Sterility of the solution has to be strictly maintained and the dispenser should not come in contact with the eye. Extreme caution is called for, while administering this medication in pregnant pets or in those having a record of hypersensitivity specifically to this drug or corticosteroids in general. Never use Prednisolone acetate if there is any fungal ophthalmic infection.Extended application of this medicine might result in glaucoma, corneal and scleral thinning, damage to the optical nerve or posterior subcapsular cataract formation. It also paves the way for a host of secondary eye infections as it has immunosuppressive properties. If bacterial infection is present in the eyes, it should be managed prior to applying Prednisolone acetate as it lacks antimicrobial features. It might also cover up purulent infections of the eye, or worsen the severity of various ophthalmic viral infections such as herpes simplex. If the situation warrants the application of Prednisolone acetate for more than ten days, intraocular pressure needs to be monitored regularly. Post operative healing of cataract might be delayed with increased chances of bleb formation. If there is no marked improvement in the condition even after 48 hours of treatment the medication should be withdrawn.