Click to zoom Tap and hold to zoom
Refills on File
Your pet {{refill.petName}} has {{refill.refillsRemaining}} refill{{refill.refillsRemaining>1?'s':''}} for ‘{{refill.options}}’ which will expire on {{refill.expiresOn}}.
{{refill.petName}}'s refills for this have expired on {{refill.expiresOn}}
At a Glance
Helps modify behavioral problems
Adjusts and balance brain chemical levels
Antidepressant that eases anxiety


List Price:
{{list_price * quantity | currency}}
List Price:
{{list_price * quantity | currency}} {{(list_price + 0.01) * quantity | currency}}
List Price:
{{list_price * quantity | currency}}
List Price:
See price in cart Why we cannot show price
List Price: {{list_price * quantity | currency}}
25% OFF w/code: CARE25
PetPlus Price:
{{petplus_price * quantity |currency}}
PetPlus Price:
See price in cart Why we cannot show price
Sale Price:
{{sale_price * quantity|currency}}w/code {{siteCode}}
Your Price:
{{map_price + 0.01 | currency}} See price in cart w/code {{siteCode}} Why we cannot show price
{{petplus_savings_amount * quantity|currency}} ({{petplus_savings_percent}}%)
{{coupon_savings_amount * quantity|currency}} ({{coupon_savings_percent}}%)
Join PetPlus today and get this for {{intro_price_total|currency}} Why we cannot show price
Join PetPlus today and {{use_strict_map_rules?"see price in cart":"get this for a special price"}} Why we cannot show price

inlowout of stock
Get notified as soon as this becomes available
Thank you.
We will email {{notifyEmail}} when this is back in stock.
Recommended Alternatives:
Limit ( {{ selected_sku_data.cartLimit }} ) per customer. Orders for more than this may not be fulfilled.
Shipping is always free with PetPlus | Arrives in 1-3 days on average
Free shipping over $48* | Arrives in 1-3 days on average
Select Autoship options at checkout
At a Glance
Helps modify behavioral problems
Adjusts and balance brain chemical levels
Antidepressant that eases anxiety

Frequently Bought Together

Total Price

An anxious or stressed-out dog or cat is cause for distress for any pet owner. Anxiety may come from depression or separation anxiety or may also be due to the occurrence of unexpected, loud noises. Regardless of the cause, such disturbances can result in behavioral problems such as inappropriate urination, spraying, obsessive grooming, excessive scratching, and other self-destructive actions. Worse, pets may become aggressive towards their owners, or they might hurt themselves in their fit of aggression.

Amitriptyline is a prescription antidepressant that helps modify such behavioral problems and also lessens anxiety. The medication alters the brain's chemicals, adjusting the levels of serotonin and norepinephrine to a fine balance.

Amitriptyline, also known by its brand names Elavil and Levate, is a tricyclic antidepressant commonly prescribed by veterinarians to treat behavior disorders in pets. This medication has proven effective in managing various conditions, including generalized anxiety, separation anxiety in dogs, excessive grooming, urine spraying, lower urinary tract disease, pica, anxiety in cats, nerve pain, and itchiness.

  • Usage and Administration:Amitriptyline is typically prescribed for off-label use in pets, following a veterinarian's directions. It is administered orally as a tablet. The medication can be given with or without food; however, administering it on an empty stomach may lead to vomiting. To mitigate this, future doses can be provided with food or a treat, as the veterinarian recommends.

  • Onset of Action and Full Effects:Following the use and storage recommendations the veterinarian provides is essential. While side effects can occur immediately, the full therapeutic effects of Amitriptyline may take a few weeks to manifest. Pet owners should be patient and closely monitor their pets for any changes in behavior during this period.

  • Potential Side Effects in Dogs:Common side effects in dogs may include drowsiness or sedation, constipation, and dry mouth. Urinary retention is also a possibility. Less commonly observed side effects encompass hyperexcitability, irregular heart rhythms, and, rarely, the development of seizures. Pet owners must be vigilant for any signs of discomfort and promptly report them to the veterinarian.

  • Potential Side Effects in Cats:In felines, common side effects may involve sedation, increased salivation, urinary retention, anorexia, vomiting, incoordination, disorientation, and an unkempt hair coat. Heart arrhythmias are also listed as a rare side effect. Pet owners should be aware of these potential reactions and report any concerns promptly to the veterinarian.

  • Risk Factors and Cautionary Measures:Certain risk factors and pre-existing conditions may necessitate caution when prescribing Amitriptyline. Pets with sensitivity to tricyclic antidepressants, hyperthyroidism, seizure disorders, thyroid disease, urinary retention, liver disorders, dry eye (keratoconjunctivitis sicca), glaucoma, heart arrhythmias, diabetes, and adrenal gland tumors should be carefully monitored during treatment. Veterinarians must consider these factors before prescribing Amitriptyline and adjust the dosage or choose alternative treatments as needed.

Amitriptyline, when used according to a veterinarian's guidance, can be a valuable tool in managing behavior disorders and various conditions in pets. Pet owners should follow the prescribed dosage and monitor their pets for any adverse reactions. The potential benefits of Amitriptyline, including gradual improvements in behavior, often outweigh the risks when used responsibly under professional supervision.

Amitriptyline for pets is essentially the same medication that is prescribed for humans, albeit in smaller dosages. As with any prescription medication, it's best to consult with your veterinarian to formulate a plan of treatment specifically suited for your pet.

Amitriptyline is the generic alternative to Elavil.

  • Behavior & Anxiety Management Pharmacy
  • Oral Application
  • Cat Pet Type
  • Dog Pet Type

How Long Does It Take for Amitriptyline to Work in Dogs?

Amitriptyline for dogs is a tricyclic antidepressant used to treat behavior disorders in small animals. In dogs, the medication is commonly used to treat behavioral problems like generalized or separation anxiety. Amitriptyline is a prescription medication that may take at least a few weeks before full effects are observed in dogs. However, gradual improvement is usually visible within a few days of starting the treatment.

Can You Give a Dog Human Amitriptyline?

Amitriptyline is, in fact, a human antidepressant drug that has also been approved for veterinary usage in dogs and cats. Usually sold under the brand name Elavil for humans and Triptagen or Triptafen-M for animals, the medication is used to treat separation anxiety and occasionally for itchiness and chronic pain in dogs. The most important thing to remember is that the recommended dose for dogs is 0.5 to 2mg per pound or 1-4 mg/kg of the body weight, to be administered every 12-24 hours orally. This is much less than 100-150mg daily for humans.

How Quickly Does Amitriptyline Work for Pain?

Amitriptyline is also prescribed to treat chronic pain in dogs and migraines in humans. If being administered as a painkiller on a veterinarian's recommendation, it's essential to know that the medication can take anywhere between a month and a half to show effects. It's advised not to stop the treatment after a week or two because the symptoms don't go away. Give the medication at least six weeks to work, as a painkiller.

What Happens if Dogs Eat Antidepressants?

A veterinarian recommended dosage of antidepressants will help your dog battle behavioral issues like separation anxiety and also some types of chronic pain. However, the key here is the veterinarian recommended dosage. The recommended dosage for a dog is 0.5 to 2mg per pound or 1-4 mg/kg of the body weight. In case your dog overdoses on the medication, there are bound to be some adverse effects. Some most common side effects include dry mouth, sedation, constipation, and urine retention. Rare side effects may include aggression, vomiting, diarrhea, staggering, disorientation, and more.

Does Amitriptyline Calm Your Dog?

Yes, Amitriptyline is usually prescribed to help calm your dog's nerves. The medication does this by regulating norepinephrine and serotonin, which act as neurotransmitters and elevate the dog's mood. In essence, Amitriptyline boosts serotonin levels to induce calmness and contentment in your dog. This, in turn, makes your dog relaxed, less nervous, and less prone to an anxiety attack. Apart from calming your dog down, Amitriptyline is also known to be beneficial to treat behavioral issues like separation anxiety, submissive urination, incessant yapping, and destructive behavior.

What Can I Give My Dog To Knock Him Out?

Usually, dogs that are anxious, aggressive or hyperactive, need to be sedated at times like vet visits. Sedating helps the dog relax and causes no harm to the handler. There are sedatives of two types - oral and injectable. Some common sedatives are acepromazine and diazepam, diazepam and butorphanol, and dexmedetomidine. Before sedating your dog, consult a veterinarian to know the best kind of sedative suitable for your dog.

What Is a Natural Sedative for Dogs?

There are several methods to help your dog calm down naturally. The most effective natural sedatives for a dog are exercise and mental stimulation. Taking your pup out for fresh air or teaching it a new trick will distract its attention away from whatever is causing the stress. Studies have also shown that playing the right music also has a calming effect on dogs. Aromatherapy, lavender oil, in particular, is known for being the most popular ancient natural remedy for stress relief in dogs. A study by JAVMA has shown that lavender oil is effective for dogs that have travel anxiety. Lastly, supplements like melatonin and pheromones are also effective in calming down a dog in the short term and help them sleep better.

What Can You Do for Dog Anxiety?

Your dog can develop anxiety for multiple reasons, the most common reasons being fear, separation, and aging. Behavioral traits like aggression, soiling the house, panting, drooling, destructive behavior, and excessive barking are telltale signs of anxiety in your dog. The best thing to do is consult a licensed veterinarian, who will be able to identify the type of anxiety and relevant treatment type for your dog. Additionally, vets can also perform checkups to determine if there's any health condition causing the anxiety.

What Do Vets Use To Calm Dogs Down?

To control mild anxiety in dogs, vets usually resort to over-the-counter options like L-theanine, melatonin, and s-adenosyl-methionine. Additionally, they might use synthetic pheromone preparations, and body wraps with reassuring pressure. In severe cases, anti-anxiety medications like alprazolam, Amitriptyline, buspirone, and Amitriptyline are used.

Active Ingredient - Amitriptyline HCL

Other Ingredients: Colloidal silicone dioxide, hydroxypropyl cellulose, hydroxypropyl methylcellulose, lactose (monohydrate), magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch (corn), titanium dioxide. 10 mg dose also includes: D & C Red # 27 Aluminum Lake, D & C Yellow #10 Aluminum Lake, and FD & C Blue #1 Aluminum Lake. 25 mg dose also includes: D & C Yellow Aluminum Lake. 50 mg dose also includes: FD & C Blue #2 Aluminum Lake, and FD & C Red #40 Aluminum Lake. 75 mg dose also includes: D & C Red #7 Calcium Lake, and FD & C Blue #2 Aluminum Lake.

Ingredients vary slightly between dosages

Side effects do not generally occur, but may include weight gain (in cats), drowsiness, dry mouth (and other symptoms resulting from the drug's function as an antihistamine), loss of appetite, increased heart rate, urine retention, vomiting, and diarrhea. There may be an increase in excitability.

Overdosing can have severe consequences for the heart, and should be treated immediately.

Amitriptyline can be administered either orally or by injection. Dosage is as prescribed by your veterinarian (generally, an oral dose is between 0.5 and 2 mg per pound once or twice a day for dogs, and between 2 and 10 mg per cat once daily for cats).

Option UPC/SKU
75mg per tablet 306032215215

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

Related Articles

Fear Aggression in Dogs: How Should You Deal With It?

Addressing Canine Aggression: What You Need to Know

Read More
Raising a Dangerous Dog: How to Manage Canine Aggression

Best practices, tips, and products to calm down your aggressive pet

Read More
Raising Bengal Cats: Tips & Products to Keep Your Pet Happy and Healthy

From the wild to your home- your guide to adopting a Bengal cat!

Read More

Customer Reviews

Rating Summary 5 review(s)
5 stars
4 stars
3 stars
2 stars
1 star
5 / 5
* = required

New Product Review

Uploaded Image 1
Uploaded Image 2
Uploaded Image 3
  • {{error}}
Showing 1 - {{visible_reviews.length}} of {{total_reviews}}

This product has no reviews yet. Write a review.

Works for storms and fireworks

Our Shih Tzu is scared of any loud noise like thunder, wind or fireworks. This help calm down until the noise is over.

Kenneth recommends this item.
Was this review helpful? 0 0


It has really helped our Weimaraners anxiety

Lynn recommends this item.
Was this review helpful? 0 0

Great product

my vet said it was exact stuff he was giving me and this site makes it soooo much cheaper than buying it from the vet it saved me more than $20 thank you so much petcarerx

Christa recommends this item.
Was this review helpful? 1 0

Bladder infections

I give this medication to my 7 year old female corgi. She has had problems with bladder infections for a long time and the vet prescribed this medicine many years ago and she has not had an infection since being on it. We love it!

Cheryl_owner_of_2_pembroke_welsh_corgis recommends this item.
Was this review helpful? 2 0

Useful for fearful Chinese Crested

It took 3 weeks to kick in but has really helped my Megs from her fear of storms and sudden noise.

Gloria_owner_of_Powder_puff_Chinese_Crested recommends this item.
Was this review helpful? 2 0

Page 1 of 1 1