Simparica Trio Chewable Tablets for Dogs
Simparica Trio Chewable Tablets for Dogs
Click to zoom Tap and hold to zoom
Refills on File
Your pet {{refill.petName}} has {{refill.refillsRemaining}} refill{{refill.refillsRemaining>1?'s':''}} for ‘{{refill.options}}’ which will expire on {{refill.expiresOn}}.
{{refill.petName}}'s refills for this have expired on {{refill.expiresOn}}
At a Glance
Simparica Trio is a monthly chewable tablet for dogs that provides comprehensive protection against fleas, ticks, heartworms, and intestinal worms.
The tablet contains three active ingredients - sarolaner, moxidectin, and pyrantel - that work together to kill and repel parasites.
The medication is available in different dosage strengths to suit different dog sizes, from small breeds to large breeds.
Simparica Trio is easy to administer and can be given with or without food, making it a convenient option for pet owners.
The tablet is FDA-approved and has been clinically proven to be safe and effective in protecting dogs against multiple parasites, helping to keep them healthy and happy.

Simparica Trio Chewable Tablets for Dogs

List Price:
{{list_price * quantity | currency}}
List Price:
{{list_price * quantity | currency}} {{(list_price + 0.01) * quantity | currency}}
List Price:
{{list_price * quantity | currency}}
List Price:
See price in cart Why we cannot show price
List Price: {{list_price * quantity | currency}}
25% OFF w/code: CARE25
PetPlus Price:
{{petplus_price * quantity |currency}}
PetPlus Price:
See price in cart Why we cannot show price
Sale Price:
{{sale_price * quantity|currency}}w/code {{siteCode}}
Your Price:
{{(map_price + 0.01) * quantity | currency}} See price in cart w/code {{siteCode}} Why we cannot show price
Savings:
{{petplus_savings_amount * quantity|currency}} ({{petplus_savings_percent}}%)
Savings:
{{coupon_savings_amount * quantity|currency}} ({{coupon_savings_percent}}%)
Join PetPlus today and get this for {{intro_price_total|currency}} Why we cannot show price
Join PetPlus today and {{use_strict_map_rules?"see price in cart":"get this for a special price"}} Why we cannot show price

inlowout of stock
{{tier1Label}}
{{tier2Label}}
{{customizeLabel}}
{{quantityLabel}}
Get notified as soon as this becomes available
Thank you.
We will email {{notifyEmail}} when this is back in stock.
Recommended Alternatives:
Limit ( {{ selected_sku_data.cartLimit }} ) per customer. Orders for more than this may not be fulfilled.
Shipping is always free with PetPlus | Arrives in 1-3 days on average
Free shipping over $48* | Arrives in 1-3 days on average
Select Autoship options at checkout
At a Glance
Simparica Trio is a monthly chewable tablet for dogs that provides comprehensive protection against fleas, ticks, heartworms, and intestinal worms.
The tablet contains three active ingredients - sarolaner, moxidectin, and pyrantel - that work together to kill and repel parasites.
The medication is available in different dosage strengths to suit different dog sizes, from small breeds to large breeds.
Simparica Trio is easy to administer and can be given with or without food, making it a convenient option for pet owners.
The tablet is FDA-approved and has been clinically proven to be safe and effective in protecting dogs against multiple parasites, helping to keep them healthy and happy.

Frequently Bought Together

Total Price

Zoetis Logo
Looking for regular Simparica?

Protect Your Dog with Just One Simparica Trio

Simparica Trio Chewable Tablets offer comprehensive protection for your furry friend against multiple threats with just one dose. This powerful preventive medication is designed to protect dogs from heartworms, fleas, ticks, and intestinal worms, ensuring their health and well-being.

Key Features and Benefits:

  • Comprehensive Protection: Simparica Trio is the first and only product that provides treatment and control for flea infestation, killing deer ticks that may cause Lyme disease and blocking infections from roundworms and hookworms, including adult Toxocara canis, adult Ancylostoma caninum, adult Toxascaris leonina, and adult Uncinaria stenocephala. The unique characteristics of Simparica Trio make it an essential tool in your dog's healthcare regimen.

  • Effective Against Multiple Parasites: The unique formulation contains sarolaner, a member of the isoxazoline class, and pyrantel chewable tablets, ensuring it acts as both a flea medication and heartworm medication while also preventing intestinal worm infections.

  • Convenient Monthly Dosing: Administered once a month, Simparica Trio ensures your dog stays protected on a prescribed monthly dosing schedule, making it easy to keep up with their preventive care. The Simparica Trio dose is easy to administer, ensuring your dog receives the correct dose every time.

  • FDA Approved: Simparica Trio is FDA-approved for its efficacy in preventing infections and controlling parasiticides in different countries. The support for FDA approval showed that this medication is a reliable and effective choice for dog owners.

Clinical Trials and Adverse Reactions:

  • Safety Evaluated in Clinical Trials: In clinical trials, dogs voluntarily ate Simparica Trio tablets, which demonstrated its palatability. Reactions in clinical trials included vomiting, tremors, ataxia, and seizures, among others.

  • Neurologic Adverse Reactions: As with other products in the isoxazoline class, neurologic adverse reactions, including tremors, ataxia, and seizures, have been reported. Frequently reported adverse reactions include these neurologic symptoms, so it is essential to use Simparica Trio with caution, especially in dogs with a history of neurologic disorders.

  • Reactions in Clinical Trials: The most commonly observed adverse reactions in clinical trials were vomiting, diarrhea, lethargy, and loss of appetite. It is vital to follow the product labeling for the correct dose to minimize these risks.

Special Considerations:

  • Use in Breeding, Pregnant, or Lactating Dogs: Simparica Trio has been evaluated in breeding, pregnant, and lactating dogs. Clinical studies showed that it is safe for use in these groups, although it is always best to consult with your vet today before starting any new medication.

  • Companion Animal Parasite Council: The Companion Animal Parasite Council recommends Simparica Trio as part of a comprehensive parasite control program to protect dogs from parasites that can spread disease.

Simparica Trio Chewable Tablets are essential to your dog's preventive care routine. Simparica Trio can protect your dog from a range of harmful parasites with just one dose. Ensure your dog's health and happiness by including Simparica Trio in their monthly care plan. For more detailed information, refer to the product labeling or replace discussions with your veterinarian to determine the best preventive measures for your beloved pet.

Simparica Trio is a preventive medication that controls roundworms and protects against flea infestation, Lyme infections, and other tick-borne diseases. This new dose form combines two or three parasiticides in one, making it a convenient choice for dog owners.

One and Three count orders of manufacturer-sealed blister packs will arrive in a resealable plastic bag.

  • Zoetis Manufacturer
  • Zoetis Brand
  • Heartworm & Deworming Pharmacy
  • Flea & Tick Pharmacy
  • Oral Application
  • Dog Pet Type

Is Simparica Safe?
Answer

Not only is Simparica safe, but it also guards your dog against fleas, helps in the control of tick infestations, roundworms, adult hookworm infections, and heartworm! It is the only product that contains the potent cocktail of sarolaner, moxidectin, and pyrantel. It is a broad-spectrum medication that your dog needs to take only once a month.

Does Simparica Trio Make Dogs Sick?
Answer

Simparica Trio protects dogs against deadly illnesses like heartworm disease. It does not make your dog sick, and it protects your dog from becoming sick. It has been demonstrated safe by the U.S Food and Drug Administration.

What Are the Side Effects of Simparica Trio for Dogs?
Answer

Simparica Trio Chewable tablets don't have many side effects. Your dog may experience vomiting and diarrhea as these were frequently reported adverse reactions during clinical trials. Along with these, you might see that your dog is being more active, drinking more water, and urinating more frequently. Some owners reported ear infections, anorexia, itching, diarrhea, and lethargy as well. Simparica Trio contains sarolaner, a part of the isoxazoline family. These classes of drugs have been known to have neurologic adverse reactions including seizures, muscle tremors, and more. However, if your dog doesn't have a history of neurologic disorders, they should be safe as the FDA has approved this medicine.

How long do Simparica Trio Side Effects Last?
Answer

Simparica Trio can be a little challenging on your dog's body. Keep an eye on your dog for the first week after you give them the first dose. However, remember that this medicine should only be given under veterinary supervision. Discuss side effects with your vet and also ask them about what emergency signs you should keep an eye out for. As different dogs react to different medicines differently, your vet would be in the best position to make this assessment after reviewing your dog's medical history.

What Is the Difference between Simparica and Simparica Trio?
Answer

Both Simparica and Simparica Trio kill fleas and ticks, are liver-flavored and need a prescription to purchase. However, this is where their similarities end. Only Simparica Trio prevents heartworm and prevents hookworms, roundworms, and five kinds of ticks. Simparica works a little faster than Trio, though. Simparica needs 3 hours to start to kill fleas and 8 hours for ticks. However, while Trio still needs 8 hours for ticks, it starts to kill fleas within 4 hours instead of 3. Finally, they are made up of different medicines as well. Simparica contains only sarolaner, while Simparica trio contains sarolaner, moxidectin, and pyrantel.

How Quickly Does Simparica Work?
Answer

This depends on the infestation that your dog has. If your dog has fleas, Simparica Trio starts killing them within 4 hours of ingestion, and it is 100% effective 8 hours after the first dose. If your dog has ticks, Simparica kills 98.9% of them within 48 hours of the first dose. If your dog has roundworms, you can rest assured that this medicine will kill 99.2% of adult roundworms and at least 94% of hookworms. It also results in a decrease in fecal egg count for roundworms, which heads off the re-infection cycle from eggs.

Does Simparica Trio Kill Ticks?
Answer

Yes, Simparica Trio kills ticks, fleas, roundworms, hookworms, and heartworms. Among ticks, it kills five different species of ticks. Most tick medications kill only 4. These 5 are the Lone Star tick, the American dog tick, the Gulf Coast tick, brown dog tick, and black-legged tick.

Can My Dog Get Fleas While on Simparica?
Answer

Fleas exist in the outdoor environment your dog visits during walks and in your yard. This means that fleas may jump onto your dog from any place outdoors. If you check your dog right after this happens, you may find fleas on your dog despite being on Simparica. However, Simparica helps with the treatment and control of flea infestations. Thus, it will kill off any adult fleas before they can lay eggs and start the infestation process.

Can You Buy Simparica Trio without a Vet Prescription?
Answer

Simparica Trio uses drugs that are classified for use only under medical supervision. Thus, it would be illegal for you to buy this medicine without a prescription from your vet. In addition to this, sarolaner, a drug used in this medicine, can cause adverse reactions, including tremors. While these adverse reactions in clinical settings might not apply to your dog, only your vet is qualified to make that assessment. Speak to them about Simparica Trio if you think your dog needs this medicine.

What Is Simparica Trio Used for in Dogs?
Answer

Simparica Trio is a chewable tablet drug used in dogs to prevent heartworm illness, certain forms of intestinal parasites, flea and tick infestations, and flea and tick bites.

What Are the Active Ingredients in the Simparica Trio?
Answer

Sarolaner, which kills fleas and ticks, Moxidectin, which prevents heartworm disease and cures some forms of intestinal parasites, and Pyrantel Pamoate, which also treats intestinal parasites, are the three active components in Simparica Trio.

How Long Does Simparica Trio Protect Against Parasites?
Answer

The effectiveness of the product against different kinds of parasites varies. For fleas, Simparica Trio starts killing fleas within 4 hours of administration and continues to kill fleas for up to 35 days. For ticks, Simparica Trio starts killing them within 8 hours of administration and provides continuous protection for up to 30 days. Simparica Trio prevents heartworm disease for heartworms by killing the immature stages of heartworms for 5 weeks after infection. For intestinal worms (roundworms, hookworms, and whipworms), Simparica Trio provides monthly treatment and controls these parasites for up to 35 days.

Can Simparica Trio Be Used to Treat Existing Parasite Infestations?
Answer

While Simparica Trio effectively prevents flea infestations, heartworm disease, and internal parasites such as hookworm and roundworm, it is not intended to be used as a treatment for existing infestations or infections.

Are There Any Age or Weight Restrictions for Dogs Using Simparica Trio?
Answer

Yes, Simparica Trio has age and weight limits for dogs. Simparica Trio is intended for use in dogs 8 weeks or older and weighing at least 2.8 pounds (1.25 kg). The appropriate dose of Simparica Trio is determined based on your dog's weight, so it's important to accurately weigh your dog and follow the dosing instructions provided by your veterinarian.

How Does Simparica Trio Differ From Other Parasite Preventatives?
Answer

What sets Simparica Trio apart from other parasite preventatives is its triple-action protection, providing three types of parasite protection in one medication, including preventing intestinal worms, which not all preventatives provide. Additionally, Simparica Trio offers long-lasting protection. Unlike some other preventatives, Simparica Trio is an oral medication that is easy to administer and doesn't require messy topical applications. It is also safe for dogs with the MDR1 gene mutation and can be used in dogs with flea allergy dermatitis. Overall, Simparica Trio offers comprehensive, convenient, and safe parasite protection for dogs.

Can Simparica Trio Be Used for Dogs With a History of Seizures?
Answer

Sarolaner, an ingredient in Simparica Trio, belongs to the isoxazoline class of medicines, which have been linked to neurologic adverse events in dogs, including seizures, tremors, and ataxia. While Simparica Trio is generally safe and effective when used as directed, dogs with a history of seizures or other neurologic disorders should be closely monitored after administering this medication.

What Should I Do if My Dog Misses a Dose of Simparica Trio?
Answer

If your dog misses a Simparica Trio dosage, give the missed dose as soon as possible and continue your usual dosing plan. However, maintain a consistent dosing schedule for maximum protection against parasites.

Are There Any Known Medicine Interactions With Simparica Trio?
Answer

Simparica Trio does not currently have any known drug interactions. However, it is always advisable to let your veterinarian know about any prescription drugs, dietary supplements, or other treatments your dog is currently taking before beginning Simparica Trio. The effectiveness of one or both medications may be lowered, or the risk of side effects may increase due to drug interactions.

How Soon After Administration Can I Bathe or Groom My Dog When Using Simparica Trio?
Answer

While it is generally recommended to wait at least 24 hours after administration before bathing or grooming your dog, Simparica Trio has been shown to maintain its effectiveness even with exposure to water and soap. This is because Simparica Trio is absorbed into your dog's bloodstream and provides systemic protection against parasites, rather than relying on surface contact with the skin or fur. This means there are no restrictions on swimming, bathing, or shampooing before or after the administration of Simparica Trio.

Is Simparica Trio Available in Different Forms?
Answer

No, Simparica Trio is only available in one form: an oral chewable tablet. The tablet is flavored and palatable, making it easy to administer to your dog.

sarolaner, moxidectin, and pyrantel (as pamoate salt).

Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Choose the appropriate dosage based on your dog's weight. The tablets come in different strengths for different sizes of dogs.

Give the tablet to your dog orally, either by placing it in their mouth or hiding it in their food. The tablets are flavored to make them more appealing to dogs.

Give the tablet with or without food, according to your preference. However, it's best to give it with food if your dog has a sensitive stomach.

Give the tablet every 30 days, year-round, to maintain protection against fleas, ticks, heartworm disease, and intestinal worms.

Follow your veterinarian's instructions for any specific dosing or administration guidelines.

If you miss a dose, give it as soon as you remember. If it's close to the time for the next dose, skip the missed dose and continue with the regular schedule.

Keep the tablets in the original packaging until ready to use, and store at room temperature.

It's important to note that Simparica Trio is a prescription medication, so you'll need to consult with your veterinarian before starting your dog on this medication. Your veterinarian can also provide more detailed instructions specific to your dog's needs.

Keep out of reach from children. Store at or below 30ยฐC (86ยฐF).

Simparica is manufactured by Zoetis
Option UPC/SKU
2.8-5.5 lb, 6 treatments (Gold) 087219131596
5.6-11.0 lb, 6 treatments (Purple) 087219131626
22.1-44.0 lb, 6 treatments (Teal) 087219131589
44.1-88 lb, 6 treatments (Green) 087219131602
88.1-132.0 lb, 6 treatments (Brown) 087219131619
11.1-22.0 lb, 6 treatments (Caramel) 087219131572

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

Related Articles

How Do Flea Collars Work?

What Makes Flea Collars Tick

Read More
Simparica Trio Chewable Tablets for Dogs

A Comprehensive Review for Pet Owners

Read More
Simparica Trio For Dog's

Bye Bye Parasites

Read More

Customer Reviews

Rating Summary 31 review(s)
5 stars
29
4 stars
1
3 stars
1
2 stars
0
1 star
0
5 / 5
* = required

New Product Review


Uploaded Image 1
Uploaded Image 2
Uploaded Image 3
  • {{error}}
SUBMIT REVIEW
Showing 1 - {{visible_reviews.length}} of {{total_reviews}}

This product has no reviews yet. Write a review.

H
All in one
VERIFIED PURCHASER

I love how easily my dog takes Simparica! And it covers all of our bases in one simple chewable. We were loyal to another monthly medication until learning about Simparica, now itโ€™s our go-to.

Hannah recommends this item.
Was this review helpful? 0 0

F
Always the BEST
VERIFIED PURCHASER

This is where I do my one stop shopping for all my service dogโ€™s medicinal needs.

Fly Williams recommends this item.
Was this review helpful? 0 0

D
Great product
VERIFIED PURCHASER

Works well my pets are tick free pest free

Debbie Jennings recommends this item.
Was this review helpful? 1 0

J
Good buy
VERIFIED PURCHASER

I have ordered the Simperica Trio for almost 2 years now..great product, great prices, fast service

Judy P recommends this item.
Was this review helpful? 0 0

D
Works amazing
VERIFIED PURCHASER

My both dogs use it and have been for over a yr. Works better than anything else we used

Debbie Jennings recommends this item.
Was this review helpful? 1 0

R
Simpaticatrio
VERIFIED PURCHASER

Great transaction with quick timely shipping

Ron Soldo recommends this item.
Was this review helpful? 0 0

B
Simparic
VERIFIED PURCHASER

It good for the dog, no itching and safe

Bre recommends this item.
Was this review helpful? 1 0

B
Simparica
VERIFIED PURCHASER

It works for dogs no scratches and safe

Brenda diaz recommends this item.
Was this review helpful? 0 0

F
Easy and effective
VERIFIED PURCHASER

Itโ€™s great only having to remember one pill a month that my dog gobbles up.

Fly Williams recommends this item.
Was this review helpful? 2 0

B
simparica
VERIFIED PURCHASER

It's awesome to have three in one

BJ recommends this item.
Was this review helpful? 3 0

T
Last batch did not help
VERIFIED PURCHASER

I have used this product for the previous two years. Not sure what happpeneed but the last three month my dogs has had fleas. I have bathed her, sprayed the house, and taken her to the vet.

Tim Colwill recommends this item.
Was this review helpful? 8 0

M
Love the trio
VERIFIED PURCHASER

Great product

Marilyn recommends this item.
Was this review helpful? 1 0

D
Trio
VERIFIED PURCHASER

much easier than the other system of many products

donna recommends this item.
Was this review helpful? 4 0

C
Multi medication
VERIFIED PURCHASER

Great product

Candace Clayton recommends this item.
Was this review helpful? 1 0

R
Simpatico Trio
VERIFIED PURCHASER

My dog was originally prescribed Trifexis which I had to force down his throat and it smelled like Pine-sol. Now my vet put him on Simparica Trio and my dog eats it like a treat! What a big difference. Highly recommend this over the Trifexis.

Robert F. recommends this item.
Was this review helpful? 5 0

D
Great price
VERIFIED PURCHASER

Canโ€™t get this great product, Simparica, at a better price!

Doris recommends this item.
Was this review helpful? 2 0

B
No complaints
VERIFIED PURCHASER

Dogs eat it easily, ticks fall off, so all seems to be working.

Brendan recommends this item.
Was this review helpful? 2 0

B
Simparica Trio
VERIFIED PURCHASER

My dogs have taken the chewable with no adverse reactions and have not had any issues. I highly recommend.

Bruce A recommends this item.
Was this review helpful? 3 0

K
It works well but the tablet is too big
VERIFIED PURCHASER

The tablet very big and thick so it is hard to cut up. My dog doesnโ€™t like the taste so I have to force her to take it. Maddy is a rescue and having to force so many pieces down her throat takes a long time and it upsets her.

Kathy Auten recommends this item.
Was this review helpful? 3 0

L
Simparica Trip
VERIFIED PURCHASER

Works well! Dogs think it is a treat! Once a month and done!

Lynn recommends this item.
Was this review helpful? 2 0

H
Administering Once a month Trio
VERIFIED PURCHASER

Excellence in applying

Happy healthy dog recommends this item.
Was this review helpful? 2 0

J
Love the convenience!
VERIFIED PURCHASER

One pill, heartworm and flea & tick preventative in one! Love it!

Jessica recommends this item.
Was this review helpful? 0 0

R
Works great!
VERIFIED PURCHASER

Our dog loves being outside in Florida and this keeps her protected on all levels!

Richelle recommends this item.
Was this review helpful? 0 0

E
Amazing price!
VERIFIED PURCHASER

Best price I found & delivery was quick!

Ensaint recommends this item.
Was this review helpful? 0 0

C
Simparica Trio
VERIFIED PURCHASER

Very good product. My fur babies love it. And we love that we only have to give it once a month

Cyrene recommends this item.
Was this review helpful? 1 1

M
Simparica Trio
VERIFIED PURCHASER

This product works great for my dogs. No fleas, no ticks, and no heartworm.

Maggie recommends this item.
Was this review helpful? 1 0

Y
Worth it
VERIFIED PURCHASER

Great product. Been using on my dogs since they were puppies. Easy to use.

Yadi recommends this item.
Was this review helpful? 3 0

Y
Great
VERIFIED PURCHASER

Love the product. Keeps my fur babies flea and tick free monthly.

Yadi recommends this item.
Was this review helpful? 0 0

L
Totally Happy
VERIFIED PURCHASER

Good product and good service!

LP recommends this item.
Was this review helpful? 0 0

F
The only brand Iโ€™ll ever use again
VERIFIED PURCHASER

Iโ€™ve tried many of the other popular brands and they donโ€™t compare to Simparica Trio. My dogs would get fleas and ticks with the competitionโ€™s and I have yet to see that happen with Simparica. Definitely recommend for all of the things it covers, itโ€™s easier just giving my dogs 1 pill

Farrah Nickerson recommends this item.
Was this review helpful? 4 0

Page 1 of 1 1