Frontline Plus for Dogs
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At a Glance
Provides fast-acting, long-lasting flea and tick protection for dogs 8 weeks or older weighing between 5 and 132 pounds
Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae
Waterproof 24 hours after application
Easy to apply for once a month for lasting protection
Proven protection trusted by veterinarians for more than 20 years, with separate formulations available for dogs and cats

Frontline Plus for Dogs

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At a Glance
Provides fast-acting, long-lasting flea and tick protection for dogs 8 weeks or older weighing between 5 and 132 pounds
Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae
Waterproof 24 hours after application
Easy to apply for once a month for lasting protection
Proven protection trusted by veterinarians for more than 20 years, with separate formulations available for dogs and cats

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Total Price

Boehringer-Ingelheim Logo

Ultimate Guide to Frontline Plus For Dogs

Meet the Trusted Parasite Treatment: Frontline Plus For Dogs!

Frontline Plus For Dogs is a veterinarian-recommended dog flea and tick treatment trusted by its customers for 20 years! Frontline Plus is a monthly, spot-on treatment that protects your pet for the next 30 days. From a first-time pet parent to a Frontline dog expert, Frontline Plus guarantees an easy-to-use and effective treatment for your dogs!

How does Frontline Plus For Dogs work?

Frontline Plus For Dogs is a medication with two powerful active ingredients (secret weapons) - Fipronil and (S)-methoprene - that kill adult ticks and fleas at every step of the flea 's life cycle. Frontline Plus kills the parasites on contact by storing itself in the oil glands in your pet 's skin and hair follicles continuously for the next 30 days.

Active ingredient Fipronil is a phenylpyrazole insecticide that disrupts the insect 's central nervous system by blocking the GABA-gated chloride channel that regulates cellular excitability and glutamate-gated chloride (GluCl) channels that controls movement, feeding, and behavior. This causes hyper excitement to the contaminated insect 's nerves and muscles.

Active ingredient (S)-methoprene is an insecticide chemical that controls hatching flea eggs and obstructs the development of the immature flea (i.e., flea pupae and larvae) into a breeding adult.

How is Frontline Plus administered?

Frontline Plus For Dogs is a monthly, spot-on treatment that is applied between a dog 's shoulders and protects your dog for the next 30 days. Frontline Plus products start killing fleas after four hours and effectively kill 100% fleas after 12 hours.

Frontline For Dogs comes in four different color boxes depending on the dog 's weight with differing milliliter (mL) application amounts. Each box has the same percentage of the active ingredients and comes in 3- and 6-month supplies. See the dosage chart below:

Body Weight

Application amount (mL)

5 - 22 lbs.


23 - 44 lbs.


45 - 88 lbs.


89 - 132 lbs.


What are the precautions of which you should be aware?

Consult your veterinarian before using Frontline Plus because of any potentially negative interactions with other medications that your dog may be taking, like another flea and tick control product.

Also, ensure that your dog is dry before application and that they are not wet for 24 hours after application.

What are the potential side effects of which you should be aware?

Slight irritation at the point of application may be experienced. If the irritation persists, contact your vet immediately.

Frequently Asked Questions
  1. Why am I seeing more fleas on my dog or in my home after applying Frontline Plus For Dogs?

    On the dog, the fleas that come into contact with Frontline Plus rise to the top of the haircoat as they die. In terms of the home, those fleas must have been eggs before you started using the medication. Consecutive monthly applications year-round of Frontline Plus For Dogs will assist with the elimination of an indoor infestation.

  2. Is there Frontline Plus for small dogs?

    Frontline Plus 5 - 22 lbs. is the orange box and for the smallest dogs that can use the medication.

  3. Is Frontline Plus for puppies?

    Frontline Plus for Dogs is safe for use on dogs 8 weeks and older.

  4. Is there other Frontline pet medicine for cats?

    Yes. Frontline Plus For Cats uses the same ingredients, has the same administration, and gives the same results. Frontline Plus can be used on dogs and cats ONLY.

  5. What are the reviews for Frontline Plus?

    Frontline Plus For Dogs reviews rate at 4.5 out of 5 stars. Most reviewers say that Frontline Plus is a quality and effective product for their dogs in any environment, and it is the only widely-trusted flea and tick medicine for their furry best friends.

  6. Explain the Frontline Plus application.

    Frontline Plus must be applied to a pet that is dry and then dry after 24-hours after application. It is a topical solution, spot-on treatment that is applied between the pet 's shoulders via a sterile applicator (i.e., pipette) every 30 days.

Concluding Thoughts

The most important thing that you should know about Frontline Plus For Dogs is its power to protect your dog and home from external parasites (i.e., fleas during their life cycle, ticks, lice, and chewing lice). Dogs should be pampered and protected with the best flea and tick treatment out there in order to have the best quality of life.

DISCLAIMER: This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian if this is a suitable product for your pet and for your home.

  • Boehringer-Ingelheim Brand
  • Flea & Tick Pharmacy
  • Boehringer-Ingelheim Manufacturer
  • Spot On/Topical Application
  • Dog Pet Type

How Effective Is Frontline Plus for Dogs?

Frontline Plus for Dogs is very effective and one of the best flea and tick control measures for dogs. When you use Frontline Plus, dogs are able to get rid of pesky parasites residing on their bodies. Frontline for ticks and fleas guarantees 100 percent flea and tick removal from your dogโ€™s skin. The medication does not only destroy adult fleas and ticks, but it also takes care of all the other stages of these parasites. Besides, Frontline for ticks and fleas starts to take effect within just 24 hours of application. And its presence in your dogโ€™s skin and hair follicles over the next 30 days continuously kills fleas and ticks in the various stages of their life cycles.

Why Is Frontline Plus Not Working on My Dog?

Before you can know why it is not working for your dog, you first need to know the answer to another question โ€“ how does Frontline work? Frontline plus has two powerful active ingredients known as Fipronil and (S)-methoprene. These two help kill the fleas and ticks, no matter what part of the life cycle they are in. They do so by positioning themselves in the hair follicles of your dogs for 30 days. The medication might not be working probably because it is being washed off and cannot store itself in the said positions. This could happen due to numerous reasons, but most probably because you are bathing your dog too early into the treatment. It is also possible that you are using a dog shampoo that is wearing out the presence of the medication. Ideally, you should wait 24 hours before bathing your dog after you have applied Frontline Plus.

How Long Does It Take Frontline Plus to Start Working?

Frontline Plus dog tick and flea control will take only 24 hours to start working. During that time, the medication will have spread all over its skin and body. Frontline Plus requires 24 hours to kill all the fleas on your dogโ€™s skin. It takes another 24 hours (total 48 hours) to destroy the tick infestation on their skin. After application, your dog will be safe from fleas and ticks for the next 30 days or so. During that time, the medication will continue to reside in the skin and hair follicles of your dog. In those positions, the Frontline Plus will continue to work its magic and fend off any flea or tick that might try to infest your dogโ€™s skin or take up territory.

How Long After Frontline Plus Can I Bathe My Dog?

You can bathe your dog 24 hours after you have applied the Frontline Plus for Dogs.

Can You Buy Frontline Plus Over the Counter?

Yes, you can buy Frontline Plus over the counter. Frontline for dog fleas is a flea and tick treatment medication that does not require any prescription for purchase. Unlike many other pet medications, this one does not need a vetโ€™s prior approval for usage. However, it is expected that you read the instructions on the bottle before you apply it, or talk to a vet if you are confused.

How Often Do You Apply Frontline Plus for Dogs?

You should apply Frontline Plus for Dogs every 30 days. Under critical circumstances, and the supervision of a vet, you can also apply every 2 weeks. Frontline for puppies should be applied in a much lesser amount (under 1 mL) per body weight than adult dogs.

What to Do if Dog Still Has Fleas After Frontline?

You can bathe your dog and reapply if your dog still has fleas after Frontline treatment. You should wait for at least 24 hours to see if the first application is working or not.

Do Fleas Jump off After Treatment?

Fleas are usually dead within 24 hours after you have used the Frontline Plus treatment.

What Differentiates Frontline for Dogs From Frontline Plus for Dogs?

Frontline is a topical flea and ticks medication that includes the active component fipronil. It is applied to the skin between the shoulder blades of the pet once a month to kill fleas, ticks, and chewing lice. Frontline is effective against adult fleas and ticks but does not kill flea eggs or larvae. Frontline Plus flea and tick for dogs, on the other hand, is also a topical flea and tick treatment with two active ingredients: fipronil and (S)-methoprene. Frontline Plus has an insect growth regulator (IGR) that stops the development of flea eggs and larvae, interrupting the flea life cycle in addition to killing adult fleas and ticks.

How Do I Know if Frontline Plus Worked?

After applying Frontline Plus to your pet, you can tell if it is working by monitoring your pet for any signs of flea or tick infestation. Check for adult fleas on your pet's skin or fur using a flea comb, or look for flea dirt (small black specks) in your pet's coat. If you see any live fleas or flea dirt, this may indicate that the Frontline Plus is not working effectively. However, remember that it may take a few days for Frontline Plus to start working and for all fleas and ticks to be eliminated. Visit your vet for more advice if you have any concerns.

Where Do You Put Frontline Plus on a Dog?

It is administered topically to the dog's skin, focusing on the area between the shoulder blades. This area is chosen because it is difficult for dogs to reach with their mouths, which reduces the likelihood of the dog licking the medication off before it has had a chance to be absorbed. Additionally, the skin in this area is thin and well-vascularized, allowing for rapid medication absorption into the bloodstream. It can then circulate throughout the dog's body to protect against fleas and ticks.

Can Too Much Frontline Plus Hurt My Dog?

Yes, it can. Frontline dog flea treatment is a popular flea and ticks preventative medication for dogs, and while it is generally considered safe, there is a risk of side effects if too much is administered. Overdosing on Frontline can cause symptoms such as vomiting, diarrhea, excessive drooling, tremors, and seizures. These symptoms can be mild or severe and can require veterinary attention.

What Are the Benefits of Frontline Plus Treatment for Dogs?

Frontline plus flea and tick treatment for dogs offers a variety of benefits. It is highly effective in killing fleas and ticks at all life cycle stages, providing long-lasting protection for up to 30 days with a single application. Also, Frontline Plus is easy to apply, with a pre-measured applicator that can be used to apply the medication directly to the dog's skin.

Is Frontline Plus Recommended by Vets?

Yes, Frontline flea treatment in dogs is recommended by many veterinarians as an effective flea and tick-preventative medication for canines. It has been on the market for many years and has a proven track record of effectiveness in controlling flea and tick infestations.

What if Frontline Plus Doesnโ€™t Work on My Dog?

If you have given Frontline Plus to your dog and it doesn't seem to be working, you can do a few things. First, ensure you are using the medication correctly and wait a bit longer to see results, as it can take up to 48 hours to kill fleas and ticks. If this doesn't work, you may want to try a different medication recommended by your veterinarian. Further, it may be necessary to address any underlying health issues or environmental factors that could make it more difficult to control fleas and ticks on your dog.

Frontline plus contains two active ingredients - Fipronil and S-methoprene.

Dogs may experience some temporary irritation at the site of application. If signs persist or become more severe within a few days of application, consult a veterinarian immediately.

Dogs/Puppies over 8 weeks of age, weighing 5 - 132 pounds

To apply, simply follow these instructions and repeat every 30 days: Remove one FRONTLINE Plus applicator by lifting and removing the plastic tab to expose foil backing. Then peel away the foil or use scissors to open. Open the applicator by holding upright with foil side toward you and snap applicator tip. Next, part your dog's hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the animal's skin. Do not apply on top of the haircoat. Avoid contact with treated area until dry.

Store unused product in original container only, out of reach of children and animals.

Frontline is manufactured by Boehringer-Ingelheim
Option UPC/SKU
Orange - 5-22 lbs., 3 Month Supply 350604287001
Blue - 23-44 lbs., 3 Month Supply 350604287100
Purple - 45-88 lbs., 3 Month Supply 350604287209
Red - 89-132 lbs., 3 Month Supply 350604287308
Orange - 5-22 lbs., 6 Month Supply 350604288008
Blue - 23-44 lbs., 6 Month Supply 350604288107
Purple - 45-88 lbs., 6 Month Supply 350604288206
Red - 89-132 lbs., 6 Month Supply 350604288305

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