Advantage II for Dogs
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At a Glance
Two active ingredients kill fleas, lice, and prevent future infestations.
Prevents new fleas and lice in two hours after application.
Kill existing fleas and lice within the first 12 hours after application.
Once-a-month application kills and prevents future infestations for 30 days.

Advantage II for Dogs

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At a Glance
Two active ingredients kill fleas, lice, and prevent future infestations.
Prevents new fleas and lice in two hours after application.
Kill existing fleas and lice within the first 12 hours after application.
Once-a-month application kills and prevents future infestations for 30 days.

Ultimate Guide to Advantage II for Dogs

Meet Dog's Most Trusted Flea and Lice Killer: Advantage II for Dogs!

Advantage II for Dogs is the veterinarian-approved dog medication with two strong active ingredients to protect your dogs from fleas and lice. Advantage II for Dogs is a once-a-month spot-on topical treatment that remains effective for the next four weeks after application.

How does Advantage II for Dogs work?

The medication works with two active ingredients: Imidacloprid and Pyriproxyfen.

Imidacloprid is the world's most used insecticide. Advantage II for Dogs attacks a flea's central nervous system causing paralysis and its imminent death. Pyriproxyfen is an Insect Growth Regulator (IGR) that prevents proper flea hatching and the healthy growth of flea larvae.

Once administered, the medication eradicates existing fleas or lice on your dog within the first 12 hours after application and protects your dog from new fleas or lice within two hours.

How is Advantage II for Dogs administered?

Advantage II for Dogs is a monthly topical formula that uses the spot-on treatment approach. Apply one to three spots on different locations along the dog's spine from between the shoulder blades to the base of the tail. Allow one hour for Advantage II to dry.

See the chart below to know the specific dosage for your dog depending on their body weight:

Weight Dosage
3 lbs. - 10 lbs. (Small Dogs) 0.4 mL (Green)
11 lbs. - 20 lbs. (Medium Dogs) 1.0 mL (Teal)
21 lbs. - 55 lbs. (Large Dogs) 2.5 mL (Red*)
55 lbs. + (Extra-large dogs) 4.0 mL (Blue*)

*Use several spots for a larger dog to avoid irritation.

Though the solution is considered waterproof, you must wait one hour for the solution to dry, and then you don't need to reapply after bathing, swimming, or petting your pup.

Which dogs should not use Advantage II for Dogs?

Pregnant and lactating dogs. Puppies under 7 weeks old or less than 3 pounds. Elderly dogs or those who are in a debilitated state. Be aware if your dog is allergic to any of the active ingredients. Lastly, keep out of reach of children or cats.

Consult your veterinarian prior to prescription. Other pesticides may not interact well with Advantage products.

What are the potential side effects of which you should be aware?

After the spot-on treatment application of Advantage II for Dogs, your furry best friend may experience skin irritation. If it persists or worsens, call your veterinarian immediately.

Frequently Asked Questions
  1. What is the Advantage flea effect?

    Advantage II for Dogs kills fleas and prevents infestations throughout the following four weeks. Advantage II for Dogs kills fleas and lice within 12 hours after application. In terms of new fleas and lice, these parasites die on contact within 2 hours and for 30 days after an application.

  2. What is the difference between Advantage II for large dogs, Advantage II for extra large dogs, and Advantage II for medium dogs?

    All formulas have the same percentages of the active ingredients (9.10% Imidacloprid, 0.46% Pyriproxyfen, and 90.44% other ingredients), but small dogs, medium dog, large dogs, and extra-large dogs require a different dosage depending on the dog's weight (see the chart above).

  3. What are the Advantage II for Dogs reviews?

    Advantage II for Dogs reviews rates the solution 4.5+ out of 5 stars. Most reviewers say that this is the only flea treatment that they trust, that it is an awesome product, and easy to use. Reach out to your vet if having any concerns or questions about your dog's use of Advantage II for Dogs.

  4. Is Advantage II for puppies?

    Advantage II for Dogs can be administered to puppies that are at least 7 weeks old and weigh 3 pounds.

  5. Is Advantage II for Dogs used for cats?

    No. Advantage II for Dogs is manufactured only for dogs. However, with the two other active ingredients (i.e., Imidacloprid and Pyriproxyfen), Advantage II for Cats is still a monthly topical solution that kills and prevents flea and lice infestations. The cat must be at least 8 weeks old and weigh 9 pounds.

Concluding Thoughts

The most important thing that you should know about Advantage II for Dogs is its power to kill lice, treat every life stage of the flea, and prevent future infestations for 30 days after one application. The medication guarantees happier, healthier, and more comfortable dogs.

DISCLAIMER: FDA law restricts Advantage II for Dogs only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian whether Advantage II for Dogs is suitable for your dog. Ask your licensed veterinarian to prescribe an exact dosage and other specifications prescribed for your dog.

  • Advantage Brand
  • Flea & Tick Pharmacy
  • Elanco Animal Health Manufacturer
  • Spot On/Topical Application
  • Dog Pet Type

What Is the Difference Between Advantage and Advantage II?
Answer

Advantage II is the successor of Advantage and comes with three new ingredients, all insect neurotoxins. Quite obviously, the new formula is more effective at getting rid of the pests than the original Advantage. The old formula was rated to kill adult fleas within 12 hours of application; however, the drawback of the Advantage flea medicine is that it only works on adult fleas and now on flea larvae or flea eggs. On the other hand, Advantage II for dogs also starts killing fleas 12 hours after the application. However, the new formulation comes with additional protection against fleas. It stops the flea life cycle as it stops larvae from developing. This means that your dog or cat gets complete flea control for 30 days at multiple flea life stages.

Which Is Better Frontline or Advantage?
Answer

Both Frontline and Advantage are effective oral flea medications for dogs and cats. However, there's a difference in both products. Merial manufactures Frontline and claims to get rid of 98% to 100% of fleas within 24 hours of application. The medicine is claimed to work on adult fleas and all stages of fleas, including eggs and larvae. It also takes care of the files allergy dermatitis and thus breaks the flea cycle. Frontline contains two ingredients, Fipronil and (S)-methoprene, which kills adult and immature fleas, respectively. The formulas also guard your dog against ticks, sarcoptic mange, and lice. On the other hand, Advantage is a topical product by Bayer and kills fleas within 12 hours. The medication treats fleas in all stages, as well as flea allergy dermatitis and lice. However, it doesn't treat ticks in dogs. It contains Imidacloprid, which attacks the flea's nervous system to kill it. It also has Pyriproxyfen, which is an insect growth regulator (IGR). The IGR mimics flea's juvenile growth hormone to kill it in the immature stage of the life cycle.

How Long Does It Take for Advantage 2 to Work on Dogs?
Answer

According to Bayer, the maker of Advantage 2, the medication starts killing fleas within 12 hours of application. The medicine remains effective for 30 days post-application and provides complete protection against fleas in all stages of its life cycle. However, if your dog has a heavy flea infestation, pet parents will have to administer the medication more than once every month. The product doesn't come with an expiry date and doesn't expire as long as it's stored as directed on the packaging.

Does Advantage 2 for Dogs Work?
Answer

Advantage 2 is a spot-on flea treatment for dogs that safeguard your pet against fleas and the adverse effects they cause. Reportedly, a single flea can lay as many as 50 eggs in a day, and before you know it, a single flea turns into a heavy infestation. To control these invasive pests, a fast-acting, effective flea treatment is a must. This is where Advantage 2 comes into the picture as a spot-on topical flea medication that kills fleas on contact. This means that the flea doesn't need to bite your dog for Advantage 2 to work. The Advantage 2 solution is applied in one spot on your dog, and it spreads through the lipid layer across the dog's skin and coats evenly to kill fleas within a day. Moreover, as your dog naturally sheds its fur, the active ingredient in the medication that is Imidacloprid is also shed in your home and pet's environment, thus killing flea larvae. With monthly treatment year long, the medicine provides long-term effective flea protection to protect your pet and family.

Is Advantage II Prescription Only?
Answer

Most spot-on flea treatment ointments like Frontline Plus, Advantage II, and K9 Advantix II are over-the-counter, which means they don't require a prescription from a veterinarian for purchase. Pet parents can purchase the medication from the local pharmacy, pet shops, or online retailers easily. However, it's worth noting here that there is an advanced product called Advantage Multi, which has a more complex formulation than Advantage and Advantage 2 and works on more parasites than just lice and flea. Advantage Multi requires a prescription from your veterinarian.

How Long Does Advantage 2 Last?
Answer

The Advantage 2 medication is rated to start killing fleas within 12 hours of application. Moreover, the medicine stays effective for 30 days after application to keep your pet protected against fleas in all stages of the life cycle. Furthermore, the Imidacloprid is also spread in the dog's natural environment as it sheds to kill flea larvae in your home and dog's immediate surroundings for all-around protection. The Advantage 2 medication is also waterproof, which means, post 24 hours of drying, it will stay on the body of your dog even if you bathe them.

Why Does My Dog Still Have Fleas After Using Advantage?
Answer

Unlike Advantage 2, Advantage only kills adult fleas. This is the main reason why your pet might still have fleas after applying the Advantage flea medication. An adult flea female can lay up to 50 eggs in a day, which soon turns into a massive infestation if not taken care of. Since Advantage is ineffective against flea eggs and larvae, you might still see fleas after application because of the flea life cycle.

Are there any food or drug interactions with Advantage II for dogs?
Answer

No, there are no known food interactions with Advantage II for dogs. But it's crucial to adhere to the dosage recommendations made by the drug's manufacturer and your veterinarian. However, when it comes to drug interactions, it is always best to consult with your veterinarian before giving any other medications to your dog while they are using Advantage II. This covers both over-the-counter and prescription drugs as well as herbal supplements. Some medications may interact with imidacloprid and pyriproxyfen, potentially affecting their effectiveness or causing side effects.

What should I do if my dog experiences any adverse reactions while taking Advantage II?
Answer

If your dog experiences any adverse reactions while taking Advantage II, it is important to stop using the medication immediately and contact your veterinarian as soon as possible.

Is Advantage II for dogs waterproof?
Answer

Yes, Advantage II for dogs is waterproof once it has dried on your dog's skin. The manufacturer advises not washing or letting your dog get wet for at least 24 hours after administering the medicine. If properly applied and given time to dry, Advantage II shouldn't be affected by water after 24 hours. This implies that the drug won't be affected by your dog swimming, taking a bath, or becoming wet.

Can I use Advantage II for dogs on my outdoor dog?
Answer

As long as the age and weight limitations outlined by the manufacturer are met, Advantage II for dogs can be used on outdoor pets. However, if your dog spends a lot of time outdoors, it may be at higher risk for flea and tick infestations, so it is important to use a flea and tick preventative consistently and according to the manufacturer's instructions.

Can Advantage II for dogs be used for flea allergy dermatitis prevention?
Answer

Advantage II for dogs is labeled and designed for flea control, which can help prevent flea bites that can trigger flea allergy dermatitis (FAD). Flea allergy dermatitis is an allergic reaction to flea saliva that can cause itching, redness, and inflammation of the skin. By controlling flea infestations, Advantage II can help reduce the risk of FAD in dogs that are sensitive to flea bites.

Can Advantage II for dogs be used for mite prevention?
Answer

No, Advantage II for dogs is not specifically designed or labeled for mite prevention. The active ingredients in Advantage II, imidacloprid and pyriproxyfen, are primarily intended for flea and tick control.

Can Advantage II for dogs be used for heartworm prevention?
Answer

No, Advantage II for dogs is not marketed nor intended for the prevention of heartworms. Imidacloprid and pyriproxyfen, the active components in Advantage II, are primarily used to control flea and tick populations.

Can Advantage II for dogs be used for hookworm prevention?
Answer

No, Advantage II for dogs is not labeled or designed for hookworm prevention. The active ingredients in Advantage II, imidacloprid and pyriproxyfen, are primarily intended for flea and tick control.

Can Advantage II for dogs be used for roundworm prevention?
Answer

No, Advantage II for dogs is neither labeled nor intended to prevent roundworms. Imidacloprid and pyriproxyfen, the active components in Advantage II, are primarily used to control flea and tick populations.

How long does it take for Advantage II for dogs to work?
Answer

Advantage II for dogs begins to work within 12 hours of application, and it is designed to kill fleas and prevent flea infestations for up to 4 weeks, as well as to kill ticks and prevent reinfestations for up to 2 weeks.

What should I do if my healthy dog accidentally ingests Advantage II?
Answer

If your healthy dog accidentally ingests Advantage II, you should contact your veterinarian or a pet poison control center immediately for guidance. Ingestion of insecticides, including those found in flea and tick preventatives, can be toxic to dogs and may cause a range of symptoms, depending on the amount ingested and the size and health of your dog. Symptoms of toxicity from Advantage II may include drooling, vomiting, diarrhea, tremors, seizures, and respiratory distress. In severe instances, ingestion of large amounts of insecticide can be life-threatening. If you have the packaging or label information for the product, have it handy when you call your veterinarian or poison control center.

Can Advantage II for dogs be used on other animals besides dogs?
Answer

No, Advantage II for dogs is solely intended for use on dogs and is labeled as such. Cats should not be subjected to it since it could not be safe or effective for them. Some drugs that are safe and effective for dogs may be hazardous for cats because dogs and cats have distinct physiological and metabolic systems. Additionally, it's critical to use the appropriate medication for each specific animal because the doses and concentrations of the active components in flea and tick preventatives may vary between species.

Advantage for dogs contains Imidacloprid and Pyriproxyfen.

As with any topical treatment, skin irritation may occur as a result of using Advantage for dogs. If irritation does not subside or worsens, contact your veterinarian. Do not combine with other spot-on flea treatments, unless recommended by your veterinarian.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Advantage for dogs eradicates any fleas or lice on your dog. The first active ingredient, Imidacloprid, targets the nervous system, paralyzing and killing 98-100% fleas within the first 12 hours after application. Pyriproxyfen, the second active ingredient, is an insect growth regulator (IGR) that hampers the development of any remaining flea eggs, preventing them from hatching.

Advantage II for Dogs is completely waterproof, guaranteeing that, no matter what your dog gets into, this medication will last the full 30 days.

Advantage II for Dogs is intended for use on dogs and puppies 7 weeks and older. Medication should be applied once a month, being careful to give the correct dosage based on your dogโ€™s weight.

Solution should be applied along the back of the dog, in 1-3 locations between the shoulders and base of the tail. The number of application spots should increase along with the weight of the dog (<20lbs = 1 spot, +20lbs = 2-3 spots). Part their fur and carefully apply solution directly to the skin, making sure there is no excessive run-off. Allow 1 hour for Advantage II to dry.

Advantage for dogs should be stored in a cool, dry place. Do not refrigerate.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Advantage is manufactured by Elanco Animal Health
Option UPC/SKU
Green - 3-10 lbs., 4 Month Supply 724089202406
Teal - 11-20 lbs., 4 Month Supply 724089202673
Red - 21-55 lbs., 4 Month Supply 724089202833
Blue - 55 lbs. and over, 4 Month Supply 724089203052
Green - 3-10 lbs., 6 Month Supply 724089202598
Teal - 11-20 lbs., 6 Month Supply 724089202758
Red - 21-55 lbs., 6 Month Supply 724089202918
Blue - 55 lbs. and over, 6 Month Supply 724089203212

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