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At a Glance
Clomipramine Hydrochloride is a tricyclic antidepressant that restores hormone (e.g., serotonin) balance in the brain
Treats obsessive compulsive disorder (OCD), separation anxiety, excessive barking, aggressive and destructive behavior, inappropriate elimination, and other anxiety-related behaviors
Oral, beef-flavored tablet given twice daily
Observe therapeutic effects in just two weeks


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At a Glance
Clomipramine Hydrochloride is a tricyclic antidepressant that restores hormone (e.g., serotonin) balance in the brain
Treats obsessive compulsive disorder (OCD), separation anxiety, excessive barking, aggressive and destructive behavior, inappropriate elimination, and other anxiety-related behaviors
Oral, beef-flavored tablet given twice daily
Observe therapeutic effects in just two weeks

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Ultimate Guide to Clomicalm

Meet the Canine Behavioral Conditioner: Clomicalm!

Clomicalm is an FDA-approved, veterinarian-recommended, prescription anti-depressant for dogs. Clomicalm is intended to treat separation anxiety, obsessive compulsive disorder (OCD), and other undesirable behavioral conditions in dogs. Use Clomicalm as a behavior modification tool to calm your dog in stressful situations.

How does Clomicalm work?

Clomicalm is a medication with one active ingredient - Clomipramine Hydrochloride.

Clomipramine Hydrochloride is a tricyclic antidepressant that works by restoring the balance of certain natural substances in the brain, including the happy chemical or feel good hormone serotonin. Clomipramine for dogs is the first FDA-approved generic substance that treats separation anxiety and any behavioral condition in dogs.

The prescription drug Clomicalm, a generic alternative for Anafranil, eliminates certain undesirable behavioral issues in dogs, including separation anxiety, OCD, excessive barking, aggressive or destructive behavior, and eliminating (urination or defecation) at inappropriate times. Most importantly, Clomicalm aids your dog in stressful situations.

How is Clomicalm administered?

Clomicalm is administered twice daily with food and lots of water. Your licensed veterinarian will prescribe the exact dosage and other specifications prescribed by your veterinarian. The usual dosage is with one to two mg per pound. Clomicalm are oral, beef flavored tablets and capsules of the active ingredient Clomipramine Hydrochloride.

The tablets come in 20 mg (blue), 40 mg (purple), and Clomicalm 80 mg (green) of Clomipramine Hydrochloride, and the dog is administered which tablet depending on their bodyweight. See the dosage chart below.

Body Weight

20 mg

40 mg

80 mg

11 - 22 lbs.


22.1 - 44 lbs.


44.1 - 88 lbs.


88.1 - 176 lbs.


What are Clomicalm side effects of which you should be aware?

Clomicalm may cause drowsiness.

Stop giving the medication Clomicalm and contact your vet if the pet experiences difficulty breathing, hives, irregular heartbeat, difficulty urinating, seizures, fever with increased panting, muscle stiffness or weakness, or swelling of the lips, tongue, or face.

Frequently Asked Questions 

What is Clomicalm used for in dogs?

Clomicalm is used to calm dogs that are feeling stressed due to some reason. It is somewhat of a behavior modification tool that can help your pet dog calm down.

Clomicalm tablets are used to treat separation anxiety in dogs. This particular medication is also used to treat behavior disorders in dogs. Be it anxiety-related, or destructive behavior in general, Clomicalm tablets can help your dog regain composure and calmness.

What does Clomicalm do for a dog?

Clomicalm relieves anxiety in dogs by restoring hormonal balance in their brains.

Clomipramine hydrochloride is a key component in Clomicalm. The name Clomicalm comes from the words clomipramine and calm meaning that it is a medicine for calming down dogs. Clomipramine hydrochloride is an antidepressant that helps promote the secretion of serotonin in the brain. This serotonin is a happy or feel-good chemical. It helps to get rid of the anxiety and calm your dog.

Clomicalm does the following things for your dog

  • Helps get rid of undesirable behavioral problems or characteristics like OCD or separation anxiety
  • Stops them from barking excessively
  • Makes them less aggressive
  • Calms them down whenever they are stressed

How long does it take for Clomicalm to work in dogs?

It can take almost eight weeks to understand whether or not Clomicalm is working for your dogs.

The impact of some medications cannot be understood instantaneously. Clomicalm is one of those medications. Unlike painkillers, you cannot see them at work right away. It needs a few weeks before you can determine whether or not your dog's anxiety or stress-related problems have been solved or not.

Can I use Clomicalm for a dog being scared of thunder?

Yes, you can use Clomicalm for a dog that is scared of thunder or fireworks.

Dogs being afraid of loud noises is a natural thing. Loud noises trigger their nervous system, and they end up feeling anxious or afraid. So to tackle this anxiety, you have to administer the Clomicalm tablets to your dogs. That way, they can remain calm even in stressful situations like a thunderstorm.

Apart from the medicine, you also need to ensure the safety of your dog during a storm. When the rumbling of the thunder grows stronger, try to suppress it with sounds from the TV or music.

Is Clomicalm the same as Prozac?

Yes, Clomicalm is the same as Prozac.

Prozac is used to treat anxiety. It does so by making sure that the brain does not reabsorb the naturally produced serotonin. As a result, the serotonin stays and ensures that the individual is in a good mood. Prozac is somewhat of a mood regulator as it helps maintain a serotonin balance in the brain, which in turn results in a less anxious mind.

Clomicalm does the same thing, except it enables the secretion of serotonin to maintain balance.

Does Clomicalm cause drowsiness?

Yes, Clomicalm does cause drowsiness. It is one of the few side effects this prescription medication has on dogs.

It is natural for prescription drugs to have side effects. Clomicalm is not an exception to this rule. It too, like many other dog medications, has certain side effects. When you keep giving your dog Clomicalm, see if it feels drowsy all the time or not. You can notice it by observing how active your dog has been lately. It will not be sleeping all the time, but will simply appear a bit fatigued.

Although it is not a concern, you can still consult with your vet to make sure everything is okay.

Can you stop Clomicalm?

Yes, you can stop Clomicalm, but not abruptly. Consult with your vet, and ask them to handle the stoppage. They will lower the dosage in an organized manner making it easier for you to gradually cut off the Clomicalm administration. It is as if you were releasing fish in a water tank; you cannot just release them in the water. You need to do so gradually.

You should stop giving your dog Clomicalm if it is having difficulty in breathing, has an irregular heartbeat, seizures, fever, weakness, swelling of the face, or muscle stiffness. Immediately consult your veterinarian for further advice afterward.

Does Clomicalm work for cats?

Yes, Clomicalm will work for cats.

However, do not give it to them without seeing a vet first. Since it is a prescription drug, you need to maintain every bit of caution necessary when it comes to using it.

Is Clomicalm a TCA?

Yes, Clomicalm is a TCA tricyclic antidepressant. It is used to handle issues related to stress, anxiety, and destructive behaviors in dogs. TCAs work by increasing the amount of serotonin in the brain.

Can traZODone be taken with Clomicalm?

No, traZODone should not be taken with Clomicalm unless specifically prescribed by the vet.

Using the two medications together can lead to serotonin syndrome, where the dog may suffer from confusion, seizure, hallucinations, etc. So it is best to avoid using these two together.

Can a dog overdose on Clomicalm?

Yes, dogs can overdose on Clomicalm.

A Clomicalm overdose can lead to a decrease in activity. Your dog will start trembling. Under extreme overdose conditions, their eyes might become droopy.
Concluding Thoughts

The most important thing that you should know about Clomicalm is its power to be effective treatment for undesirable behavioral issues in your dogs, such as separation anxiety, aggressive and destructive behavior, and other anxiety-related issues. Clomicalm is the advocate to calm your dogs in stressful situations.

DISCLAIMER: FDA law restricts Clomicalm only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian whether Clomicalm is suitable for your dog. Ask your licensed veterinarian to prescribe an exact dosage and other specifications prescribed for your dog.

Clomicalm 40mg has been discontinued by the manufacturer. Please speak to your Veterinarian about a different dosage.

Clomicalm is the Generic Alternative to Anafranil.
  • Elanco Animal Health Brand
  • Behavior & Anxiety Management Pharmacy
  • Care Wellness Philosophy
  • Clomicalm Pharmacy Brands
  • Anxiety Behavior Issues
  • Compulsive Behavior Behavior Issues
  • Aggression Behavior Issues
  • Separation Anxiety Behavior Issues
  • Ivermectin Sensitivity Allergies
  • Prescription Pharmacy Type
  • Behavior, Destructive Symptom
  • Elanco Animal Health Manufacturer
  • Senior Life Stage
  • Kitten Life Stage
  • Oral Application
  • Dog Pet Type

Can Clomicalm cause vomiting in dogs?

Yes, Clomicalm (clomipramine hydrochloride) is known to cause vomiting as a side effect in dogs. Vomiting is listed as a common side effect of Clomicalm in dogs in the prescribing information provided by the manufacturer. If your dog is experiencing vomiting or any other side effects while taking Clomicalm, it's important to contact your veterinarian right away to discuss the best course of action.

Can Clomicalm cause changes in appetite in dogs?

Yes, dogs can have changes in appetite as a side effect of taking Clomicalm (clomipramine hydrochloride). In dogs receiving Clomicalm, both increased and decreased appetite have been noted. The manufacturer's prescribing instructions for Clomicalm in dogs list changes in appetite as a frequent side effect. However, it's crucial to get in touch with your doctor if you observe any changes in your dog's appetite while they are taking Clomicalm to discuss any worries and decide on the best course of action.

Can Clomicalm cause changes in behavior in dogs?

Yes, dogs that take the drug Clomicalm (clomipramine hydrochloride) may exhibit behavioral changes as a side effect. The drug Clomicalm is generally used to treat separation anxiety in dogs, but it also has the potential to have an impact on other behaviors. While on Clomicalm, some dogs could become more sluggish or sleepy, while others might become more lively or anxious.

Can Clomicalm cause allergic reactions in dogs?

Yes, Clomicalm (clomipramine hydrochloride) can cause allergic reactions in dogs, although this is a rare side effect. Swelling of the face, lips, tongue, or neck, breathing problems, hives, or excruciating itching are all indications of an allergic response.

Can Clomicalm be used for long-term anxiety management in dogs?

Clomicalm (clomipramine hydrochloride) can be administered in dogs for long-term anxiety treatment. Dogs with separation anxiety are treated with Clomicalm since it is a chronic illness that frequently needs continuous treatment. It can take several weeks or even months for Clomicalm to take effect, and the medication may need to be continued for an extended period of time to maintain its effectiveness. However, the use of Clomicalm for long-term anxiety management in dogs should always be supervised by a veterinarian, who can monitor the dog's response to the medication and adjust the dosage as needed.

How can I tell if my dog is experiencing anxiety-related behaviors that could benefit from Clomicalm?

Different anxiety-related behaviors that dogs could have may be treated by Clomicalm therapy. Anxiety at being alone, excessive barking or wailing, destructive behavior, improper elimination (urinating or defecating inside the home), pacing or restlessness, and aggression toward people or other animals are a few examples. It is critical to speak with a veterinarian if you detect any of these behaviors in your dog and think they might be caused by anxiety.

Is behavioral modification training necessary while using Clomicalm for anxiety management in dogs?

Yes, behavioral modification training is often necessary while using Clomicalm (clomipramine hydrochloride) for anxiety management in dogs. Clomicalm is a medication that can help to reduce anxiety symptoms in dogs, but it is not a cure for anxiety. Behavioral modification training, which involves working with a professional trainer or behaviorist to modify your dog's behavior and teach them coping skills for managing anxiety, is an important component of long-term anxiety management in dogs.

Can Clomicalm be used to manage aggression in dogs?

While Clomicalm (clomipramine hydrochloride) may be effective in reducing aggressive behavior in some dogs, it is not specifically indicated for the treatment of aggression and is not recommended as a first-line treatment for this behavior problem.

Can Clomicalm be used to treat obsessive-compulsive disorders in dogs?

Yes, Clomicalm (clomipramine hydrochloride) can be used to treat obsessive-compulsive disorders (OCD) in dogs.

Can Clomicalm be used to treat noise scare in dogs?

Yes, Clomicalm (clomipramine hydrochloride) can be used to treat noise phobias in dogs. Noise phobia is a common condition in dogs that is characterized by an excessive fear of loud noises such as fireworks, thunderstorms, or gunshots. Clomicalm is an antidepressant medication that can help to reduce anxiety and fear in dogs. It works by increasing the availability of certain neurotransmitters in the brain, which can help to regulate the dog's response to stress and fear-inducing stimuli.

Can Clomicalm be given with other medications?

Yes, but under the close watch of a vet. It is important to consult with a veterinarian before giving Clomicalm (clomipramine hydrochloride) with other medications. Clomicalm can interact with other medications, and it is important to ensure that it is safe to give Clomicalm with any other medications that your dog may be taking. In particular, Clomicalm should not be given with monoamine oxidase inhibitors (MAOIs) or other tricyclic antidepressants, as this can increase the risk of side effects such as seizures, tremors, and hypotension. Clomicalm may also interact with certain medications that affect liver function, as it is metabolized by the liver.

Clomipramine Hydrochloride


This tricyclic antidepressant medication helps to tackle behavioral problems in cats and dogs. The medication intake happens orally as per a prescribed dosage to treat behavioral issues of the pets. It is a prescription drug that can help tackle obsessive-compulsive behavior, dominance aggression, or separation anxiety among pets. In cats, it can specifically help to take care of using marking or spraying and reduce inter-cat aggression.



The use of the medication happens in the pads to control separation anxiety and help provide behavior modification. It also helps tackle destructive behavior, inappropriate aggression, defecation, and inappropriate urination.ย 

Special Precautions

The use of the drug should not happen in their pets that have an allergy to Clomipramine. The same applies to any other tricyclic antidepressants. If any monoamine oxidase inhibitors are currently used, this medication should not be given to your pet. It is advisable to avoid the medicine if your pet is aging and if they have a history of seizures. Breeding males should also avoid this medication, and caution is advisable for the pets.

Giving medication to pets that have a prevailing condition should happen cautiously. These conditions can include glaucoma, aggression, overactive thyroid, decreased gastrointestinal movement, dry eye syndrome, difficulty urinating, adrenal tumors, heart disease, diabetes, and liver disease. Caution is also advisable for lactating and pregnant pets that are old or very young.

Mechanism of Action

The elevated neurotransmitter serotonin due to the action of clomipramine in the brain helps trigger a different response and tackle the issues. The class of medication gets classified as a tricyclic antidepressant because it is a tree rings structure that can affect several neurotransmittersโ€”the compound serotonin links to a feeling of happiness and comfort. The action of the drugs innovates the removal of serotonin in the brain to keep it for longer.

Known Drug Interactions

Caution is advisable for administering the medication with other drugs, including NSAIDs, antifungals, sympathomimetic agents, butyrophenone antipsychotic agents, anticholinergic agents, and monoamine oxidase inhibitors. Alteration of blood glucose levels also takes place after starting this medication.

Brand/Generic Equivalents


Clomipramine has several adverse side effects such as lethargy/depression, elevation in liver enzymes, vomiting, diarrhea, and increased thirst. Clomicalm may cause drowsiness. Stop giving your pet Clomicalm and contact your vet if the pet experiences difficulty breathing, hives, irregular heartbeat, difficulty urinating, seizures, fever with increased panting, muscle stiffness or weakness, or swelling of the lips, tongue, or face.

Clomipramine is not authorized to be used in breeding dogs. Attention should be paid to breeding dogs suffering from cardiovascular dysfunction, epilepsy, narrow angle glaucoma, reduced gastrointestinal motility or urinary retention. Clomipramine should be prescribed with extreme care, only after making a true assessment of the benefit and the risks associated with the medication. Clomipramine is not advisable when consumed in combination with monoamine oxidase inhibitors. Never use Clomipramine or any other tricyclic antidepressants in animals that are allergic to it. Do not use Clomipramine in pregnant, nursing or breeding females, or with other central nervous system (CNS) depressants such as barbiturates. Inform the veterinarian about what other medications the pet is taking.

Clomicalm is a tricyclic antidepressant, which is used in the treatment of dogs suffering from separation anxiety. Clomipramine, FDA approved for human use, is used to treat aggression and obsessive-compulsive disorders such as tail chasing. Clomipramine hydrochloride blocks the reuptake of neurotransmitters. Clomipramine is prescribed in the treatment of separation-related disorders symptomized by destruction and inappropriate defecation and urination. Clomipramine is also used for the control of stereotypies in dogs and in urine spraying in cats

Clomipramine is administered orally at a usual dose of 1 - 2 mg/kg, clomipramine twice daily to give a total daily dose of 2 - 4 mg/kg. The medicine is available in oral, beef flavored tablets of 3 strengths: Clomicalm 5, 20 and 80 containing 5.00 mg, 20.00 mg and 80.00 mg clomipramine hydrochloride, respectively. Clomipramine is available by prescription in the form of tablets and capsules. The usual dosage of Clomipramine in dogs is 0.9-1.8mg/pound every 24 hours.

Administer Clomicalm to the exact specifications prescribed by veterinarian. Give Clomicalm orally with food and lots of water.

Dogs: Weight / Dosage

11-22 Lbs / One 20mg tablet daily
22.1-44 Lbs / One 40mg tablet daily
44.1-88 / One 80mg tablet daily
88.1-176 / Two 80mg tablets daily

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

Clomicalm is manufactured by Elanco Animal Health

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