Piroxicam
Piroxicam
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At a Glance
Non-Steroidal Anti-Inflammatory drug (NSAID) used for the treatment of inflammation
Typically prescribed to pets with joint disease, fevers, and minor aches
Effective in the treatment of cancer, especially bladder cancer

Piroxicam

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At a Glance
Non-Steroidal Anti-Inflammatory drug (NSAID) used for the treatment of inflammation
Typically prescribed to pets with joint disease, fevers, and minor aches
Effective in the treatment of cancer, especially bladder cancer

Piroxicam was initially created for humans as a pain reliever. But with the proper dosage by your vet, it can also be administered to cats and dogs with some cancers and as a pain reliever for arthritis. Piroxicam is a non-steroidal anti-inflammatory drug (NSAID), so it reduces both pain and inflammation. This drug is typically recommended for dogs experiencing neoplasia, a condition in which abnormal masses of tissue develop into tumors within the body. Consult your veterinarian if this is the right drug for you pet's symptoms.

Does Piroxicam Shrink Tumors in Dogs?
Answer

Piroxicam is a non-steroidal anti-inflammatory (NSAID) medication that belongs to the oxicam class. The drug is often prescribed to treat certain cancers like bladder, colon, and prostate cancer in cats and dogs. The medication is also effective against arthritis pain, but there are better, more effective medications available for this purpose. While the exact cause is not known as to how Piroxicam battles cancers like squamous cell carcinoma, TCC, and mammary adenocarcinoma, among others, its effectiveness in shrinking tumors is well documented. In a study conducted on 76 dogs with transitional cell carcinoma (TCC) treated with Piroxicam, the tumor went into complete remission in 2 dogs, reduced in size by over 50 percent in 14 dogs, remained stable in 45 dogs, and increased in size in 15 dogs. Therefore, there are solid pieces of evidence that Piroxicam does indeed reduces tumor size in dogs.

How Long Can a Dog Take Piroxicam?
Answer

Piroxicam is advised to be administered orally with food to avoid issues like stomach upset daily or every other day. The dosage and frequency differ from dog to dog, and since it comes with a set of severe side effects, the dosage shouldn't be just eyeballed. More importantly, don't ever double dose to make up for a missed dose. Therefore, you must administer the pet Piroxicam exactly as suggested or prescribed by your veterinarian. The medication is pretty fast-acting and should show pain relief in your pet within an hour or two of administering medication. And while there's no set timeline as to how long a dog can take Piroxicam, it's said to show the full benefits and effects in eight to twelve weeks. In some dogs, it may take up to six months to show the impact.

Can You Give a Dog Piroxicam?
Answer

If pet parents see their dog or cat in pain, it warrants a trip to the veterinarian. The pain could be caused by anything from arthritis to cancer. If the pet has an inflammatory condition, vets often prescribe Piroxicam as it's fast-acting and treats pain in like a couple of hours from the time of administering. The drug manages pain by reducing the COX-2 enzyme, which is responsible for forming prostaglandins. Notably, prostaglandins is what causes swelling and inflammation in dogs. It's this ability to reduce COX-2 enzyme that Piroxicam is used to treat many types of tumors in dogs. These include nasal epithelial tumors, mammary tumors, prostatic carcinoma, transitional cell carcinoma (TCC) of the urinary bladder, oral squamous cell carcinoma, oral melanoma, and more. This is mainly because COX-2 is quite often unregulated in such tumors. Therefore, yes, Dogs can be given Piroxicam, but it's only to be given if prescribed to your pet. The medication is known to be troublesome for the gastrointestinal tract. Therefore it should be used with caution in pets with known GI and renal issues.

How Long Does It Take Piroxicam to Start Working?
Answer

Piroxicam is given orally to the dog, typically with the food to reduce any chance of stomach upset or GI issues. Piroxicam is a fast-acting medicine, which means you will likely see improvement in your dog within one or two hours of administering the medication. The improvement in clinical symptoms follows throughout the treatment. Usually, it takes eight to twelve weeks or longer before your pet exhibits the full benefits of the Piroxicam.

What Are Side Effects of Piroxicam in Dogs?
Answer

Since Piroxicam is known for causing severe GI tract-related issues in dogs, it's no longer often used as an anti-inflammatory medication. Instead, the drug is now more commonly used as part of a chemo treatment program. Some of the most common side effects of Piroxicam include GI irritation, appetite loss, reduced energy, weakness, diarrhea, and vomiting. In more severe cases, it might cause ulceration in the gastrointestinal tract or nephrotoxicity. To avoid any complications with Piroxicam treatment, make sure to tell your vet about any other medication or supplement your pet might be on. This will help the vet to determine the dose accordingly and avoid any possible interaction with Piroxicam. The drug interacts with quite a few medications like corticosteroids, antibiotics, aspirin, and anticoagulants, among many other medications.

Does Piroxicam Increase Blood Pressure?
Answer

Yes, Piroxicam is known for causing high blood pressure in humans and could do the same in pets. The medication is likely to increase the chance of a fatal heart attack or stroke. Therefore, it's advised not to administer Piroxicam to dogs with known cardiac issues. Moreover, ensure that you don't increase dosage quantity and frequency without consulting your veterinarian first.

Piroxicam is a non-steroidal anti-inflammatory drug (NSAIDs) that is commonly used for managing pain and inflammation in dogs. The action mechanism of Piroxicam is to hinder the secretion of prostaglandins, thereby bringing relief from fever, pain and inflammation. It could also be combined with other drugs in the treatment of transitional cell carcinoma- a type of bladder cancer in dogs.


Clinical results have proved that this drug is well tolerated by dogs, even though side effects might occur in rare cases. Stomach and intestinal ulcers, bleeding, dark stools, peritonitis, vomiting etc., are some of the common side effects. A few of these could be life threatening as well. Piroxicam can hamper the smooth functioning of kidneys which might lead to papillary necrosis. Piroxicam could also damage the natural blood clotting mechanism, thereby increasing the risks of bleeding.

Desist from using Piroxicam in animals that are allergic to this drug, and in those with a noted history of bleeding, intestinal inflammation and high blood pressure. Use extreme caution while administering this medication in pets with heart ailments. Some medicines such as diuretics or ACE-inhibitors could have serious interactions with Piroxicam. So, make sure to verify that the medications administered to the pet do not belong to any of these groups. Piroxicam, when used along with corticosteroids is found to enhance the risks of ulcers.

When administering Piroxicam, contact your veterinarian if your pet shows signs of depression, an increase in drinking, jaundice, dizziness, seizures, behavior changes, lethargy, swelling, shedding, itching, constipation, or hot spots. In some cases, Piroxicam can cause stomach ulceration. Signs of this include loss of appetite, diarrhea, vomiting, and bloody or black stools.

Do not use Piroxicam in pets with kidney or liver disease, bleeding disorders, gastric ulcers, or high blood pressure. Use with caution in cats and pets with severe heart disease.

Negative interactions can occur with ACE-inhibitors such as enalapril, benazepril, and quinapril. Piroxicam may interact with other drugs like phenylbutazone, heparin, aspirin, corticosteroids, methotrexate, flunixin, diazepam, propranolol, and warfarin.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Piroxicam is available in 10 mg and 20 mg capsules. The dosage might differ according to the condition for which it is used, and the response to the treatment. Normally for anti-inflammatory effect, piroxicam is dosed at 0.15 mg per pound (0.3 mg/kg) every 48 hours, while a daily dose of 0.15 mg per pound (0.3 mg/kg) might be required to manage transitional cell carcinoma.

Piroxicam is a prescription drug. Administer Piroxicam orally per instruction by your veterinarian.

Store in a cool, dry place.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

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