Revolution is usually available as spot on applicators and is applied once a month to the skin at the base of the neck. Apply the medicine depending on the weight of the dog. Spot on applicators are available in 0.25 ml (15 mg/tube), for dogs weighing up to 5 pounds; 0.25 ml (30 mg/tube), for dogs weighing from 5.1 to 10 pounds; 0.5 ml (60 mg/tube), for dogs of 10.1 to 20 pounds; 1 ml (120 mg/tube) for dogs of 20.1 to 40 pounds; and 2 ml (240 mg/tube) for dogs weighing from 40.1 to 80 pounds. For dogs, apply one pipette topically every 30 days. Spot on applicators are available in 0.25 ml (15 mg/tube) for cats weighing less than 5 pounds. For cats weighing from 5.1 to 15 pounds, 0.75 ml (45 mg/tube) pipette is available; apply one pipette once monthly.