Simparica Trio Chewable Tablets for Dogs
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At a Glance
Simparica Trio is a monthly chewable tablet for dogs that provides comprehensive protection against fleas, ticks, heartworms, and intestinal worms.
The tablet contains three active ingredients - sarolaner, moxidectin, and pyrantel - that work together to kill and repel parasites.
The medication is available in different dosage strengths to suit different dog sizes, from small breeds to large breeds.
Simparica Trio is easy to administer and can be given with or without food, making it a convenient option for pet owners.
The tablet is FDA-approved and has been clinically proven to be safe and effective in protecting dogs against multiple parasites, helping to keep them healthy and happy.

Simparica Trio Chewable Tablets for Dogs

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At a Glance
Simparica Trio is a monthly chewable tablet for dogs that provides comprehensive protection against fleas, ticks, heartworms, and intestinal worms.
The tablet contains three active ingredients - sarolaner, moxidectin, and pyrantel - that work together to kill and repel parasites.
The medication is available in different dosage strengths to suit different dog sizes, from small breeds to large breeds.
Simparica Trio is easy to administer and can be given with or without food, making it a convenient option for pet owners.
The tablet is FDA-approved and has been clinically proven to be safe and effective in protecting dogs against multiple parasites, helping to keep them healthy and happy.

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Looking for regular Simparica?

Simparica Trio Chewable Tablets for Dogs is specially formulated for canine companions 8 weeks of age and older. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palpable liver flavor and can be taken with or without food.

Simparica Trio is the ultimate in comprehensive parasite protection, combining the power of three different active ingredients to keep your dog safe and healthy. First, there's sarolaner, which helps to kill fleas and ticks on contact, preventing these pesky parasites from causing irritation, illness, or disease. Then there's moxidectin, which works to prevent heartworm disease by killing off immature heartworms before they have a chance to mature and cause damage. Finally, there's pyrantel, which helps to prevent and treat intestinal worms, including roundworms and hookworms.

But that's not all that sets Simparica Trio apart from other parasite preventatives on the market. With its beef-flavored chewable tablets, this medication is not only easy to administer, but also delicious for your dog to eat. Plus, its fast-acting formula starts to work within hours, giving you peace of mind that your dog is protected against parasites around the clock.

One and Three count orders of manufacturer-sealed blister packs will arrive in a resealable plastic bag.

  • Zoetis Manufacturer
  • Zoetis Brand
  • Heartworm & Deworming Pharmacy
  • Flea & Tick Pharmacy
  • Oral Application
  • Dog Pet Type

Is Simparica Safe?

Not only is Simparica safe, but it also guards your dog against fleas, helps in the control of tick infestations, roundworms, adult hookworm infections, and heartworm! It is the only product that contains the potent cocktail of sarolaner, moxidectin, and pyrantel. It is a broad-spectrum medication that your dog needs to take only once a month.

Does Simparica Trio Make Dogs Sick?

Simparica Trio protects dogs against deadly illnesses like heartworm disease. It does not make your dog sick, and it protects your dog from becoming sick. It has been demonstrated safe by the U.S Food and Drug Administration.

What Are the Side Effects of Simparica Trio for Dogs?

Simparica Trio Chewable tablets don't have many side effects. Your dog may experience vomiting and diarrhea as these were frequently reported adverse reactions during clinical trials. Along with these, you might see that your dog is being more active, drinking more water, and urinating more frequently. Some owners reported ear infections, anorexia, itching, diarrhea, and lethargy as well. Simparica Trio contains sarolaner, a part of the isoxazoline family. These classes of drugs have been known to have neurologic adverse reactions including seizures, muscle tremors, and more. However, if your dog doesn't have a history of neurologic disorders, they should be safe as the FDA has approved this medicine.

How long do Simparica Trio Side Effects Last?

Simparica Trio can be a little challenging on your dog's body. Keep an eye on your dog for the first week after you give them the first dose. However, remember that this medicine should only be given under veterinary supervision. Discuss side effects with your vet and also ask them about what emergency signs you should keep an eye out for. As different dogs react to different medicines differently, your vet would be in the best position to make this assessment after reviewing your dog's medical history.

What Is the Difference between Simparica and Simparica Trio?

Both Simparica and Simparica Trio kill fleas and ticks, are liver-flavored and need a prescription to purchase. However, this is where their similarities end. Only Simparica Trio prevents heartworm and prevents hookworms, roundworms, and five kinds of ticks. Simparica works a little faster than Trio, though. Simparica needs 3 hours to start to kill fleas and 8 hours for ticks. However, while Trio still needs 8 hours for ticks, it starts to kill fleas within 4 hours instead of 3. Finally, they are made up of different medicines as well. Simparica contains only sarolaner, while Simparica trio contains sarolaner, moxidectin, and pyrantel.

How Quickly Does Simparica Work?

This depends on the infestation that your dog has. If your dog has fleas, Simparica Trio starts killing them within 4 hours of ingestion, and it is 100% effective 8 hours after the first dose. If your dog has ticks, Simparica kills 98.9% of them within 48 hours of the first dose. If your dog has roundworms, you can rest assured that this medicine will kill 99.2% of adult roundworms and at least 94% of hookworms. It also results in a decrease in fecal egg count for roundworms, which heads off the re-infection cycle from eggs.

Does Simparica Trio Kill Ticks?

Yes, Simparica Trio kills ticks, fleas, roundworms, hookworms, and heartworms. Among ticks, it kills five different species of ticks. Most tick medications kill only 4. These 5 are the Lone Star tick, the American dog tick, the Gulf Coast tick, brown dog tick, and black-legged tick.

Can My Dog Get Fleas While on Simparica?

Fleas exist in the outdoor environment your dog visits during walks and in your yard. This means that fleas may jump onto your dog from any place outdoors. If you check your dog right after this happens, you may find fleas on your dog despite being on Simparica. However, Simparica helps with the treatment and control of flea infestations. Thus, it will kill off any adult fleas before they can lay eggs and start the infestation process.

Can You Buy Simparica Trio without a Vet Prescription?

Simparica Trio uses drugs that are classified for use only under medical supervision. Thus, it would be illegal for you to buy this medicine without a prescription from your vet. In addition to this, sarolaner, a drug used in this medicine, can cause adverse reactions, including tremors. While these adverse reactions in clinical settings might not apply to your dog, only your vet is qualified to make that assessment. Speak to them about Simparica Trio if you think your dog needs this medicine.

What Is Simparica Trio Used for in Dogs?

Simparica Trio is a chewable tablet drug used in dogs to prevent heartworm illness, certain forms of intestinal parasites, flea and tick infestations, and flea and tick bites.

What Are the Active Ingredients in the Simparica Trio?

Sarolaner, which kills fleas and ticks, Moxidectin, which prevents heartworm disease and cures some forms of intestinal parasites, and Pyrantel Pamoate, which also treats intestinal parasites, are the three active components in Simparica Trio.

How Long Does Simparica Trio Protect Against Parasites?

The effectiveness of the product against different kinds of parasites varies. For fleas, Simparica Trio starts killing fleas within 4 hours of administration and continues to kill fleas for up to 35 days. For ticks, Simparica Trio starts killing them within 8 hours of administration and provides continuous protection for up to 30 days. Simparica Trio prevents heartworm disease for heartworms by killing the immature stages of heartworms for 5 weeks after infection. For intestinal worms (roundworms, hookworms, and whipworms), Simparica Trio provides monthly treatment and controls these parasites for up to 35 days.

Can Simparica Trio Be Used to Treat Existing Parasite Infestations?

While Simparica Trio effectively prevents flea infestations, heartworm disease, and internal parasites such as hookworm and roundworm, it is not intended to be used as a treatment for existing infestations or infections.

Are There Any Age or Weight Restrictions for Dogs Using Simparica Trio?

Yes, Simparica Trio has age and weight limits for dogs. Simparica Trio is intended for use in dogs 8 weeks or older and weighing at least 2.8 pounds (1.25 kg). The appropriate dose of Simparica Trio is determined based on your dog's weight, so it's important to accurately weigh your dog and follow the dosing instructions provided by your veterinarian.

How Does Simparica Trio Differ From Other Parasite Preventatives?

What sets Simparica Trio apart from other parasite preventatives is its triple-action protection, providing three types of parasite protection in one medication, including preventing intestinal worms, which not all preventatives provide. Additionally, Simparica Trio offers long-lasting protection. Unlike some other preventatives, Simparica Trio is an oral medication that is easy to administer and doesn't require messy topical applications. It is also safe for dogs with the MDR1 gene mutation and can be used in dogs with flea allergy dermatitis. Overall, Simparica Trio offers comprehensive, convenient, and safe parasite protection for dogs.

Can Simparica Trio Be Used for Dogs With a History of Seizures?

Sarolaner, an ingredient in Simparica Trio, belongs to the isoxazoline class of medicines, which have been linked to neurologic adverse events in dogs, including seizures, tremors, and ataxia. While Simparica Trio is generally safe and effective when used as directed, dogs with a history of seizures or other neurologic disorders should be closely monitored after administering this medication.

What Should I Do if My Dog Misses a Dose of Simparica Trio?

If your dog misses a Simparica Trio dosage, give the missed dose as soon as possible and continue your usual dosing plan. However, maintain a consistent dosing schedule for maximum protection against parasites.

Are There Any Known Medicine Interactions With Simparica Trio?

Simparica Trio does not currently have any known drug interactions. However, it is always advisable to let your veterinarian know about any prescription drugs, dietary supplements, or other treatments your dog is currently taking before beginning Simparica Trio. The effectiveness of one or both medications may be lowered, or the risk of side effects may increase due to drug interactions.

How Soon After Administration Can I Bathe or Groom My Dog When Using Simparica Trio?

While it is generally recommended to wait at least 24 hours after administration before bathing or grooming your dog, Simparica Trio has been shown to maintain its effectiveness even with exposure to water and soap. This is because Simparica Trio is absorbed into your dog's bloodstream and provides systemic protection against parasites, rather than relying on surface contact with the skin or fur. This means there are no restrictions on swimming, bathing, or shampooing before or after the administration of Simparica Trio.

Is Simparica Trio Available in Different Forms?

No, Simparica Trio is only available in one form: an oral chewable tablet. The tablet is flavored and palatable, making it easy to administer to your dog.

sarolaner, moxidectin, and pyrantel (as pamoate salt).

Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Choose the appropriate dosage based on your dog's weight. The tablets come in different strengths for different sizes of dogs.

Give the tablet to your dog orally, either by placing it in their mouth or hiding it in their food. The tablets are flavored to make them more appealing to dogs.

Give the tablet with or without food, according to your preference. However, it's best to give it with food if your dog has a sensitive stomach.

Give the tablet every 30 days, year-round, to maintain protection against fleas, ticks, heartworm disease, and intestinal worms.

Follow your veterinarian's instructions for any specific dosing or administration guidelines.

If you miss a dose, give it as soon as you remember. If it's close to the time for the next dose, skip the missed dose and continue with the regular schedule.

Keep the tablets in the original packaging until ready to use, and store at room temperature.

It's important to note that Simparica Trio is a prescription medication, so you'll need to consult with your veterinarian before starting your dog on this medication. Your veterinarian can also provide more detailed instructions specific to your dog's needs.

Keep out of reach from children. Store at or below 30ยฐC (86ยฐF).

Simparica is manufactured by Zoetis
Option UPC/SKU
2.8-5.5 lb, 6 treatments (Gold) 087219131596
5.6-11.0 lb, 6 treatments (Purple) 087219131626
22.1-44.0 lb, 6 treatments (Teal) 087219131589
44.1-88 lb, 6 treatments (Green) 087219131602
88.1-132.0 lb, 6 treatments (Brown) 087219131619
11.1-22.0 lb, 6 treatments (Caramel) 087219131572

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