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At a Glance
Treats behavioral disorders in dogs and cats, including depression, noise phobia, and obsessive-compulsive disorder
Can work on skin conditions caused by anxiety
Is a potent antihistamine


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At a Glance
Treats behavioral disorders in dogs and cats, including depression, noise phobia, and obsessive-compulsive disorder
Can work on skin conditions caused by anxiety
Is a potent antihistamine

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Doxepin is a prescription antihistamine and antidepressant drug commonly prescribed for cats and dogs. It falls within the class of tricyclic antidepressants and is the generic version of Sinequan. Veterinarians often prescribe Doxepin to manage allergies and skin conditions related to anxiety or nervousness in pets.

  • Medical Uses and Mechanism of Action:Doxepin is primarily prescribed for its antihistamine properties, which help alleviate itching and discomfort associated with allergies in pets. Allergies trigger the release of histamine, leading to itchy skin. By blocking histamine's effects, Doxepin provides relief from itching and related symptoms. Additionally, its antidepressant properties may help in managing behavioral issues linked to anxiety or nervousness in pets.

  • Administration and Dosage:Doxepin should be administered regularly as per the veterinarian's instructions. It works best if given before exposure to allergens or stressful situations. It may take several days or weeks to determine its effectiveness when used for behavior modification. It may be given with or without food, but it's crucial to follow the veterinarian's dosage guidelines precisely.

  • Potential Side Effects and Precautions:Common side effects of Doxepin in pets include sleepiness, dry mouth, and constipation. However, pet owners should be vigilant for signs of more serious adverse reactions such as abnormal bleeding, lack of appetite, seizures, collapse, or profound sleepiness. In case of any such symptoms, immediate veterinary assistance is necessary. Overdoses can be serious, so it's essential to keep Doxepin out of reach of children and other animals.

  • Additional Considerations:Ensure your pet has access to plenty of fresh water while taking Doxepin. It may be given alongside other antihistamines if the veterinarian deems it necessary. Pet owners should refrain from using flea collars on their pets without consulting a veterinarian, as interactions with Doxepin or other medications could occur.

Doxepin is an FDA-approved generic drug commonly used in veterinary medicine to manage allergies and related skin conditions in cats and dogs. Its dual action as an antihistamine and antidepressant makes it a versatile option for addressing both physical and behavioral symptoms in pets. However, pet owners should adhere strictly to the veterinarian's instructions and remain vigilant for any adverse effects or signs of overdose.

  • Behavior & Anxiety Management Pharmacy
  • Senior Life Stage
  • Oral Application
  • Cat Pet Type
  • Dog Pet Type

Doxepin Hydrochloride

Side effects include low blood pressure, high blood pressure, rapid heart rate, constipation, dry mouth, and blue-green urine. Doxepin should not be used in animals with known hypersensitivity or allergy to the drug, glaucoma or problems associated with urinary retention. Use with caution in seizure-prone animals.

Notify your veterinarian of other medications that your pet is taking. Drug interactions occur with monoamine oxidase inhibitors, thyroid medications, atropine sedatives, antihistamines, norepinephrine and phenytoin. The following drugs may increase the effects of doxepin: cimetidine (Tagamet) estrogens fluoxetine (Prozac) some sedatives enalapril verapamil and ranitidine (Zantac).

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Follow exact directions prescribed by veterinarian.

The usual dosage is 0.25 to 0.5 mg per pound (0.5 to 1 mg/kg) orally, every 12 hours, or 1.5 to 2.5 mg per pound (3 to 5 mg/kg) orally every 8 to 12 hours.

Keep in the container it came in, tightly closed, and out of reach of children. Store at room temperature and away from excess heat and moisture (not in the bathroom).

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

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