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At a Glance
Active ingredient Oclactinib inhibits receptors that cause skin disorders.
Treatment in the dog's skin therapy.
Relieves intense itchiness from skin disease.
Administered orally twice a day.


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At a Glance
Active ingredient Oclactinib inhibits receptors that cause skin disorders.
Treatment in the dog's skin therapy.
Relieves intense itchiness from skin disease.
Administered orally twice a day.

Ultimate Guide to Apoquel

Meet the Itchy Skin Reliever: Apoquel!

Apoquel is the veterinarian-approved and FDA-approved dog medication that is used to control a dog 's pruritus (i.e., itchiness) from skin disease caused by allergic and atopic dermatitis. Apoquel is a twice-daily, oral tablet for up to 14-day skin therapy to guarantee your pup 's comfort.

What is Apoquel?

Apoquel is a medication that treats a dog 's skin disease which causes intense itching. Pruritus is the medical term for itching and scratching in dogs that is commonly associated with skin disorders from flea dermatitis and other allergic skin diseases.

What causes skin disease in dogs?

Skin disease is most often caused by dermatitis or other allergens, in which dog owners need to seek veterinary care.

Flea allergy, atopic, and contact (e.g., soaps and perfumes) dermatitis are very common causes of skin disease in dogs. Additionally, seasonal environmental allergies, food allergies, and sarcoptic mange from mites cause skin disease and irritation in pups.

How does skin disease appear?

Skin disease appears as red, inflamed areas of skin may lead to a common bacterial skin infection in dogs called pyoderma. If severe enough, the dog may develop hair loss, scabs, and bleeding skin from self-trauma.

Is it easy to treat skin diseases?

It can be very challenging and frustrating for both dog owners and veterinarians to treat skin disease. To diagnose the specific cause of itching on a dog, several tests and treatments are necessary for weeks to months. The tests may be skin scrapings and skin cytology to look for mites (e.g., mange), other insects, or various infections.

Varied treatments, such as Apoquel, can aid in relieving skin irritability, pain, and development from a dog 's self-trauma.

How does Apoquel work?

Apoquel targets a key itch signal in the dog 's nervous system that allows your veterinarian to diagnose the underlying cause of itch while providing your dog with relief. Brand Apoquel 's active ingredient is Oclactinib, its trade name.

Oclactinib inhibits the activity of signal transducer JAK (Janus kinase) that causes inflammatory diseases. This then prevents the expression of inflammatory cytokines under the skin that causes skin disease and itchiness.

How is Apoquel for dogs administered?

Apoquel is an oral pill administered twice a day. Apoquel dosing provides 3.6 mg, 5.4 mg, or 16 mg of oclacitinib per tablet, and each manufactured bottle is packaged with 20 counts or 100 counts of scored tablets. See the dosage chart below where the size of the tablet is perfectly suited for your dog 's size:

Body Weight

Apoquel 3.6 mg

Apoquel 5.4 mg

Apoquel 16 mg

6.6 to 9.9 lbs.

Half (0.5 tablets)

10 to 14.9 lbs.

Half (0.5 tablets)

15 to 19.9 lbs.

One tablet

20 to 29.9 lbs.

One tablet

30 to 44.9 lbs.

Half (0.5 tablets)

45 to 53.9 lbs.

Half (0.5 tablets)

Half (0.5 tablets)

54 to 59.9 lbs.

Half (0.5 tablets)

Half (0.5 tablets)

60 to 89.9 lbs.

One tablet

90 to 129.9 lbs.

One and a Half (1.5 tablets)

130 to 175.9 lbs.

Two tablets

What are the precautions to which you should be aware?

Apoquel is not for use in dogs that are:

  • Less than 12 months of age.
  • Breeding
  • Pregnant
  • Lactating
  • Suffering from serious infections
  • Susceptible to infection

This product is for oral use in dogs ONLY, not for humans or children. This also means that you must wash your hands immediately after administering pills.

Taking Apoquel in combination with systemic immunosuppressive agents medications has not been evaluated yet. However, Apoquel for dogs has been safely used in conjunction with antibiotics, parasiticides, and vaccinations.

What are the Apoquel side effects of which you should be aware?

Apoquel 's most common adverse reactions reported are vomiting and diarrhea. Dogs should be monitored for the potential development of infections, such as neoplasia or demodicosis.

Frequently Asked Questions
  1. What is the Apoquel dosage?

    The dosage of Apoquel tablets should be 0.18 to 0.27 milligrams per pound. Apoquel should be given twice daily for up to 14 days of therapy. The medication can be taken with or without food. However, the product can be taken for the short term or long term, according to your veterinarian.

  2. What do the Apoquel reviews say?

    Apoquel reviews rate at 5 out of 5 stars. Most reviewers say that Apoquel is a miracle worker because it reduces and eliminates their dog 's itchiness and improves their dog 's quality of life.

  3. Is Apoquel for puppies?

    Apoquel can be administered to young dogs that are at least 12 months of age and are at least weighing 6.6 pounds.

  4. How long does it take for Apoquel to work?

    After administration, relief starts taking effect after four hours and then is fully controlled after 24 hours.

Concluding Thoughts

The most important thing that you should know about Apoquel is its power to improve your dog 's quality of life as it relieves intense itching, scratching, and painful developments on the dog 's skin.

DISCLAIMER: FDA law restricts Apoquel only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian if you should keep using the veterinarian product.

  • Zoetis Brand
  • Skin & Coat Pharmacy
  • Allergy Relief Pharmacy
  • Oral Application
  • Dog Pet Type

Is Apoquel the Same as Benadryl?

No, Apoquel is not the same as Benadryl. While both Benadryl and Apoquel tablets are used as dog itching medication, they have a major difference. Dog allergy medication, Apoquel, is an anti-itching pill for dogs who are over a year old. Benadryl on the other hand can be used as dog medications for itching for puppies under 12-months of age, as well as dogs over a year old. Hence, Benadryl is not an Apoquel alternative, even though an Apoquel tablet works the same as its counterpart.

How Long Can a Dog Take Apoquel?

You can continue an Apoquel dose for both short and long-term conditions. The FDA has not put any restriction on these pills regarding how long you can use them. Ideally, your vet will examine the dog and how it is making progress healthwise to let you know how long you should be using that medication. Clinical studies have used Apoquel for up to 2 years on adult dogs. However, this itching medication is not for pups that are under 12-months of age.

Can I Buy Apoquel Without a Vet Prescription?

No, you cannot buy Apoquel without a vet prescription. Apoquel is used to fight dog allergies and itching. It is a prescription medication, and as the FDA states, these types of drugs or medications can in no way be sold without authorization from a licensed vet. If any drugstore is willing to sell Apoquel to you without seeing a licensed vetโ€™s prescription, they are doing so illegally. Avoid these stores and buy Apoquel only when you have been prescribed by a vet.

Can I Just Stop Giving My Dog Apoquel?

Yes, you can just stop giving your dog Apoquel. Many drugs or steroids, however, cannot be stopped all of a sudden. You have to slowly lower the dosage over time, and then eventually stop giving the drug. With Apoquel, you can simply stop the dosage whenever you feel like it or as prescribed by your vet. Your dog is unlikely to show any withdrawal symptoms, but you will have to restart the dosage if the itching returns.

Is Apoquel Safe Long Term?

Yes, Apoquel is safe for long-term use. The FDA has no restrictions regarding how long you can use Apoquel. However, studies show that you can use Apoquel on dogs for up to two years. Your vet will determine how long you actually need to continue the Apoquel dosage.

Can I Give My Dog Apoquel Every Other Day?

Yes, you can give your dog Apoquel every other day, but only if that is what the vet prescribes. Generally, the dosage requires two pills a day for 14 days.

Will Apoquel Make a Dog Sleepy?

Drowsiness is one of the known Apoquel side effects in dogs. So yes, this drug will make your dog sleepy. Other side effects of Apoquel include vomiting, diarrhea, and anorexia. Besides, your dog will also start getting thirsty more easily and will feel tired. These side effects are somewhat mild, and will not need vet consultation unless things get worse. However, many adverse side effects like skin disorders or pneumonia are also possible. Urgent veterinary care will be needed if you notice these effects.

Can I Give My Dog 2 Apoquel?

Yes, you can give your dog 2 Apoquel pills for itching, but only for 14 days at a stretch. The FDA has not approved the two-pill dosage for any longer than 14 days.

Can Apoquel Cause Anxiety in Dogs?

Apoquel is not known to cause anxiety in dogs. However, there are other side effects of Apoquel in dogs including vomiting, diarrhea, anorexia, lethargy, drowsiness, and an increase in thirst.

APOQUELยฎ should not be used in dogs less than 12 months of age or in dogs with serious infections. APOQUEL may increase susceptibility to infection and demodicosis and may exacerbate neoplastic conditions. APOQUEL has not been evaluated in combination with systemic immunosuppressive agents such as glucocorticoids or cyclosporine. APOQUEL should not be used in breeding dogs or pregnant or lactating dogs. The most common APOQUEL side effects in dogs post-administration were vomiting and diarrhea. APOQUEL has been safely used in conjunction with other common medications including antibiotics and parasiticides and with vaccinations.

The dose of APOQUEL tablets is 0.18 to 0.27 mg/lb (0.4 to 0.6 mg/kg) APOQUEL should be given twice daily for up to 14 days of therapy and once daily thereafter for maintenance APOQUEL may be given with or without food APOQUEL may be used concomitantly with many common therapies including vaccines, NSAIDs, antibiotics and allergen immunotherapy3

Keep Apoquel safely secured at room temperature.

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

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