Acepromazine (generic of PromAce)
Acepromazine (generic of PromAce)
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At a Glance
The top tranquilizer and neuroleptic agents for dogs, cats, and horses
Can be used as an antihistamine
Stabilizes heart rate

Acepromazine (generic of PromAce)

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At a Glance
The top tranquilizer and neuroleptic agents for dogs, cats, and horses
Can be used as an antihistamine
Stabilizes heart rate

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Your Complete Guide to Acepromazine for Dogs and Cats

What Is Acepromazine for Dogs and Cats?

Acepromazine or Acepromazine maleate is a chemical tranquilizer or sedative. Acepromazine can be used before anesthesia to restrain your dog or cat and prevent them from hurting themselves or the surgeons. Acepromazine for cats and dogs can be used to avoid motion sickness in your pets.

If your pet has issues with trimming their nails and reacts very adversely to being taken to the grooming salon, Acepromazine for dogs can be used to calm them down.

How Does Acepromazine for Cats and Dogs Work?

Acepromazine for dogs and cats is a neuroleptic agent that is used by vets for cats, dogs, and even horses. This class of chemicals is called Phenothiazines and works by suppressing dopamine levels in the brain and repressing some parts of the reticular activating system. Usually, it is processed by the body quickly and is excreted with urine.

Besides being a sedative, Acepromazine for cats and dogs can be used to treat allergic reactions and as an antispasmodic. Additionally, this medicine is used as an antiemetic, an anticholinergic, and blocks alpha-adrenergic properties. Anticholinergic means that it surpasses the functions of the parasympathetic nervous system.

This helps your anxious cat or dog to calm down and maintain composure. An antiemetic means any substance that prevents your dog or cat from vomiting. This is why it is used frequently in cases of motion sickness. Acepromazine for dogs and cats decreases blood pressure in your pets and slows down their heart rate.

What Is the Acepromazine Dosage for Dogs and Cats?

When giving your pet Acepromazine for cats and dogs, you should follow your vet's recommendations. Surprisingly, the Acepromazine dose for cats and dogs decreases inversely to the animal's size or weight. This means larger animals can get smaller doses. For dogs, the dosage is 0.25 mg/lb of body weight.

The Acepromazine dose for cats and dogs that your vet prescribes for your pet can vary depending on the condition being treated, the severity of the situation, and your pet's health. Please follow your vet's guidelines for how much of this medicine to give to your pet.

Are There Any Precautions I Should Take When Giving Acepromazine for Dogs and Cats?

You should ensure that you give this medication before the anxiety-causing event. It has been observed that the effects of the medicine are more pronounced when given before the situation your pet needs it for occurs. You can give this with or without food.

You should not give this to animals who are in shock or have just gone through a traumatic event. Animals who are dehydrated or anemic should not be given this medicine. This medicine is to be used with caution in senior cats and dogs, especially those with liver or heart disease.

If your cat or dog has a history of epilepsy, you should not give them this medicine. Animals who are injured, under treatment for tetanus, pregnant animals, and lactating animals should not be given Acepromazine. Acepromazine is problematic in dogs who have a history of strychnine poisoning.

In dogs, giant dog breeds and Greyhound dogs have been shown to have a sensitivity to Acepromazine. On the other hand, if you have a terrier, you might need a larger dose. All brachycephalic or short-nosed dog breeds are more prone to the heart-related side effects of this drug.

What Are the Acepromazine for Dogs Side Effects?

When you give your dog or cat Acepromazine, you might notice that their heartbeat has slowed down or they have hypotension. Cats have an increased risk of cardiovascular collapse, though dogs are prone to cardiovascular side effects. You might notice your pet has pale gums, a reduced pulse, and they might collapse suddenly.

While it is rare, Acepromazine can sometimes be fatal when used in conjunction with anesthetics. Another extremely rare side effect is penile paralysis in horses.

Frequently Asked Questions
  1. Is This Safe to Give to All My Animals?

    This drug is safe to use on horses, dogs, and cats. You should not give Acepromazine to any animals without a vet's supervision. This drug works on animals' sensitive nervous systems, and only your vet will be able to tell you the correct dosage you need to give to ensure your animal's safety.

  2. How Should I Store This?

    You need to store Acepromazine for cats and dogs away from any light. Ensure that the tablets are in an airtight container and are not exposed to extreme temperatures. Otherwise, the drug can lose its efficacy and become unstable.

  3. Are There Any Drug Interactions I Should Know?

    Acepromazine can cause reactions when combined with antacids, anti-diarrhea medicine, acetaminophen, dopamine, and fluoxetine, among others. If your dog is on long-term medication or if you give them over-the-counter drugs or supplements, make sure your vet knows before starting Acepromazine.

  4. What Will My Vet Do if My Dog or Cat Suffers From Side Effects?

    If your pet has eaten too much of this medicine, your vet is likely to pump the stomach and empty its contents. This takes the drug out of your pet and prevents their bodies from absorbing it. If your pet suffers seizures from Acepromazine, your vet will likely use barbiturates or diazepam to help them recover.

  5. Does This Need a Prescription?

    Acepromazine is a regulated drug as it has tranquilizing properties. You need a vet's prescription to buy it. Vet prescriptions can expire, so you will need an updated one to purchase if you have an old prescription.

Acepromazine is the generic alternative to PromAce.
  • Itch Relief Pharmacy
  • Heart & Blood Pressure Pharmacy
  • Behavior & Anxiety Management Pharmacy
  • Allergy Relief Pharmacy
  • Boehringer-Ingelheim Manufacturer
  • Oral Application
  • Cat Pet Type
  • Dog Pet Type

How Much Acepromazine Can I Give My Dog?

The administration of Acepromazine Tablets in dogs can be done orally. The proper dosage of Acepromazine Tablets in your pets can vary due to your petโ€™s body weight, size, and metabolism. Generally, the amount of Acepromazine administered to your dog can be around a quarter of a milligram to one milligram per pound of your petโ€™s body weight. According to studies, if the prescription given by your veterinarian is strictly followed chances of your pet overdosing are very low. Acepromazine maleateโ€™s acute and chronic toxicity research has revealed a very low order of toxicity for it.

What Will Acepromazine Do to My Dog?

Acepromazine or Acepromazine maleate is one of the most commonly used sedatives or chemical tranquilizers for cats and dogs found in the market. Normally, Acepromazine for dogs and cats helps in lowering the blood pressure and heart rate of your pet. It can also cause depression in the central nervous system and a decrease in anxiety level for your pet. As a preoperative medication Acepromazine can also be used alongside atropine for its antidysrhythmic effects and anxiety-related issues. To avoid motion sickness in your pets Acepromazine for cats and dogs can also be used.

How Long Does Acepromazine Last in Dog?

Acepromazine for cats and dogs is a long-lasting sedative. Acepromazine can be considered one of the best tranquilizers that can be bought from pharmaceutical stores. The tranquilizing effect of Acepromazine generally lasts for six to eight hours. It is also noted that in some of the extremely rare instances after the application of Acepromazine, few pets tend to show very aggressive or agitated behavior.

How Much Acepromazine Can I Give My Cat?

Acepromazine can be used as a pre-hospital sedation agent for your cat. Acepromazine is generally used before anesthesia to restrain your dog or cat. This prevents the pets from hurting themselves or the medical personnel. For prehospital sedation of your cat, it is recommended that you make a solution containing 0.01 mg to 0.05 mg of the drug per kilogram weight of the pet and 0.9% saline and administer it to your pet.

Should Acepromazine Be Given With Food?

To avoid stomach upset of your pet it is recommended that you should administer Acepromazine with your petโ€™s food. If by any chance your pet has missed the dose, give the missed dosage of Acepromazine to your pet as soon as possible. But if you notice that it is almost time for the next dosage of your pet then you can omit the missed dosage. You should continue with the next dosage of Acepromazine at the fixed time as per schedule. It is advisable that you should never administer two doses of Acepromazine to your pet, whether it is a cat or dog at the same time. And if you have accidentally done so, you must contact your veterinarian as soon as possible for further instruction.

Can Acepromazine Make Dogs Aggressive?

If your dog is an aggressive kind of pet, you should be very cautious while administering the Acepromazine maleate as a restraining or suppressing agent. This may cause the dog to become more susceptible to various sensory inputs such as any kind of smell, noise, and touch. This phenomenon can very much alarm or frighten your pet. There is also a chance that if your dog is of an aggressive kind then they can oftentimes become even more aggressive or agitated after the administration of Acepromazine.

Does Acepromazine Cause Shaking in Dogs?

After the application of Acepromazine to your dog, he or she may show various types of side effects. These side effects may contain bloodshot eyes, constant shivering, altered breathing pattern, protrusion, or bulging of the eye lead that may appear as a pink fleshy outgrowth at the corner of the eye socket. If you notice any one of the above-mentioned ailments in your pet, you should immediately contact your veterinarian for an expert opinion.

Can Acepromazine Cause Anxiety in Dogs?

Acepromazine can be considered one of the best medicines for your cats and dogs. Acepromazine can be categorized under antiemetic, antispasmodic, and anticholinergic medicine. It has the ability to inhibit dopamine receptors. As dopamine is known to be a type of neurotransmitter, it plays a huge role in your petโ€™s body that helps him or her with the sensation of pleasure. Even though at times, this sensation of pleasure is considered to be a positive thing. But too much of it can lead your pet to some undesirable affliction such as laziness, anxiety, nausea, and other unpleasant symptoms. But by bringing down those dopamine levels, Acepromazine can help your pet to get rid of these unpleasant ailments.

Can Acepromazine be used in puppies?

It is recommended that Acepromazine not be used in puppies less than 4 months of age, as they are still developing and may be more susceptible to the medication's adverse effects.

Can Acepromazine be used in pregnant or nursing dogs?

The use of Acepromazine in pregnant or nursing dogs is generally not recommended, as the medication can potentially affect the developing fetus or nursing puppies. Acepromazine is known to cross the placenta and can cause sedation, hypotension (low blood pressure), and other adverse effects in the developing fetus. In nursing puppies, the medication can also pass into the milk and affect their neurological development.

Can Acepromazine be used in dogs with heart disease?

Acepromazine is not generally recommended for use in dogs with heart disease or other cardiovascular problems, as the medication can potentially worsen the condition and cause serious complications. Acepromazine is a tranquilizer that works by suppressing the central nervous system and reducing blood pressure, which can lead to decreased cardiac output and reduced blood flow to vital organs. In dogs with heart disease, this can further compromise their already compromised cardiovascular function and potentially cause serious cardiac problems such as arrhythmias or heart failure.

Can Acepromazine be used in dogs with liver or kidney disease?

No, it should not be. If at all, Acepromazine should be used with caution in dogs with liver or kidney disease, as the medication is metabolized and eliminated by these organs and may potentially cause further harm. In dogs with liver disease, Acepromazine may be metabolized more slowly, leading to a prolonged duration of action and increased risk of toxicity. Similarly, in dogs with kidney disease, Acepromazine may be eliminated more slowly, leading to a buildup of the medication in the bloodstream and an increased risk of adverse effects.

Can Acepromazine affect dogs with seizures?

Acepromazine should not be used in dogs with a history of seizures or seizure disorders, as the medication can potentially lower the seizure threshold and trigger seizures or convulsions. Further, Acepromazine is a central nervous system depressant that can alter the balance of neurotransmitters in the brain, which can potentially trigger seizures in susceptible dogs.

Can Acepromazine be used in dogs with hypothyroidism?

Acepromazine can be administered to dogs that have hypothyroidism, but it must be done carefully and under a veterinarian's guidance. This is due to the possibility that Acepromazine might worsen hypothyroidism's symptoms by slowing down metabolism and possibly causing tiredness, weakness, and weight gain.

Can Acepromazine be used in dogs with diabetes?

Acepromazine may be administered to diabetic dogs, but only with a veterinarian's approval and close monitoring. Acepromazine has the potential to further lower blood sugar levels and result in hypoglycemia, which is a metabolic condition that affects a dog's capacity to manage blood sugar levels.

Can Acepromazine be used to treat dogs with aggression issues?

Acepromazine is a sedative and tranquilizer that can cause sedation and reduced reactivity, which can potentially reduce aggressive behavior in some dogs. However, the medication does not address the underlying emotional or psychological factors that contribute to the aggression, and can potentially interfere with a dog's ability to respond to training or behavior modification.

What is the shelf life of Acepromazine?

Depending on the medication's composition and manufacturer, acepromazine's shelf life might change. However, if properly maintained in a cool, dry location away from light, Acepromazine pills or injections typically have a shelf life of two to three years from the date of manufacture.

How does Acepromazine compare to other anti-anxiety medications for dogs?

Acepromazine is not typically used as a primary anti-anxiety medication in dogs, as it is primarily a sedative and tranquilizer. Instead, other medications such as benzodiazepines, SSRIs, TCAs, and gabapentin are more commonly used for treating anxiety in dogs. These medications work by different mechanisms, such as enhancing the effects of GABA, increasing the levels of serotonin or other neurotransmitters in the brain, or affecting the levels of certain neurotransmitters.

Can Acepromazine be used in conjunction with behavior modification training?

It is not usually recommended as Acepromazine is not typically recommended as a sole treatment for behavior problems in dogs. Instead, behavior modification training, which involves teaching the dog new, more appropriate behaviors, is often recommended in conjunction with medication to help manage the dog's anxiety or other behavioral issues.

What should I do if my dog misses a dose of Acepromazine?

The health or well-being of the dog may not be significantly impacted by missing a single dose in some circumstances, while in other situations it may be required to modify the dosing plan or deliver the missed dose as soon as possible.

Acepromazine Maleate

The depression of the central nervous system can cause sedation, depression, lack of coordination, low blood pressure, slower heart rate and breathing; there have been instances of profound hypotension (low blood pressure), bradycardia, and collapse in individual animals. In some cases, the opposite may occur, and uses of acepromazine may trigger aggression and hyperactivity.

Acepromazine also displays anti-cholinergic and alpha-adrenergic blocking properties, and affects thermoregulation, possibly leading to either hypothermia or hyperthermia.

In rare cases, penile paralysis can occur in horses administered acepromazine.

Pale gums are a recognized side effect, and as with any phenothiazine, this medication may color the urine pink.

Due to its effect on heart rate, acepromazine is not recommended for geriatric animals or those in a weakened state. Some studies suggest that the boxer breed of dog is particularly sensitive, though this has been rebutted as well. It is recommended that acepromazine be used cautiously in sighthounds, and in animals prone to seizures.

Acepromazine is administered intramuscularly, intravenously, or orally. It is most effective if given when the animal is not stimulated or excited. When provided for horses in the treatment of exertional rhabdomyolysis, acepromazine is often supported by the use of an IV. Use as directed by your veterinarian.

Should be stored at room temperature away from moisture and heat.

Acepromazine (generic of PromAce) is manufactured by Boehringer-Ingelheim

How to Order Prescriptions Online

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2. Add to Cart

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3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

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Customer Reviews

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Best price

Best price for my pups necessary meds.

Aaron G recommends this item.
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Helps my chiweenie

I have a very high anxiety chiweenie, this helps with nail trims. Best price!

Aaron recommends this item.
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Works if given early

This works well if given well before an event happens (fireworks, t-storm and so on). With my dog, he will not calm if given too late but will sleep it off after everything is over. I am here to order more, yes it works well.

DJ recommends this item.
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Acepromazine aka Tranquilizers

This product is great for a hyper active dog who needs to stay calm during heartworm treatment. It's small, easy to hide in cheese or peanut butter and works quickly!

Meredith recommends this item.
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Be Very Careful when combining this with other Meds!

Our very old dachshund is on Selegrine and we were told that we might want to try Acepromazine as well to help him sleep through the night. We gave him a 1/4 of the recommended dose and thought that we had killed him... he was **** near comatose for an entire day, and it turns out that "Ace" concentrates the Selegrine out of the bloodstream. Our vet should have known this, and it was only PetCare RX hotline to a vet who was able to let us know what was going on. THANK GOODNESS FOR PET CARE RX and their 24/7 on-call vet service... If used without any other meds, this is likely safe, but be VERY careful when mixing with other meds!

Hugo's Dad recommends this item.
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If your dog is crazy and excitable you may need acepromazine.

Daniel Boehling recommends this item.
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Life saver for me and Gabe

My fur baby Gabriel had to have surgery on his elbow and inter arm which was exposed down to the bone, to remove what the vet thought was a cancerous lipomas which turn out to be just a large fatty tissue. I brought ACEPROMAZINE to calm him down and to keep him from being stressed out and licking his arm so that it would heal quicker and properly. It really works. I highly recommend this to anyone who fur baby have to go threw anything that is stressful..

Deloise Kaunda recommends this item.
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Finally she is calm....thunderstorms!!

Delilah has been frightened of thunder and lightening since she was a baby. I have tried everything I have heard to ease her fear. Bought a thundershirt...did not help. My vet suggested acepromazine. I have to give it to her before the storm is near..she hears MUCH better than I do!! So I watch the weather maps and when I see a storm approaching I give her 1 tablet. It calms her down ALOT! I feel bad that she is so out of it, but it is better than watching her pant and pace and dig trying to hide. I highly recommend, as long as your vet approves!

Kim recommends this item.
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Love the change in our dog!

Our rescue dog gets very excited in the car and, at a little over a year and 60 pounds, still nips as part of play, especially in the car. With a minimum dose our boy can now travel as well as our girl. We only give him enough to calm him, not knock him out. Our monthly six hour trips are pleasant again.

AndreaF recommends this item.
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This works for my Cedar. German Shorthaired Pounter age 12

Try using this. It works for me, I'm happy to use this with Cedar

sckoolguy recommends this item.
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Never leave home without it.

This medication is great if your dogs have problems in the car. My two English Springer Spaniels get very afraid of being closed up in a vehicle and this medicatioin is good also fabulous for fireworks and a mircle medication for storms and hurricanes. There is no sense in my little guys to be so anxious, upset and terrified. This is a must in an upsetting situation.

poodle_runner recommends this item.
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My golden puppy had a terrible reaction to this drug. Swelling and rash. Come to find out that she is very allergic. After she got spayed I was prescribed this drug to keep her calm. She was calm alright but her lips and ears were very swollen and she had a rash all over her stomach. I was so afraid it would effect her breathing. I had to give her Bennedryl for two days! I donโ€™t have to say what a total nightmare that experience was, her getting spayed and to have such a radical reaction to the drug.

A_Golden_owner recommends this item.
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My dog is deadly affraid of storms (thunder). When I'm not home he will destroy everything and anything. I talked to my vet and she gave me ace and it is wonderful. He just sleeps through the storms!

Shannon recommends this item.
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Awesome Product, Great Price

We just adopted a female Golden Retriever and was she ever hyper, our vet gave us some samples of the acepromazine. Well it worked the dog could sleep and so could we.Got a hyper dog? This stuff will do the job.. Excellent service and fast shipping from PetCareRx.

Ken_Carol_Golden_Owners recommends this item.
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He's still upset, but can ride in a car now

malcom and I recently relocated about two hours away. He's always been fine in the car before the move, but during, and ever since the move, he's a trembling wreck. He actually shakes the car he breathes so hard. My vet prescribed 1.5 of these tablets (he's ~77 lbs) but I've found that it requires 2 whole tablets for him to be affected at all. With 2 tablets, about 1.5 hours afterwards he's still shaking wildly in the car, but he's laying down while he does it, and the slobber is kept below the 1 gallon mark.

The_adopter_of_an_emotionally_wrecked_lab recommends this item.
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Ear Infections

My 9 year old Rottweiler gets these horrible ear infections several times a year. They are deep ear infections which cause the nerve in the right side of his face to be pinched from the swelling of his inner ear. This causes him numbness in the side of his face and it freaks him out and he snaps at the air like he is trying to catch invisible bugs. The antibodics work great but take 24-48 hrs to kick in. This medication was a life saver. We can all sleep at night now and he can rest and realx while he is healing and waiting for the antibodics to kick in.

Colleen_Mommy_to_a_Rottie recommends this item.
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Car Trips are now fun for everyone (Including Joey)

I recently purchased a vacation home, and decided to bring the dog (Joey) with us on vacation. Car rides were a disaster! My Vet proscribed Acepromazine, and what an amazing difference. He rests and relaxes through the entire ride (about 3 hours). I've learned through trial and error, that I must give him the pill at least 45 minutes prior to starting on the trip. The calmer he is when he gets the pill, the calmer he stays. Also, don't give on a full stomach. Can cause stomach upset.

Lisa recommends this item.
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avoiding the hebe jeebies

like if give at proper time she is good as good, but if she is to excited may not work at all.

Niki_2_dog_owner_large_dog_is_a_big_chicken_fo recommends this item.
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It is absolutely impossible to brush my 4 year old IG's teeth (which is absolutely necessary with IG's as they can develop life-threatening illnesses as a result of poor oral care). I was given this by my vet for carry-on air travel (which also worked great) and tried the left-over pills for teeth brushing - AMAZING - she not only let me brush but also let me scrape every tooth with a scaling tool!! WOW!!

Italian_greyhound_mom recommends this item.
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4th of July terror!

My Siberian Husky Penny was scared to death when the fireworks would start. She would break down doors, pull off screens, scale tall block walls. When I discovered Acepromazine, it was amazing. Now she rests easy and relaxes. Her ears don't even go back when she hears the noise. I am happy that this holiday doesn't traumatize her anymore.

Leslie_pet_owner recommends this item.
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This product is very affordable to me and without it my Stanley would never sleep!

Linda_Senf recommends this item.
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Great for Road trips

Our little ones (american eskimo and pomeranian shelty mix) have always been finicky in the car. Lots of carsickness and high stress. Acepromazine calms them for the ride, and seems to put their minds at rest. Would not use any other time, but the car trips are 100% worth using it for.*This is a prescription item

SanMateoLiving recommends this item.
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Exercise caution when using with Boxers

Boxers demonstrate a greater sensitivity to Ace - use with caution, ask your veterinarian for a different medication for use with a boxer. This is a prescription only product.

KDE_Boxers recommends this item.
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