Selegiline Hydrochloride acts monoamine oxidase-B inhibitor. The drug is used for the canine cognitive dysfunction treatment among the pats and helps tackle Cushing’s disease. The dopamine levels of the brain increase by the action of this medication. The metabolization of the drug leads to methamphetamine, amphetamine, and L-desmethylselegiline. These together act as stimulants for the central nervous system.
This medication is the only FDA-approved treatment available for nine cognitive dysfunctions. The onset of the actions of this medication can vary between 4 to 12 weeks, but most pets show improvement after a month of treatment. This condition can only improve with time. The medication’s neuroprotective effects lead to an increase in dopamine levels. However, it is worth mentioning that the drug does not cure can and cognitive dysfunction but can help in improving the quality of life under such a condition.
If any accidental overdosing of this drug happens, it is crucial to inform a veterinarian and seek medication immediately.
Mechanism of Action
The old administration of the medication leads to a rapid release of the drug into saliva. An active pharmaceutical ingredient gets through the buccal mucosa. It helps to trigger the metabolism rapidly due to the fast-paced action. There are mild clinical benefits available from MAO inhibitors during the treatment. One of the byproducts of MAO catalyzed a mind oxidation reaction is hydrogen peroxide, and it can further convert reactive oxygen species leading to cytotoxic. It can ultimately impact reducing the oxidative stress of the animal. The antioxidant property is a critical neuroprotection mechanism that this medication helps provide.
Known Drug Interactions
Numerous drug interactions can happen with this medication. In the event of sighting such interactions, it is ideal to stop using the drugs for two weeks before giving selegiline. This period will serve as a good wash-off period and help avoid any aggravating drug interaction scenarios.
The interactions can happen with the drugs like phenylpropanolamine, monoamine oxidase inhibitors, pseudoephedrine, tricyclic and tetracyclic anti-depressants, selective serotonin, etc.
Anipryl is a medication for veterinary use in treating certain complications in dogs alone. The medication is found extremely effective in dealing with canine cognitive dysfunction syndrome as well as various Cushing’s diseases due to pituitary tumors in dogs. Selegiline Hydrochloride, a monoamine oxidase inhibitor is an active ingredient in the medicine that helps in controlling the clinical signs associated with the abovementioned complications in dogs. The medication is available only on prescription and is in the form of a tablet meant to be taken orally.