When administering Piroxicam, contact your veterinarian if your pet shows signs of depression, an increase in drinking, jaundice, dizziness, seizures, behavior changes, lethargy, swelling, shedding, itching, constipation, or hot spots. In some cases, Piroxicam can cause stomach ulceration. Signs of this include loss of appetite, diarrhea, vomiting, and bloody or black stools.
Do not use Piroxicam in pets with kidney or liver disease, bleeding disorders, gastric ulcers, or high blood pressure. Use with caution in cats and pets with severe heart disease.
Negative interactions can occur with ACE-inhibitors such as enalapril, benazepril, and quinapril. Piroxicam may interact with other drugs like phenylbutazone, heparin, aspirin, corticosteroids, methotrexate, flunixin, diazepam, propranolol, and warfarin.