IMPORTANT SAFETY INFORMATION: Quinolones have been shown to cause arthropathy in immature animals of most species tested, the dog being particularly sensitive to this side effect. Orbifloxacin is contraindicated in dogs and cats known to be hypersensitive to quinolones. In animals with known or suspected central nervous system (CNS) disorders, quinolones, in rare instances, have been associated with CNS stimulation, which may lead to convulsive seizures. The use of fluoroquinolones in cats has been reported to adversely affect the retina and should be used with caution in cats. Blindness has also been reported post-approval in cats. In some cases, blindness has been temporary. See Package Insert for full information including side effects, precautions, warnings, and contraindications.
Do not administer the drug should to animals allergic to it or other quinolone antibiotics. Avoid dispensing the medication to pregnant or nursing animals, puppies, and those with central nervous system disorders such as seizures or epilepsy. The active ingredient may interact with other medicines. Practice caution when used with antacids, vitamin and mineral products, phenytoin, stomach protectants, sucralfate, theophylline, probenecid, and NSAIDs like aspirin and Rimadyl. To be on the safer side, inform the veterinarian or pharmacist about the medications the pet is taking.