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At a Glance
Credelio provides fast-acting protection that works hard all month long.
Small, beef-flavored tablet.
Credelio acts fast to protect puppies and dogs* against ticks and fleas.
Kills 100% of fleas in 12 hours and stays effective throughout the entire month.


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At a Glance
Credelio provides fast-acting protection that works hard all month long.
Small, beef-flavored tablet.
Credelio acts fast to protect puppies and dogs* against ticks and fleas.
Kills 100% of fleas in 12 hours and stays effective throughout the entire month.

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Elanco Animal Health Logo

The Comprehensive Guide To Credelio

What Is Credelio?

Fleas and ticks are a perennial problem for dog owners. These pesky parasites can cause severe problems in your dog, and getting rid of them should be your number one priority. Credelio for dogs is an innovative solution of chewable tablets that protects your dog from an infestation every month!

Why Should Getting Rid of Ticks and Fleas Be a Priority for Dog Owners?

Many dog owners think of ticks and fleas as the doggy equivalent of lice. Unfortunately, ticks and fleas are far more problematic than lice because of the many diseases they carry. Your dog can get tularemia, Rocky Mountain Spotted Fever, Lyme disease, Murine Typhus, Tick Paralysis, and more!

Fleas carry tapeworms that can infect not only your dog but any other dogs or cats and even humans in the area! Severe infestations can result in anemia, which causes tissue damage and can be fatal if left untreated. Cat's Ehrlichia and Haemobartonellosis are caused by ticks and fleas.

Ehrlichia damages your dog's blood cells, while Haemobartonellosis can need the removal of the spleen for treatment. Finally, if your dog is already allergic to other things, then they are predisposed to develop Flea Allergic Dermatitis.

This condition occurs when your dog develops an allergy to the saliva of fleas. It can result in itching, infections, and it can lower your dog's immunity. Ticks and fleas can transfer many of these diseases to your human family.

How Does Credelio Work?

The active ingredient in Credelio flea and tick medication is called Lotilaner. Lotilaner is a novel isoxazoline, an approved drug that rapidly kills ticks and fleas. This medication is absorbed into your dog's bloodstream and starts to work within two hours. You can see fleas dying as fast as four hours after giving your dog these tablets.

Credelio for dogs kills 99 % of fleas within eight hours for over a month. You can see ticks start to get killed in four hours after you give your dog this medication. When these parasites bite into your dog's skin, they get a dose of this medicine along with blood, which kills them. Lotilaner stays in your dog's system for 35 days.

How Many Credelio Flea and Tick Tablets Should I Give My Dog?

You have to provide Credelio flea and tick tablets according to your dog's weight. There are different dosage packs available that cater to varying weights of dogs. You can use the following guideline:

Your Dog's Weight Dosage of Lotilaner Box's Color # of Tablets
4.4 - 6 lbs 56.25 mg Yellow One tablet
6.1 - 12 lbs 112.5 mg Pink One tablet
12.1 - 25 lbs 225 mg Orange One tablet
25.1 - 50 lbs 450 mg Green One tablet
50.1 - 100 lbs 900 mg Blue One tablet

Choose the correct color box for your dog's weight, and give them one tablet every month. Don't try to estimate the dosages yourself if you bought the wrong box or if you have dogs of different weights. If you have any other questions about dosage, you should contact your veterinarian.

Are There Any Credelio Side Effects?

When you give your dog Credelio flea and tick medication, you might notice some mild side effects like vomiting, diarrhea, an increase in urine output, and a decrease in food intake. While these side effects are mild, if they become worse over time, you need to contact your vet.

However, if your dog totally stops eating, experiences any tremors or seizures, has difficulty walking, or has vomiting that doesn't stop, then you should contact your vet immediately.

Are There Any Precautions I Should Take When Giving Credelio Flea and Tick Tablets to My Dogs?

You should only give Credelio flea and tick tablets to dogs who are more than two months old and weigh more than 4.4 pounds. Avoid giving these tablets to pregnant or lactating mothers. Ensure your dog eats all of these chewable tablets so that they get the full dose of the medicine.

You should make sure that you give your dogs these medicines after food, or with food. This will help to minimize any stomach issues they might experience.

Frequently Asked Questions
  1. Can I Give This to My Cat?

    You should not give Credelio for dogs to cats. Cats need different dosages for medicines as their physiology is different from canines. If you want to protect your cat from ticks and fleas with monthly medication, you should look up Credelio for cats.

  2. Does This Need a Prescription?

    Yes, you need a vet's authorization if you want to purchase Credelio for dogs. You should only administer Credelio flea and tick medication under a vet's supervision. Please remember that prescriptions can expire, and you may need to contact your vet for a fresh one.

  3. Does Credelio Contain Any Allergens?

    While this medication is beef-flavored, it does not contain any actual beef. However, it does contain pork liver, soy, barley, wheat, and lactose. If your dog is allergic to any of these items, you need to speak with your vet before giving your dog any medication. Additionally, these tablets are gluten-free.

  4. What if My Dog Doesn't Eat These Tablets?

    There have been trials that have been conducted showing that Credelio flea and tick medication was accepted by 94 % of dogs when offered by hand. The 6% of dogs who did not eat this when offered by hand ate it when placed in their mouths. Thus it is highly unlikely that your dog will not eat these tablets.

  5. How Should I Store Credelio Flea and Tick Tablets?

    Credelio flea and tick tablets come packaged in blister packs. Keep them stored at room temperature in a cool, dark place away from extreme temperatures. You should store the tablets in the blister packs until you need them. There have been no studies on how long these tablets last outside the packaging.

  • Elanco Animal Health Brand
  • Flea & Tick Pharmacy
  • Elanco Animal Health Manufacturer
  • Dog Pet Type

Do you need a prescription for Credelio?

Yes, Credelio is a veterinarian medication that requires a prescription for purchase. The Credelio chewable tablets are prescription tick and flea medicine designed to act swiftly and kill all fleas and ticks on your dog. Once administered, the medication can hold off any tick for one month, adult or otherwise. The active ingredient in Credelio is Lotilaner, which is a member of the isoxazoline family. It's a novel class of parasiticides, targeting the nerve receptors of ticks and fleas for effective protection. According to the brand, Credelio starts acting in just four hours and terminates almost 99 percent of the infestation within eight hours for the next 35 days.

Is Credelio safe for dogs?

Credelio is an FDA-approved medication to treat the infestation of ticks and fleas on dogs. The drug is intended for veterinary use in dogs at least 8 weeks of age and weighs 4.4 pounds or greater. These are the conditions to ensure that Credelio is safe for usage. However, how safe the medication is actually depends on the dog itself. Breeding, pregnant, and lactating dogs will be at risk when Credelio is administered. It's best to consult your veterinarian to discuss the safety of the dog. The reasons mentioned above are not the only instances where it would be unsafe to give Credelio. Your vet will be able to check up on your dog and suggest whether or not it's safe to give Credelio.

Does Credelio kill flea eggs?

Credelio is designed to act on adult fleas. According to the brand, the medication was reported to have killed all fleas on dogs within 12 hours of dosing and offer protection up to 35 days. This result was obtained as part of a speed-of-kill study undertaken by the brand. Bear in mind that an adult female flea starts laying eggs within 24 hours of biting the dog. Considering that the medication works swiftly and eliminates all adult fleas within 12 hours of administration, and is effective for the entire month, Credelio kills fleas before they can even lay eggs. However, pet parents need to be swift and give the medication as soon as they notice ticks on their dog's body.

Does Credelio prevent Lyme disease?

Credelio comes formulated as palatable chewable treats and thus is easy to administer. Dogs also love the medication because of its palatability, but it is advised to administer it with a meal to avoid any gastrointestinal tract upsets. The medication works within 12 hours and kills all adult fleas for 35 days. The swift action of the medicine helps prevent flea infestation as well as tick infestation in dogs. It covers ticks like a black-legged tick, lone star tick, American dog tick, and brown dog tick. Some of these ticks spread diseases like Rocky Mountain Spotted fever, Anaplasmosis, and Lyme disease. By eliminating the tick infestation, Credelio also helps prevent these diseases effectively.

What happens if you give your dog too much Credelio?

Credelio has been tested rigorously and approved by many regulatory authorities worldwide, including the FDA, for use on dogs. It has been deemed safe to use on healthy dogs. However, as is the case with all medications, overdosing on Credelio might result in some health discomfort for your dog. These include critical weight loss, elevated blood urea nitrogen (BUN), increased urination, and diarrhoea. If your dog has consumed more than the recommended dosage of the Credelio and is showing any of the above symptoms, consult your vet immediately.

Is Credelio the same as NexGard?

Credelio and NexGard are both FDA-approved medications for eliminating fleas and ticks on dogs. The main difference is that Credelio's active ingredient is Lotilaner, whereas NexGardโ€™s is Afoxolaner. This also affects the time taken to eliminate the fleas by these medications. Credelio starts acting within four hours and eliminates all annoying pests within 12 hours. On the other hand, NexGard also starts working in four hours but takes 24 hours to eliminate all fleas.

Is Credelio better than Trifexis?

Trifexis and Credelio are both manufactured by Elanco and are effective against flea infestation. However, Trifexis with Spinosad and Milbemycin Oxime as its active ingredient is also effective against roundworm, hookworm, and whipworm but not against ticks. It can kill all biting fleas within four hours of administering. Credelio, on the other hand, is effective only against fleas and ticks. It's guaranteed to kill all fleas within 12 hours and 98.7 percent of fleas in eight hours. In case your dog has only fleas or ticks, Credelio should be your preferred medication. For dogs with more issues like heartworm, roundworm, and more along with fleas, Trifexis should be the way to go.

Can I give Credelio and Heartgard together?

Credelio and Heartgard are both oral medications administered once a month. The former can be administered to dogs above eight weeks of age and a minimum of 4.4 pounds; Heartgard is safe to use on dogs above six weeks of age. Heartgard is a medication that uses Pyrantel Pamoate and Ivermectin to protect against roundworms and hookworms. The drug is safe for use on pregnant and breeding female dogs. Credelio, on the other hand, uses Lotilaner to kill fleas quickly and is not safe to use on breeding, pregnant, or lactating dogs. These are two different medications with different courses of action. Your vet might suggest taking them both together for complete protection against parasites.

Is Credelio toxic to humans?

No, Credelio is not toxic to dog parents. Lotilaner, the active ingredient of Credelio, has been reported to have no severe reaction in humans. The medication is not irritant to the skin, might cause mild irritation in the eyes, and cannot induce skin sensitisation.

Do flea and tick chewable work?

Yes, flea and tick chewable can be effective in controlling and preventing infestations of fleas and ticks in dogs and cats. These chewable medications are designed to be orally administered to pets, and they work by releasing active ingredients into the bloodstream that kill or repel fleas and ticks when they bite the animal. Flea and tick chewable typically contain ingredients such as lotilaner, afoxolaner, fluralaner, or isoxazoline compounds, which are insecticides that target the nervous systems of fleas and ticks. When the fleas or ticks bite the treated pet, they are exposed to these active ingredients, leading to their death. These chewable medications are often preferred by pet owners because they are easy to administer and provide long-lasting protection. They can be more convenient compared to topical treatments, as there is no need to apply any liquids or spot-on treatments to the pet's skin.

What is the safest tick prevention for dogs?

The Natural Resources Defense Council (NRDC) is an environmental advocacy group that promotes the use of safer and less toxic alternatives for pest control, including tick prevention for pets. S-methoprene and pyriproxyfen are two such ingredients that are commonly used in certain tick-prevention products. S-methoprene and pyriproxyfen belong to a class of insect growth regulators (IGRs). These compounds work by disrupting the normal growth and development of insects, including ticks. They target the immature stages of ticks, preventing them from maturing into adults and reproducing. This can help reduce the overall tick population and prevent infestations. IGRs like s-methoprene and pyriproxyfen are considered to have low toxicity to mammals, including dogs. They have a targeted mode of action and are designed to affect the biology of insects rather than mammals. This makes them relatively safe for use in tick prevention products for dogs.

How do you permanently kill ticks?

Use tick control products that are specifically designed to kill ticks on your pets. These can include oral medications, topical treatments, tick collars, or sprays. Consult with your veterinarian to determine the most suitable and effective tick control method for your pet. Ticks can also be present in your home and yard, so it's important to address these areas. Vacuum your home thoroughly, paying particular attention to areas where your pet spends time. Wash your pet's bedding regularly in hot water. For outdoor areas, keep grass and vegetation trimmed, remove leaf litter, and create a barrier between wooded areas and your yard if possible. In severe infestations or if you're unable to control ticks on your own effectively, it may be necessary to seek professional pest control services. They can help identify the extent of the infestation and implement appropriate measures to eliminate ticks from your property.

Are flea collars better than pills?

Flea collars can be a suitable choice for pet owners who prefer not to follow a monthly schedule for topical applications or oral medications. Flea collars are designed to provide long-lasting protection, typically ranging from several months up to 6 to 8 months, as you mentioned. This extended duration can be convenient for pet owners who want continuous flea protection without frequent application or administration. Flea collars work by releasing active ingredients onto the pet's fur and skin, creating a protective barrier against fleas and, in some cases, ticks. The active ingredients in the collar gradually disperse over time, providing sustained effectiveness against these parasites. Flea pills are designed to work systemically, meaning the active ingredients are absorbed into the bloodstream and circulate throughout the pet's body. This allows for comprehensive coverage, ensuring that fleas are killed wherever they may be on the pet's body. In contrast, flea collars primarily provide localized protection around the neck and head area. Some flea pills can start killing fleas within hours of administration, providing quick relief for pets suffering from flea infestations. This can be particularly beneficial if you need rapid control of fleas in your home or if your pet is experiencing intense itching or discomfort. Some pets may have sensitivities or adverse reactions to the materials used in flea collars, such as skin irritation or allergies. With flea pills, you don't have to worry about any potential discomfort or negative reactions associated with wearing a collar. Flea pills typically have a monthly dosing schedule, but there may be options available that offer extended protection for up to three months. In some cases, a combination of different flea control methods, such as using a flea collar in conjunction with periodic flea pills, may provide the most comprehensive and effective protection against fleas and other parasites.

How long do flea chewable last?

The duration of effectiveness for flea chewable can vary depending on the specific product and active ingredient used. However, most flea chewables are designed to provide protection against fleas for a month. They typically contain active ingredients that are released into the bloodstream after ingestion, killing fleas when they bite and feed on your pet. Some flea chewable may also provide additional benefits, such as killing ticks or preventing other types of parasites. However, the duration of effectiveness against these parasites may vary, so please check the product label or consult with your veterinarian for specific information.


Potential side effects of Credelio can include weight loss, elevated blood urea nitrogen (BUN), polyuria (excesssive urination), and diarrhea. Use with caution in dogs with a history of seizures. Credelio is only for oral use in dogs.

Credlio must be adminstered with food or 30 minutes after feeding. Administer the appropriate dosage monthly based on your pet's weight. Your veterinarian will determine that correct dose of Credelio for your pet.

Store at 59-77 degrees Fahrenheit.

Credelio is manufactured by Elanco Animal Health
Option UPC/SKU
4.4 - 6.0 lbs, 6pk 727804353858
6.1 - 12.0 lbs, 6pk 727804354855
12.1 - 25.0 lbs, 6pk 727804355852
25.1 - 50.0 lbs, 6pk 727804356859
50.1-100 lbs, 6pk 727804357856

How to Order Prescriptions Online

1. Find the Right Product

Make sure it matches your pets prescription. Donโ€™t forget to compare the dosage for pills/capsules!

2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

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Works Great

Jeff B recommends this item.
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It Works

Credelio was prescribed by my dogs' veterinarian to control fleas. It truly works! All four of my dogs have been flea free since they started this medicine, 3 months now. It works better than the Advantage topical solutions. I highly recommend.

flower4flor recommends this item.
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Quick and Reliable

Quick and reliable service and the credlio has worked wonder for my dog.

Mackieboy recommends this item.
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