.

  • You should consult a veterinarian before using K9 Advantix on pregnant or nursing dogs.

Frontline Vs Advantix: How do they work?

  • Both products are topical medications, meaning you place the medicine on your dog’s skin. You’ll have to brush aside your dog’s hair and be sure the medicine is applied directly to the skin, to prevent it from coming off.

  • When applying Frontline Plus, apply the entire dose to one spot on your dog’s shoulder blades.

  • When applying K9 Advantix to a dog that weighs up to 20 pounds, apply the dose to 2 or 3 spots on your dog’s back from the shoulder blades to the base of the tail. If your dog is over 21 pounds, separate the dose into 4 to 6 spots along the back from the shoulder to the tail.

Having a dog that’s suffering from fleas and ticks can be stressful on you as well as uncomfortable and dangerous for your dog. Be sure to treat your pet for the pests in your area, and you’ll both be happier and healthier.

Frequently Asked Questions

Which is better K9 Advantix II or Frontline?

K9 Advantix II. According to, K9 Advantix II fully controls (i.e., kills AND repels) flea and tick infestation, while Frontline does not kill biting fleas.

Which is better Frontline Plus or Advantage II?

Frontline Plus. According to Canine Journal, Frontline Plus is slightly less expensive than K9 Advantage II and protects against fleas in all life stages and ticks. K9 Advantage II only treats fleas and is more costly.

Is K9 Advantix the same as Frontline?

PetCareRX reads that while K9 Advantix II and Frontline both keep your dog safe from pests. The biggest difference between these medications is that K9 Advantix II kills AND repels fleas, ticks, mosquitoes, and chewing lice, but Frontline Plus kills these pests AND prevents fleas from laying new eggs. Pregnant dogs are also approved to use Frontline Plus, and vets must be consulted to use K9 Advantix II.

Is K9 Advantix II a good flea medicine?

PetCareRx says that K9 Advantix II is an effective flea treatment with a status of killing 98-100% of the fleas on dogs within 12 hours and continues to prevent infestations for at least four weeks. The medication also kills fleas before they lay eggs and kills flea larvae upon contact.
More on Fleas and Ticks

Flea and Tick Questions Answered
How do Dogs Get Fleas?
Get Rid of Fleas in 8 Steps - Infographic
My Dog Has Fleas, What Should I Do?
Are Flea and Tick Treatments Safe?
All Your Advantage II Questions Answered

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian with respect to your pet. It has, however, been verified by a licensed veterinarian for accuracy.

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