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At a Glance
Effectively treats nausea, vomiting, and reflux in dogs and cats
Normalizes the digestive system
Also useful in treating vomiting from chemotherapy and post-surgery digestive symptoms


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At a Glance
Effectively treats nausea, vomiting, and reflux in dogs and cats
Normalizes the digestive system
Also useful in treating vomiting from chemotherapy and post-surgery digestive symptoms

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A painful belly for your pet can be bad enough. But when it's accompanied by vomiting and reflux, you may need to talk to your vet. Metoclopramide is a prescription medication used to treat nausea, vomiting, and reflux in dogs and cats. It can also help to control vomiting associated with chemotherapy, and stomach and gastrointestinal upset following surgery. Metoclopramide is sold per tablet, or as an injectable or syrup.
  • Gastrointestinal Pharmacy
  • Oral Application
  • Cat Pet Type
  • Dog Pet Type

What is Metoclopramide used to treat?

Metoclopramide is often prescribed to stimulate gastrointestinal motility and improve the movement of food through the digestive tract in pets. It can be used to treat conditions such as gastric stasis, ileus, and delayed gastric emptying. Metoclopramide is effective in managing vomiting and regurgitation in dogs and cats. It helps to reduce nausea and increase muscle contractions in the stomach and intestines, aiding in the movement of food and preventing vomiting. Pets undergoing chemotherapy treatment may experience nausea and vomiting as side effects. Metoclopramide can be used as an antiemetic to help control these symptoms and improve the pet's quality of life during chemotherapy. In some cases, metoclopramide is prescribed to stimulate appetite in pets that have a reduced or suppressed appetite. It can be used to encourage food intake in animals with certain medical conditions or recovering from illnesses.

What is the main side effect of Metoclopramide?

The main side effect of metoclopramide in pets is the potential for central nervous system (CNS) effects. These effects can include sedation, restlessness, and behavioral changes. While these side effects are generally rare, they can occur, especially with higher doses or prolonged use of the medication. Some pets may experience diarrhea, constipation, or changes in appetite while taking metoclopramide. In rare cases, pets may develop an allergic reaction to metoclopramide, resulting in symptoms such as swelling, itching, hives, or difficulty breathing. Seek veterinary assistance immediately if any signs of an allergic reaction occur. Extrapyramidal effects are movement disorders that can occur in some animals, particularly in dogs. Symptoms may include repetitive movements, tremors, muscle spasms, or involuntary facial or body movements. These effects are more commonly observed with higher doses or prolonged use of metoclopramide.

Is Metoclopramide a high-risk drug?

Metoclopramide is generally considered a relatively safe medication when used appropriately and under the guidance of a veterinarian. However, like any medication, it does carry certain risks and potential side effects. One of the primary concerns with metoclopramide use in pets is the potential for central nervous system (CNS) effects, such as sedation, restlessness, and behavioral changes. These effects are generally rare but can occur, especially with higher doses or prolonged use of the medication. In addition, some pets may experience gastrointestinal disturbances, such as diarrhea, constipation, or changes in appetite, while taking metoclopramide. Allergic reactions and extrapyramidal effects (movement disorders) are also possible, but they are relatively uncommon.

What is the best medicine for vomiting?

The choice of medication depends on the underlying cause of vomiting and the individual pet's condition. Metoclopramide is frequently used in veterinary medicine to manage vomiting in pets. It helps stimulate gastrointestinal motility and can be effective in reducing nausea and vomiting. Ondansetron is an antiemetic medication that can be used in pets to control vomiting, particularly in cases such as chemotherapy-induced nausea and vomiting. Cerenia (maropitant) is a medication specifically developed for managing vomiting and preventing motion sickness in dogs. It blocks certain receptors in the brain that trigger vomiting. Famotidine is an H2 blocker commonly used in pets to reduce stomach acid production and manage vomiting associated with gastric ulcers, gastritis, or other gastrointestinal issues. Cimetidine is another H2 blocker that can be used in pets to decrease stomach acid production and alleviate vomiting caused by various conditions.

What class of drug is Metoclopramide?

Metoclopramide is classified as a prokinetic agent and antiemetic. It belongs to the class of drugs known as dopamine receptor antagonists. It primarily acts on the dopamine receptors in the gastrointestinal tract and the central nervous system to increase gastrointestinal motility and reduce nausea and vomiting. In addition to its prokinetic and antiemetic properties, metoclopramide also has some effects on other receptors, such as serotonin receptors. Its mechanism of action involves blocking dopamine receptors and increasing the release of acetylcholine, a neurotransmitter that promotes gastrointestinal motility.

Metoclopramide 5mg or 10mg

Metoclopramide is classified under the drug group โ€˜anti-emeticsโ€™ or anti-vomiting drugs and is effective in the treatment of gastrointestinal disorders and managing vomiting in cats and dogs. It also helps in stimulating the stomach and intestinal motility. Metoclopramide also effectively treats and manages reflux diseases. Metaclopramide works by blocking the chemical dopamine in different parts of the brain and thus provides a central anti-vomiting effect. It works to stimulate the contraction of the stomach, and also of the upper portion of the small intestine. Another significant effect of this medication is that it increases the pressure at the lower esophagus, thereby preventing stomach acid from entering the esophagus. The medication can be administered in pets with gastroenteritis or kidney failure.ย 

Dosage should be strictly as per veterinary instructions. The ideal dosage usually administered in animals is 0.1 to 0.2 mg per pound (0.2 to 0.5 mg/kg) every six to eight hours. The administration can be done orally, subcutaneously or intravenously. The ideal time for administration is half an hour prior to food. Continue the dosage and duration unless the animal shows any symptoms of adverse effect. Take care not to stop medication unless prescribed by the veterinarian.ย 

Metoclopramide can bring about side effects in some animals if used without the prescription of a veterinarian. At times, the side effects exhibited include changes in the behavior and mental states in cats. Anxiety and frenzied behavior is usually noted in some animals especially in cats. In certain cases, the medication can also cause symptoms of nausea, sedation and mild constipation.ย 

If your pet exhibits any of the following symptoms, stop use of the medication and contact your veterinarian immediately: allergic reaction (symptoms may include swelling, itching, hives, difficulty breathing, etc.), spasms, anxiety/agitation, seizures, insomnia, depression, or yellowing of the skin or eyes. Less serious side effects may include: nausea, diarrhea, lethargy, dizziness, confusion, bloating, increased urination. If your pet exhibits these side effects, continue use of the medication and contact your veterinarian.

Metoclopramide is not for use in animals who have seizures, as this medication could cause seizures. Do not use in animals with stomach or intestinal blockage or stomach bleeding. This medication should not be used in animals who have pheochromocytoma, a type of adrenal tumor.

Tell your veterinarian if your pet has diabetes, kidney disease, high blood pressure, or recent stomach surgery. Use with caution in pregnant or lactating pets.

Monoamine oxidase inhibitors (MAOI), such as Anipryl, Selegiline, or certain flea collars, should not be used while giving this medication. Tell your veterinarian if your pet is taking digoxin, tetracycline, insulin, cyclosporine, a narcotic pain reliever or anticholinergic, antispasmodic medications, pain relievers, muscle relaxants, or anxiety medications.

Tell your veterinarian about any other medications, vitamins, or supplements that your pet is taking.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Follow the directions provided by your veterinarian. Dosage is typically 1-2 mg/lb every 6-8 hours, preferably half an hour before meals.

Metoclopramide can be administered orally, subcutaneously or intravenously.

Refrain from administering the medication on animals with known hypersensitivity to the drug. Metoclopramide has a tendency to interact with drugs like cimetidine, tetracycline, insulin, diazepam, atropine and digoxin. Therefore, do not administer the medication if the pet is under treatment that involves any of these medications.ย 

Store at room temperature, away from moisture and heat.

Option UPC/SKU
16oz Syrup 301210576164

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Very Happy with PetCareRx

I have had up to 5 dogs at one time, all needing various medications. I have relied on PetCareRx for several years and have been extremely happy with their service. I have recommended PetcareRx to friends and will continue to do so.

Julia recommends this item.
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Good stuff

Keeps our dog happy. No more stomach issues

Kim recommends this item.
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Great service as always

Easily ordering fast accurate service.

Michael J Silvetti recommends this item.
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Works great for our dogs stomach problems

simfamco recommends this item.
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