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Trifexis is a powerful and effective means of preventing heartworm disease, as well as protect against fleas and a number of other worms and parasites.

Options Available: 5-10 lbs., 6 pack 10.1-20 lbs., 6 pack 20.1-40 lbs., 6 pack 40.1-60 lbs., 6 pack 60.1-120 lbs., 6 pack

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Rated 4.5 out of 5 by 159 reviewers.
Rated 4 out of 5by Most successful product we have tried in this category.Very good, easy, and expensive. Most successful product we have tried in this category. 12/08/2013
Rated 4 out of 5by I like the convenience of TrifexisGreat product to combat multiple problems that happento pets. Use to use Comfortis (made with same drug tocombat fleas) but now this is combined to helpwith heartworms!Product is expensive, but my 3 big dogs are worth everypenny!Thanks! 11/27/2013
Rated 5 out of 5by Needed for protection and better price than at the Vet officeAs far as I can tell triflexis works for my two dogs but as far as any far reaching side effects , it is difficult to know....One dog requires me to crush the pill otherwise I cannot get her to take it even with food etc.... 11/23/2013
Rated 2 out of 5by Not so hot, but it worksIf you can get your dog to eat this, good for you! It smells like pesticide, not beef! and the tablet for my 25 lb dog is huge. You can't hide the smell so the dog won't eat the stinking thing which means you have to shove it down his throat! 11/18/2013
Rated 3 out of 5by mixed resultsmy smaller dog (let's call him a maltepoo) has thrown up each of the first two times we have given it to him. he is 15 lbs and we have given him the pill for 10 lbs to 20lbs. expensive trial gone larger dog (let's call him a husky shepherd) acted a bit sluggish after the first (and only) time we have given it to him but he did not get sick. he is 55 lbs and we gave him the pill for 40 lbs to 60 lbs. 11/11/2013
Rated 5 out of 5by Easy and effective for dual protectionTrifexis is a once a month chewable tablet that protects your pet against heartworm and fleas. It's so easy to administer and the dog much prefers a treat than having to endure the application of topical flea prevention! 11/04/2013
Rated 5 out of 5by Great Product!I used to use Sentinel (until it was recalled) and was always happy with everything it did, EXCEPT the fact that it didn't kill fleas (it only sterilized them.) So even though this was a pretty expensive change, its well worth it to only have to give my dogs ONE pill to cover all bases.My only issues are 1. The pills are BIG. I usually have to cut them in half because my 65lb dogs can't/won't swallow them whole. 2. They're not offered in a 12 month supply, so I have to purchase a pack every 3 months because I have 2 dogs. 10/29/2013
Rated 5 out of 5by Great response from product but...My concern is my dog is not quite at 22lbs and will be dropping 2-4 lbs. Currently dosage for her goes up to 40lbs. I'm not comfortable giving her meds for almost twice her weight and vet won't drop dosage to 20lbs dosage. For that reason ONLY I've stopped Trifexis. 10/27/2013
Rated 4 out of 5by Dogs Hate TheseMy dogs hate these! I have a 100lb dog who has to take a very large pill & it is very hard getting it down her. My smaller dog doesn't like them either, but I can wrap pill in a piece of meat and get it down her, since her pill is small. My friends with dogs have the same problem. They need to do something to make these more palatable to dogs.I assume the are effective since I see no sign of fleas and hope never have a heart worm problem. 10/22/2013
Rated 3 out of 5by It worksOne stop shopping for dogs & their owners. One pill for multiple uses than giving dogs three different pills. 10/19/2013
Rated 4 out of 5by All in one heart guard and pest control medicineGreat product for the one and done folks. Pill itself is a little large and must be broken up (and mixed with treats) for our pet to take. 10/16/2013
Rated 5 out of 5by Great ProductI will definitely continue to use Trifexis for my two dogs. I have been using it for a couple of years now and I have had zero problems with fleas and/or ticks. Usually, I smash the pill up inside a plastic bag with a rolling pin and then empty the pill into some wet dog food. My dogs eat it up like they normally would eat a treat like that. My dogs are very healthy and happy! It is a little pricey, but I think it is worth it!! It definitely beats having to worry about fleas on your dog, on you, and all over your house! 10/11/2013
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