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At a Glance
Two powerful active ingredients expel a catโ€™s internal parasitic worm infestation
Ingredient Emodepside kills adult and immature stages of roundworms and hookworms
Ingredient Praziquantel eliminates adult tapeworms, inhibits reaching adulthood, and prevents reproduction as an IGR
One-time topical treatment on a catโ€™s exposed skin will eliminate all worms


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At a Glance
Two powerful active ingredients expel a catโ€™s internal parasitic worm infestation
Ingredient Emodepside kills adult and immature stages of roundworms and hookworms
Ingredient Praziquantel eliminates adult tapeworms, inhibits reaching adulthood, and prevents reproduction as an IGR
One-time topical treatment on a catโ€™s exposed skin will eliminate all worms

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Elanco Animal Health Logo

Ultimate Guide to Profender

Meet the One-Time Topical Cat Dewormer: Profender!

Profender is a vet-recommended dewormer for cats that provides a one-time topical deworming treatment. This exclusive product is administered on your cat's skin with an easy-to-use applicator that eliminates parasitic worms (i.e., tapeworms, roundworms, and hookworms) all at once, guaranteeing a comfortable and lovable condition.

How does Profender work?

Profender is a medication with two powerful active ingredients - Emodepside and Praziquantel. Emodepside is only found in Profender for cats and is effective against adult and immature stages of roundworms and hookworms.

Praziquantel is a prescription anthelmintic (de-wormer) that expels anti-parasitic worms like trematodes (e.g, tapeworms). Praziquantel is also an Insect Growth Regulator (IGR) that inhibits newly hatched insect larvae from reaching adulthood or reproducing.

After one treatment, all of the worms (i.e., adult tapeworms, roundworms, and hookworms, as well as immature roundworms and hookworms) will be expelled through the cat's feces.

How is Profender administered?

Profender is a liquid topical solution that is administered with a spot-on treatment with single-dose efficacy. According to the cat's weight, a customer will be able to choose the appropriate size and box with one full tube of Profender medication contents.

The recommended dosage is 1.36 mg per pound of Emodepside and 5.45 mg per pound of Praziquantel. See the dosage chart below:

Cat Weight & Size Color Dosage (mL) Emodepside (mg) Praziquantel (mg)
2.2 - 5.5 lbs. (Small) Blue 0.35 7.5 30.0
5.5 - 11 lbs. (Medium) Orange 0.70 15.0 60.1
11 - 17.6 lbs. (Large) Purple 1.12 24.0 96.1
Cats that weigh over 17.6 pounds should be treated with the appropriate mL tube amount.

The medication is applied directly to the base of the cat's neck. Make sure that it is not being applied to damaged skin or if the hair is wet. Place the opened applicator on the cat's exposed skin and squeeze the entire contents there. Only if a second application is needed due to a new infection, wait only after 30 days.

What are the precautions of which you should be aware?

Consult your veterinarian about using cat deworming products and about all of the medications that your cat is already taking. Flea and tick medications or preventatives have negative interactions with Profender for cats.

Sick or debilitated cats are cautioned to use the product. Pregnant women are cautioned to touch or apply the product to their cat. Children are cautioned to touch or even come into contact with your cat until after 24 hours after application.

What are side effects of Profender for cats that you should be aware of?

Profender for cat's most common adverse reactions reported are licking and excessive grooming at the treatment site, which can cause hypersalivation or vomiting. Scratching, hypersalivation, lethargy, hair loss, anxiety, vomiting, and diarrhea are very rare reactions.

Frequently Asked Questions

What is Profender for Cats?

Profender for cats is a deworming medication. It is a one-time topical solution for cats and kittens that are affected by worms. A single topical dose of the Profender and you can help with the treatment of all sorts of worms in your cats, including intestinal worms, tapeworms, and hookworm infections.

Does Profender Work?

Yes, Profender works, and it has been clinically tested and proven by experts in the field.

Studies suggest that Profender is very effective when used to treat and control infections caused by worms. It showed great results when it came to dealing with tapeworm infections. Profender also resulted in a 90 percent success rate where there was no roundworm or tapeworm infection after it was administered to the cats.

How Fast Does a Profender Work?

A Profender works quite fast usually within 24 to 48 hours.

For tapeworm infections, the Profender takes effect within 24 hours of applying. On the other hand, for other types of worms like roundworms or intestinal worms, it takes effect within 48 hours of applying.

How To Apply Profender to Cats?

Profender is a topical solution that is applied to the cat's neck region. To be more specific, cat owners need to administer the Profender directly to the base of the cat's neck.

Profender dosages can vary from 0.35 mL to 1.12 mL, and the amount you have to administer depends on the weight of your cat. To apply the Profender, locate the base of the cat's neck. Then, squeeze the contents of the applicator onto the exposed skin. Use with caution; make sure the medication is not coming in contact with damaged skin. Follow the vet's prescription if you are not sure how, or whether or not to apply the Profender.

Does Profender for Cats Kill Fleas?

No, Profender for cats does not kill fleas.

While it may be administered topically, the Profender gets absorbed by the cat's skin. It then deals with your cat's internal parasites. However, the Profender does not offer any sort of protection, nor does it help kill external parasites like fleas.

How Long for a Profender to Work?

It takes 24 to 48 hours for a Profender to work.

In normal conditions, the medication will take effect within 24 hours of applying in the case of tapeworms. For all other types of worms, it needs at least 48 hours to take effect. You do not have to wait for a long period to see whether or not the medication is working.

Is Profender Safe for Cats?

Yes, Profender is safe for cats, both adults as well as kittens.

However, cat owners need to be careful and make sure that their cats do not lick the medicine. Hence, the treated cats need to be isolated from other cats or pets inside the house until the medicine dries. You might want to use a cone for your cat if it has a habit of licking itself all the time.

Can You Use Profender and Revolution at the Same Time?

Yes, you can use Profender and Revolution at the same time.

Revolution is a flea treatment medication for cats. It can be used alongside Profender. However, it is better to use the two different types of medications at least two days apart.

Does Profender Kill Ear Mites?

Yes, Profender can kill ear mites.

Profender is proven to be very effective against roundworms, hookworms, and tapeworms. It has also shown great promise when it comes to killing ear mites. So you should feel free to use Profender for killing ear mites without any worry.

How Long Does Profender for Cats Last?

Profender for cats lasts two weeks from the time it has been administered.

After two weeks, if the cat catches worms, you will again have to deworm through the Profender treatment or any other deworming treatment for cats.

How Often to Apply Profender for Cats?

Profender needs to be applied every time your cat has worms.

You need to understand the Profender is a purge dewormer, meaning that is an instantaneous killer when it comes to worms. However, it is not a vaccine or a worm-preventing dosage. Hence, regular applications will only be required if your cat continues to get the worms, even after it has been treated for them.

So even after you are done applying the Profender, your job is not done. You then have to make sure that your cat does not come in contact with worms again. Otherwise, you will have to repeat the Profender treatment.
Concluding Thoughts

The most important thing that you should know about Profender is its one-time use treatment to expel internal parasitic worms - tapeworms, roundworms, and hookworms - from your cat. Forget about pills! Just apply a few drops on your cat's skin and you are that much closer to a worm-free kitty!

DISCLAIMER: FDA law restricts Profender only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian if it's a good idea to treat all of the animals in your household to control intestinal parasites.

  • Elanco Animal Health Brand
  • Heartworm & Deworming Pharmacy
  • Elanco Animal Health Manufacturer
  • Senior Life Stage
  • Liquid Application
  • Spot On/Topical Application
  • Cat Pet Type

Is Profender Safe for Cats?

Profender is safe to use on adult cats and kittens who are at least eight weeks old and weigh 2.2 pounds or more. But as with any medication, strictly adhere to your veterinarian's recommendations. Owners should keep their pets from eating the product, as it can be harmful if ingested. Keeping treated cats separate from other pets until the product dries is also recommended, as this can help prevent accidental ingestion or contact with the medication.

Can Profender Be Given to Puppies?

Yes, depending on its age and weight. Puppies under 12 weeks old or weighing less than 1 kilogram shouldn't use Profender.

Can Profender Be Given to Pregnant or Nursing Cats?

Unless specifically authorized by a veterinarian, Profender should not be administered to nursing or pregnant cats. Profender may be a risk to growing fetuses or nursing kittens because their safety during pregnancy or lactation has not been thoroughly proven.

What Are the Possible Side Effects of Profender in Cats?

Possible side effects of Profender in cats may include vomiting, diarrhea, loss of appetite, lethargy, and irritation or redness at the application site. More severe side effects such as tremors, convulsions, anxiety, unsteadiness, and allergic responses may manifest less frequently.

How Is Profender Administered to Cats?

Profender is administered topically by applying the pre-measured medication directly to the skin on the back of the cat's neck. The medication comes in a tube designed for a single dose based on the cat's weight. To administer, part the fur at the base of the cat's neck, place the tube tip directly against the skin, and squeeze the entire tube contents onto the skin in one spot.

Can I use Profender On Cats With Open Wounds or Sores?

No, you should not. Profender is not designed to be used on open wounds or sores. In fact, using Profender on cats with open wounds or sores can irritate and potentially make the wound worse.

Can Profender Be Given With Other Medications?

Yes, it can be given with some medications. Using Profender in conjunction with a topical flea treatment such as Frontline or Advantage is safe. However, applying these products at least two days apart is recommended to minimize the risk of adverse effects. This is because both Profender and topical flea treatments are applied to the skin and may interact with each other, potentially causing skin irritation or other negative side effects. Applying the products on separate days allows each medication to be fully absorbed before the other is applied.

Can Profender Be Used to Treat Tapeworms in Cats?

Yes, Profender can be used to treat tapeworms in cats. Tapeworms are one of the intestinal parasites that Profender is effective against. The active ingredients in Profender, emodepside, and praziquantel work together to attack both adult and immature stages of these parasites, killing them and allowing them to be eliminated from the cat's body through their feces.

Can Profender Cause Adverse Reactions in Cats With Certain Health Conditions?

Yes, Profender may cause adverse reactions in cats with certain health conditions. It is important to inform your veterinarian if your cat has any pre-existing medical conditions or is taking any medications before administering Profender. Cats with liver or kidney disease and pregnant or lactating cats may be more sensitive to the effects of Profender and may require special monitoring or dosing adjustments. In addition, if your cat has a weakened immune system or is currently undergoing treatment for another medical condition, it may be more susceptible to side effects from Profender.

Can Profender Cause Allergic Reactions in Cats?

Yes, Profender can potentially cause allergic reactions in cats. Allergic reactions occur when a cat's immune system overreacts to one of the ingredients in the medication. Signs of an allergic reaction to Profender may include difficulty breathing, hives, swelling of the face or tongue, and pale gums.

When Should Profender Be Discontinued in Cats?

Profender should be discontinued in cats if they experience an allergic reaction or any other adverse side effects. Additionally, if the cat's condition does not improve or worsens after treatment, you should follow up with your veterinarian for further evaluation and possible alternative treatment options.

Can I Administer Profender to My Cat Without Consulting a Veterinarian?

No, it is not recommended to administer Profender to your cat without first consulting a veterinarian. Profender is a prescription drug that should only be used under the guidance and supervision of a licensed veterinarian.

Praziquantel and Emodepside

Consult your veterinarian regarding the diagnosis of worms before administering. Use with caution in sick or debilitated cats. Keep out of reach of children. Pregnant women or women who may become pregnant should avoid direct contact with, or wear disposable gloves when applying this product. Allow 24 hours after application before letting children come into contact with your cat.

Let your veterinarian know before combining with other medications, especially flea and tick prevention.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Dosage runs according to your cats weight, typically one full tube is applied directly to your cats skin.

Make sure youโ€™re applying to exposed skin with the tip directly and lifting tube away from the skin before releasing pressure on the tube.

Store at room temperature 59- 86° F (15- 30° C).

Profender is manufactured by Elanco Animal Health
Option UPC/SKU
1 Dose - 0.35mL per tube, Cats 2.2 - 5.5 lbs. 724089825216
1 Dose - 0.70mL per tube, Cats 5.5 - 11 lbs. 724089825728
1 Dose - 1.12mL per tube, Cats 11 - 17.6 lbs. 724089825803

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

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Customer Reviews

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Profender cat review

This product works great. I give every 3 months.

Donna recommends this item.
Was this review helpful? 0 0

Caused a local reaction on my cat's skin between shoulder blades :(

My cat has taken the deworming medicine by injection before and I decided to try the topical form. Unfortunately the medicine 2 days after I applied it caused a local reaction with my cat's skin, the skin became inflamed and hair came out where the medicine was placed between the shoulder blades, not sure if it helped with the original problem at hand but I haven't seen any rice looking specks where my cat sleeps so I'm thinking it did help. I have ordered products from you before and never had a problem so I'm thinking that my cat's skin was sensitive even though she handles frontline and advantage ok.

Dotthenurse recommends this item.
Was this review helpful? 5 0

great product

you guys are great and so helpful and the coupons add extra savings...Thank you so much Nancy

Albion68 recommends this item.
Was this review helpful? 2 0

This product seems safe and works

I was afraid of this new product and sent the first script back and exchanged for cestex which did not work very well. I finally got the courage to use this on my 12 year old domestic short hair and it really did the job. He got it at 8:30 am and by 9:30 he pooped a 5 inch tapeworm.It also gave him diarhara on the first day. but by next day was fine. He seems rid of tapes and hopefully hooks and other rounds. I plan to use it one more time in 30 days, then switch him to revolution flea (and worm )meds monthly. Or will use it once more then keep him on Advantage Purple and treat tapeworms(and other worms) with Profender as they occur.

Myrbailey recommends this item.
Was this review helpful? 6 0

happy with product, but very unhappy with the service.

I recently ordered this product. I have used this before and it works great. Problem I had was I thought I was getting more of the product then I recieved. When I called to complain they said there was nothing they could do. It was misleading ordering it online. I have seven cats and thought I was recieving 20 tubes as the box reads, but only got one. very unhappy.

Anonymous Pet Parent recommends this item.
Was this review helpful? 4 1

Profender is Great!

It's a liquid dewormer you apply on the back of a cat's neck and it kills hook, tape & round worms. I always get scratched or bitten when trying to give a pill to my cat. This is a wonderful product!

poodle_runner recommends this item.
Was this review helpful? 7 0

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