Tri-Heart Plus
Tri-Heart Plus
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At a Glance
Prevents fatal heartworm disease and controls other gastrointestinal parasites.
Active ingredient Ivermectin is a parasiticide that protects against two intestinal parasites (i.e., roundworms and hookworms) and is a 100% effective heartworm disease preventative.
Active ingredient Pyrantel paralyzes and kills internal parasites.
One beef-flavored chewable tablet per month works for 30 days.

Tri-Heart Plus

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At a Glance
Prevents fatal heartworm disease and controls other gastrointestinal parasites.
Active ingredient Ivermectin is a parasiticide that protects against two intestinal parasites (i.e., roundworms and hookworms) and is a 100% effective heartworm disease preventative.
Active ingredient Pyrantel paralyzes and kills internal parasites.
One beef-flavored chewable tablet per month works for 30 days.

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Ultimate Guide to Tri-Heart Plus

Meet the Heart Protector from Parasites: Tri-Heart Plus!

Tri-Heart Plus is an FDA-approved, veterinarian-recommended medication that protects against life-threatening canine heartworm disease and treats and controls roundworms and hookworms.  Tri-Heart Plus is a monthly, beef-flavored chewable tablet that is safe to take year-round. Tri-Heart Plus ensures that your pup is in the best lovable condition!

How do the Tri-Heart Plus ingredients work?

Tri-Heart Plus is a medication with two active ingredients - Ivermectin and Pyrantel.

Ivermectin is a broad-spectrum, anti-parasitic agent that prevents heartworm disease and cures parasitic infections to help to improve your dog's quality of life. Ivermectin paralyzes the parasite through the insect's nervous system and eventually kills the parasite.

The second active ingredient, Pyrantel, is an anti-worm drug (i.e., anthelmintic) that is used to treat roundworm, hookworm, pinworm, and other worm infections.  It also works by paralyzing the parasite so that the body can remove them naturally in the stool.

How is Tri-Heart Plus administered?

Dogs must be tested for heartworm infection before starting a preventive program and before starting to use the medication.  Tri-Heart Plus for dogs is a beef-flavored chewable tablet administered orally once a month and protects your dog for the next 30 days.

Depending on the body weight of your dog, there are three different colored boxes provided with different micrograms of Ivermectin and milligrams of Pyrantel in every tablet.  See the dosage chart below:

Body Weight

Ivermectin (mcg)

Pyrantel (mg)

0 - 25 lbs.

68

57

26 - 50 lbs.

136

114

51 - 100 lbs.

272

227

What are the precautions of which you should be aware?

Test your dog for heartworm disease before using Tri-Heart Plus and before any heartworm prevention therapy. Already infected dogs need to be dewormed before administering Tri-Heart Plus.  

What are the potential side effects of which you should be aware?

Tri-Heart Plus's most common adverse reactions reported are vomiting, depression, depression, anorexia, ataxia (a degenerative neurological disease that causes bad body coordination), convulsions, mydriasis (pupil dilation), hypersalivation, and diarrhea.

Frequently Asked Questions
  1. What do the Tri-Heart Plus reviews say?

    Tri-Heart Plus reviews rate 4.5 out of 5 stars. Most reviewers say that Tri-Heart Plus is a highly effective product that they trust for all of their dogs' hearts.

  2. Which Tri-Heart Plus dosages available?

    The Tri-Heart Plus blue box is for 0 - 25 lbs. dogs, the green box is for Tri-Heart Plus 26 - 50 lbs., and the Tri-Heart Plus 51 - 100 lbs. is the brown box. The Tri-Heart Plus tablets come in 12-pack boxes.

  3. Is the product Tri-Heart Plus heartworm prevention for dogs?

    Tri-Heart Plus is a chewable heartworm medication that is an effective preventative for canine heartworm disease.

  4. Is Tri-Heart Plus for cats?

    No. Tri-Heart Plus is not approved for use for cats. Tri-Heart Plus was made to be an effective preventative for canine heartworm disease and to eliminate other internal parasites only.

  5. Does Tri-Heart Plus prevent fleas?

    No. Tri-Heart Plus tablets are labeled for heartworm prevention, roundworms, and hookworms. The medication is not to affect external parasites.

Concluding Thoughts

The most important thing that you should know about Tri-Heart Plus is its power to prevent, treat, and control for three internal parasites that threaten your furry best friend's heart health and quality of life.

DISCLAIMER: FDA law restricts Tri-Heart Plus to use by or on the order of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.  This informative article does not substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Tri-Heart Plus is a prescription medication for dogs ONLY.

What Does Tri-Heart Plus Cover?
Answer

Tri-Heart Plus is a chewable tablet that is effective against heartworms and other hazardous parasites. Dogs can get infected with hookworms, roundworms, or heartworms at any point in life. Tri-Heart Plus is formulated with a tested combination of Ivermectin and Pyrantel to protect your dogs from these parasites. Tri-Heart Plus chewable tablets effectively prevent heartworms in dogs triggered by Dirofilaria immitis. The tablet is also effective in controlling and treating Ascarids and hookworms in canines and also six-week-old pups.

Are Triheart and Heartgard the Same?
Answer

It is surprising to know that both the top-line medicines are very similar when compared to their differences. The similarities are because of the two main ingredients in their making (Ivermectin and Pyrantel Pamoate). The similarity in ingredients makes them equally effective in preventing heartworms and treating roundworms and hookworms. Both Heartgard Plus and Tri-Heart Plus are available only on a veterinarian prescription. The dosage is also the same and given once every month. Both the medications are safe for breeding and pregnant dogs. The minimum age of puppies should be at least six weeks or more for administering both medicines. However, with all these similarities, the medications still have two key differences. The first difference is that Tri-Heart Plus is a beef-flavored chewable tablet, whereas Heartgard Plus is a soft beefy chew. The second difference is the rates; Tri-Heart Plus is much cheaper than Heartgard Plus, making the former a preferred choice.

Does Tri-Heart Plus Need to be Given with Food?
Answer

The effective dosage of Tri-Heart Plus is once every month or as per the dosage prescribed by your veterinarian. You can give the tablet directly or can even mix it with your dogโ€™s routine food. It totally depends on how comfortable your dog is with taking these chewable tablets. However, the Tri-Heart Plus tablets come in beef flavor, and most dogs just eat it like some treat. We must ensure that the dosage is regular and once every month to protect your dog by eliminating any growing larva before it reaches your dogโ€™s heart.

How Long is Tri-Heart Plus Good For?
Answer

Tri-Heart Plus is good for 30 days only. Hence, be sure to repeat the dosage immediately after a month. If you have missed a dose, give it as soon as you realize it and continue monthly. If the missed dose is over by two weeks, your dog must undergo microfilariae and antigen tests in 6 months. Repeat the tests in 6 months, as sometimes the results are not visible in the initial 6-month heartworm test. Because of its effectiveness of 30 days, you should set reminders for medication so that you do not miss any dose.

Does Tri-Heart Plus Prevent Tapeworms?
Answer

A simple answer to this can be a Yes. The monthly dosage of Tri-Heart Plus is capable of doing a lot more than preventing heartworm diseases. The medication can also control intestinal parasites like tapeworms, whipworms, hookworms, and roundworms. The only thing to remember is a regular dosage every 30 days and without skipping any dosage.

Can I Give My Dog Expired Tri-Heart Plus?
Answer

Any medication that includes Tri-heart Plus, which has reached its expiry date, should not be administered on pets. Tri-Heart Plus is only effective when used within its expiration date and when stored as mentioned on the medicine pack. The expiration date specifies that the active ingredients (Ivermectin and Pyrantel Pamoate) will not work effectively beyond the date.

What's the Difference between Tri-Heart Plus and Heartgard Plus?
Answer

There are two main differences between Tri-Heart Plus and Heartgard Plus. The first difference is that Tri-Heart Plus comes as a beef-flavored chewable tablet, whereas Heartgard Plus is a soft beefy chew. The second difference is the price; Tri-Heart Plus is much cheaper than Heartgard Plus, making the former a preferred choice.

What is the Difference between Trifexis and Tri-Heart Plus?
Answer

The main difference between the two medications is their active ingredients. While Tri-Heart Plus has Ivermectin and Pyrantel Pamoate, Trifexis contains Spinosad and Milbemycin Oxime. Other differences include the minimum dosage age, which is six weeks for Tri-Heart Plus, while it is eight weeks and 6 lbs of weight for Trifexis. Tri-Heart Plus is safe for breeding and pregnant dogs, but Trifexis is not yet proven for safety in pregnant, breeding, and lactating dogs. Trifexis provides extra protection from other hazardous parasites like fleas and whipworms, which cannot be said for Tri-Heart Plus.

Does Tri Heart Plus Require a Prescription?
Answer

Yes, it is mandatory to have a prescription to buy Tri-Heart Plus chewable tablets. You can consult your veterinarian about the same and get them prescribed for your pet dog.

Tri Heart Plus contains Ivermectin and Pyrantel pamoate

All dogs should be tested for heartworm infection before starting a preventive program. In a small percentage of ivermectin/ pyrantel treated dogs, digestive and neurological side effects may occur.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427 before giving your pet Tri Heart Plus.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Dogs must be tested for heartworm infection before starting a preventive program like Tri-Heart Plus.

Tri Heart Plus may be administered orally once a month, at the veterinarian prescribed dose. Most dogs will readily chew the medication, but if your dog is used to swallowing pills, break it up into smaller pieces. Make sure the dog consumes the entire dose.

Store Tri Heart Plus in a cool, dry place. Keep Tri Heart Plus away from light. Keep Tri Heart Plus in a secure area away from children or pets.

Tri-Heart Plus is manufactured by Merck Animal Health

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

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