Click to zoom Tap and hold to zoom
Refills on File
Your pet {{refill.petName}} has {{refill.refillsRemaining}} refill{{refill.refillsRemaining>1?'s':''}} for ‘{{refill.options}}’ which will expire on {{refill.expiresOn}}.
{{refill.petName}}'s refills for this have expired on {{refill.expiresOn}}
At a Glance
100% protection again fleas and ticks
Kills pests within 8 hours of administration
Once a month chewable tablet


List Price:
{{list_price * quantity | currency}}
List Price:
{{list_price * quantity | currency}} {{(list_price + 0.01) * quantity | currency}}
List Price:
{{list_price * quantity | currency}}
List Price:
See price in cart Why we cannot show price
List Price: {{list_price * quantity | currency}}
25% OFF w/code: CARE25
PetPlus Price:
{{petplus_price * quantity |currency}}
PetPlus Price:
See price in cart Why we cannot show price
Sale Price:
{{sale_price * quantity|currency}}w/code {{siteCode}}
Your Price:
{{(map_price + 0.01) * quantity | currency}} See price in cart w/code {{siteCode}} Why we cannot show price
{{petplus_savings_amount * quantity|currency}} ({{petplus_savings_percent}}%)
{{coupon_savings_amount * quantity|currency}} ({{coupon_savings_percent}}%)
Join PetPlus today and get this for {{intro_price_total|currency}} Why we cannot show price
Join PetPlus today and {{use_strict_map_rules?"see price in cart":"get this for a special price"}} Why we cannot show price

inlowout of stock
Get notified as soon as this becomes available
Thank you.
We will email {{notifyEmail}} when this is back in stock.
Recommended Alternatives:
Limit ( {{ selected_sku_data.cartLimit }} ) per customer. Orders for more than this may not be fulfilled.
Shipping is always free with PetPlus | Arrives in 1-3 days on average
Free shipping over $48* | Arrives in 1-3 days on average
Select Autoship options at checkout
At a Glance
100% protection again fleas and ticks
Kills pests within 8 hours of administration
Once a month chewable tablet

Frequently Bought Together

Total Price

Zoetis Logo
Looking for Simparica Trio?

Simparica Chewables for Dogs: The Ultimate Solution for Flea and Tick Control

Simparica Chewables for Dogs offers comprehensive protection for your pet against a wide range of parasites, ensuring its health and well-being. These chewable tablets are designed to treat and prevent tick and flea infestations and the diseases they can carry, such as Lyme disease.

Effective Against Multiple Tick Species -Simparica targets several tick species, including the brown dog tick, American dog tick, lone star tick, and Gulf Coast tick. These ticks are notorious for spreading infections and causing severe health issues in dogs. By using Simparica, you can safeguard your pet from the dangers of tick-borne diseases.

Flea Prevention and Control -Simparica treats adult fleas and prevents them from laying eggs, effectively breaking the flea life cycle and controlling flea infestations. This ensures your dog is free from the discomfort and health risks associated with fleas.

Safe for Various Life Stages -Simparica Chewables are suitable for dogs of various life stages, including lactating, pregnant, and breeding dogs. They have been carefully evaluated to ensure safety and effectiveness, making them a reliable choice for your pet's parasite prevention needs.

Easy and Convenient Administration -Each Simparica tablet is easy to administer and can be given with or without food. To maintain continuous protection against fleas and ticks, the next dose should be given on schedule for optimal results. If your dog experiences symptoms like vomiting or seizures, consult your veterinarian immediately, as these could be signs of adverse reactions to the medication.

Prescription Required - Simparica Chewables requires a prescription from your veterinarian. This ensures that the treatment is appropriate for your dog's age, weight, and overall health condition, providing the most effective and safe control of flea and tick infestations.

Why Choose Simparica?

  • Comprehensive treatment and prevention of flea and tick infestations.

  • Protects against various tick species including brown dog ticks, American dog ticks, lone star ticks, and Gulf Coast ticks.

  • Prevents adult fleas from laying eggs, ensuring thorough flea control.

  • Suitable for pregnant, lactating, and breeding dogs.

  • Convenient, easy-to-administer chewable tablet form.

  • Requires a veterinarian prescription for tailored treatment.

Simparica Chewables for Dogs is your pet's best defense against fleas and ticks. Effective treatment and prevention help keep your dog healthy and happy, free from the discomfort and dangers of parasite infestations. Always follow your veterinarian's advice for the appropriate dose and schedule to ensure maximum protection for your furry friend.

What Is Simparica for Dogs?

Fleas and ticks post a significant threat to your dog's health. While common, they are parasitic bugs that latch on to your dog's body and drink their blood. They can pass on many types of infections to your dog, and if the infestation is bad enough, they can even give your dog anemia. Simparica for dogs is a medication designed to prevent this.

You can use Simparica Flea and Tick Medication monthly to keep your dogs safe from these pesky parasites. This medicine protects your dog for 35 days, after which you can give your dog another dose. This is excellent for dogs who work a lot outdoors as you cannot control the outside environment.

Why Are Fleas and Ticks Bad for Dogs?

Fleas and ticks can pass on several different types of diseases. They can pass on these diseases to your pets and you and your family as well. Fleas multiply really quickly as they can say up to 50 eggs a day! Ticks can stay on your dog's body without anyone noticing for nearly a week.

Dogs can develop Flea Allergy Dermatitis, which is an allergy to the saliva of fleas. They can also transmit canine tapeworm or Dipylidium Caninim to other dogs, cats, and humans. If the flea has encountered any dangerous bacteria, it can pass that on to animals as well.

Ticks carry their own set of problems. The biggest fear with ticks is Lyme disease, which is an extremely dangerous and painful condition. They can also spread Rocky Mountain Spotted Fever, Colorado tick fever, Heartland virus, ehrlichiosis, and tularemia, among many others. Both people and dogs can be allergic to tick bites.

How Much of Simparica Should I Give My Dog?

Simparica Trio for dogs should be used at the dosage of 0.91mg per pound of weight or 2mg per kilo of bodyweight. Thus, a dog between 2.8 and 5.5 pounds should get one piece of 5mg Simparica chewables per month. A dog who is between 5.6 and 11 pounds gets one piece of 10mg Simparica chewables per month.

If your pet is between 11 and 22 pounds, you should give them one tablet of 20mg Simparica chewables. A dog who weighs between 22 and 44 pounds should get one piece of 40mg Simparica chewables per month. A dog who weighs between 44 and 88 pounds per month needs an 80mg dose of Simparica for dogs.

Finally, a dog who is between 88-132 pounds needs a 120mg dose of this medication. Ensure you weigh your dog at your vet before giving him any medication whose dosage depends on weight. You can weigh your dog at home, but the vet's office will be more accurate.

What Are the Side Effects of Simparica?

When you give your dog Simparica Flea and Tick Medication, they might get mild side effects like vomiting, diarrhea, weakness, or low energy levels. These side effects are usually mild and pass once your dog's body adjusts to this medicine.

However, if the vomiting or diarrhea doesn't stop, then you should contact your vet. Additionally, you should also contact your vet if your dog has a seizure after taking this medicine or if you see tremors in their body. Other signs you should contact your vet are if your dog has trouble walking or is stumbling around.

Frequently Asked Questions
  1. Can I Give Simparica Trio to My Cats?

    You should not give medication meant for dogs to cats. Additionally, there is tick and flea medication meant for dogs made with ingredients toxic to cats. Always ask for cat-specific medication when treating your cat for anything.

  2. Do the Different Colours Mean Anything?

    Simparica Flea and Tick Medication come in different colors according to the dosages in each tablet. The yellow box has 5mg of Sarolaner in each pill, purple has 10mg, orange has 20 mg, and mint has 40 mg. Finally, the green box has 80mg Simparica chewables while the brown box has 120mg Simparica chewables.

  3. How Often Should I Give This Medicine?

    You should give Simparica for dogs once a month. The medicine is effective for 35 days. Thus, even if you forget to give this medicine exactly 30 days later, you have a window of 5 days to give another dose.

  4. How Should I Administer This Medicine?

    You can give Simparica for dogs orally. This medicine is in the form of a chewable tablet. Simparica reviews show that most dogs find this highly palatable and have no trouble eating this. If your dog is a fussy eater, you can wrap this tablet up in some boiled chicken or other high-value treats, so your dog eats the full dose of this medicine.

  5. Are There Any Other Precautions I Should Take When Giving This Medicine?

    You should not give Simparica Flea and Tick Medication to dogs who are less than six months old. You should use caution when giving Simparica to dogs who are currently pregnant or lactating as its effect on these conditions hasn't been evaluated. Ask your vet before you give your dog any medication.

  6. Do I Need a Prescription to Buy This Medicine?

    Yes, you need a prescription to buy Simparica Flea and Tick Medication. If your dog is getting recurrent tick and flea infestations, then you should speak to your vet about Simparica for dogs. If your dog frequently works in an outdoor environment like a farm, then you can talk to your vet about protecting your dogs using Simparica.

  7. My Dog Is Allergic to Protein. Does Simaprica for Dogs Contain Any Protein or Other Allergens?

    Simparica for dogs contains protein, but it is in the form of hydrolyzed soy protein. This means that it is likely to be safe even for dogs with a protein allergy. This medicine also contains starch, corn, wheat germ, Anhydrous Dibasic Calcium Phosphate, corn syrup, and gelatine. The active ingredient in this medicine is Sarolaner.

  • Zoetis Manufacturer
  • Zoetis Brand
  • Flea & Tick Pharmacy
  • Oral Application
  • Dog Pet Type

Is Simparica Better Than Frontline?

Both Simparica for dogs and Frontline are used as flea medicines for dogs, and they are both effective in flea and tick treatment. However, Simparica is not the better flea medicine for dogs when compared to Frontline flea treatment. Simparica kills ticks and fleas, and it is not safe to use this flea and tick medicine on pregnant, lactating, or breeding dogs. On the other hand, not only does Frontline kill fleas and ticks, but it also destroys their eggs and larvae. Hence, Frontline is arguably the best flea treatment for dogs. That being said, Simparica is one of the best dog flea treatments available right now. It can successfully eliminate all adult fleas on dogs. However, it cannot match the standards of Frontline.

Is Simparica Safe?

Yes, Simparica is a safe and effective treatment for fleas as well as ticks in dogs. The drug is approved by the FDA and has been given clearance for prescribed usage. That means you will need a vetโ€™s authorization or prescription for buying this medicine. You also need to maintain certain precautions from your end to ensure the safety of your dog while starting or continuing the Simparica dosage. Do not give this flea treatment drug to dogs that are under six months of age. You must also avoid, or stop giving Simparica to your dogs if they are lactating, breeding, or pregnant. The drug might interfere with these biological processes, which is why it is best to maintain caution. Ask your vet if you can use Frontline flea treatment on your pregnant dog if you must use a flea and tick medication.

Can My Dog Still Get Fleas With Simparica?

Yes, your dog can still get fleas with Simparica. There are mainly two reasons for this. Firstly, it is possible that the fleas came back after the medication wore out. In that case, there is a chance that your house has a flea infestation somewhere, or perhaps your dog was in a flea-infested place. Secondly, since Simparica does not destroy larvae or eggs of fleas and ticks, it is likely that the fleas came from there. This has a higher chance of happening if your dog seldom leaves the house and still has fleas despite the Simparica treatment.

Does Simparica Make Dogs Sick?

Simparica might make your dogs sick, but it is not a common occurrence. The medication can lead to tremors or seizures. This is common in dogs that have a history of neurological disorders, however, it can also happen to those without such history. The drug can also make a dog sick if it is pregnant or breeding. Some of the most adverse side effects of Simparica include vomiting and diarrhea. You should take your dog to the vet if you notice these symptoms. Continuous shaking for a long period also requires urgent medical attention.

Should I Give My Dog Simparica Trio?

You can give your dog Simparica Trio if you need to treat it for both fleas and ticks, as well as worms. However, you will still need a vetโ€™s prescription to be able to use this drug. Simparica Trio cannot be used on dogs that are less than 8 weeks of age.

What Does Simparica Trio Not Cover?

Simparica Trio does not cover anything except ticks, fleas, and worms. It is very effective against these three parasites in dogs and can guarantee proper treatment for them.

Does Simparica Deworm?

Yes, Simparica Trio can deworm. It can work effectively against heartworm and lungworm in dogs. Besides, the medicine can take care of fleas and ticks just as well.

What kills fleas naturally?

There are several natural methods that can help in killing fleas. While these methods may be effective to some extent, severe infestations may require additional treatments. Food-grade diatomaceous earth is a fine powder made from fossilized remains of algae. It is harmless to humans and pets but can be lethal to fleas. Sprinkle it on carpets, pet bedding, and areas where fleas are present. The powder damages their exoskeletons, leading to dehydration and death. Certain herbs and plants act as natural repellents for fleas. These include rosemary, lavender, eucalyptus, and peppermint. You can create a spray by steeping these herbs in boiling water, straining the liquid, and spraying it on your pet's fur or around the house. Salt is a simple yet effective method. Sprinkle finely ground salt on carpets, furniture, and other flea-infested areas. The salt dries out the fleas and eggs, ultimately killing them. Fleas dislike the scent of lemons. Create a natural flea spray by boiling sliced lemons in water, allowing them to steep overnight. Transfer the liquid into a spray bottle and apply it to your pet's fur, furniture, and bedding. Regular vacuuming helps to remove fleas, eggs, and larvae from carpets, rugs, and furniture. Be sure to discard the vacuum bag or empty the canister immediately after use. While these methods can be helpful, they may not completely eliminate a flea infestation. For severe infestations or persistent problems, consult with a professional pest control service or a veterinarian for appropriate treatment options.

What kills fleas immediately on dogs?

There are several topical and oral flea medications available that are designed to kill fleas quickly. These medications contain insecticides or insect growth regulators that target fleas specifically. Examples include products like Simparica, Frontline, Advantage, NexGard, Bravecto, and Seresto. Consult with your veterinarian to determine the most suitable option for your dog based on their age, weight, and health condition. Flea shampoos are formulated to kill fleas on contact. They usually contain ingredients like pyrethrins or permethrin, which are insecticides effective against fleas. Thoroughly lather your dog with the shampoo, ensuring that it reaches all areas of their body. Leave the shampoo on for the recommended duration before rinsing it off. Follow the instructions on the product label and avoid using products meant for dogs on cats, as they can be toxic to felines. While not an immediate solution, flea combs can help physically remove fleas from your dog's fur. Regularly comb through your dog's coat, paying attention to areas where fleas tend to hide, such as around the neck, behind the ears, and along the back. Have a bowl of soapy water nearby to drown any fleas you comb out.

How do I protect my dog from ticks?

Use tick preventatives recommended by your veterinarian. There are various options available, including topical treatments, oral medications, and tick collars. These products are designed to repel or kill ticks and prevent infestations. Follow the instructions provided by your veterinarian and administer the chosen product regularly, as directed. After your dog spends time outdoors, thoroughly check their coat for ticks. Pay close attention to areas like the ears, head, neck, underarms, and between the toes. Use a fine-toothed tick comb to help locate and remove any ticks. Promptly remove any ticks you find using tweezers or a tick removal tool. Grasp the tick close to the skin and gently pull it straight out. Avoid squeezing or twisting the tick, as this can increase the risk of disease transmission. Create a tick-free environment in your yard by regularly mowing the grass, trimming vegetation, and removing leaf litter. Consider creating a barrier of wood chips or gravel between the lawn and wooded areas to reduce tick migration. Additionally, restrict access to tick-prone areas such as tall grasses, wooded areas, and leaf piles during peak tick seasons. When possible, avoid areas known to have a high population of ticks, such as heavily wooded areas or tall grasses. Stick to well-maintained trails and paths when walking your dog. Some natural products, such as essential oils like citronella, eucalyptus, or neem, may have a repellent effect on ticks. However, consult with your veterinarian before using any natural tick deterrents to ensure they are safe for your dog and effective against ticks. Also, check with your veterinarian about tick-borne diseases prevalent in your area and whether a vaccination is available to help protect your dog against specific tick-borne illnesses.

What can I feed my dog to repel ticks?

Some pet owners add a small amount of apple cider vinegar to their dog's food or water. The belief is that the odor emitted through the dog's skin after ingestion repels ticks. However, there is limited scientific evidence to support this claim. Garlic is thought to have natural insect-repellent properties, but excessive garlic consumption can be quite harmful to dogs. Brewer's yeast is often suggested as a dietary supplement that may help repel ticks. Some pet owners believe that it alters the odor of the dog's skin, making it less attractive to ticks. However, the effectiveness of brewer's yeast as a tick repellent is unproven.

Do dog ticks go on humans?

Yes, ticks that infest dogs, such as the common dog tick (Dermacentor variabilis) or the brown dog tick (Rhipicephalus sanguineus), can also bite and infest humans. While ticks have preferred hosts, they can opportunistically feed on different animals, including humans, if given the opportunity. Ticks are attracted to warmth, carbon dioxide, and certain odors, so if a tick is in close proximity to a human, it may attempt to feed. Ticks typically crawl onto the body and seek areas with thin skin, such as the scalp, neck, armpits, groin, or behind the ears. Not all ticks carry diseases, but some species can transmit pathogens that cause illnesses such as Lyme disease, Rocky Mountain spotted fever, or Ehrlichiosis.


Simparica is for use only in dogs, 6 months of age and older. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications. The most frequently reported adverse reactions were vomiting and diarrhea.

Simparica is manufactured by Zoetis
Option UPC/SKU
2.8 - 5.5 lbs 3-dose 087219120064

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

Related Articles

Simparica Trio Chewable Tablets for Dogs

A Comprehensive Review for Pet Owners

Read More
Simparica Trio For Dog's

Bye Bye Parasites

Read More
Simparica Trio

Protection From Pesky Parasites

Read More

Customer Reviews

Rating Summary 15 review(s)
5 stars
4 stars
3 stars
2 stars
1 star
5 / 5
* = required

New Product Review

Uploaded Image 1
Uploaded Image 2
Uploaded Image 3
  • {{error}}
Showing 1 - {{visible_reviews.length}} of {{total_reviews}}

This product has no reviews yet. Write a review.

So Happy

My purchase was processed quickly and delivered within a few days. Good prices too!

Ken kerns recommends this item.
Was this review helpful? 0 0

Dead ticks

Ticks fall off within hours and die.

Nalani recommends this item.
Was this review helpful? 1 0

Simparica 88-132 dogs

Works great and dog likes the taste.

Lawrence Meccariello recommends this item.
Was this review helpful? 1 0


Great product

Vic recommends this item.
Was this review helpful? 1 1

Refills and service

Excellent customer service and fast refills.

Larry Meccariello recommends this item.
Was this review helpful? 1 0

No Flea and Ticks in our house!

Works great we have had no ticks on our dogs and no fleas on dogs or in our house. I haven't noticed any side effects with our dogs and our tiny dog is usually susceptible to even small amounts of chemicals (e.g winter rock salt cause her major problems).

Chris recommends this item.
Was this review helpful? 2 0


Only flea med. That's hassle free and works great.

Rocky recommends this item.
Was this review helpful? 1 0

Easy to order!

I received my order in a timely manner, and have no complaints! ??

Ashley recommends this item.
Was this review helpful? 0 0

Great overall product

Simparica for dogs 44.1-88.0 works fine. Does the job.

Skipmac55 recommends this item.
Was this review helpful? 1 0

Smooth process

I did not have to do anything. PetCareRx took care of everything for prescription order.

Nisha recommends this item.
Was this review helpful? 2 0

great medicine

I tried various medicine for my dogs so far Simparica is the best

Mia Kok recommends this item.
Was this review helpful? 3 0


I love this product! It has worked great for my 9 year old Shih Tzu and it is cheaper than the other brands.

Rissa recommends this item.
Was this review helpful? 2 0

Great Price

great price on the simparica

Janis recommends this item.
Was this review helpful? 2 1


our dogs have been using these oral meds for years and we haven't had any issues.

Kim recommends this item.
Was this review helpful? 5 0

Great product

Haven't seen a Flea all Summer (or at least the last 2 months) We have 2 dogs and the just gobble the pills down......Thanks Simparica and our Vet who recommended them....

Cliff recommends this item.
Was this review helpful? 10 0

Page 1 of 1 1