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CARDALIS is indicated with concurrent therapy (e.g. furosemide, etc.) for the management of clinical signs of mild, moderate, or severe congestive heart failure in dogs due to atrioventricular valvular insufficiency (AVVI) in dogs only. CARDALIS (spironolactone and benazepril hydrochloride chewable tablets) for dogs contains two active ingredients, spironolactone and benazepril hydrochloride, in a fixed ratio of 8:1 respectively. CARDALIS is supplied as oblong half scored flavored chewable tablets in three sizes:

20 mg spironolactone and 2.5 mg benazepril hydrochloride,
40 mg spironolactone and 5 mg benazepril hydrochloride, and
80 mg spironolactone and 10 mg benazepril hydrochloride.

Note that the option dosages available reflect the benazepril hydrochloride (2.5mg, 5mg, 10mg)
  • CEVA Animal Health Brand
  • Heart & Blood Pressure Pharmacy
  • Dog Pet Type

What is Cardalis used for?

Cardalis is a veterinary medication primarily used in the treatment of congestive heart failure in dogs, particularly those suffering from chronic degenerative valvular disease. CDVD is a common heart condition in older dogs, especially small breeds, where the heart valves become thickened and lose their functionality. This leads to a backward flow of blood, causing the heart to work harder and ultimately resulting in heart failure. Cardalis is a combination medication that contains two active ingredients: benazepril hydrochloride and spironolactone. According to Stephanie Howe, a DVM from Florida, benazepril is an angiotensin-converting enzyme (ACE) inhibitor. PetMD notes that it helps dilate blood vessels and reduce the workload on the heart. Spironolactone is a diuretic that helps remove excess fluid from the body, reducing the strain on the heart. The synergistic action of these two components helps manage the symptoms of heart failure, such as fluid retention and decreased cardiac function.

What is the side effect of Cardalis?

One of the most common side effects associated with Cardalis is renal impairment. This can manifest as an increase in blood urea nitrogen (BUN) and creatinine levels, indicating potential kidney dysfunction. According to, monitoring renal function through regular veterinary check-ups is crucial during Cardalis treatment. Additionally, the diuretic component, spironolactone, may lead to electrolyte imbalances, particularly high potassium levels (hyperkalemia). Hyperkalemia can have serious consequences, affecting the heart's electrical activity and potentially leading to arrhythmias or other cardiac issues. Therefore, regular monitoring of electrolyte levels is essential. Other possible side effects of Cardalis include lethargy, weakness, vomiting, diarrhea, and changes in appetite. It's important for pet owners to be vigilant and report any unusual behaviors or symptoms to their veterinarian promptly. In some cases, the veterinarian may need to adjust the dosage or discontinue the medication if side effects are severe.

What is the best medicine for dogs for heart disease?

According to Sonya G. Gordon, a DVM from Texas A&M University, angiotensin-converting enzyme (ACE) inhibitors are the most commonly prescribed medications for dogs with heart disease. These drugs help dilate blood vessels, reduce fluid buildup, and improve overall heart function. Another common type of medication is diuretics, like furosemide, which helps eliminate excess fluid from the body, alleviating symptoms of congestion and breathing difficulties. In certain cases, veterinarians may also prescribe pimobendan, a drug that enhances the heart's ability to pump blood and improves overall cardiac function. Additionally, beta-blockers, such as carvedilol, might be recommended to regulate heart rhythm and reduce strain on the heart. It's crucial to note that medication alone might not be sufficient, and a comprehensive treatment plan may include dietary modifications and regular check-ups. Nutrition plays a vital role in managing heart disease, and specialized prescription diets with restricted sodium content are often recommended.

Is Cardisure the same as Cardalis?

Cardisure and Cardalis are related medications designed for the management of heart conditions in dogs, but they are not exactly the same. Both medications are commonly prescribed for dogs with heart disease, specifically for congestive heart failure associated with chronic valvular disease. However, they have different active ingredients and serve slightly different purposes. According to a document shared by HPRA, Cardisure typically contains the active ingredient pimobendan. Pimobendan is a positive inotrope and vasodilator, meaning it helps the heart pump more effectively while also dilating blood vessels. This can be particularly beneficial for dogs with conditions like dilated cardiomyopathy. On the other hand, Cardalis is a combination medication that contains two active ingredients: benazepril and spironolactone. Benazepril is an angiotensin-converting enzyme (ACE) inhibitor, which helps dilate blood vessels and reduce fluid buildup. Spironolactone is a diuretic that aids in removing excess fluid from the body, reducing congestion in the lungs, and improving overall heart function. Cardalis is often prescribed for dogs with congestive heart failure due to chronic valvular insufficiency. While both medications aim to manage heart disease in dogs, the choice between Cardisure and Cardalis depends on the needs of the individual dog.

How quickly does Cardalis work?

The speed at which Cardalis works can vary among individual cases and depends on various factors. This includes the severity of the dogโ€™s condition, the dog's overall health, and its response to the medication. While some dogs may show signs of improvement within a few days, it typically takes several weeks to observe the full therapeutic effects. The initial phase of treatment may involve stabilizing the dog's condition, managing symptoms, and addressing any immediate concerns. Over time, Cardalis aims to slow the progression of heart failure and improve the dog's quality of life. Owners should be patient and vigilant during the treatment period, as individual responses to medication can vary.

Do not administer CARDALIS in conjunction with non-steroidal anti-inยญammatory drugs (NSAIDs) in dogs with renal insuโ€‘ciency. Do not administerCARDALIS to dogs with hypoadrenocorticism (Addisonโ€™s Disease), hyperkalemia, or hyponatremia. Do not administer CARDALIS to animals with known hypersensitivity to ACE inhibitors or spironolactone.

How to Order Prescriptions Online

1. Find the Right Product

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2. Add to Cart

Just like any other online store. Make sure the quantity matches whatโ€™s been prescribed by your vetinarian.

3. Tell Us About Your Pet and Vet

Answer some questions during checkout and weโ€™ll contact your vet and verify the prescription for you. You can also mail us the written prescription.

4. Thatโ€™s It!

If the prescription has any refills, processing your future orders for that medication can be expedited.

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Awesome medicine

Thank you so much for helping my family and I with the medication that is needed for my loving Furbaby Boo Boo

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I have been doing business with your company for almost a year now and I have never had not one complaint. Thank you so much for your time and patience with the help and care for my baby. God bless you all and continue to keep doing the amazing work.

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