Extreme caution is required when used in animals with digitalis overdose, ventricular fibrillation, electrolyte abnormalities and other kidney, heart or lung disorders. The medication should not be used in animals with hyperthyroidism, ventricular fibrillation, kidney failure or allergy to the drug. Using the drug in animals with allergy to digoxin could result in adverse side effects. Antacids and metoclopramide tend to reduce the effect of digoxin. Avoid using the medication with diuretics like furosemide or HCTZ, quinidine, verapamil, laxatives, tetracycline, chemotherapy drugs, erythromycin or corticosteroids like prednisone. It is advised to inform the veterinarian or pharmacist about the medications the pet is taking. Keep the medication at room temperature, away from excess heat, moisture and light. The dosage of the drug should be chosen with care, depending on the clinical condition of the pet.