A Guide to Desoximetasone, Generic of Topicort for Pets

An Extremely Potent Anti-Inflammatory Cream for Cats and Dogs

By Sam Bourne.

  • Arthritis (Osteoarthritis)
  • Cushing's Disease
  • Hot Spots
  • Pruritus (Scratching/Itching)
  • Pyoderma (Skin Infection)

indications for Desoximetasone

Desoximetasone is a Group II topical steroid, which means it belongs to the second strongest classification of this type of drug. Topical steroids are used to help reduce inflammation, such as ear or eye infections, rashes, or other skin ailments. Being such a potent variation of the corticosteroid drug family, Desoximetasone is mainly used for serious skin conditions, like psoriasis or eczema, or for serious ear or eye infections that are not responding to milder treatments. Because of its immunosuppressive tendencies (reduces the bodies immune response), it can also be used to treat chronic disorders stemming from an overactivity of the immune system, like Rheumatoid arthritis. Desoximetasone is also frequently used in diagnostic tests, helping to see how cortisol levels are affected by the presence of this drug, which can help in detecting various types of illness, such as Cushing’s disease.


Being such a powerful corticosteroid, this drug should be used with a fair amount of caution. Pets with diabetes, Cushing’s, hypertension, systemic infections, osteoporosis, glaucoma, heart problems, ulcers, pregnancy, or kidney disease, should all notify their vet before taking Desoximetasone.

Desoximetasone may cause a negative reaction when taken with Aspirin, Cyclophosphamide, Cyclosporine, Amphotericin, Digoxin, Daunorubicin HCl, Doxorubicin HCl, Insulin, Mitotane, Phenobarbital, Phenytoin sodium, Rifampin, or Rimadyl.


Since desoximetasone is a topical cream intended for use in humans, its usage in pets is considered ‘extra-label’ and should only be given if directed by a vet, and only in the amount decided upon.

Brand/Generic equivalents


Side Effects

Desoximetasone may cause a change in disposition, an increased likelihood for seizures, increase in appetite and thirst, urination, and a lowered immune response. Symptoms of a problem with desoximetasone might be vomiting, panting, diarrhea, and lethargy.

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Desoximetasone at a glance

  • 1For dogs and cats
  • 2A steroid medication
  • 3A topical medication
  • 4Reduces inflammation and immune response

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