Cyclosporine (Modified)
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At a Glance
Helps treat skin infections & allergies in dogs & cats
Approved by the FDA
Less invasive and less expensive than a shot

Cyclosporine (Modified)

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At a Glance
Helps treat skin infections & allergies in dogs & cats
Approved by the FDA
Less invasive and less expensive than a shot

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Total Price

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Cyclosporine Capsules, USP (Modified), mark a significant milestone in veterinary medicine, offering a sophisticated and effective solution for managing skin infections and allergies in dogs and cats. These capsules are designed for oral administration and provide a less invasive and more accessible alternative to traditional injectable treatments.

Composition and Mechanism of Action

The active ingredient in these capsules is Cyclosporine, a potent immunosuppressive agent adapted for veterinary use. Its mechanism of action involves selectively inhibiting the activation of T-lymphocytes, key immune cells involved in inflammatory responses. By modulating the immune system at the cellular level, Cyclosporine addresses immune-mediated disorders, including canine atopic dermatitis and chronic mild inflammatory diseases in pets.

Cyclosporine Pharmacokinetics and Metabolism

The modified formulation ensures optimal absorption and distribution of Cyclosporine, leading to consistent therapeutic blood concentrations. Metabolism primarily occurs in the liver of dogs and cats, allowing for precise control over the drug's effects. Understanding the pharmacokinetics of Cyclosporine is crucial for tailoring treatment plans and providing veterinarians with the necessary tools to achieve therapeutic efficacy while minimizing potential side effects.

Clinical Efficacy and Specific Applications

Cyclosporine Capsules demonstrate clinical efficacy in managing various conditions prevalent in pets, including mild inflammatory bowel disease, urinary tract infections, and immune-mediated diseases like chronic hepatitis. By specifically targeting immune cells involved in the inflammatory cascade, Cyclosporine proves to be a versatile and comprehensive solution for addressing a spectrum of immune-mediated conditions in companion animals.

Less Invasive Option with Oral Administration

The oral administration of Cyclosporine Capsules presents a less invasive alternative to injectable treatments, ensuring ease of compliance for both pets and their caretakers. The convenience of oral administration fosters a stress-free experience, contributing to improved treatment adherencea critical factor in achieving long-term therapeutic success in veterinary care.

Optimal Cyclosporine Concentrations and Pharmacokinetics

Maintaining optimal blood concentrations of Cyclosporine is crucial for therapeutic effectiveness. The modified formulation and minimal renal excretion contribute to a controlled release of the drug, reducing the risk of fluctuations in blood levels. This precision in pharmacokinetics enhances the safety profile of Cyclosporine, addressing concerns related to potential organ toxicity in pets.

Individualized Treatment through Adjusting Drug Doses

Cyclosporine therapy for pets allows for individualized treatment plans by adjusting drug doses based on the specific needs of each patient. This tailored approach is particularly beneficial in chronic conditions, where adjusting the Cyclosporine dose ensures sustained efficacy while minimizing the risk of adverse effects. Dosing intervals can be personalized to accommodate the unique requirements of each pet, enhancing the overall success of the treatment.

Cyclosporine Capsules, USP (Modified), offer advanced veterinary care for canine and feline skin conditions, providing a less invasive and tailored solution for pets facing immune-mediated challenges. The formulation's adaptability and precise pharmacokinetics position these capsules as a valuable tool for veterinarians striving to achieve optimal therapeutic outcomes in companion animals.

  • Novartis Brand
  • Eye Care Pharmacy
  • Novartis Manufacturer
  • Oral Application
  • Cat Pet Type
  • Dog Pet Type

What is the main use of cyclosporine in dogs?
Answer

Cyclosporine is a vital treatment in veterinary medicine for dogs, primarily addressing immune-mediated ailments and allergic reactions. Cyclosporine is commonly prescribed to manage conditions like atopic dermatitis, characterized by itching and skin irritation due to environmental allergens. Cyclosporine is also effective in treating immune-mediated diseases like polyarthritis and inflammatory bowel disease. It is beneficial for certain autoimmune disorders where the immune system mistakenly attacks the body's own tissues. Additionally, cyclosporine aids in boosting tear production for dogs with dry eye conditions (keratoconjunctivitis sicca).

Is Cyclosporine classified as a steroid?
Answer

Cyclosporine does not belong to the category of steroids. It's an immunosuppressive medication that works differently from steroids. Steroids like prednisone or cortisone work by reducing inflammation through diverse mechanisms. In contrast, cyclosporine operates by suppressing the immune system's response, primarily by inhibiting the activation of specific immune cells, particularly T lymphocytes.

Which is a major adverse effect of cyclosporine?
Answer

One of the major adverse effects of cyclosporine is its potential to cause nephrotoxicity, which refers to kidney damage or impairment. Prolonged use of cyclosporine can lead to renal dysfunction, affecting the kidneys' ability to filter waste products and maintain proper fluid balance. Regular blood tests are essential for individuals taking cyclosporine to monitor kidney function and mitigate the risk of nephrotoxicity. Adjusting the dosage as needed based on these tests helps minimize the potential adverse effect on the kidneys.

How can I manage my dog's dermatitis using home remedies?
Answer

Andie Lenhard, a specialized DVM and RN from Southeastern Appalachia, highlights the multifaceted origins of dermatitis in dogs. It can arise from flea allergies, other allergic reactions, fungal or bacterial infections, and may even be associated with specific cancers or hormonal imbalances. Each root cause requires a unique and tailored treatment method. Lenhard strongly cautions against trying unproven remedies proposed by untrained sources and strongly recommends seeking professional veterinary advice. This approach ensures targeting the precise underlying causes of the condition, preventing unnecessary expenditure on ineffective medications and supplements.

Can dermatitis in dogs be cured?
Answer

Dermatitis in dogs, especially atopic dermatitis (allergic skin inflammation), is often managed rather than completely cured. The goal of treatment is to control and alleviate the symptoms, reduce flare-ups, and improve the dog's quality of life. Treatment typically involves identifying and minimizing exposure to allergens and managing secondary infections. It often includes using antihistamines, steroids, immunosuppressive drugs such as cyclosporine, and medicated shampoos to control itching and inflammation. In some cases, allergy testing and allergen-specific immunotherapy may be considered to desensitize the dog's immune system to specific allergens.

What food is good for dogs with atopic dermatitis?
Answer

For dogs with atopic dermatitis, choosing an appropriate diet often involves exploring options like limited ingredient diets (LID) or novel protein diets. These diets aim to identify and manage potential food allergies or sensitivities associated with the condition. They often feature a single protein source or novel proteins like duck, venison, or unique fish to minimize allergic reactions. Hydrolyzed protein diets can also be beneficial to break down proteins into smaller components. Including omega-3 fatty acids from fish oil or fish-rich diets supports healthy skin and reduces inflammation. Avoiding potential trigger ingredients such as certain grains, soy, or specific proteins like beef or chicken might also be necessary.

What foods to avoid for dogs with skin allergies?
Answer

For dogs with skin allergies, it's often recommended to avoid potential trigger ingredients that can exacerbate allergic reactions. Common food allergens in dogs include wheat, corn, soy, dairy products, beef, chicken, and certain artificial additives or preservatives. These ingredients may contribute to skin irritation and allergic responses. Additionally, avoiding table scraps and human foods with high salt or fat content is advisable for dogs with skin allergies. Opting for a balanced, hypoallergenic commercial dog food can be beneficial in managing their condition effectively.

How frequently should you wash a dog experiencing skin irritation?
Answer

Michael Hoover, a former veterinarian from Manchester, advises bathing your dog 1-2 times weekly with a medicated shampoo for skin needs. This routine helps address skin issues effectively and maintain the dog's cleanliness. However, if an over-the-counter (OTC) shampoo is used, Hoover recommends limiting baths to once a week. He advises that bathing every two weeks would be a preferable option when using OTC shampoos to prevent potential skin irritation or drying.

Do eggs help dogs with itchy skin?
Answer

Eggs can potentially contribute to improving a dog's skin health due to their nutritional content. They are a good source of protein, vitamins, and essential fatty acids, particularly omega-3 fatty acids, which can support healthy skin and a shiny coat. Omega-3 fatty acids have anti-inflammatory properties that may help alleviate itching and reduce skin inflammation associated with conditions like atopic dermatitis.

Active ingredient:
Cyclosporine USP - 25, 50, or 100 mg Other ingredients:
Dehydrated Alcohol 18.6%, dl-alpha-tocopherol, FD&C blue #2 aluminum lake, ferric oxide (yellow), gelatin, glycine, glycerol 85%, polyoxyl 40 hydrogenated castor oil, polyglycerol (3) oleate, polyglycerol (10) oleate, sorbitol solution, titanium dioxide

Please consult your veterinarian for side effects or any drug interactions.

Dogs/Puppies: (6 months and older over 4 lbs.)

Give 2.5mg per pound of body weight. The medication is usually given once a day to start until satisfactory improvement is seen, usually 4-8 weeks. The medication can then be given every other day until the clinical signs of atopic dermatitis are satisfactorily controlled, then the medication can be given every 3 or 4 days. Always give 1 hour before or 2 hours after a meal. Allow plenty of water for the pet to drink.

Cats/Kittens:(6 months and older over 4 lbs.)

Give 2.3-3.1mg per pound of body weight. The medication is usually given once a day to start until satisfactory improvement is seen, usually 4-8 weeks. The medication can then be given every other day until the clinical signs of atopic dermatitis are satisfactorily controlled, then the medication can be given every 3 or 4 days. Always give 1 hour before or 2 hours after a meal. Allow plenty of water for the pet to drink

Store at room temperature. Some variation in the color of the powder may occur from batch to batch.

Cyclosporine (Modified) is manufactured by Novartis

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