About the Proin Dosage for Urinary Incontinence Phenylpropanolamine (the Medication in Proin) is Effective in Treating Urinary Incontinence in Dogs

Urinary Incontinence

Proin (Phenylpropanolamine)

Bladder Control
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Indications for Proin

Phenylpropanolamine is an adrenergic agent effective in the treatment of urinary incontinence in animals. This extra-label medication is fit to be used only in dogs. Phenylpropanolamine works by increasing the sphincter tone of urethra, which tightens the bladder sphincter muscles thereby preventing urine leakage.


Avoid using Phenylpropanolamine in animals with a history of allergy to the ingredients of this drug. Animals suffering from conditions of glaucoma, enlarged prostate, hyperthyroidism, diabetes, heart problems, or high blood pressure should be kept away from proin. Abstain from using Phenylpropanolamine in pregnant and breeding animals as it can cause harmful effects.


Proin is available in 25 mg, 50 mg, and 75 mg chewable tablets. Dosage of proin generally depends on the body weight of the animal. However, a dose of 12.5 mg to 50 mg can be administered three times daily, depending on weight. The usual dose of Proin in dogs is 0.4-0.8 mg/pound every 12 hours. Over dosage can bring about symptoms of high blood pressure, increased heart rate, seizures, or coma. Do not increase or reduce the dosage without veterinary prescription.

Side Effects

The most common side effects noted while administering Phenylpropanolamine are restlessness, irritability, increased heart rate, increased blood pressure, and loss of appetite. Restlessness, weakness, pale gums, seizures, or difficulty in urinating are also reported as occasional side effects in animals being treated with Phenylpropanolamine.

Brand/Generic Equivalents

Phenylpropanolamine, Propaline, Cystolamine

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