1. Snap the re-sealable cap off the tip of the tube.2. Lift or spread fur between the shoulder blades of your dog until you can see the skin.3. Place the tube tip on the dog's skin area and apply down the spine.4. Hold the dog briefly allowing the liquid to absorb. To optimize product absorption by the skin, the tube content may be applied in this manner over several days, resealing the tube until all the liquid is used.5. To reseal the tube, turn the cross-shape cap upside down and insert it back in the tube.