Zycortal Suspension
Zycortal Suspension
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Zycortal Suspension

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Canine Addison's Disease (hypoadrenocorticism) is a condition in which a dog's adrenal glands aren't working properly. Adrenal glands produce chemicals and hormones that help regulate many bodily functions such as metabolism, blood pressure, and stress response. Zycortal Suspension is used as replacement therapy for the mineralocorticoid deficit in dogs with primary adrenocortical insufficiency (Canine Addison's Disease).

What Is Zycortal Used For?

Zycortal is a veterinary medicine that is prescribed to treat Addison's disease in dogs. Dogs with primary hypoadrenocorticism or Addison's disease are unable to produce cortisol and aldosterone. The main side effects of this disease include weight loss, dehydration, and fluid loss. In such cases, Zycortal is used to substitute the missing aldosterones. Usually, another corticosteroid is also prescribed alongside to replace the cortisol deficiency. The active ingredient of Zycortal is desoxycortone pivalate.

Is Zycortal the Same As Percorten?

Percorten came before Zycortal and was approved for veterinary use by FDA in 1998. Zycortal, on the other hand, was approved for canine use by FDA in 2016. Both these medicines comprise 25 mg desoxycorticosterone per milliliter and are microcrystalline suspensions. The microcrystalline suspension formulation allows for slow dissolution and prolonged drug release in dogs. While being similar, they differ in their usage of preservatives and surfactants. Percorten is labeled for intramuscular injection, whereas Zycortal is labeled for subcutaneous injection. However, in clinical practice, Percorten is also administered subcutaneously.

Is Zycortal a Steroid?

The active ingredient in Zycortal, desoxycortone pivalate, is a synthetic steroid hormone that resembles the natural hormone called aldosterone. Zycortal retains sodium and eliminates potassium to maintain a sufficient level of water in the body. Since dogs suffering from Addison's disease have aldosterone deficiency, Zycortal is administered to replace the missing hormone.

What Is Zycortal Injection?

The Zycortal injection is a desoxycorticosterone pivalate injectable suspension. It's used as replacement therapy for dogs suffering from mineralocorticoid deficiency caused by primary hypoadrenocorticism (Addison's disease). The Zycortal suspension is available as a prolonged-release injection for use on dogs only. Prolonged-release injection means that the active ingredient, desoxycorticosterone pivalate, is released slowly over a few weeks after being injected. Speaking of being injected, Zycortal is administered subcutaneously.

What Are the Side Effects of Zycortal in Dogs?

As is the case with all prescription medicines, Zycortal also has its own set of side effects in dogs. Some of the most common side effects of Zycortal are lethargy, pain, weight gain, frequent urination, polyuria, polydipsia, alopecia, decreased appetite, panting, vomiting, diarrhea, trembling, polyphagia, and urinary tract infection, to name a few. In some cases, death has also been reported due to the side effects mentioned above. It's advised that Zycortal injection should be administered with a high level of caution in dogs suffering from congestive heart disease, edema, severe renal disease, and primary hepatic failure. Additionally, a suitable intravenous treatment for hydration before starting Zycortal administration.

How Often Is Zycortal Given?

Zycortal is a slow-releasing suspension and is administered depending on the dog's response and the level of sodium and potassium in the blood. The first dose is given as a subcutaneous injection at an initial dose of 2.2mg per kg of the body weight. After 25 days of the first injection, the blood sodium and potassium levels are tested, and the dog's response is observed. If the results are satisfactory, the exact dosage and interval are continued long term.

Who Makes Zycortal?

Zycortal suspension is a trademark of Dechra Ltd., based in the UK. The medication is manufactured in the UK and is sold in 4ml vial cartons with a concentration of 25mg/ml. Zycortal is approved for subcutaneous use in dogs only and cannot be purchased without a legit prescription from a licensed veterinarian. The Committee for Medicinal Products for Veterinary Use (CVMP) approved the use of Zycortal in Europe after concluding that the benefits of Zycortal far outweigh the risk associated with it.

Can Zycortal Be Given Intramuscularly?

No, Zycortal has been approved by the FDA to be administered only subcutaneously in dogs. Percorten, a similar medication, is designed to be injected intramuscularly but not Zycortal. The initial dose of Zycortal is 2.2mg/kilo of the dog's body weight. 25 days after the initial dose, the dog's response to the medication and blood sodium and potassium levels are recorded to determine the further course of the treatment.

Can a Dog Overdose on Zycortal?

Yes, like any other drug, if the dosage administered is higher than the dosage recommended by the veterinarian, your dog will overdose on Zycortal. The most common side-effects of Zycortal overdose are polyuria, polydipsia, alopecia, polyphagia, and urinary tract infection, to name a few. There have been reports of dogs succumbing to these side effects if proper precautions are not taken. Apart from sticking to vet-recommended dosage, the do must also receive intravenous hydration therapy before starting the Zycortal treatment.

Desoxycorticosterone Pivalate

Desoxycorticosterone Pivalate

Possible side effects of Zycortal Suspension include polyuria (excessive urination), polydipsia (excessive thirst), increased blood volume, edema, and cardiac enlargement. Excessive weight gain may indicate fluid retention secondary to sodium retention. Do not use Zycortal Suspension on pets who may be pregnant or lactating. Zycortal Suspension should be injected subcutaneously (under the skin); do not inject intravenously (in the vein). Do not use in dogs with congestive heart failure, kidney disease, or edema. Do not use in dogs who are allergic or hypersensitive to Zycortal Suspension or any of its ingredients.

Zycortal Suspension is administered by SQ (subcutaneous) injection. Use as directed by your veterinarian.

Store at controlled room temperature 25ยฐC (77ยฐF) with excursions between 15-30ยฐC (59-86ยฐF) permitted. Do not freeze. Use within 120 days of first puncture and puncture a maximum of 4 times.

Option UPC/SKU
25mg/ml, 4ml 317033382042

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