At a Glance
FDA-approved for treating canine bacterial skin infections
Simple one-a-day dosing
Can be given with or without food
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Simplicef is an oral once-daily cephalosporin that's FDA approved for veterinary use in the treatment of canine skin infections. It's designed to be convenient and a good value if you have a large dog.
Cefpodoxime proxetil 100 mg
Cefpodoxime proxetil 200 mg
Side Effects and Warnings
Stop giving Simplicef and seek emergency veterinary medical care in the event of an allergic reaction (shortness of breath; hives; swelling of the lips, tongue, or face; rash; or fainting), severe nausea, vomiting or diarrhea, mucus or blood in the stool, and unusual bleeding or bruising. Other, less serious side effects such as mild nausea, diarrhea, or yeast infection may be more likely to occur. Continue to give Simplicef and notify your veterinarian if these symptoms occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
Contact your veterinarian in the event of an allergic reaction (such as shortness of breath, hives, swelling, rash, fainting, vomiting, diarrhea, muous or blood in the stool, unusual bleeding, or bruising). Do not give Simplicef at the same time as antacids such as Maalox or other stomach acid-reducers, like Tagamet.
Available in 100 and 200 mg doses.
Store in a cool, dry place.
Should be given with food to increase absorption by the body.
Dogs (All weights): Give exactly as directed by your veterinarian. The usual dose of Simplicef in dogs is 2.3-4.5 mg/pound, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days.
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