Depo medrol has been contraindicated for use in fungal, bacterial, and viral diseases, as well as in pregnant pets, or pets with idiopathic thrombocytopenia. Depo medrol should be used with caution in pets suffering from heart disease, osteoporosis, diabetes, tuberculosis, chronic nephritis, Cushing’s disease, or gastrointestinal ulcers.
Depo medrol might cause an increase in glucose, cholesterol, potassium, and alkaline phosphatase blood levels.
Use with other corticosteroids could increase the risk of side effects. Antacids can cause glucocorticoid absorption. Anticholinesterase use in patients with myasthenia gravis can cause muscle weakness. Use with diuretics can cause hypokalemia as a result of excessive potassium depletion. Estrogen agents may increase the effects of depo medrol. Use with macrolide antibiotics might lead to an increase in glucocorticoid activity and longevity. NSAID type drugs are not to be given to patients taking depo medrol. Taking with ulcerogenic drugs may increase the likelihood of a GI ulcer. Live attenuated virus vaccines should not be given at the same time as depo medrol, since the replication of the virus might be augmented.