Aminophylline Injections should be used cautiously in patients with cardiac disease, gastrointestinal ulcers, hyperthyroidism, renal or hepatic disease, severe hypoxia or hypertension, or glaucoma. Taking this medication may cause cardiac arrhythmias to worsen. Elderly patients may be more prone to side effects, along with patients suffering from congestive heart failure. An intramuscular injection of aminophylline is extremely painful.
Aminophylline Injections should not be taken with sympathomimetic or beta adrenergic blockers, due to potential toxic synergism or antagonistic effects.
Drugs like allopurinol, cimetidine, clindamycin, erythromycin, lincomycin, or thiabendazole may increase the effects of aminophylline
Ciprofloxacin and enrofloxacin are likely to cause a reduced ability to metabolize aminophylline, resulting in toxicity.
Halothane might increase the risk of arrhythmias.
Isoproterenol can cause toxic synergism.
Ketamine can increase the risk of seizures.
Pancuronium bromide and sucralfate might decrease the effects of aminophylline.
Phenobarbital and phenytoin sodium increase the clearance of aminophylline, lessening its efficacy.