1. Methimazole
Methimazole
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Methimazole
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At a Glance
Effective in fighting hyperthyroidism, or Graves disease
Reduces overall thyroid hormone levels
Comes in tablet form and taken orally
  1. Methimazole

Methimazole

RXPrescription required
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At a Glance
Effective in fighting hyperthyroidism, or Graves disease
Reduces overall thyroid hormone levels
Comes in tablet form and taken orally

Frequently Bought Together

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Methimazole is an anti-thyroid tablet administered for the treatment of hyperthyroidism in cats. Hyperthyroidism, often known as Graves disease, is an autoimmune disease that causes hyperactivity within the thyroid gland leading to the overproduction of the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Methimazole is the generic of Tapazole.

Hyperthyroidism is a condition that may lead to weight loss, abnormal appetite, and heart issues.

In this instance, the medication works by restoring the thyroid hormone levels to normal by interfering with iodine, which plays a major role in thyroid performance. Overall, Methimazole has been proven incredibly effective against Graves disease in cats.

Though it is generally safe when administered under the direction of a veterinarian, methimazole can cause side effects in some animals. Adverse effects include frequent bouts of vomiting, lack of appetite, weakness, bleeding disorders, or liver problems.

Mechanism of Action

Methimazole exerts its therapeutic effect by interfering with the synthesis of thyroid hormones. The thyroid gland produces two main hormones, thyroxine (T4) and triiodothyronine (T3), essential for regulating metabolism. The medication inhibits the activity of an enzyme called thyroperoxidase, essential for synthesizing these hormones. By doing so, Methimazole impedes the thyroid gland's ability to produce excessive amounts of T4 and T3, effectively reducing the overall levels of thyroid hormones.

Normalization of Thyroid Function

In hyperthyroidism and Graves' disease, the thyroid gland becomes overstimulated, leading to an uncontrolled release of thyroid hormones. Methimazole helps normalize thyroid function by suppressing the excess production of T4 and T3. This, in turn, alleviates symptoms associated with hyperthyroidism, such as rapid heart rate, weight loss, and anxiety. Thoroughly restoring thyroid hormone levels allows for a more balanced and regulated metabolism.

Treatment Duration and Monitoring

Methimazole is typically prescribed for a specific duration, often ranging from several weeks to months, depending on the severity of the condition. Healthcare professionals closely monitor thyroid function during this period through regular blood tests to assess hormone levels. Adjustments to the dosage may be made to ensure optimal control of thyroid hormones while avoiding hypothyroidism, a condition characterized by insufficient thyroid hormone production.

Considerations and Potential Side Effects

While Methimazole is effective in managing hyperthyroidism, it is essential to be aware of potential side effects. Some individuals may experience allergic reactions, skin rashes, or gastrointestinal symptoms. Additionally, the medication may affect white blood cell production, necessitating regular blood tests for any signs of bone marrow suppression.

Methimazole stands as a cornerstone in the treatment of hyperthyroidism and Graves' disease, offering a targeted approach to normalizing thyroid function. This medication relieves symptoms and helps restore a balanced metabolic state by inhibiting thyroid hormone synthesis. As with any medication, individuals must work closely with healthcare professionals to ensure proper dosing, monitoring, and management of potential side effects throughout treatment.

  • Thyroid Pharmacy
  • King Pharma Manufacturer
  • Oral Application
  • Cat Pet Type

What is the drug methimazole used for?
Answer

David Bruyette, a DVM in West Los Angeles notes that methimazole is a medication commonly prescribed for the treatment of hyperthyroidism in cats. Cats with hyperthyroidism face a range of health issues as a result of the thyroid gland producing too many thyroid hormones. NIH notes that methimazole works by inhibiting the production of thyroid hormones, specifically blocking the synthesis of thyroxine (T4) and triiodothyronine (T3). These hormones are essential for controlling the cat's metabolism. Their overproduction can result in symptoms such as weight loss, increased appetite, hyperactivity, and other systemic complications. Administered orally, usually in the form of tablets or a transdermal gel, methimazole helps to manage the symptoms associated with hyperthyroidism. Regular monitoring of thyroid levels is essential during treatment to ensure the medication effectively controls hormone production without causing adverse effects.

What is the best medicine for hyperthyroidism?
Answer

Hyperthyroidism in cats is commonly treated with medications that help regulate thyroid hormone levels. The primary medication is methimazole, an antithyroid drug that inhibits the production of excessive thyroid hormones. It can be applied directly to the ear or administered orally. However, some cats may not respond adequately to methimazole alone, or they may experience side effects. In such cases, a combination approach may be considered. According to Cornell University, radioactive iodine therapy is another effective option, especially for cats with well-controlled kidney function. This treatment involves a single injection of radioactive iodine, which selectively destroys overactive thyroid tissue while sparing healthy tissue. Beta-blockers, such as timolol or atenolol, may also be prescribed to manage symptoms like elevated heart rate and hypertension. These medications don't address the underlying cause but help alleviate the immediate effects of hyperthyroidism.

How does methimazole work?
Answer

  1. Methimazole is typically administered orally in pill or liquid form. According to MedicineNet, it functions by preventing the production of thyroid hormones, most especially by preventing the action of the thyroid peroxidase enzyme. Thyroid peroxidase facilitates the iodination and coupling of thyroglobulin molecules, which is a critical step in the synthesis of thyroid hormones T3 and T4. Methimazole inhibits this process by decreasing the synthesis of T3 and T4 and blocking the incorporation of iodine into thyroglobulin. By decreasing the levels of circulating thyroid hormones, methimazole helps normalize the feline thyroid function. This alleviates the symptoms associated with hyperthyroidism, such as weight loss, increased appetite, hyperactivity, and other related issues.

What to avoid while taking methimazole?
Answer

When administering methimazole to cats, it's crucial to be mindful of potential interactions and considerations. First and foremost, avoid concurrently using medications that may adversely interact with methimazole. Notably, drugs like amitriptyline and theophylline can interact with methimazole, leading to increased side effects or altered efficacy. To make sure that these prescriptions are not given at the same time, it is essential to speak with a veterinarian. It's also critical to keep an eye out for any negative side effects, such fatigue, nausea, or vomiting. This might be a sign of methimazole intolerance. To evaluate thyroid function and modify the amount of medicine as necessary, routine veterinarian examinations and blood tests are essential. Furthermore, steering clear of self-adjusting the dosage without professional guidance is crucial, as improper management can lead to thyroid imbalances. Pet owners should not discontinue or modify the treatment plan without consulting their veterinarian, as abrupt changes can result in serious health complications.

What is the most serious side effect of methimazole?
Answer

The most serious side effect of methimazole in cats is agranulocytosis. Agranulocytosis is a rare but potentially life-threatening condition characterized by a severe decrease in white blood cell count, specifically neutrophils. These white blood cells are essential for the immune system's proper functioning. R. Darren Wood, a DVM from the Ontario Veterinary College notes that this condition is called neutropenia. It leaves cats vulnerable to infections that their weakened immune system may struggle to combat. Agranulocytosis is an idiosyncratic reaction to methimazole, meaning it occurs unpredictably and is not necessarily related to the dosage. Cats undergoing methimazole treatment should be closely monitored for signs of agranulocytosis, such as lethargy, fever, and reluctance to eat. If any of these symptoms manifest, immediate veterinary attention is crucial. Regular blood tests are essential to detect early signs of hematological abnormalities and adjust the methimazole dosage accordingly. If agranulocytosis is suspected or confirmed, discontinuation of methimazole is typically recommended, and alternative treatments or therapies may be explored under veterinary guidance.

Methimazole

Side effects occur in less than 5% of all cases, but can be serious, such as a decreased white blood cell count (agranulocytosis); contact a veterinarian immediately if your pet display signs of a sore throat. Excessive bleeding can also occur as a result of a decrease in blood platelets. Very rarely, liver failure and its ensuing complications have been associated with Methimazole.

More common side effects are skin-related, including rash, itching, hives, abnormal hair loss, and skin pigmentation. Other side effects may include swelling, nausea, vomiting, heartburn, loss of taste, joint or muscle aches, drowsiness, dizziness, numbness, and headache. Do not use in pregnant or nursing animals.

Methimazole must be used only in cats. It should never be used on animals, which are prone to allergy to the drug. Extreme care should be taken while using this medication in animals with a known history of liver impairment, immune-system disease or blood disorders. Regular blood tests to monitor toxicity on blood cells and liver are suggested in cats, which are on methimazole for a long period.The medication should be administered life long as the symptoms might reappear once the medication is stopped. It is advisable to use methimazole for the short term management of the disease as it involves side effects. Surgical removal of the thyroid gland or radiation treatment would be more appropriate for a lasting solution. Pregnant and nursing cats should not be given this drug. Drug overdose might result in blood disorders or liver toxicity.ย 

Do not take with theophylline (Theo-Dur), warfarin (Coumadin), digoxin (Lanoxin), a beta blocker such as atenolol (Tenormin), metoprolol (Lopressor), or propranolol (Inderal). Talk to your vet before starting any serious treatment plan.

Methimazole is an anti-thyroid tablet used in the treatment of hyperthyroidism in cats, which, might result in weight loss, abnormal appetite and heart problems. When administered, methimazole restores the thyroid hormone levels back to normal by interfering with iodine, which has a major role in thyroid function.ย 

Methimazole comes as 5 mg and 10 mg tablets. The recommended primary dose of methimazole is 5 mg per cat, three times daily and the dosage should be increased, if no improvement is noticed in the situation. Once the condition stabilizes, the dose could be reduced after taking the opinion of the veterinarian. Ensure that the full course is completed to prevent relapse or the chances of developing resistance to the drug.ย 

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Methimazole comes as an oral tablet. Be sure to administer medication with food and water two to three times a day (or every eight hours). A blood test will be conducted by your veterinarian to determine proper dosage levels. Do not use in pregnant or nursing animals

Store methimazole at room temperature, between 68 and 77° F (20 and 25° C). Brief storage at temperatures between 59 and 86° F (15 and 30° C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom.

Methimazole is manufactured by King Pharma

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Customer Reviews

Rating Summary 38 review(s)
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R
Quality product
VERIFIED PURCHASER

Excellent shipping and handling. Medicine is as described.

Robert Hsu recommends this item.
Was this review helpful? 0 0
A
5 stars
VERIFIED PURCHASER

This rx really works for my cat for Thyroid issues. He is going strong now then before medication. My boy has been on this for months and what a positive result

A Marvan recommends this item.
Was this review helpful? 1 0
M
Great price and value
VERIFIED PURCHASER

I had been getting this medicine from my vet but it was higher priced and I had to drive to my vetโ€™s office to get it. I love that I can save money and have this delivered right to my door. Thanks PetCareRX!

Mandi Barwell recommends this item.
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B
Order for meds
VERIFIED PURCHASER

Website easy to maneuver

Bunny Hofberg recommends this item.
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T
Excellent product
VERIFIED PURCHASER

So much less expensive than getting it at the vet and itโ€™s the same stuff. Highly recommend! Super fast delivery!

Tracie Peddy recommends this item.
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B
Good for my cat
VERIFIED PURCHASER

Meow said the kitty

Submitted User Image
BG recommends this item.
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V
Methimazole
VERIFIED PURCHASER

Have 2 cats with hyperthyroidism, since taking medication have gained weight and look more like their usual perky fur babies

Vickie recommends this item.
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J
Great and Fast Shipping!
VERIFIED PURCHASER

This is a great option and far cheaper than getting my catโ€™s thyroid meds through his Vet. Fast shipping, too! They contact the Vet for you.

JRB recommends this item.
Was this review helpful? 3 0
B
Great for my cat
VERIFIED PURCHASER

Butterscotch was happy to have these

Butterscotchโ€™s owner recommends this item.
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A
Great Prices
VERIFIED PURCHASER

I was able to get my cat's medication at a lower price then through my vets office.

Alisha recommends this item.
Was this review helpful? 3 0
S
Great prices
VERIFIED PURCHASER

I was able to get my cat's thyroid medication cheaper then most sites and quick. I recommend this company to all of my friends with fur babies!

Starr recommends this item.
Was this review helpful? 2 0
J
Great Buy!
VERIFIED PURCHASER

So much cheaper than the vets office and super fast delivery!

Jennifer recommends this item.
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T
Methimazole
VERIFIED PURCHASER

The Methimazole prescription for my cat, Gabriel, was affordable, easy to order, and delivered quickly.

Tim recommends this item.
Was this review helpful? 2 0
E
Finally our dosage in pill form!
VERIFIED PURCHASER

Finding this medication in pill form has been a Godsend. Our 14-year-old has hyperthyroid and we were prescribed Methimazole compound cream for her ears, but it was very pricey and left a nasty residue in her ears (not to mention she didn't love having a cream rubbed inside her ears) and I had to use gloves and then wash my hands since I am pregnant and not supposed to handle the cream. These pills are so much easier - I just cut them in half with a pill splitter (for her dosage) and drop in her daily wet food. Works just as well as the ear compound and much more affordable and convenient. Please keep this particular dosage for this medication - it is somewhat hard to find this dose and these are perfect for cutting in half for our lightweight senior.

Elizabeth recommends this item.
Was this review helpful? 3 0
C
Happy Cat
VERIFIED PURCHASER

Kitty's thyroid levels have been kept in check. He's very good about taking his meds...gobble them up since I hide them in pill pockets. :)

Carla recommends this item.
Was this review helpful? 1 0
S
Methimazole
VERIFIED PURCHASER

My cat has gone from a skeleton to a much calmer, happier, healthy cat again. He sleeps more like he used to, has filled out and has a healthier coat. The tablets crush easily so they disappear into his favorite wet food. Purchasing through Pet Rx is less than half the price of purchasing at my vet.

SFoote recommends this item.
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W
works for hyperthyroidism
VERIFIED PURCHASER

my cat has gained weight since taking methimazole. i've had hyperthyroid cats in the past who had been on it and it definitely helps with that issue.

whatever recommends this item.
Was this review helpful? 1 0
J
Worth it!
VERIFIED PURCHASER

All I have to say is I'm pleased with its effectiveness AND ease of splitting. I've had different brands where they could barely be cut properly! (My cat was on 1/8 tab two times a day at one point, then moved to 1/4 tab twice a day) So, 1, I am very pleased with this medicine!

JuliaFinalea recommends this item.
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M
Seems to work well.
VERIFIED PURCHASER

Works for my cat's condition. His hyperthyroidism is under control. I will definitely re-order from PetCareRx.

mrtedders recommends this item.
Was this review helpful? 1 0
Z
prompt delivery, excellent value
VERIFIED PURCHASER

hassle free! they contact the vet directly and ship promptly. the product appears to be of high-quality and effective. very satisfied

zackdad recommends this item.
Was this review helpful? 1 0
S
It works!
VERIFIED PURCHASER

I have a cat that was diagnosed with hyperthyroidism and the vet prescribed this medicine and it has definitely lowered her levels.

sammy12 recommends this item.
Was this review helpful? 1 0
F
Not same as received from vet. They were larger & chicken flavored
VERIFIED PURCHASER

Tiny tablets. Difficult to split. Not flavored. Prompt delivery.

Frethtx recommends this item.
Was this review helpful? 1 0
F
Not same as received from vet. They were larger & chicken flavored

Tiny tablets. Difficult to split. Not flavored. Prompt delivery.

Frethtx recommends this item.
Was this review helpful? 1 0
S
Not as effective as brand for my kitty

When my cat had a mild problem with his thyroid, this was fine, for a few years actually, but then when it started to get worse I tried Tapazole name brand and within days he was tested again and the numbers dropped 5 points (not sure what the medical term is) to within normal range. The vet had previously tried another generic he uses in his office which usually works well, for 2 weeks, and still no change. So, as it turns out, in this case, sometimes the generic of this type of medicine just isn't as effective. If you must use it, please get your pet tested more often. I have insurance which covers most of my cost, and therefore have switched to the name brand this time.

sherri32 recommends this item.
Was this review helpful? 2 0
A
Cheap and effective

A lot cheaper then what the vet charges and it works great! My cat has been on it over a year and after a month she gained her weight back and she's been doing great ever since. Thanks to Pet-rx. Fast shipping too.

Anonymous Pet Parent recommends this item.
Was this review helpful? 0 0
L
so far so good

my angel girl has done well on this med for the past year and a half, although sometimes goes through a weird period of vomiting and soiling in inappropriate places...not sure why. Service at Pet care was great. fast and professional

Lori recommends this item.
Was this review helpful? 1 0
A
Local Vet Much Cheaper

This RX saved my cat's life! Unfortunately, I can get it much cheaper at my local vet clinic....60 cents a 10 mg pill

Anonymous Pet Parent recommends this item.
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A
Cat and cost effective!

When I first found out Buddy had thyroid problems, I was devestated. He was on this medicine for about a year and didn't seem to improve, but it was not this medication. Turned out he has CRF and between this medication and his 3x a week fluid treatment, my cat has outlived all his nine lives and then some! PetCareRx has been nothing short of a lifesaver for Buddy and his momma. The cost is the best I have seen on the internet or locally. Thanks for everything PetCareRx!

Anonymous Pet Parent recommends this item.
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M
Great Customer Service

After finding out the devastating news about my 17 yr old cat, Macy's overactive thyroid, it was a blessing to find the Methimazole at a fraction of the cost of my vets. He charges $60 for a month's supply. I saved over $20 through PetCareRx and it's autoshipped too! The meds arrived quickly and the customer service was wonderful. I highly recommend this company for pet care needs. They deliver!!! As for Macy, she's responding well to the medication. She's eating more although not gaining weight. She's meowing again and seems more alert. Her vomiting is almost eliminated too!

Mary_the_cats_servant recommends this item.
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L
Was a nightmare for my cat

My cat proved to be highly allergic to this product. She was vomiting every day, not eating her food anymore, not drinking, and her skin was bright red. She felt so sick that she hid in the darkest places, and I thought I will lose her. I will never use this awful stuff again!!! Same thing with Tapazole, they are both the same.

Leticia recommends this item.
Was this review helpful? 1 0
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