As is true for any other medication, dexamethasone should not be used in animals that are hypersensitive to the drug. Care must be taken when using the medicine in animals that are already suffering from certain inner-organ complaints, diabetes, or such other disorders. Also, use with caution when given with other medications, since dexamethasone is reported to cause reactions when in certain combinations. Given in overdose, the animal will suffer from Cushingoid symptoms, extreme hunger, thirst, and abnormality in urination. Moreover when prescribed for long term therapy, it would be unhealthy for the animal if the medication is stopped abruptly. This might lead to Addison’s disease with symptoms like vomiting, lethargy, etc.