Piroxicam
Piroxicam
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At a Glance
Non-Steroidal Anti-Inflammatory drug (NSAID) used for the treatment of inflammation
Typically prescribed to pets with joint disease, fevers, and minor aches
Effective in the treatment of cancer, especially bladder cancer

Piroxicam

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At a Glance
Non-Steroidal Anti-Inflammatory drug (NSAID) used for the treatment of inflammation
Typically prescribed to pets with joint disease, fevers, and minor aches
Effective in the treatment of cancer, especially bladder cancer

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Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used in veterinary medicine. Initially developed for human use, its efficacy and safety profile have led to its adoption in veterinary practice. Veterinarians often prescribe piroxicam for various conditions, including cancer treatment in animals.

  • Medical Applications:One of the most common uses of piroxicam in veterinary medicine is its application as an anti-tumor medication. It has shown promise in treating various types of cancers in animals, including bladder transitional cell carcinoma, squamous cell carcinoma, mammary adenocarcinoma, inflammatory mammary carcinoma, and transmissible venereal tumors. Additionally, piroxicam is used in managing degenerative joint disease in aging pets, providing relief from pain and inflammation associated with this condition.

  • Administration and Dosage:Piroxicam is typically administered orally, often in capsule form. However, its use may be off-label or extra-label in certain cases, as determined by the prescribing veterinarian. It's crucial to follow the prescribed dosage and administration instructions carefully to ensure its effectiveness and minimize the risk of adverse effects.

  • Potential Side Effects:Common side effects can include stomach upset, vomiting, diarrhea, or poor appetite. More severe side effects can include gastrointestinal ulceration and bleeding, kidney damage, central nervous system effects, elevated liver enzymes, decreased red blood cell counts, and impaired heart function.

  • Considerations for Special Cases:Special attention is required when administering piroxicam to certain groups of animals. Pregnant or nursing pets should not receive piroxicam due to potential risks to offspring. Aging pets may also require careful monitoring due to their increased susceptibility to adverse effects.

  • Drug Interactions:Piroxicam can interact with a variety of other medications, including aminoglycosides, anticoagulants, aspirin, bisphosphonates, cisplatin, corticosteroids, cyclosporine, digoxin, diuretics, highly protein-bound drugs, methotrexate, SNRIs and SSRIs, tacrolimus, and tricyclic antidepressants. These interactions can have adverse effects or reduce the efficacy of either medication, which necessitates close monitoring and potential dosage adjustments.

  • Monitoring and Storage:Regular monitoring is essential when administering piroxicam to animals. This may involve periodic blood tests to assess liver enzymes, kidney function, and red blood cell counts. Piroxicam should be stored at room temperature and seek emergency veterinary care immediately in case of overdose or adverse reactions.

Piroxicam is a valuable medication in veterinary oncology and pain management. However, its use requires careful consideration of potential side effects, drug interactions, and monitoring protocols to ensure the safety and well-being of animals undergoing treatment.

  • Arthritis & Pain Pharmacy
  • Senior Life Stage
  • Oral Application
  • Dog Pet Type

Does Piroxicam Shrink Tumors in Dogs?
Answer

Piroxicam is a non-steroidal anti-inflammatory (NSAID) medication that belongs to the oxicam class. The drug is often prescribed to treat certain cancers like bladder, colon, and prostate cancer in cats and dogs. The medication is also effective against arthritis pain, but there are better, more effective medications available for this purpose. While the exact cause is not known as to how Piroxicam battles cancers like squamous cell carcinoma, TCC, and mammary adenocarcinoma, among others, its effectiveness in shrinking tumors is well documented. In a study conducted on 76 dogs with transitional cell carcinoma (TCC) treated with Piroxicam, the tumor went into complete remission in 2 dogs, reduced in size by over 50 percent in 14 dogs, remained stable in 45 dogs, and increased in size in 15 dogs. Therefore, there are solid pieces of evidence that Piroxicam does indeed reduces tumor size in dogs.

How Long Can a Dog Take Piroxicam?
Answer

Piroxicam is advised to be administered orally with food to avoid issues like stomach upset daily or every other day. The dosage and frequency differ from dog to dog, and since it comes with a set of severe side effects, the dosage shouldn't be just eyeballed. More importantly, don't ever double dose to make up for a missed dose. Therefore, you must administer the pet Piroxicam exactly as suggested or prescribed by your veterinarian. The medication is pretty fast-acting and should show pain relief in your pet within an hour or two of administering medication. And while there's no set timeline as to how long a dog can take Piroxicam, it's said to show the full benefits and effects in eight to twelve weeks. In some dogs, it may take up to six months to show the impact.

Can You Give a Dog Piroxicam?
Answer

If pet parents see their dog or cat in pain, it warrants a trip to the veterinarian. The pain could be caused by anything from arthritis to cancer. If the pet has an inflammatory condition, vets often prescribe Piroxicam as it's fast-acting and treats pain in like a couple of hours from the time of administering. The drug manages pain by reducing the COX-2 enzyme, which is responsible for forming prostaglandins. Notably, prostaglandins is what causes swelling and inflammation in dogs. It's this ability to reduce COX-2 enzyme that Piroxicam is used to treat many types of tumors in dogs. These include nasal epithelial tumors, mammary tumors, prostatic carcinoma, transitional cell carcinoma (TCC) of the urinary bladder, oral squamous cell carcinoma, oral melanoma, and more. This is mainly because COX-2 is quite often unregulated in such tumors. Therefore, yes, Dogs can be given Piroxicam, but it's only to be given if prescribed to your pet. The medication is known to be troublesome for the gastrointestinal tract. Therefore it should be used with caution in pets with known GI and renal issues.

How Long Does It Take Piroxicam to Start Working?
Answer

Piroxicam is given orally to the dog, typically with the food to reduce any chance of stomach upset or GI issues. Piroxicam is a fast-acting medicine, which means you will likely see improvement in your dog within one or two hours of administering the medication. The improvement in clinical symptoms follows throughout the treatment. Usually, it takes eight to twelve weeks or longer before your pet exhibits the full benefits of the Piroxicam.

What Are Side Effects of Piroxicam in Dogs?
Answer

Since Piroxicam is known for causing severe GI tract-related issues in dogs, it's no longer often used as an anti-inflammatory medication. Instead, the drug is now more commonly used as part of a chemo treatment program. Some of the most common side effects of Piroxicam include GI irritation, appetite loss, reduced energy, weakness, diarrhea, and vomiting. In more severe cases, it might cause ulceration in the gastrointestinal tract or nephrotoxicity. To avoid any complications with Piroxicam treatment, make sure to tell your vet about any other medication or supplement your pet might be on. This will help the vet to determine the dose accordingly and avoid any possible interaction with Piroxicam. The drug interacts with quite a few medications like corticosteroids, antibiotics, aspirin, and anticoagulants, among many other medications.

Does Piroxicam Increase Blood Pressure?
Answer

Yes, Piroxicam is known for causing high blood pressure in humans and could do the same in pets. The medication is likely to increase the chance of a fatal heart attack or stroke. Therefore, it's advised not to administer Piroxicam to dogs with known cardiac issues. Moreover, ensure that you don't increase dosage quantity and frequency without consulting your veterinarian first.

Piroxicam is a non-steroidal anti-inflammatory drug (NSAIDs) that is commonly used for managing pain and inflammation in dogs. The action mechanism of Piroxicam is to hinder the secretion of prostaglandins, thereby bringing relief from fever, pain and inflammation. It could also be combined with other drugs in the treatment of transitional cell carcinoma- a type of bladder cancer in dogs.


Clinical results have proved that this drug is well tolerated by dogs, even though side effects might occur in rare cases. Stomach and intestinal ulcers, bleeding, dark stools, peritonitis, vomiting etc., are some of the common side effects. A few of these could be life threatening as well. Piroxicam can hamper the smooth functioning of kidneys which might lead to papillary necrosis. Piroxicam could also damage the natural blood clotting mechanism, thereby increasing the risks of bleeding.

Desist from using Piroxicam in animals that are allergic to this drug, and in those with a noted history of bleeding, intestinal inflammation and high blood pressure. Use extreme caution while administering this medication in pets with heart ailments. Some medicines such as diuretics or ACE-inhibitors could have serious interactions with Piroxicam. So, make sure to verify that the medications administered to the pet do not belong to any of these groups. Piroxicam, when used along with corticosteroids is found to enhance the risks of ulcers.

When administering Piroxicam, contact your veterinarian if your pet shows signs of depression, an increase in drinking, jaundice, dizziness, seizures, behavior changes, lethargy, swelling, shedding, itching, constipation, or hot spots. In some cases, Piroxicam can cause stomach ulceration. Signs of this include loss of appetite, diarrhea, vomiting, and bloody or black stools.

Do not use Piroxicam in pets with kidney or liver disease, bleeding disorders, gastric ulcers, or high blood pressure. Use with caution in cats and pets with severe heart disease.

Negative interactions can occur with ACE-inhibitors such as enalapril, benazepril, and quinapril. Piroxicam may interact with other drugs like phenylbutazone, heparin, aspirin, corticosteroids, methotrexate, flunixin, diazepam, propranolol, and warfarin.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Piroxicam is available in 10 mg and 20 mg capsules. The dosage might differ according to the condition for which it is used, and the response to the treatment. Normally for anti-inflammatory effect, piroxicam is dosed at 0.15 mg per pound (0.3 mg/kg) every 48 hours, while a daily dose of 0.15 mg per pound (0.3 mg/kg) might be required to manage transitional cell carcinoma.

Piroxicam is a prescription drug. Administer Piroxicam orally per instruction by your veterinarian.

Store in a cool, dry place.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

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P
Seemingly effective for remedial/palliative care of mouth melanoma.

Dog was diagnosed with oral melanoma in upper gum and lip in November, and was given 2-4 months WITH piroxicam. I elected to combine it with carboplatin treatments for a period of time. The cancer definitely paused in its growth, but eventually resumed. Since the carboplatin had some side effects, I gave it up and switched course to palliative care, combining piroxicam with tramadol (for pain), amitriptyline (for anxiety), and clindamycin (for oral infections). Although the cancer has continued to grow, it has not metastasized, the dog's appetite and mood is good, and she is now in her seventh month since the diagnosis!

PaulH recommends this item.
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T
Easy transaction
VERIFIED PURCHASER

company offers excellent service and products at a reasonable price.

Tbone1258 recommends this item.
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L
Almost Put Cat to Sleep

I found a sick kitten and her whole nasal cavity was just a big hole. She was so congested she could scarcely breathe, antibiotics did no good, and I spent a fortune on vet bills. Another vet did some research and tried Piroxicam. I carefully mix it with almond oil to my vet's specifications with a mortar and pestle and it costs like 8 cents per month. This kitten (now a cat) has totally forgotten she was ever sick. She is and probably will always be Itta Bitty Tiny Kitty as she is named, but she is alive and happy. (This is a prescription drug and requires a prescription.)

Lynn_kitty_mommy_and_chemistry_major recommends this item.
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L
Almost Put Cat to Sleep

I found a sick kitten and her whole nasal cavity was just a big hole. She was so congested she could scarcely breathe, antibiotics did no good, and I spent a fortune on vet bills. Another vet did some research and tried Piroxicam. I carefully mix it with almond oil to my vet's specifications with a mortar and pestle and it costs like 8 cents per month. This kitten (now a cat) has totally forgotten she was ever sick. She is and probably will always be Itta Bitty Tiny Kitty as she is named, but she is alive and happy. (This is a prescription drug and requires a prescription.)

Lynn_kitty_mommy_and_chemistry_major recommends this item.
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J
Can't Live with out it

My dog byron who is 6 years old has nasal cancer. Our vet gave him a 3 month life expectancy. They put him on this medication and ever since then he has been doing great. He is now on month 5 and is larger then life, he hasnt changed a bit. He is just as happy as he was if he was still a puppy.*This is a prescription item

Jaime recommends this item.
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