Amlodipine besylate may have slight negative inotropic effects, and therefore should be taken with great care when given to patients with heart failure or cardiogenic shock. Should only be given to patients with liver disease, pregnant, or at risk of hypotension, with caution. Possible contraindication in cases with aortic stenosis. Use with antihypertensives, beta adrenergic blockers, diuretics, or vasodilators may cause hypotension. Taking amlodipine besylate with protein bound drugs may cause an increased activity in both.