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At a Glance
Trifexis kills fleas, prevents heartworm, and treats and controls intestinal parasites
Trifexis is a once monthly beef flavored chewable tablet
No isolation from other pets necessary when using Trifexis
This product requires a prescription.

Trifexis

An alternative to Trifexis is Sentinel

Trifexis is a powerful and effective means of preventing heartworm disease, as well as protect against fleas and a number of other worms and parasites. [+]

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    Add to Cart

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    Answer some questions during checkout and we'll contact your vet and verify the prescription for you. (you can also mail us the written prescription)

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    If the prescription has any refills, processing your future orders for that medication can be expedited.

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Rated 4.5 out of 5 by 148 reviewers.
Rated 5 out of 5by GreatI've never used any other medicine for my dog's flea/heart worm prevention. Very happy with it. 06/11/2018
Rated 5 out of 5by Its greatI have not had any issues with this product and my girl has been using Trifexis for 2 years now the only thing is I have to crush it up for my girl and mix it with coconut oil for her to take it but other then that she is flea and heartworm free for 2 years now. 06/01/2018
Rated 4 out of 5by You may need to force your dog to take it.its a great product, it just smells bad for the dog. you make need to make a pill pocket with meat or cheese. you make still need to force her to take it with some help. 05/26/2018
Rated 3 out of 5by TrifexisThe pill is very effective but my dog would not take it. I had to chop it up and sprinkle it over her food. It was time consuming to get her to take her medicine. If you have a picky dog or large breed I wouldn't recommend it. I was to scared to allow her to dry swallow it due to the size of the pill. 04/26/2018
Rated 5 out of 5by Great ProductMy vet initially prescribed Trifexis to my dog. It seems to be effective and replaces numerous products. I put the small pill in a piece of meat of cheese and he gobbles it up. I highly recommend. 04/12/2018
Rated 4 out of 5by Horrible TastingMy dog hates the taste of the product . I crush it into a million of little pieces and he will try to eat around that area. Other than that ,it is great... 04/09/2018
Rated 5 out of 5by Works GreatHave not had any issues with fleas, ticks or worms. Dog seems to have no reaction to pills what so ever. 03/31/2018
Rated 5 out of 5by Recommended by VetWe went with the Vet recommendation for our adopted dog. It seems to do the trick and she does not have any side effects from it. If I can prevent all three parasites from affecting my dog, it's a win-win. 03/08/2018
Rated 5 out of 5by PerfectMy long hair chihuahua was having a terrible time last summer with fleas because it didn't get cold the previous winter. Fleas were terrible last summer and nothing got rid of the problem. She's a senior lady only weighing 7 lbs so I'm very cautious what to use on her. Tried the Trifexis and that did the trick. In the fall we switched back to Heartguard, she loves the taste. We will see how the fleas are this coming summer (it got unusually cold last winter) but won't hesitate to use the Trifexis if needed. 03/01/2018
Rated 2 out of 5by DissapointedI have read a number of good reviews but we are on month 7 of using this product and we still have fleas. I am very confused of why it is not working on my dog. I will be switching from this product. 02/13/2018
Rated 4 out of 5by NO FLEASI believe this product works very well... if you can get your dog to ingest it. I wish Trifexis can come in a different form so it would be lot easier to feed it to my small dog who can smell the pill 30 feet away. 02/06/2018
Rated 4 out of 5by Easy and Effective for an Aging WestieI found it much easier to administer than most other medications for our mature West Highland Terrier. He fights most other meds. 01/04/2018
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