ProZinc Insulin U-40 for Dogs and Cats
ProZinc Insulin U-40 for Dogs and Cats
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At a Glance
FDA-approved for the use in cats and dogs diagnosed with diabetes mellitus
Reduces hyperglycemia and hyperglycemia-associated clinical signs in both cats and dogs with diabetes mellitus¹,²
PROZINC must be administered with U-40 syringes² (sold separately)
Always follow your veterinarian's directions regarding dosage amount, and when to administer PROZINC

ProZinc Insulin U-40 for Dogs and Cats

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At a Glance
FDA-approved for the use in cats and dogs diagnosed with diabetes mellitus
Reduces hyperglycemia and hyperglycemia-associated clinical signs in both cats and dogs with diabetes mellitus¹,²
PROZINC must be administered with U-40 syringes² (sold separately)
Always follow your veterinarian's directions regarding dosage amount, and when to administer PROZINC

ProZinc (protamine zinc recombinant human insulin) is an injectable insulin for cats and insulin for dogs. PROZINC is an aqueous protamine zinc suspension of recombinant human insulin that is used to reduce hyperglycemia (high blood glucose or high blood sugar) and clinical signs associated with hyperglycemia in cats and dogs with diabetes mellitus.,

If your cat or dog has been diagnosed with diabetes mellitus, you understand the challenges associated with regulating blood glucose and controlling clinical signs. With its appropriate duration of action in each species, PROZINC will provide glycemic control and help improve the quality of life of your cat or dog.,

PROZINC works by helping your pet break down blood sugar glucose. Cells typically use insulin to break down glucose, but cats and dogs with diabetes mellitus don't produce enough insulin, and this causes glucose to build up in their blood and leads to health problems. PROZINC boosts their blood insulin levels, allowing them to break down that glucose and avoid the health problems.

PROZINC should only be administered to the cat or dog for whom it was prescribed, and at the dosage and frequency for which it was prescribed. If you have any questions or concerns about the product or about diabetes mellitus, talk to your veterinarian. PROZINC requires refrigeration, as well as the use of U-40 syringes, which are sold separately.


References: 1. PROZINC (protamine zinc recombinant human insulin) [Freedom of Information Summary; NADA 141-297]. St. Joseph, MO: Boehringer Ingelheim Vetmedica, Inc.; 2009/2019. 2. PROZINC (protamine zinc recombinant human insulin) [prescribing information]. St. Joseph, MO: Boehringer Ingelheim Vetmedica, Inc.; 2019.
  • Boehringer-Ingelheim Brand
  • Diabetes & Metabolic Care Pharmacy
  • Cat Pet Type
  • Dog Pet Type

What Is the Difference Between Vetsulin and Prozinc?
Answer

Dog and cat owners use both Vetsulin and Prozinc to help minimize the risk of diabetes in their pets. They are both insulins and are used to control blood sugar levels. Low blood sugar signs may include weakness, weight gain, muscle spasms, increased thirst and urination, and so on. These are also treated as common signs of hypoglycemia. Vetsulin and Prozinc are to be given in such conditions after it is recommended by a vet. While they are not that different, Vetsulin has a bad reputation, mostly because it was called back due to quality issues. Prozinc, however, has not had such bad fortune. It maintains its quality and the drug seems to show maximum effectiveness with little to no adverse reactions.

Do You Shake Prozinc Insulin?
Answer

No, you should not shake the Prozinc insulin for cats and dogs. Instead, you simply have to roll the insulin vial between your palms. Shaking the insulin bottle will cause insulin particles to stick to the vial. That in turn will make the vial look frosted, and might even reduce the effectiveness of the insulin. Shaking can also lead to clumping. Besides, air bubbles might form because of vigorous shaking, and enter into the syringe when you try to draw from those vials. Rolling, on the other hand, helps mix the insulin properly while making sure that no air bubbles are formed. Hence, you should roll the vial instead of shaking it before using the insulin.

Do You Need a Prescription for Prozinc?
Answer

Yes, you need a prescription from a licensed vet for Prozinc. You can administer Prozinc to dogs and cats only if you have been authorized to do so by a professional vet. Along with the permission, they will also inform you regarding the dosage and the frequency. As it is a prescription drug, you cannot purchase or use Prozinc without the written authorization from a veterinary doctor.

Is 10 Units of Insulin a Lot for a Dog?
Answer

10 units of insulin is not a lot for a dog if it is of the right weight. The usual dosage is around ¼ unit per pound of the dogโ€™s body weight. Hence, for a 20-pound dog, 5 units are sufficient, whereas 10 units will suffice for a 40-pound dog, and so on. The dosage amount will be prescribed by the vet, and you should not deviate from it.

What Kind of Insulin Is Prozinc?
Answer

Prozinc is injectable insulin for dogs and cats with diabetes. You can use Prozinc for diabetic cats and dogs as long as your vet prescribes the drug to you. You have to administer the injectable Prozinc through U-40 syringes. When you are not using them, store the vials away from light and inside a refrigerator at 2-8 degrees celsius. Keep the vials upright, and do not let them freeze. Make sure you are using up the 10 mL vial within 60 days of puncturing, and the 20 mL one within 80 days.

Can I Put Insulin in My Catโ€™s Food?
Answer

You should not put insulin in your catโ€™s food, because it will not be effective. Insulin should be injected using a syringe. Mixing it in your catโ€™s food, although not seen as harmful, will not be as effective. However, oral hypoglycemic drugs are currently being tested out. Although oral insulin administration is not as effective as injectable ones at the moment, perhaps a breakthrough will be seen sometime in the future.

Where Is the Best Place to Give a Dog an Insulin Shot?
Answer

The best place to give a dog insulin shots is just under the skin, and a couple of inches from the middle of its back. Ideally, the shoulder blade or hip bone will do. You should also change the location of the shot each time so that the skin does not feel sore.

What Happens if a Dog Misses an Insulin Shot?
Answer

Your dog might show mild signs of high blood sugar once again if it misses an insulin shot. Missing a single dose, however, is not life-threatening.

When Does Prozinc Insulin Peak?
Answer

Prozinc insulinโ€™s effect peaks after 5 to 7 hours. The duration of the action lasts 9 hours. That means you can inject insulin twice a day for your diabetic cats or dogs.

How Do I Use Prozinc?
Answer

Prozinc is injectable insulin that you have to administer through a U-40 syringe. You have to administer Prozinc either with or right after a meal. Roll the vial containing the Prozinc between the palms of your hand. After mixing, use the U-40 syringe to draw up the prescribed dosage. Then, you inject the insulin under your dogโ€™s or catโ€™s skin, either on the back of the neck or on the side.

"ProZincยฎ contains protamine zinc recombinant human insulin. "

Please call your veterinarian and refer to prescribing information. PROZINC is for use in cats and dogs only. Keep out of the reach of children. Avoid contact with eyes. In case of contact, immediately flush eyes with running water for at least 15 minutes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals. As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia is essential to attain and maintain adequate glycemic control and to prevent associated complications. Overdose can result in profound hypoglycemia and death. The most common adverse reactions were lethargy, anorexia, hypoglycemia, vomiting, seizures, shaking (dogs only), diarrhea, and ataxia. Many of the adverse reactions, such as lethargy, seizures, shaking (dogs only), and ataxia, are associated with hypoglycemia. The safety and effectiveness of PROZINC in puppies, kittens, or breeding, pregnant, and lactating animals has not been evaluated. PROZINC is contraindicated during episodes of hypoglycemia and in animals sensitive to protamine zinc recombinant human insulin or any other ingredients in PROZINC.

"USE OF A SYRINGE OTHER THAN A U-40 SYRINGE WILL RESULT IN INCORRECT DOSING. FOR SUBCUTANEOUS INJECTION ONLY. DO NOT SHAKE OR AGITATE THE VIAL. PROZINC should be mixed by gently rolling the vial prior to withdrawing each dose from the vial. Once mixed, PROZINC suspension has a white, cloudy appearance. Clumps or visible white particles can form in insulin suspensions: do not use the product if clumps or visible white particles persist after gently rolling the vial. Using a U-40 insulin syringe, the injection should be administered subcutaneously on the back of the neck or on the side of the cat. Always provide the Client Information Sheet with each prescription. The initial recommended PROZINC dose is 0.1 โ€“ 0.3 IU insulin/pound of body weight (0.2 โ€“ 0.7 IU/kg) every 12 hours. The dose should be given concurrently with or right after a meal. The veterinarian should re-evaluate the cat at appropriate intervals and adjust the dose based on both clinical signs and glucose nadirs until adequate glycemic control has been attained. In the effectiveness field study, glycemic control was considered adequate if the glucose nadir from a 9-hour blood glucose curve was between 80 and 150 mg/dL and clinical signs of hyperglycemia such as polyuria, polydipsia, and weight loss were improved. Further adjustments in the dosage may be necessary with changes in the catโ€™s diet, body weight, or concomitant medication, or if the cat develops concurrent infection, inflammation, neoplasia, or an additional endocrine or other medical disorder."

Store in an upright position under refrigeration at 36-46ยฐF (2-8ยฐC). Do not freeze. Protect from light. Use the 10 mL vial within 60 days of first puncture. Use the 20 mL vial within 80 days of first puncture.

http://www.prozinc.us/
For adverse events call: 1.866.638.2226

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

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