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October 04, 2013
The generic name for Diflucan, Fluconazole is a great way to get rid of a fungal infection, inhibiting the formation of the fungal cell wall, thereby resulting in cell death and the death of the organism. Working against infections under the nails, ringworm, blastomycosis, or cryptococcosis, this medication does a number on some dangerous fungal infections that might otherwise do damage to the skin, claws, brain, respiratory tract, bones, or other tissues. An ‘extra-label’ medication, it is not approved for use in pets by the FDA, but can legally be prescribed by a vet.
Fluconazole should never be used in patients with liver disease, and patients with kidney disease may need to have the intervals and dosage adjusted. Pregnant pets should only take fluconazole if the benefits outweigh the risks.
Fluconazole might increase the risk of heart problems caused by terfenadine and astemizole. Anticoagulants might cause increased prothrombin times, and antidiabetic drugs might increase their serum levels, resulting in hypoglycemia, when taken with fluconazole. Fluconazole might inhibit the metabolism of cisapride, resulting in high plasma concentrations, which has been linked to fatal cardiac arrhythmias. Fluconazole might increase cyclosporine levels or plasma levels (when used with hydrochlorothiazide). Rifampin might increase the metabolism rate of fluconazole.
Dogs -- 2.5 - 5 mg/kg orally or IV once a day, or 1.25 - 2.5 mg/kg orally or IV twice a day, for 8 - 12 weeks Cats -- 2.5 - 10 mg/kg orally every 12 hours for 1 month
Vomiting, diarrhea, skin rashes, loss of appetite, increased liver enzymes, hepatic toxicity, or thrombocytopenia are all possible, but not common, side effects of fluconazole.
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