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At a Glance
Treats certain cancers in dogs and cats
Also used in some immune mediated conditions
May help to reduce severity and spreading of the disease


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At a Glance
Treats certain cancers in dogs and cats
Also used in some immune mediated conditions
May help to reduce severity and spreading of the disease

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Comprehensive Guide To Leukeran For Cats and Dogs

What Is Leukeran?

Leukeran is the brand name of the drug, called Chlorambucil. It is a medicine that suppresses the immune system and is used in the treatment of cancers like lymphoma, leukemia, multiple myeloma, and more.

What Causes Cancer in Dogs and Cats?

Cancer is a tricky illness. It can be a genetic disorder, or it can be caused by environmental issues. While the exact cause of the relationship between old age and cancer remains unclear, many vets have observed that dogs and cats have an increased tendency to develop cancer when they are older.

Just like in humans, if your dog or cat has had cancer in their family, they are more likely to develop cancer themselves. Some breeds of dogs like Golden Retrievers, Bernese Mountain Dogs, Rottweilers, and Boxers are predisposed to getting cancer. Additionally, there are environmental factors that increase the chances of your pet getting cancer.

These environmental factors are excessive exposure to the sun's UV rays, second-hand tobacco smoke, extreme smog, and air pollution. All contribute to the formation of cancer cells in your cat or dog. The risk of cancer increases if your cat or dog is exposed to pesticides, insecticides, or herbicides that are frequently used in agriculture.

There are a few substances around the house or home environment that are carcinogenic. These substances are uranium, radon, vinyl chloride, nickel, benzidine, cadmium, and asbestos. Not only is asbestos carcinogenic for your dogs and cats, but it is highly hazardous for humans as well!

Cancer can be transmitted during sexual intercourse. If you mate your dog, make sure their partners are checked for canine transmissible venereal tumors. Some viruses can cause cancer in cats and dogs.

What Are Some Symptoms of Cancer in Dogs and Cats?

There are so many different types of cancers that it can be challenging to find specific symptoms that are unique to only cancer. However, some signs that you can look out for. If there are any lumps or growths on your dog or cat that were not there before, you should get it checked out by a vet.

Oddly enough, ear infections and teary eyes can be symptoms of tumors. Growths on your pet's mouth area, including inside the mouth like on the tongue, can be symptoms of oral cancer. The development of cancer can cause behavioral changes. Your cat or dog can become irritated or fearful and shun contact.

Unfortunately, many of these symptoms overlap with other medical conditions. If you suspect your dog or cat has cancer, the surefire way to get an answer will be at the vet.

How Does Leukeran Help?

Chlorambucil is typically used to treat the painful symptoms of chronic lymphocytic leukemia and malignant lymphomas. This includes Hodgkin's disease, lymphosarcoma, and giant follicular lymphoma. Vets can use Leukeran for cats to treat inflammatory bowel disease (IBD).

Leukeran helps to ease symptoms like polydipsia, polyuria, persistent fever, bruising, and enlarged lymph nodes.

Leukeran is not considered a cure for cancer. However, while they get treatment to rid themselves of cancer, Chlorambucil can increase the quality of life for your pet.

What are the precautions I should take before giving Leukeran to my pets?

You should determine if your cat or dog has any resistance to Chlorambucil before starting this medication. Additionally, you should not give Leukeran to pets who have had adverse reactions to this medicine before.

If your dog is on any other long term medication, you should go over the list with your vet before starting your pet on Leukeran. This includes supplements and vitamins, as your vet knows which drugs or conditions can affect the efficiency of Leukeran.

Are There Leukeran Side Effects I Should Know?

Most drugs that treat severe conditions come with a few side effects. When you give your pet Leukeran, you might notice that the severity of the side effects peak a week or two after you start the initial dose. Reviews say that the severity tapers off after that.

In dogs, you might notice your furry friend's fur is becoming sparse, and it looks very different from before. The coat becomes dull and patchy. Usually, this is a minor side effect that does not need further intervention. Some side effects indicate a severe problem.

These include a loss of appetite, difficulty breathing, twitching in the eye or face, bleeding, vomiting, bruising, and diarrhea. Along with this, if your pet experiences any seizures or epileptic episodes, you need to contact your vet immediately.

Frequently Asked Questions
  1. Does This Need a Prescription?

    Yes, Leukeran is a prescription medication. Because it is used to alleviate the symptoms of cancer, you should never administer it on your own. If you think your cat, dog, or horse has cancer, you should contact your vet for confirmation and treatment.

  2. Can This Be Used on Other Animals?

    Vets commonly use Leukeran for extra-label use in dogs, cats, and horses. If you have exotic pets, you should make sure they are never given this prescription medicine without a vet's supervision.

  3. How Should I Store Leukeran?

    Leukeran should be stored in a cool, dark place away from direct sunlight.

  4. What Are the Dosage Guidelines for Leukeran in Dogs and Cats?

    Leukeran is a prescription medicine and has a wide variety of uses. The dosage for your pet will depend on what condition they have, the severity of that condition, and the overall health and unique characteristics of your dog. Please stick to whatever dosage your et has recommended for you as it can vary widely.

Please note: Leukeran must be refrigerated and will be shipped overnight automatically.
  • Antibiotics Pharmacy
  • GlaxoSmithKline Manufacturer
  • Oral Application
  • Cat Pet Type
  • Dog Pet Type

How long does it take for the Leukeran to work with cats?

Leukeran takes two to four weeks to work with cats. Given that it is used in the treatment of cancer, you can expect Leukeran to take a bit of time before it starts showing its effects. As is the case with most cancer medications, Leukeran too will require a bit of time before it can work its magic. Hence, you should not make any sort of judgment call before that time. Be patient with it. Get in touch with your vet if the medication fails to show any positive effect after the mentioned time. Your vet will then advise you regarding the next steps you should take.

What is Leukeran for cats?

Leukeran is an FDA-approved drug used for cancer treatment in cats. It is a type of medication that is used for suppressing the immune system and to treat cancers such as leukemia, lymphoma, and multiple myeloma. Cancer is dangerous to your cat just as it is for any regular human being. They are more prone to this disease as they grow older. And while veterinary doctors and experts are still unsure as to why this connection between old age and cancer exists, they know one thing for sure โ€“ cancer is life-threatening. You should note that Leukeran is in no way a cure for cancer. It is merely part of the treatment process. It helps improve the quality of life of your cat.

How long will my cat be on Leukeran?

Your cat will be on Leukeran as prescribed by your vet. For dogs, usually, a two-week dosage is administered. Cats are given a daily dose for as long as the vet asks. You must not pause or stop the dosage at any cost, even if your cat is showing signs of improvement. Otherwise, the whole chain will collapse, and the medication might end up showing no positive result.

How long can a cat with lymphoma live on steroids?

A cat with lymphoma can live on steroids for one to two months. Steroids like prednisone alone can ensure a one to two-month survival time for your cat if it has a severe case of lymphoma. Your vet will be able to give you a more accurate timeline if they can have a closer look at your cat.

Should I give my cat Chlorambucil?

Yes, you should give your cat chlorambucil if it has inflammatory bowel disease or lymphocytic leukemia. However, before you give the medicine to your cat, you must first consult with a veterinary doctor. They will help you decide on the appropriate dosage for your cat. Otherwise, you might not be able to administer it properly or in the right amounts.

What happens if I touch Chlorambucil?

If you touch chlorambucil, it might lead to severe allergic reactions. To understand whether or not you have had an allergic reaction, check for rash or redness on the skin or slight peeling of the skin.

Should you put your cat through chemotherapy?

Yes, you should be able to put your cat through chemotherapy. Cats can tolerate chemo better than humans. So it should not be a problem.

Does Leukeran need to be refrigerated?

Yes, Leukeran needs to be refrigerated. It can tolerate normal temperatures for a week or so if not refrigerated.

Is Chlorambucil chemotherapy?

Chlorambucil is not chemotherapy, but it is a chemotherapy drug and part of the cancer treatment procedure.

What is the best medicine for dogs with cancer?

The best medicine for dogs with cancer depends on several factors, including the type of cancer, the stage of the disease, and the overall health of the dog. Treatment options for canine cancer can vary and may include a combination of surgery, radiation therapy, chemotherapy, immunotherapy, and palliative care. Chlorambucil is an alkylating agent that is sometimes used in veterinary oncology. It is primarily prescribed for certain types of cancer, including lymphoma and leukemia. Chlorambucil works by interfering with the growth of cancer cells. It is typically administered orally and should be given under the supervision of a veterinarian. Prednisolone is a corticosteroid commonly used in veterinary medicine. It has anti-inflammatory and immunosuppressive properties. Prednisolone is often prescribed to manage symptoms and reduce inflammation in dogs with certain types of cancer, such as lymphoma. It may help alleviate discomfort, improve appetite, and provide temporary relief. However, it's important to note that Prednisolone alone is not a curative treatment for cancer. There are various chemotherapy medications used in veterinary oncology to target and kill cancer cells. The specific drugs and protocols will depend on the type of cancer. Some commonly used chemotherapy drugs for dogs include doxorubicin, vincristine, cyclophosphamide, and carboplatin. Bisphosphonates, like pamidronate and zoledronate, may be used in cases where cancer has spread to the bones, causing pain or bone damage. These medications can help strengthen bones and reduce pain. Medications like Lomustine (CCNU) or Piroxicam can be used as immunomodulatory agents, which can help modulate the immune system's response to cancer cells and potentially slow down tumor growth.

What antibiotics treat cancer in dogs?

Antibiotics are primarily used to treat bacterial infections and are not typically used as a direct treatment for cancer in dogs. However, in some cases, antibiotics may be prescribed for dogs with cancer to prevent or treat secondary infections that can occur due to a weakened immune system or as a result of cancer treatments. Amoxicillin/Clavulanate combination antibiotic is effective against a broad range of bacteria and is commonly used to treat skin, respiratory, and urinary tract infections. Cephalexin is frequently prescribed to treat skin and soft tissue infections in dogs. Enrofloxacin is a fluoroquinolone antibiotic that is often used to treat urinary tract infections, respiratory infections, and some gastrointestinal infections.

What stops cancer in dogs?

The prevention and control of cancer in dogs involve various strategies, but there is no guaranteed method to completely stop cancer from occurring. In female dogs, spaying before the first heat cycle significantly reduces the risk of mammary gland tumors, which are often malignant. Neutering male dogs can help prevent testicular cancer and reduce the risk of certain prostate and perianal tumors. Provide your dog with a balanced diet, regular exercise, and a healthy lifestyle. Maintaining a healthy weight can help reduce the risk of certain cancers. Minimize exposure to environmental factors that may increase the risk of cancer in dogs. This includes limiting exposure to secondhand smoke, chemicals, pesticides, and other potentially harmful substances. Schedule regular check-ups with a veterinarian who can perform routine physical examinations, blood tests, and screenings to monitor your dog's health. Early detection of tumors or suspicious masses can lead to prompt diagnosis and treatment. Some breeds have a higher predisposition to certain types of cancer. For these breeds, regular cancer screening tests such as X-rays, ultrasounds, or blood tests may be recommended as part of their preventive care.

Can cat cancer be cured?

The outcome of cat cancer depends on various factors, including the type of cancer, its stage at the time of diagnosis, the cat's overall health, and the treatment options available. While some types of cancer in cats can be cured or effectively managed, it's important to note that not all cancers have curative treatment options. The treatment approach for cat cancer typically involves a combination of surgery, chemotherapy, radiation therapy, immunotherapy, and supportive care. The specific treatment plan will depend on the type and stage of cancer, as well as the veterinarian's recommendations. In some cases, early detection and intervention can lead to successful treatment and remission. For example, certain types of skin tumors or localized tumors may be surgically removed, resulting in a complete cure. However, other types of cancer, such as advanced or metastatic cancers, may have a less favorable prognosis, and the goal of treatment may shift towards palliative care to improve the cat's quality of life.

Is chemo painful for cats?

Chemotherapy treatment in cats is generally well-tolerated, and most cats do not experience significant pain during the administration of chemotherapy drugs. However, individual reactions and side effects can vary. Some cats may experience mild discomfort or side effects, while others may have a more pronounced response. Cats may experience nausea, vomiting, diarrhea, or loss of appetite. Anti-nausea medications can be prescribed to help manage these side effects. Chemotherapy drugs can affect the bone marrow, leading to a decrease in white blood cells, red blood cells, and platelets. This can result in a weakened immune system, anemia, and increased susceptibility to infections or bleeding. Blood tests are often performed to monitor these parameters, and supportive care measures may be taken to address any deficiencies or complications. Some chemotherapy drugs may cause hair loss or thinning of the coat in cats. This is generally temporary, and the hair usually regrows once treatment is completed. Cats undergoing chemotherapy may experience mild lethargy or reduced energy levels. They may need more rest and sleep during this time.

What is an anticancer diet for cats?

There is no specific "anticancer diet" that guarantees the prevention or cure of cancer in cats. However, a balanced and nutritious diet can support overall health and well-being, potentially aiding in disease prevention and management. Choose a high-quality, commercially prepared cat food that is specifically formulated for the cat's life stage (kitten, adult, senior) and meets the nutritional requirements set by recognized authorities, such as the Association of American Feed Control Officials (AAFCO). Cats are obligate carnivores and require a diet rich in animal-based protein. Ensure that the cat's food contains high-quality sources of protein, such as meat or fish. Cats have limited carbohydrate requirements, and excessive carbohydrate intake is not optimal for their health. Choose cat foods that have low levels of carbohydrates and are primarily focused on protein and fat. Cats have a low thirst drive and are prone to urinary tract issues. Feeding wet or canned food can help provide them with the necessary hydration and promote urinary tract health. Offer a variety of different protein sources (e.g., chicken, fish, turkey) and rotate flavors to provide a well-rounded diet. However, sudden dietary changes should be avoided as they can upset a cat's digestive system. Additionally, feeding in moderation and monitoring calorie intake are crucial to prevent obesity.

Each tablet contains 2mg Chlorambucil

Leukeran, a derivative of the nitrogen mustard chemical group is a veterinary medication used in treating leukemia as well as Hodgkinโ€™s disease in dogs and cats. Recognized as the alkylating agent, the medication is also effective in the management of the cancer affecting lymphatic system and tumors. The drug is also used in treating certain other immune-mediated conditions in animals. Leukeran, the active ingredient present in the medication is an antineoplastic and immunosuppressant, which acts by connecting DNA strands to modify protein formation. The medication also augments the production of lymphocytes, thus proving effective in the management of diseases that affects the immune system of animals, especially in cats. Leukeran is available only by prescription and comes in 2mg sugar coated tablets.

If your pet exhibits bruising, bleeding, infection, difficulty breathing, or low-energy, contact your veterinarian as these symptoms may be due to anemia or a bleeding disorder. Other side effects may include: low white blood cell count, low platelet count, damage to the gastrointestinal tract, bone marrow suppression, damage to the kidneys or liver, blood cell deficiency, lung disease, infertility in males, and hair loss in some breeds. Contact your veterinarian if you notice anything unusual.

Talk to your veterinarian and use with caution pregnant or young pets. Not for use in pets with pre-existing bone marrow suppression, already immune suppressed pets, or pets with chronic infections. Tell your veterinarian if your pet has experienced any medical diseases or conditions, digestive upset, or allergic reactions to Chlorambucil or similar products.

Tell your veterinarian about any other medications, vitamins, or supplements that your pet is taking. Possible drug interactions include: azathioprine, allopurinol, amphotericin B, colchicine, chloramphenicol, corticosteroids, and cyclophosphamide.

Leukeran works similar to chemotherapy that is sure to have issues with side effects. Bone marrow suppression is one of the most common of the adverse reactions that animals encounter. This can lead to anemia, or/and a decrease in the WBC count, though the animals will regain health when the medication is discontinued. Also, the hairy breeds in cats and dogs can experience hair loss.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.

The conditions for which the animals are being treated differ, so is the dosage, frequency and duration of medication. Always follow the directions provided by your veterinarian.

However, dogs are usually prescribed a dosage of 0.1mg/lbs to be provided orally for about two weeks. In cats, it is 0.05-0.1mg/lbs daily. In either case, continue the medication till the prescribed duration, even if the animal is registering steady improvement.

This medication is administered by mouth. Wear gloves when handling this medication. As a cancer drug, the usual dose is once a day, once every other day, or every 2-3 weeks. As an immunosuppressant, the usual dose is once a day or once every other day.

Store in a tightly sealed container in the refrigerator. Keep out of reach of children.

Leukeran is manufactured by GlaxoSmithKline

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