Incurin Tablets - 1 mg
Incurin Tablets - 1 mg
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At a Glance
Controls estrogen-responsive urinary incontinence in spayed female dogs
Active ingredient Estriol maintains urethral strengthening for urinary control
Returns and retains a female dog 's natural processes, especially urinary control
One milligram a day of short-acting estrogen tablet returns a female 's confidence
Safely used worldwide for more than 16 years

Incurin Tablets - 1 mg

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At a Glance
Controls estrogen-responsive urinary incontinence in spayed female dogs
Active ingredient Estriol maintains urethral strengthening for urinary control
Returns and retains a female dog 's natural processes, especially urinary control
One milligram a day of short-acting estrogen tablet returns a female 's confidence
Safely used worldwide for more than 16 years

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Ultimate Guide to Incurin Tablets - 1 mg

Meet the Urinary Incontinence Fighter: Incurin!
Manufacturer Brochure (pdf)

Incurin Tablets are an FDA-approved and veterinarian-approved female dog medication that treats female canine urinary incontinence with an estrogen tablet that retains a spayed female dog 's natural processes with 1 mg a day. Help your girl gain back her confidence as a house-trained pup!

How does Incurin for dogs work?

Incurin contains short-acting estrogen Estriol which is a naturally occurring hormone in females. Just one milligram of Estriol in the female dog 's system allows her to retain natural processes, like urinary control after being spayed (i.e., sterilization by removing her ovaries).

How is Incurin for dogs administered?

Incurin estriol tablets are administered orally once a day and protect your girl all day. Despite differing weights or sizes, any dog will take a 1 mg tablet once a day for seven to 14 consecutive days. The dosage will then be reduced to half a tablet once a day and then every alternate day.

Two milligrams a day is the maximum amount that any dog can take. If only one 1 mg tablet is ineffective, a dog can ingest two milligrams every day for seven consecutive days, and then take 2 mg every other day.

If effective, this is a life-long product.

Are there any precautions of which I should be aware?

Evaluation of factors that may have contributed to her urinary incontinence still should be considered before using Incurin - 1 mg. Most safe use of Incurin estriol tablets have not been evaluated yet: those with liver disease, intact dogs, male dogs, pregnant dogs, lactating dogs, and dogs that are less than one year of age.

Additionally, Incurin 1 mg taken in combination with glucocorticoids has not been evaluated yet. However, it is recommended to not take Incurin tablets with other estrogens concurrently.

What are Incurin 's side effects of which you should be aware?

Incurin 's rare side effects that have been observed are vulvar swelling, gastrointestinal signs, and partial alopecia (i.e., baldness).

Frequently Asked Questions
  1. What do the Incurin reviews say?

    Incurin reviews rate 4.5+ out of 5 stars. Most reviewers say that Incurin is a miracle worker and is an equivalent to homeopathic and natural substances (e.g., corn silk) that they trust for their furry best friend.

  2. What is Estriol for dogs?

    Estriol is the trade name or generic name for the brand Incurin. It is meant to control estrogen-responsive urinary incontinence in spayed female dogs.

  3. What is the Incurin dosing?

    Incurin dosing oral administration is fixed depending on size or weight. Each dog will have the same amount of milligrams (e.g., 1 mg). Some dogs might need two mg, if 1 mg once daily is not effective.

  4. Is Incurin safe for dogs?

    Absolutely! However, various categories of dogs have not been evaluated yet: dogs less than 1 year of age, intact female dogs, male dogs, breeding dogs, pregnant dogs, lactating dogs, those with liver disease, or kidney failure.

  5. What are Estriol 's side effects?

    Estriol 's most common side effects associated with the Incurin treatment include loss of appetite, vomiting, polydipsia (i.e., abnormally excessive thirst), and swollen vulva. It is cited that short estrogen-related receptor binding time can cause these side effects.

Concluding Thoughts

The most important thing that you should know about Incurin Tablet - 1 mg is that it returns and retains natural processes to a spayed female dog, especially urinary control, with just 1 mg of this estrogen tablet (i.e., estriol) a day. Help your girl gain back her confidence by making her feel like a safe and effective woman!

DISCLAIMER: FDA law restricts Incurin Tablet - 1 mg only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian if you should keep using the veterinarian product.

  • Merck Animal Health Brand
  • Urinary Health Pharmacy
  • Bladder Control Pharmacy
  • Merck Animal Health Manufacturer
  • Oral Application
  • Dog Pet Type

How Long Does Incurin Take To Work?

Incurin is a prescription medication recommended by veterinarians to relieve urinary incontinence in female dogs. This happens in spayed female dogs due to hormonal changes. Since the medication comes in tablet form and requires oral administration, it can be given in a pill pocket, as treat, or in your dog's favorite wet food. Usually, Incurin is administered in 1mg dosage per day for at least a week or two. If the dog shows or doesn't show any effect to the normal or lower dosage, it's then modified with increased dosage to show the impact. However, don't make any dosage-related decisions without consulting your trusted veterinarian first.

Do I Need a Prescription for Incurin?

Incurin tablets are counted among the most effective treatments for the control of estrogen-responsive urinary incontinence in spayed dogs. This mediation is beneficial for female dogs who have had surgery to remove ovaries and uterus through a process called Ovariohysterectomy. The medication has been widely used for this purpose globally for over 12 years. Since Incurin is a medication that causes bodily change, it requires a prescription from a reliable and licensed veterinarian. The drug has a natural estrogen called Estriol as the active ingredient. This increases the urethra's resting muscle tone and supplements estrogen in the body.

How Long Can a Dog Take Incurin?

Like most other dog meds, Incurin is not dependent on the body weight of the dog. Regardless of the size, age, and weight, all dogs must receive an initial dose of two tablets of 1 mg Incurin tablets, orally administered once per day. The dosing schedule is a minimum of 14 days for the initial dose. Once the urinary incontinence has been controlled, the effective daily dose of Incurin should be brought to lower doses. This should be done by decreasing it stepwise from 2 mg once daily to 1 mg daily and then 0.5mg daily. This will depend on the response of the individual dog to the treatment. Maintain at least a week of the gap between each dose adjustment. Once the lowest daily dose has been identified, the dose must be further reduced by administering once every two days.

Which Is Better Incurin or Proin?

Both Incurin and Proin are US Food and Drug Administration (FDA-approved) tablets for controlling urinary incontinence in dogs. These medications are intended to aid with urethral sphincter hypotonus, which occurs due to age or spaying. The active ingredient in Proin is phenylpropanolamine hydrochloride, whereas it's Estriol in Incurin. A scientific test conducted on 119 client-owned dogs on Incurin and Proin revealed that both medications are on par with each other in terms of efficacy. However, Proin gets a slight edge because it needs to be administered only once a day instead of 2-3 times a day with Incurin.

Can Incurin Make My Dog Aggressive?

Incurin is a relatively safe medication for dogs and shouldn't cause aggressiveness in them. However, a study on 224 dogs by revealed that on prolonged dosage duration between 14 to 42 days, around 1.8 percent of dogs showed aggressiveness. A total of three dogs had to be euthanized because of uncontrolled aggressiveness. While the number is pretty small, there are still chances that the medication might cause aggressiveness in some dogs. It's imperative to consult your veterinarian if you see any signs of aggressiveness in your dog when on Incurin.

Can Incurin and Propalin Be Used Together?

Incurin and Propalin are both used to treat incontinent dogs. While the former is an estrogen, Propalin is alpha-adrenergic phenylpropanolamine. While spayed dogs might respond well to estrogen therapy, they sometimes cease to respond to the treatment because of the desensitization of estrogen receptors. Despite increasing the dosage, some dogs don't show any response. A similar phenomenon happens with Propalin as well. In such cases, veterinarians sometimes recommend a combination of both to increase the efficiency of the medication. Therefore, it's safe to deduct that both these medicines can be used together. However, dog parents will need to keep an eye on the dosage and frequency of dosing for both medications.

Is Incurin the Same as Des?

Incurin and DES are both used to treat canine urinary incontinence in spayed females effectively. However, Incurin is a newer medication with a nuclear retention time of 1 to 4 hours. DES, on the other hand, has a nuclear retention time of 6 to 24 hours. The shorter nuclear retention time of Incurin lowers the risk of undesirable side effects.

Can Incurin be used on male dogs?

Incurin should not be given to male canines. Incurin includes estriol, a type of estrogen, and it can cause feminization as well as other major health issues in male dogs. Incurin is only licensed for the treatment of hormone-responsive urine incontinence in spayed female dogs. If you are concerned about your male dog's urinary health, consult your veterinarian about alternate treatment choices.

Is Incurin safe for pregnant or lactating dogs?

No, Incurin shouldn't be administered to dogs who are nursing or pregnant. Estriol, a kind of estrogen found in Incurine, has been shown to be damaging to fetal development and milk supply. It's vital to discuss alternative urine incontinence treatments with your veterinarian if you think your dog might be pregnant or nursing puppies. Your veterinarian can provide a safe and efficient treatment regimen for your dog and her puppies.

What should I do if I miss a dose of Incurin?

Give Incurin as soon as you remember if you miss a dose. If the time for the subsequent dose is approaching, omit the missed dose and go back to your regular dosing plan. To make up for a missed dose, avoid giving a double dose as this may raise the chance of unwanted effects. To make sure the drug is successful in treating your dog's urine incontinence, it's crucial to stick to a regular dosing plan. Consult your veterinarian if you have any questions about missing doses or the Incurin dosage schedule.

Does Incurin cause cancer in dogs?

The risk of cancer linked to Incurin is thought to be extremely low and there is no proof of Incurin canine cancer. Although Estriol, a type of estrogen is found in Incurin, the likelihood of developing cancer while using this prescription is extremely low. According to certain research, long-term estrogen treatment use in dogs may raise their risk of developing certain cancers such as uterine and mammary tumors, however, these studies have not specifically looked at its use. You should see your veterinarian if you have any questions about the safety of Incurin.

Can Incurin be used for dogs with spinal cord injuries?

No, it is not advised for canine spinal cord injury. Before giving Incurin to dogs with spinal cord injuries, it's crucial to speak with a veterinarian. Dogs with urine incontinence brought on by spinal cord injury may not respond well to Incurin, which is often used to treat this condition in dogs. The veterinarian can identify the underlying cause of the incontinence and suggest a suitable treatment strategy that can involve medication, surgery, or other measures. Dogs with spinal cord injuries may occasionally require a mix of therapies to address incontinence.

How long does Incurin stay in a dogโ€™s system?

In dogs, Incurin has an elimination half-life of around 8 hours, meaning that it takes roughly 8 hours for half of the drug to leave the body. Approximately 97% of the medicine should have left the body after 5 half-lives or 40 hours. However, the precise time it takes for Incurin to be eliminated from a dog's body can differ based on things like the dog's age, weight, and general state of health. Even if your dog's symptoms go better before the medication is done, it's still crucial to provide Incurin exactly as the doctor instructs and finish the entire course of treatment.

How long should a dog take Incurin?

Depending on the individual dog and how they respond to the drug, a dog may need to take Incurin for a different amount of time. Many dogs may need to take Incurin for the remainder of their life because it is often used as a long-term treatment for urine incontinence. The dog's response to the drug and any alterations in its health status may necessitate modifying the Incurin dosage over time. When administering Incurin, it's crucial to follow the veterinarian's instructions, and regular checkups can help you keep track of how well your dog is responding to the drug.

The active ingredient in Incurin, estriol, is a naturally occurring, short-acting estrogen. Estriol can help restore estrogen levels in spayed dogs to support a dogโ€™s natural processes for maintaining urethral tone for urinary control.

IMPORTANT SAFETY INFORMATION: Incurin is indicated for the control of estrogen-responsive urinary incontinence in ovariohysterectomized dogs. The most common side effects associated with Incurin treatment under field conditions included loss of appetite, vomiting, excessive water drinking, and swollen vulva. The safety and effectiveness of Incurin Tablets have not been evaluated in dogs less than 1 year of age, intact female dogs, male dogs, dogs used for breeding, or lactating dogs. Incurin is contraindicated in dogs showing polyuria secondary to polydipsia, or in pregnant dogs. Please see the full prescribing information for more details.

Incurin is intended for once daily oral administration. There is no relationship between the size of the dog and the dose required, so a fixed mg/kg dose rate is not feasible.

Effectiveness is defined as no signs of incontinence for 7 consecutive days. An improvement will usually be noticed within a few days. However, adjustment of the initial dose will often be necessary, so at least 7 days should be allowed before judging the full effect of a certain dose rate.

The following dosing schedule is advised:
Initial dose: 1 tablet (1mg) per day for 7-14 days.
If treatment with 1mg daily is effective, try to reduce the dose to the minimum possible with 7 days treatment as follows:
ยฝ tablet/day, then ยฝ tablet on alternate days
If treatment is ineffective at the lower doses, titrate back to the next lowest dose.

If treatment with 1mg daily is ineffective, increase the dose to 2mg daily for 7 days. (Maximum dose should not exceed 2mg/day). If effective, try reducing dose to 2mg on alternate days. However, if treatment with 2mg/day is ineffective, reassess case to confirm diagnosis, then consider supplementary therapy.

Treatment will continue for the remainder of the life of the dog.

Store in cool, dry place.

Incurin Tablets is manufactured by Merck Animal Health

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Customer Reviews

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My aging miniature schnauzer was having leakage problems. The Vet ran some tests and ruled out any urinary infections and prescribed Incurin to help with the problem. After her second day on it she was no longer having the issues. No side effects and no more pee pads everywhere she lay.

Laura recommends this item.
Was this review helpful? 1 0

Does the trick.

These are really helping her!

Bethann recommends this item.
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Thorough communication! Made those process very easy.

A. Bellair recommends this item.
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Exactly what was needed!

This is exactly what I got at the vet's office for 30% less.

Chris M recommends this item.
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This product is really helping my 12yo Munsterlander, Sallie. Has a very occasional dribble when excited. Have not been able to wean below 1mg every day, so will stay on that dose. Thanks!

Karen recommends this item.
Was this review helpful? 0 0

Works very well.

These tablets do the trick. No pee problems.

C.K. Scoville recommends this item.
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works pretty well on my sweet girl with kidney problems

bb recommends this item.
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This product started out being very effective. I could tell the difference in a couple of dosage. However now, I really don't see a difference. It maybe it is because of my dog's age or other issues.

R Sewell recommends this item.
Was this review helpful? 0 0

Incurin is quite literally a God send!

My dog, Cassie, had been struggling with incontinence for a couple of years when my vet suggested this product. Cassie had been on Proin, which worked quite well, until she had a bad spell of vestibular disease. That is when I learned that one of the potential side effects of Proin is seizures, especially in senior pets. I don't know that Proin is what triggered her vestibular, but I certainly was no long comfortable giving a medication with seizure risks to an elderly dog with a history of vestibular disease. I tried a natural supplement for a while. The supplement did reduce symptoms but it didn't completely eliminate them. Eventually the incontinence led to multiple infections. I was about at my wits end when I consulted with a new vet who recommended Incurin. I find it expensive and a challenge to my budget, but all the vet bills from all those incontinence infections certainly weren't cheep. Not to mention how uncomfortable my dog was. Incurin saved the day! It took some trial and error to determine what dosage she needed, but since that has been established, I haven't seen any leaks or infections. After dealing for years with all of the struggles and complications of incontinence, I can't tell you how thankful I am for this product! My bank account wishes it was a little less expensive but regardless, it is worth every penny.

MMB recommends this item.
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This product has great features

This product works great my Maggie doesn't have to where a diaper any more.

Eagleofwind42 recommends this item.
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Most effective drug to date for bladder control

This product has been more effective than Proin and I have been able to cut down the dosage of Incurin from every day to every three days. I was unable to do this with Proin, and my dog has been on this medication since she was very young. Very happy with this medication.

martinimeanie recommends this item.
Was this review helpful? 2 0

Very happy with this product....

I had previously tried everything... all the homeopathic & natural stuff, corn silk, everything... ... nothing made any difference.... I really did not think anything would work .. But the Incurin stopped it from day one... I was totally amazed... I did it per instructions... 2 tabs a day for 14 days.. she did not have one leak or drip in all that time... so went down to one a day... still no leaks... one every other day... nothing... she is down to one a week now... I may try one every 10 days or so and see what happens... It makes it very inexpensive at one pill a week... I am very happy and so is she... :)

Pauline2931 recommends this item.
Was this review helpful? 4 0

effective, but has drawbacks

only comes in 30 pill about at least 90---a 3 month supply????also---packaging is terrible with that foil/blister pack thing....the little round pieces fall off....hard to tell which contain a pill vs. which are about a plastic container like most other pills come in?????????

capecodbob recommends this item.
Was this review helpful? 1 4


effective product, but there are 2 major flaws---only 30 pills, per package......should be more than 1 month's worth.2nd----the packaging is AWFUL---- that little foil piece pops off when you remove pill----it either sticks to the pill or falls on the floor.

capecodbob51 recommends this item.
Was this review helpful? 0 1

actually works

I wanted to give this a try for my 13 yr old Aussie as she's been exhibiting all the symptoms this product says it helps with. It took about two weeks, but I haven't seen her leave puddles on the floor any longer.My only complaint is that it's expensive at almost $1/day if I decide to keep her on it. It would be much less expensive to put a towel on the floor where she lays, which I will probably do.

CarolS recommends this item.
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Not effective for a large breed dog

I like the ease of dispensing this product and the price was reasonable. Unfortunately, now after two weeks of giving the proper dosage to our 85lb Weimaraner/lab mix she is still wetting her bed at any time while she is relaxed. I don't think a 1mg pill is enough for a large breed dog.

Dani0331 recommends this item.
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