Side effects are frequently a result of chronic, subclinical overdosage.
Some dogs may develop polyuria and polydypsia. These dogs in particular may need a re-evaluation of their glucocorticoid status. Contact your veterinarian if your pet experiences increased thirst and urination, fluid accumulation in the limbs, weakness, or weight gain while being treated with fludrocortisone.
Fludrocortisone acetate and amphotericin B: increased likelihood of hyperkalemia.
Fludrocortisone acetate and potassium depleting diuretics (furosemide): increased possibility of developing hypokalemia.
Fludrocortisone acetate and aspirin: reduced salicylates levels.